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PE20080274A1 - Derivados de dioxo-alcanos y dioxo-alquenos sustituidos como moduladores del receptor vanilloide subtipo 1 (trpv1) - Google Patents

Derivados de dioxo-alcanos y dioxo-alquenos sustituidos como moduladores del receptor vanilloide subtipo 1 (trpv1)

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Publication number
PE20080274A1
PE20080274A1 PE2007000872A PE2007000872A PE20080274A1 PE 20080274 A1 PE20080274 A1 PE 20080274A1 PE 2007000872 A PE2007000872 A PE 2007000872A PE 2007000872 A PE2007000872 A PE 2007000872A PE 20080274 A1 PE20080274 A1 PE 20080274A1
Authority
PE
Peru
Prior art keywords
dioxo
alkyl
trpv1
alkanes
modulators
Prior art date
Application number
PE2007000872A
Other languages
English (en)
Inventor
Daryl Davis Rees
Philip James Gunning
Antonia Orsi
Patrick A Howson
Paul Barraclough
Noelle Callizot
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Publication of PE20080274A1 publication Critical patent/PE20080274A1/es

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  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE DIOXO-ALCANOS Y DIOXO-ALQUENOS SUSTITUIDOS DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H, ALQUILO(C1-C10), CO-ALQUILO(C1-C10), CICLOALQUILO(C3-C10), ALQUENILO(C2-C10), ENTRE OTROS; R3 ES ALQUILO(C1-C10), CICLOALQUILO(C3-C10), ALQUENILO(C2-C10), ENTRE OTROS; R4, R5 Y R6 SON CADA UNO H, ALQUILO(C1-C10), ALCOXI(C1-C10), HALO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (E)-1-(4-HIDROXI-3-METOXIFENIL)-6,6-DIMETIL-HEPT-1-EN-3,5-DIONA, (E)-1-(4-HIDROXI-3-METOXIFENIL)-6-METIL-HEPT-1-EN-3,5-DIONA, (E)-5-(4-HIDROXI-3-METOXIFENIL)-1-FENIL-PENT-4-EN-1,3-DIONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR VANILLOIDE SUBTIPO 1 (TRPV1) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, PRURITO, PSORIASIS, DERMATITIS ALERGICA, ARTRITIS REUMATOIDEA
PE2007000872A 2006-07-06 2007-07-05 Derivados de dioxo-alcanos y dioxo-alquenos sustituidos como moduladores del receptor vanilloide subtipo 1 (trpv1) PE20080274A1 (es)

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