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PE20020541A1 - Agonistas del receptor b3-adrenergico y usos de los mismos - Google Patents

Agonistas del receptor b3-adrenergico y usos de los mismos

Info

Publication number
PE20020541A1
PE20020541A1 PE2001001039A PE2001001039A PE20020541A1 PE 20020541 A1 PE20020541 A1 PE 20020541A1 PE 2001001039 A PE2001001039 A PE 2001001039A PE 2001001039 A PE2001001039 A PE 2001001039A PE 20020541 A1 PE20020541 A1 PE 20020541A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
compounds
so2r9
nr9r10
Prior art date
Application number
PE2001001039A
Other languages
English (en)
Inventor
Robert Francis Day
Jennifer Anne Lafontaine
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20020541A1 publication Critical patent/PE20020541A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07—ORGANIC CHEMISTRY
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
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  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • AIDS & HIV (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS ARILETANOLAMINAS DE FORMULA I DONDE R ES H, OH, OXO, HALOGENO, ALQUILO C1-C6, ALCOXI C1-.C6, CICLOALQUILO C3-C8, NR9R10, SO2R9; R1 ES H, ALQUILO C1-C6, HALOGENO, ALCOXILO C1-C6, OH; Ar ES PIRIDILO, OXAZOLILO, TIAZOLILO, FENILO; R2, R3, R4 SON H, ALQUILO C1-C6; X ES UN ENLACE O; R8 ES H, ALQUILO C1-C4, HALOGENO; Y ES UN ENLACE, ALQUILO C1-C6, OCH2, CH2O; R5 ES UN HETEROCICLO DE 5-6 MIEMBROS; R6 Y R7 SON H, HALOGENO, CIANO, OXO, CO2R9, NR9R10, OH, ALCOPXI C1-C6, CONR9R10, NR9SO2R10, SO2NR9R10, SO2R9, ALQUILO C1-C6; R9 Y R10 SON H, ALQUILO C1-C6, ALQUILALCOXILO, ALCOXILO C1-C6, ARILO, HETEROCICLO. SON COMPUESTOS PREFERIDOS (R)-2-{2-[4-(4-BENZOFURAN-2-IL-TIAZOL-2-IL)-FENOXI]-ETILAMINO}-1-PIRIDIN-3-ILETANOL; (R)-N-[2-CLORO-5-(2-{2[4-(2-ETIL-OXAZOL-4-IL)-FENOXI]-ETILAMINO}-1-HIDROXI-ETIL)-FENIL]METANOSULFONAMIDA; TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS UN AGENTE ANTIOBESIDAD COMO INHIBIDOR DE APO-B(MTP), AGONISTA DE MCR-4, AGONISTA DE CCK-A, UN INHIBIDOR DE LA REABSORCION MONOAMINICA, UN AGENTE SIMPATICOMIMETICO, AGENTE SEROTONERGICO, AGONISTA DE DOPAMINA, ENTRE OTROS; SIENDO DE PREFERENCIA FENTERMINA, EFEDRINA, LEPTINA, FENILPROPANOLAMINA, PSEUDOEFEDRINA, SIBUTRAMINA, FENFLURAMINA, DEXFENFLURAMINA, BROMOCRIPTINA, ORLISTAT, BOMBESINA. LOS COMPUESTOS SON AGONISTAS DEL RECEPTOR ß3 ADRENERGICO Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE OBESIDAD DIABETES, SINDROME DEL COLON IRRITABLE, ENFERMEDAD INTESTINAL INFLAMATORIA, ESOFAGITIS, DUODENITIS
PE2001001039A 2000-10-20 2001-10-18 Agonistas del receptor b3-adrenergico y usos de los mismos PE20020541A1 (es)

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US24227400P 2000-10-20 2000-10-20

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PE20020541A1 true PE20020541A1 (es) 2002-06-20

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US (2) US6566377B2 (es)
EP (1) EP1326861A1 (es)
JP (1) JP2004511555A (es)
KR (1) KR20030044013A (es)
CN (1) CN1469876A (es)
AP (1) AP2001002307A0 (es)
AR (1) AR035716A1 (es)
AU (1) AU2001292161A1 (es)
BG (1) BG107652A (es)
BR (1) BR0114836A (es)
CA (1) CA2423792A1 (es)
CR (1) CR6935A (es)
CZ (1) CZ20031012A3 (es)
DO (1) DOP2001000270A (es)
EA (1) EA200300305A1 (es)
EC (1) ECSP034562A (es)
EE (1) EE200300191A (es)
GT (1) GT200100210A (es)
HR (1) HRP20030297A2 (es)
HU (1) HUP0301382A2 (es)
IL (1) IL154911A0 (es)
IS (1) IS6748A (es)
MA (1) MA26954A1 (es)
MX (1) MXPA03003455A (es)
NO (1) NO20031573L (es)
PA (1) PA8530401A1 (es)
PE (1) PE20020541A1 (es)
PL (1) PL362076A1 (es)
SK (1) SK4612003A3 (es)
SV (1) SV2003000697A (es)
TN (1) TNSN01148A1 (es)
UY (1) UY26974A1 (es)
WO (1) WO2002032897A1 (es)
ZA (1) ZA200302191B (es)

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WO2002089729A2 (en) 2001-05-04 2002-11-14 Tularik Inc. Fused heterocyclic compounds
WO2003072571A1 (en) * 2002-02-27 2003-09-04 Pfizer Products Inc. Salt of a pyridyl ethanolamine derivative and its use as a beta-3-adrenergic receptor agonist
US6864268B2 (en) 2002-02-27 2005-03-08 Pfizer Inc. β3 adrenergic receptor agonists
WO2003072573A1 (en) * 2002-02-27 2003-09-04 Pfizer Products Inc. Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
WO2003072547A1 (en) * 2002-02-27 2003-09-04 Pfizer Products Inc. PROCESSES AND INTERMEDIATES USEFUL IN PREPARING β3-ADRENERGIC RECEPTOR AGONISTS
DOP2003000587A (es) * 2002-02-27 2003-08-30 Pfizer Prod Inc AGONISTAS DEL RECEPTOR ß3-ADRENERGICO
WO2003077847A2 (en) 2002-03-12 2003-09-25 Merck & Co., Inc. Substituted amides
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