PE20011125A1 - Derivados de indol-3-ilo como inhibidores de la integrina - Google Patents
Derivados de indol-3-ilo como inhibidores de la integrinaInfo
- Publication number
- PE20011125A1 PE20011125A1 PE2001000143A PE2001000143A PE20011125A1 PE 20011125 A1 PE20011125 A1 PE 20011125A1 PE 2001000143 A PE2001000143 A PE 2001000143A PE 2001000143 A PE2001000143 A PE 2001000143A PE 20011125 A1 PE20011125 A1 PE 20011125A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- nhr6
- het
- ilo
- nr6c
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title abstract 2
- 108010044426 integrins Proteins 0.000 title abstract 2
- 101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE INDOL-3-ILO DE FORMULA I DONDE A Y B SON O, S, NH; NR7, CO, CONH, NHCO, ENLACE; X ES ALQUILENO SUSTITUIDO CON R4 O R5; R1 ES H, Z, (CH2)o-Ar, R2 ES H, R7, COZ; R3 ES NHR6, -NR6C(=NR6)NHR6, C(=NR6)-NHR6, NR6C(=NR9)-NHR6, HET1; R4 Y R5 SON H, OXO, R7, (CH2)o-Ar, CO(CH2)oAr, O-HET, ENTRE OTROS; R6 ES H, COR7, CO-Ar, CO-HET; ENTRE OTROS; R7 ES ALQUILO C1-C10, CICLOALQUILO C3-C10; R8 ES Hal, NO2, CN, Z, (CH2)o-Ar, ENTRE OTROS; R9 ES CN, NO2 ; Z ES ALQUILO C1-C6; Ar ES ARILO; HAL ES F, Cl, Br, I; HET ES MONO O BICICLO DE 5-10 MIEMBROS; HET1 ES BICICLOHETEROCICLO CON 5-10 MIEMBROS; n ES 0-2; m ES 0-6; o ES 0-2. SON COMPUESTOS PREFERIDOS ACIDO 3-FENIL-3-{6-[3-(PIRIDIN-2-IL-AMINO)-PROPOXI]-1H-INDOL-3-IL}-PROPIONICO; ACIDO 3-FENIL-3-{6-[4-(PIRIDIN-2-IL-AMINO)-BUTOXI]-1H-INDOL-3-IL}-PROPIONICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE INTEGRINA av, ß3, ß5 CON LIGANDOS Y PUEDE SER UTIL PARA TRATAMIENTO DE TROMBOSIS, INFARTO DEL MIOCARDIO, ENFERMEDAD CARDIACA CORONARIA, ARTERIOESCLEROSIS, INFLAMACION, RESTENOSIS, ARTRITIS REUMATICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10006139A DE10006139A1 (de) | 2000-02-11 | 2000-02-11 | Indol-3-yl-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011125A1 true PE20011125A1 (es) | 2001-11-07 |
Family
ID=7630611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000143A PE20011125A1 (es) | 2000-02-11 | 2001-02-09 | Derivados de indol-3-ilo como inhibidores de la integrina |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6743810B2 (es) |
| EP (1) | EP1254133B9 (es) |
| JP (1) | JP4938194B2 (es) |
| KR (1) | KR20020073585A (es) |
| CN (1) | CN1214026C (es) |
| AR (1) | AR027398A1 (es) |
| AT (1) | ATE293620T1 (es) |
| AU (2) | AU3166401A (es) |
| BR (1) | BR0108154A (es) |
| CA (1) | CA2399813C (es) |
| CO (1) | CO5261548A1 (es) |
| CZ (1) | CZ20022616A3 (es) |
| DE (2) | DE10006139A1 (es) |
| EC (1) | ECSP013923A (es) |
| ES (1) | ES2240400T3 (es) |
| HU (1) | HUP0302671A2 (es) |
| IL (1) | IL151154A0 (es) |
| MX (1) | MXPA02007732A (es) |
| NO (1) | NO20023770L (es) |
| NZ (1) | NZ521260A (es) |
| PE (1) | PE20011125A1 (es) |
| PL (1) | PL356427A1 (es) |
| PT (1) | PT1254133E (es) |
| RU (1) | RU2257380C2 (es) |
| SK (1) | SK11152002A3 (es) |
| WO (1) | WO2001058893A2 (es) |
| ZA (1) | ZA200207273B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040063790A1 (en) * | 1996-05-31 | 2004-04-01 | The Scripps Research Institute | Methods for inhibition of angiogenesis |
| US20040138284A1 (en) * | 2000-02-11 | 2004-07-15 | Matthias Wiesner | Indol-3-yl derivatives |
| WO2002018377A1 (en) * | 2000-08-29 | 2002-03-07 | Pharmacia Corporation | Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists |
| PL204102B1 (pl) * | 2000-11-01 | 2009-12-31 | Merck Patent Gmbh | Zastosowanie inhibitorów αvß₃ i/lub αvß₅ do otrzymywania leku do profilaktyki i/lub terapii chorób oczu. |
| GB0028367D0 (en) * | 2000-11-21 | 2001-01-03 | Celltech Chiroscience Ltd | Chemical compounds |
| KR100854424B1 (ko) | 2001-01-29 | 2008-08-27 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 치환된 인돌 및 인테그린 길항제로서의 이들의 용도 |
| US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
| MXPA04000839A (es) | 2001-08-01 | 2004-05-14 | Merck Patent Gesellscahft Mit | Metodos y composiciones para el tratamiento de enfermedades oftalmicas. |
| RU2004127577A (ru) * | 2002-02-14 | 2005-05-27 | Мерк Патент ГмбХ (DE) | Способы и композиции для лечения заболеваний глаз |
| BR0313871A (pt) * | 2002-08-30 | 2005-07-19 | Eisai Co Ltd | Derivados aromáticos contendo nitrogênio |
| CA2521135A1 (en) * | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | N-containing heteroaromatic compounds as modulators of ppars and methods of treating metabolic disorders |
| EP1620088A4 (en) * | 2003-04-28 | 2007-08-29 | Bayer Pharmaceuticals Corp | ACETIC INDOLE ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS |
| US7211588B2 (en) | 2003-07-25 | 2007-05-01 | Zentaris Gmbh | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation |
| DE10337863A1 (de) * | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Verwendung von Chromen-4-on-Derivaten |
| MXPA06003477A (es) * | 2003-10-01 | 2006-06-05 | Merck Patent Gmbh | Uso terapuetico de antagonistas de alfavbeta3 y alfavbeta6 integrinas como agentes antifibroticos. |
| JP2007536344A (ja) * | 2004-05-04 | 2007-12-13 | ノボ ノルディスク アクティーゼルスカブ | 新規のインドール誘導体 |
| WO2006053342A2 (en) * | 2004-11-12 | 2006-05-18 | Osi Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
| EP1676834A1 (en) * | 2004-12-30 | 2006-07-05 | Sanofi-Aventis Deutschland GmbH | Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| CN102335168B (zh) * | 2011-10-25 | 2014-04-02 | 合肥博太医药生物技术发展有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗骨质疏松药物中的应用 |
| AR094812A1 (es) * | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| JP5925978B1 (ja) | 2014-08-18 | 2016-05-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 単環ピリジン誘導体の塩およびその結晶 |
| ES2887148T3 (es) | 2015-03-25 | 2021-12-21 | Nat Cancer Ct | Agente terapéutico contra el cáncer de vías biliares |
| CN108367000A (zh) | 2015-12-17 | 2018-08-03 | 卫材R&D管理有限公司 | 用于乳腺癌的治疗剂 |
| EP3777860A4 (en) | 2018-03-28 | 2021-12-15 | Eisai R&D Management Co., Ltd. | THERAPEUTIC FOR HEPATOCELLULAR CARCINOMA |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT290523B (de) * | 1962-01-05 | 1971-06-11 | Merck & Co Inc | Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren |
| GB1148908A (en) * | 1965-04-19 | 1969-04-16 | Sumitomo Chemical Co | Indole derivatives and processes for making them |
| US4824850A (en) * | 1982-05-18 | 1989-04-25 | University Of Florida | Brain-specific drug delivery |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| IL100091A (en) * | 1990-12-12 | 1998-08-16 | Zeneca Ltd | Pharmaceutical compositions containing a physical form of n-[4-[5-(cyclopentyloxycarbonyl)amino-1-methyl indol-3-yl-methyl]-2-methylbenzenesulpho-namide and process for their preparation |
| IT1244548B (it) * | 1991-02-06 | 1994-07-15 | Poli Ind Chimica Spa | Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche |
| GB9225141D0 (en) * | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
| JP2000508319A (ja) | 1996-04-10 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | αｖβ３拮抗薬 |
| DE69719765T2 (de) * | 1996-08-27 | 2003-10-16 | Wyeth, Madison | 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden |
| WO1999033798A1 (en) * | 1997-12-25 | 1999-07-08 | Yamanouchi Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic derivatives |
| NZ506260A (en) * | 1998-02-23 | 2003-05-30 | Univ South Alabama | Indole-3-propionic acids, salts and esters thereof used as medicaments |
| TR200002447T2 (tr) * | 1998-02-25 | 2000-11-21 | Genetics Institute, Inc. | Fosfolinaz enzimlerinin inhibitörleri |
| CA2327359A1 (en) * | 1998-04-08 | 1999-10-14 | Wyeth | N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents) |
| WO1999051576A1 (en) * | 1998-04-08 | 1999-10-14 | American Home Products Corporation | N-aryloxyethylamine derivatives for the treatment of depression |
| JP4425699B2 (ja) * | 2004-05-17 | 2010-03-03 | 川崎重工業株式会社 | 小型滑走艇 |
-
2000
- 2000-02-11 DE DE10006139A patent/DE10006139A1/de not_active Withdrawn
-
2001
- 2001-01-05 ES ES01903624T patent/ES2240400T3/es not_active Expired - Lifetime
- 2001-01-05 EP EP01903624A patent/EP1254133B9/de not_active Expired - Lifetime
- 2001-01-05 CZ CZ20022616A patent/CZ20022616A3/cs unknown
- 2001-01-05 PL PL01356427A patent/PL356427A1/xx unknown
- 2001-01-05 HU HU0302671A patent/HUP0302671A2/hu unknown
- 2001-01-05 KR KR1020027010302A patent/KR20020073585A/ko not_active Withdrawn
- 2001-01-05 IL IL15115401A patent/IL151154A0/xx unknown
- 2001-01-05 JP JP2001558443A patent/JP4938194B2/ja not_active Expired - Fee Related
- 2001-01-05 PT PT01903624T patent/PT1254133E/pt unknown
- 2001-01-05 DE DE50105955T patent/DE50105955D1/de not_active Expired - Lifetime
- 2001-01-05 US US10/203,406 patent/US6743810B2/en not_active Expired - Fee Related
- 2001-01-05 AT AT01903624T patent/ATE293620T1/de not_active IP Right Cessation
- 2001-01-05 BR BR0108154-3A patent/BR0108154A/pt not_active IP Right Cessation
- 2001-01-05 WO PCT/EP2001/000084 patent/WO2001058893A2/de not_active Ceased
- 2001-01-05 AU AU3166401A patent/AU3166401A/xx active Pending
- 2001-01-05 CN CNB018046703A patent/CN1214026C/zh not_active Expired - Fee Related
- 2001-01-05 MX MXPA02007732A patent/MXPA02007732A/es unknown
- 2001-01-05 NZ NZ521260A patent/NZ521260A/en unknown
- 2001-01-05 CA CA002399813A patent/CA2399813C/en not_active Expired - Fee Related
- 2001-01-05 RU RU2002123332/04A patent/RU2257380C2/ru not_active IP Right Cessation
- 2001-01-05 AU AU2001231664A patent/AU2001231664C1/en not_active Ceased
- 2001-01-05 SK SK1115-2002A patent/SK11152002A3/sk not_active Application Discontinuation
- 2001-02-09 CO CO01009901A patent/CO5261548A1/es not_active Application Discontinuation
- 2001-02-09 PE PE2001000143A patent/PE20011125A1/es not_active Application Discontinuation
- 2001-02-09 EC EC2001003923A patent/ECSP013923A/es unknown
- 2001-02-09 AR ARP010100595A patent/AR027398A1/es not_active Application Discontinuation
-
2002
- 2002-08-09 NO NO20023770A patent/NO20023770L/no not_active Application Discontinuation
- 2002-09-10 ZA ZA200207273A patent/ZA200207273B/en unknown
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