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PE20020509A1 - Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih - Google Patents

Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih

Info

Publication number
PE20020509A1
PE20020509A1 PE2001001008A PE2001001008A PE20020509A1 PE 20020509 A1 PE20020509 A1 PE 20020509A1 PE 2001001008 A PE2001001008 A PE 2001001008A PE 2001001008 A PE2001001008 A PE 2001001008A PE 20020509 A1 PE20020509 A1 PE 20020509A1
Authority
PE
Peru
Prior art keywords
alkyl
fluoroalkyl
poliaza
aza
inhibitors
Prior art date
Application number
PE2001001008A
Other languages
English (en)
Inventor
Neville J Anthony
Linghang Zhuang
Melissa Egbertson
Mark Embrey
Thorsten E Fisher
Timothy W Funk
Robert P Gomez
James P Guare
Samson M Jolly
Michelle S Kuo
H Marie Langford
Jeffrey Y Melamed
Debra S Perlow
Lekhanh Tran
John S Wai
Steven D Young
Jennifer J Bennett
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20020509A1 publication Critical patent/PE20020509A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS AZA Y POLIAZA-NAFTALENIL CARBOXAMIDAS DE FORMULA I DONDE A ES GRUPO AROMATICO, GRUPOS BICICLICOS; L ES UNA SOLA UNION, -(CH2)1-3, -(CH2)1-2OH, ENTRE OTROS; Q2 ES H, ALQUILO C1-C4, FLUOROALQUILO C1-C4, ENTRE OTROS; Q4 ES H, ALQUILO C1-C4, FLUOROALQUILO C1-C4, -O- ALQUILO C1-C4, ENTRE OTROS; R1 Y R2 SON H, ALQUILO C1-C4, FLUOROALQUILO C1-C4, -O-ALQUILO C1-C4, OH, ENTRE OTROS; R3 Y R4 SON H, HALO, CN, OH, ALQUILO C1-C4, FLUOROALQUILO C1-C4, ENTRE OTROS; R5 ES H, ALQUILO C1-C4, FENILO, ALQUILO C1-C4 SUSTITUIDO CON FENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-1-(7-{[(4-FLUOROBENCIL)AMINO]CARBONIL}-8-HIDROXI-1,6-NAFTIRIDIN-5-IL)-N-1-,N-2,N-2-TRIMETILETANDIAMIDA, 5-(1,1-DIOXIDO-1,2-TIACINAN-2-IL)-N-(4-FLUOROBENCIL)-8-HIDROXI-1,6-NAFTIRIDIN-7-CARBOXAMIDA, N-(4-FLUOROBENCIL)-5-(1,1,-DIOXIDO-1,2,5-TIADIACEPAN-2-IL)-8-HIDROXI-[1,6]NAFTIRIDIN-7-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON UTILES COMO INHIBIDORES DE LA INTEGRASA DEL VIH UTIL PARA LA PREVENCION Y TRATAMIENTO DEL INICIO DE SIDA
PE2001001008A 2000-10-12 2001-10-11 Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih PE20020509A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23970700P 2000-10-12 2000-10-12
US28165601P 2001-04-05 2001-04-05

Publications (1)

Publication Number Publication Date
PE20020509A1 true PE20020509A1 (es) 2002-06-20

Family

ID=26932782

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001008A PE20020509A1 (es) 2000-10-12 2001-10-11 Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih

Country Status (26)

Country Link
US (2) US6921759B2 (es)
EP (1) EP1326865B1 (es)
JP (1) JP4252797B2 (es)
KR (1) KR20030036922A (es)
CN (1) CN1469878A (es)
AR (1) AR033845A1 (es)
AT (1) ATE430745T1 (es)
AU (3) AU2002211527B2 (es)
BG (1) BG107677A (es)
BR (1) BR0114610A (es)
CA (1) CA2425440C (es)
CZ (1) CZ20031028A3 (es)
DE (1) DE60138635D1 (es)
EA (1) EA200300449A1 (es)
EE (1) EE200300145A (es)
HU (1) HUP0302367A2 (es)
IL (1) IL155089A0 (es)
IS (1) IS6760A (es)
MX (1) MXPA03003263A (es)
NO (1) NO20031672L (es)
NZ (1) NZ525088A (es)
PE (1) PE20020509A1 (es)
PL (1) PL360944A1 (es)
SK (1) SK4322003A3 (es)
WO (2) WO2002030931A2 (es)
YU (1) YU27903A (es)

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WO2002030930A2 (en) 2002-04-18
JP4252797B2 (ja) 2009-04-08
ATE430745T1 (de) 2009-05-15
BG107677A (bg) 2003-11-28
JP2004511483A (ja) 2004-04-15
CA2425440A1 (en) 2002-04-18
EP1326865A2 (en) 2003-07-16
NO20031672L (no) 2003-06-05
IL155089A0 (en) 2003-10-31
AU1152702A (en) 2002-04-22
EP1326865B1 (en) 2009-05-06
EE200300145A (et) 2003-06-16
CA2425440C (en) 2010-04-13
PL360944A1 (en) 2004-09-20
WO2002030931A2 (en) 2002-04-18
WO2002030930A3 (en) 2002-08-29
CZ20031028A3 (cs) 2003-08-13
SK4322003A3 (en) 2003-09-11
DE60138635D1 (de) 2009-06-18
KR20030036922A (ko) 2003-05-09
YU27903A (sh) 2006-05-25
US20030055071A1 (en) 2003-03-20
NO20031672D0 (no) 2003-04-11
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NZ525088A (en) 2004-11-26
AR033845A1 (es) 2004-01-07
WO2002030931A3 (en) 2002-10-24
EA200300449A1 (ru) 2003-10-30
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