PE20011190A1 - Compuestos de 3,4-dianilino-ciclobut-3-en-1,2-diona como antagonistas de los receptores de interleuquina-8 (il-8) - Google Patents
Compuestos de 3,4-dianilino-ciclobut-3-en-1,2-diona como antagonistas de los receptores de interleuquina-8 (il-8)Info
- Publication number
- PE20011190A1 PE20011190A1 PE2001000204A PE2001000204A PE20011190A1 PE 20011190 A1 PE20011190 A1 PE 20011190A1 PE 2001000204 A PE2001000204 A PE 2001000204A PE 2001000204 A PE2001000204 A PE 2001000204A PE 20011190 A1 PE20011190 A1 PE 20011190A1
- Authority
- PE
- Peru
- Prior art keywords
- diona
- cyclobut
- compounds
- dianilino
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 2
- -1 2-BROMOANILINO Chemical class 0.000 abstract 3
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- DUAJIKVIRGATIW-UHFFFAOYSA-N trinitrogen(.) Chemical class [N]=[N+]=[N-] DUAJIKVIRGATIW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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Abstract
SE REFIERE A COMPUESTOS DE 3,4-DIANILINO-CICLOBUT-3-EN-1,2-DIONA DE FORMULA I DONDE R ES OH, SH, NHSO2Rd; Rd ES NR6R7, ALQUILO, ARILALQUILO C1-C4, ARILALQUENILO C2-C4, HETEROARILO, HETEROARILALQUILO C1-C4, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C4, R6 Y R7 JUNTO A N FORMAN UN ANILLO DE 5 A 7 MIEMBROS; R1 ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10, ALQUENILO C2-C10, ALCOXI C1-C10, AZIDO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 3-(4-CIANO-2-HIDROXIANILINO)-4-(2-BROMOANILINO)-CICLOBUT-3-EN-1,2-DIONA, 3-(4-CIANO-2-HIDROXIANILINO)-4-(2-CLOROANILINO)-CICLOBUT-3-EN-1,2-DIONA, 3-(4-CIANO-2-HIDROXIANILINO)-4-(2,3-DICLOROANILINO)-CICLOBUT-3-EN-1,2-DIONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS DE 3,4-DIANILINO-CICLOBUT-3-EN-1,2-DIONA ACTUAN COMO ANTAGONISTAS DE LOS RECEPTORES DE INTERLEUQUINA-8 (IL-8) Y SON UTILES PARA EL TRATAMIENTO DE PSORIASIS, DERMATITIS, OSTEOARTRITIS, ARTRITIS REUMATOIDE, ASMA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18618300P | 2000-03-01 | 2000-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011190A1 true PE20011190A1 (es) | 2002-01-06 |
Family
ID=22683958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000204A PE20011190A1 (es) | 2000-03-01 | 2001-03-01 | Compuestos de 3,4-dianilino-ciclobut-3-en-1,2-diona como antagonistas de los receptores de interleuquina-8 (il-8) |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1261328B1 (es) |
| JP (1) | JP2003525242A (es) |
| KR (1) | KR20020080460A (es) |
| CN (1) | CN1416339A (es) |
| AP (1) | AP2002002605A0 (es) |
| AR (1) | AR033803A1 (es) |
| AT (1) | ATE299698T1 (es) |
| AU (1) | AU2001239970A1 (es) |
| BG (1) | BG107014A (es) |
| BR (1) | BR0108866A (es) |
| CA (1) | CA2401659A1 (es) |
| CZ (1) | CZ20022932A3 (es) |
| DE (1) | DE60112051T2 (es) |
| DZ (1) | DZ3309A1 (es) |
| EA (1) | EA200200933A1 (es) |
| ES (1) | ES2245976T3 (es) |
| HU (1) | HUP0300599A3 (es) |
| IL (1) | IL151429A0 (es) |
| MA (1) | MA25657A1 (es) |
| MX (1) | MXPA02008589A (es) |
| NO (1) | NO20024133L (es) |
| OA (1) | OA12184A (es) |
| PE (1) | PE20011190A1 (es) |
| PL (1) | PL358540A1 (es) |
| SK (1) | SK12352002A3 (es) |
| UY (1) | UY26601A1 (es) |
| WO (1) | WO2001064208A1 (es) |
| ZA (1) | ZA200206988B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2411323A1 (en) * | 2000-05-30 | 2001-12-06 | Michael R. Palovich | Il-8 receptor antagonists |
| ATE419845T1 (de) * | 2001-01-16 | 2009-01-15 | Smithkline Beecham Corp | Il-8-rezeptor-antagonisten |
| SK9782003A3 (en) * | 2001-02-02 | 2004-01-08 | Schering Corp | 3,4-Di-substituted cyclobutene-1,2-diones as CXC chemokine receptor antagonists |
| US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| CN1990457A (zh) * | 2001-04-16 | 2007-07-04 | 先灵公司 | 作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮 |
| CA2462862A1 (en) * | 2001-10-12 | 2003-04-17 | Schering Corporation | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
| US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| BR0308739A (pt) | 2002-03-18 | 2005-01-11 | Schering Corp | Tratamentos em combinação para doenças mediadas por quimiocina |
| JP4664074B2 (ja) * | 2002-10-09 | 2011-04-06 | シェーリング コーポレイション | Ｃｘｃ−ケモカインレセプターリガンドおよびｃｃ−ケモカインレセプターリガンドとしてのチアジアゾールジオキシドおよびチアジアゾールオキシド |
| WO2005066147A1 (en) * | 2003-12-19 | 2005-07-21 | Schering Corporation | Thiadiazoles as cxc- and cc- chemokine receptor ligands |
| CN1918156B (zh) * | 2003-12-22 | 2010-10-27 | 先灵公司 | 作为cxc-和cc-趋化因子受体配体的异噻唑二氧化物 |
| DE602006017849D1 (de) | 2005-06-29 | 2010-12-09 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors |
| US7718678B2 (en) | 2005-06-29 | 2010-05-18 | Schering Corporation | Di-substituted oxadiazoles as CXC-chemokine receptor ligands |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| AU2019205786B2 (en) | 2018-01-08 | 2023-12-14 | Chemocentryx, Inc. | Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2 |
| CN112851635B (zh) * | 2019-11-28 | 2022-09-16 | 中国医学科学院药物研究所 | 环状砜类化合物及其制备方法、用途和药物组合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
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2001
- 2001-02-27 AR ARP010100889A patent/AR033803A1/es unknown
- 2001-03-01 MX MXPA02008589A patent/MXPA02008589A/es unknown
- 2001-03-01 EA EA200200933A patent/EA200200933A1/ru unknown
- 2001-03-01 AU AU2001239970A patent/AU2001239970A1/en not_active Abandoned
- 2001-03-01 IL IL15142901A patent/IL151429A0/xx unknown
- 2001-03-01 UY UY26601A patent/UY26601A1/es not_active Application Discontinuation
- 2001-03-01 ES ES01914603T patent/ES2245976T3/es not_active Expired - Lifetime
- 2001-03-01 CA CA002401659A patent/CA2401659A1/en not_active Abandoned
- 2001-03-01 OA OA1200200261A patent/OA12184A/en unknown
- 2001-03-01 AT AT01914603T patent/ATE299698T1/de not_active IP Right Cessation
- 2001-03-01 AP APAP/P/2002/002605A patent/AP2002002605A0/en unknown
- 2001-03-01 PE PE2001000204A patent/PE20011190A1/es not_active Application Discontinuation
- 2001-03-01 HU HU0300599A patent/HUP0300599A3/hu unknown
- 2001-03-01 BR BR0108866-1A patent/BR0108866A/pt not_active Application Discontinuation
- 2001-03-01 CN CN01805908A patent/CN1416339A/zh active Pending
- 2001-03-01 EP EP01914603A patent/EP1261328B1/en not_active Expired - Lifetime
- 2001-03-01 SK SK1235-2002A patent/SK12352002A3/sk unknown
- 2001-03-01 PL PL01358540A patent/PL358540A1/xx not_active Application Discontinuation
- 2001-03-01 DE DE60112051T patent/DE60112051T2/de not_active Expired - Fee Related
- 2001-03-01 KR KR1020027011448A patent/KR20020080460A/ko not_active Withdrawn
- 2001-03-01 DZ DZ013309A patent/DZ3309A1/fr active
- 2001-03-01 CZ CZ20022932A patent/CZ20022932A3/cs unknown
- 2001-03-01 JP JP2001563105A patent/JP2003525242A/ja not_active Withdrawn
- 2001-03-01 WO PCT/US2001/006564 patent/WO2001064208A1/en not_active Ceased
-
2002
- 2002-08-20 BG BG107014A patent/BG107014A/bg unknown
- 2002-08-30 ZA ZA200206988A patent/ZA200206988B/en unknown
- 2002-08-30 NO NO20024133A patent/NO20024133L/no not_active Application Discontinuation
- 2002-09-02 MA MA26799A patent/MA25657A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1261328A4 (en) | 2003-05-28 |
| DE60112051D1 (de) | 2005-08-25 |
| JP2003525242A (ja) | 2003-08-26 |
| ES2245976T3 (es) | 2006-02-01 |
| ZA200206988B (en) | 2003-10-16 |
| WO2001064208A1 (en) | 2001-09-07 |
| MXPA02008589A (es) | 2003-02-24 |
| IL151429A0 (en) | 2003-04-10 |
| KR20020080460A (ko) | 2002-10-23 |
| NO20024133L (no) | 2002-10-31 |
| AR033803A1 (es) | 2004-01-07 |
| EP1261328A1 (en) | 2002-12-04 |
| EA200200933A1 (ru) | 2003-02-27 |
| SK12352002A3 (sk) | 2003-02-04 |
| UY26601A1 (es) | 2001-08-27 |
| OA12184A (en) | 2006-05-09 |
| CN1416339A (zh) | 2003-05-07 |
| NO20024133D0 (no) | 2002-08-30 |
| DZ3309A1 (en) | 2001-09-07 |
| CZ20022932A3 (cs) | 2003-05-14 |
| AP2002002605A0 (en) | 2002-09-30 |
| HUP0300599A3 (en) | 2003-09-29 |
| ATE299698T1 (de) | 2005-08-15 |
| MA25657A1 (fr) | 2002-12-31 |
| BG107014A (bg) | 2003-05-30 |
| EP1261328B1 (en) | 2005-07-20 |
| AU2001239970A1 (en) | 2001-09-12 |
| PL358540A1 (en) | 2004-08-09 |
| BR0108866A (pt) | 2004-02-25 |
| DE60112051T2 (de) | 2006-04-27 |
| HUP0300599A2 (hu) | 2003-07-28 |
| CA2401659A1 (en) | 2001-09-07 |
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