PE20011085A1 - Compuestos isoxazolquinolin o imidazolquinolin como inhibidores de la proteina resistente a multifarmacos - Google Patents
Compuestos isoxazolquinolin o imidazolquinolin como inhibidores de la proteina resistente a multifarmacosInfo
- Publication number
- PE20011085A1 PE20011085A1 PE2000001372A PE0013722000A PE20011085A1 PE 20011085 A1 PE20011085 A1 PE 20011085A1 PE 2000001372 A PE2000001372 A PE 2000001372A PE 0013722000 A PE0013722000 A PE 0013722000A PE 20011085 A1 PE20011085 A1 PE 20011085A1
- Authority
- PE
- Peru
- Prior art keywords
- isoxazolquinolin
- imidazolquinolin
- inhibitors
- compounds
- drug resistant
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108010066052 multidrug resistance-associated protein 1 Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UNA QUINOLONA DE FORMULA I DONDE A ES CICLOALQUILO C3-C8, HET ES UN HETEROCICLO DE 5 MIEMBROS; p ES 0-1; n ES 0-2; Y ES ECOR3, ECH=CHR13, ENR4R5; C(R11)=NR6, HETEROCICLO, ENTRE OTROS; E ES UN ENLACE, C(R11)2; R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, ARIL(ALQUILO C1-C4), ENTRE OTROS; R5 ES H, ALQUILO C1-C6, ALCOXI C1-C4; ENTRE OTROS; R6 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R11 ES H, ALQUILO C1-C6, HETEROCICLO; R10 ES H, HALO, COR3, CIANO, HETEROCICLO; R13 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8. UN COMPUESTO PREFERIDO ES N-[(3S,1R)-3-(9-CLORO-3-METIL-4-OXO-5H-ISOXAZOLO[4,3-c]-QUINOLIN-5-IL))CICLOHEXIL]-PIPERIDILACETAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICON QUE COMPRENDE ADEMAS CAMPTOSAR, MELFALANO, PACLITAXEL, VINORELBINA, MITOXANTRONA, DOXORUBICINA, DAUNORUBICINA, EPIRUBICINA, VINCRISTINA, ETOPOSIDIO. EL COMPUESTO ES UN INHIBIDOR SELECTIVO DE LA PROTEINA RESISTENTE A MULTIFARMACOS MRP1, INHIBE NEOPLASMA RESISTENTE, SUCEPTIBLE
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17137399P | 1999-12-22 | 1999-12-22 | |
| US22607600P | 2000-08-17 | 2000-08-17 | |
| US23453900P | 2000-09-22 | 2000-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011085A1 true PE20011085A1 (es) | 2001-10-24 |
Family
ID=27389968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001372A PE20011085A1 (es) | 1999-12-22 | 2000-12-20 | Compuestos isoxazolquinolin o imidazolquinolin como inhibidores de la proteina resistente a multifarmacos |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1250340B1 (es) |
| JP (1) | JP2003518125A (es) |
| AT (1) | ATE282623T1 (es) |
| AU (1) | AU2251901A (es) |
| CA (1) | CA2395513A1 (es) |
| CO (1) | CO5261493A1 (es) |
| DE (1) | DE60016039T2 (es) |
| ES (1) | ES2233487T3 (es) |
| PE (1) | PE20011085A1 (es) |
| PT (1) | PT1250340E (es) |
| SV (1) | SV2002000244A (es) |
| WO (1) | WO2001046199A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1301518A1 (en) * | 2000-06-14 | 2003-04-16 | Eli Lilly And Company | Tricyclic compounds as mrp1-inhibitors |
| EP1296953A2 (en) | 2000-06-23 | 2003-04-02 | Eli Lilly And Company | Methods and compounds for inhibiting mrp1 |
| WO2004016741A2 (en) * | 2002-08-14 | 2004-02-26 | Ppd Discovery, Inc. | Prenylation inhibitors containing dimethyl-cyclobutane and methods of their synthesis and use |
| CA2537841A1 (en) | 2003-09-06 | 2005-03-24 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| ITMI20032121A1 (it) * | 2003-11-04 | 2005-05-05 | Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm | Procedimento per la preparazione di imiquimod e suoi intermedi |
| US7230002B2 (en) | 2004-02-03 | 2007-06-12 | Glenmark Pharmaceuticals Ltd. | Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof |
| WO2005075426A1 (en) * | 2004-02-03 | 2005-08-18 | Glenmark Pharmaceuticals Ltd. | Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof |
| WO2005118583A1 (en) * | 2004-05-28 | 2005-12-15 | Millennium Pharmaceuticals, Inc. | 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors |
| WO2006011035A1 (en) * | 2004-07-23 | 2006-02-02 | Glenmark Pharmaceuticals Ltd. | Novel dipeptidyl peptidase iv inhibitors; process for their preparation and compositions containing them |
| KR20070073887A (ko) | 2004-10-12 | 2007-07-10 | 그렌마크 파머수티칼스 에스. 아. | 신규한 디펩티딜 펩티다제 ⅳ 억제제, 이를 함유하는약제학적 조성물, 및 이의 제조공정 |
| JP4845372B2 (ja) * | 2004-11-30 | 2011-12-28 | 広栄化学工業株式会社 | 光学活性２−ヒドロキシエステル化合物の製造方法 |
| RU2524949C2 (ru) * | 2007-11-23 | 2014-08-10 | Лео Фарма А/С | Новые циклические углеводородные соединения для лечения заболеваний |
| US20090246198A1 (en) * | 2008-03-31 | 2009-10-01 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
| WO2012000498A1 (en) * | 2010-06-30 | 2012-01-05 | Leo Pharma A/S | New polymorphic form of a calcimimetic compound |
| CN102958908A (zh) * | 2010-06-30 | 2013-03-06 | 利奥制药有限公司 | 钙敏感受体激动化合物的新多晶型 |
| TW201534586A (zh) | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎ｃｙｐ１７抑制劑／抗雄激素劑 |
| CN104230744B (zh) * | 2014-09-01 | 2016-06-08 | 湖南尔康制药股份有限公司 | 一种替加环素原料药的生产方法 |
| BR112017008809A2 (pt) | 2014-11-05 | 2017-12-19 | Flexus Biosciences Inc | agentes imunorreguladores |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| CN112409207B (zh) * | 2019-08-22 | 2022-11-22 | 新发药业有限公司 | 一种醚菌胺的制备方法 |
| CN114890940A (zh) * | 2022-04-21 | 2022-08-12 | 嘉兴瑞驰生物科技有限公司 | 一种6-甲氧基-2-吡啶甲酸的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980608A (en) * | 1998-01-07 | 1999-11-09 | Advanced Technology Materials, Inc. | Throughflow gas storage and dispensing system |
| PL343312A1 (en) * | 1998-04-08 | 2001-08-13 | Lilly Co Eli | Methods for inhibiting mrp1 |
| HUP0101508A3 (en) * | 1998-04-08 | 2002-04-29 | Lilly Co Eli | Isoxazolo[3,4-c]quinoline derivatives, their use and pharmaceutical compositions containing them |
| TR200002804T2 (tr) * | 1998-04-08 | 2001-02-21 | Eli Lilly And Company | MRP1 inhibe etmek için yöntemler |
-
2000
- 2000-12-11 ES ES00986242T patent/ES2233487T3/es not_active Expired - Lifetime
- 2000-12-11 PT PT00986242T patent/PT1250340E/pt unknown
- 2000-12-11 AU AU22519/01A patent/AU2251901A/en not_active Abandoned
- 2000-12-11 CA CA002395513A patent/CA2395513A1/en not_active Abandoned
- 2000-12-11 EP EP00986242A patent/EP1250340B1/en not_active Expired - Lifetime
- 2000-12-11 WO PCT/US2000/032443 patent/WO2001046199A1/en not_active Ceased
- 2000-12-11 JP JP2001547109A patent/JP2003518125A/ja not_active Withdrawn
- 2000-12-11 AT AT00986242T patent/ATE282623T1/de not_active IP Right Cessation
- 2000-12-11 DE DE60016039T patent/DE60016039T2/de not_active Expired - Fee Related
- 2000-12-20 PE PE2000001372A patent/PE20011085A1/es not_active Application Discontinuation
- 2000-12-20 CO CO00096626A patent/CO5261493A1/es unknown
- 2000-12-21 SV SV2000000244A patent/SV2002000244A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60016039D1 (de) | 2004-12-23 |
| SV2002000244A (es) | 2002-07-16 |
| EP1250340A1 (en) | 2002-10-23 |
| DE60016039T2 (de) | 2005-08-11 |
| PT1250340E (pt) | 2005-04-29 |
| WO2001046199A1 (en) | 2001-06-28 |
| CO5261493A1 (es) | 2003-03-31 |
| AU2251901A (en) | 2001-07-03 |
| ES2233487T3 (es) | 2005-06-16 |
| CA2395513A1 (en) | 2001-06-28 |
| ATE282623T1 (de) | 2004-12-15 |
| JP2003518125A (ja) | 2003-06-03 |
| EP1250340B1 (en) | 2004-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |