PE20010636A1 - Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topica - Google Patents
Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topicaInfo
- Publication number
- PE20010636A1 PE20010636A1 PE2000000842A PE0008422000A PE20010636A1 PE 20010636 A1 PE20010636 A1 PE 20010636A1 PE 2000000842 A PE2000000842 A PE 2000000842A PE 0008422000 A PE0008422000 A PE 0008422000A PE 20010636 A1 PE20010636 A1 PE 20010636A1
- Authority
- PE
- Peru
- Prior art keywords
- chor
- ch2o
- fatty acids
- ch2or
- formulation
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 229930012538 Paclitaxel Natural products 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 title abstract 2
- 229960001592 paclitaxel Drugs 0.000 title abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 229930105110 Cyclosporin A Natural products 0.000 title 1
- 108010036949 Cyclosporine Proteins 0.000 title 1
- 229960001265 ciclosporin Drugs 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title 1
- 229960001597 nifedipine Drugs 0.000 title 1
- 238000011200 topical administration Methods 0.000 title 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 4
- 229930195729 fatty acid Natural products 0.000 abstract 4
- 239000000194 fatty acid Substances 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 4
- 150000004665 fatty acids Chemical class 0.000 abstract 3
- -1 TRIGLYCERIDE MACROGOL GLYCEROL ESTERS Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229920000223 polyglycerol Polymers 0.000 abstract 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000007863 gel particle Substances 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 229960003511 macrogol Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 abstract 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
Abstract
SE REFIERE A UN METODO PARA INCREMENTAR LA VISCOSIDAD DE UNA FORMULACION DE ADMINISTRACION ORAL O TOPICA LA CUAL COMPRENDE LOS PASOS DE COMBINAR: a)DE 0,1% A 30% DE UN AGENTE ACTIVO HIDROFOBICO TAL COMO TAXANOS (DOCATAXEL, PACLITAXEL), CICLOSPORINAS; b)DE 5% A 50% DE ESTERES DE POLIGLICEROL DE ACIDOS GRASOS DE FORMULA CH2OR-CHOR-CH2O-[CH2CHOR-CH2O-]nCH2-CHOR-CH2OR; n ES 4-13; R ES H, CO.R; R` ES ALQUILO C8-C22; R NO ES H; c)DE 5% A 50% DE ESTERES DE POLIGLICEROL DE ACIDOS GRASOS Y ACIDOS GRASOS INSATURADOS DE FORMULA CH2OR-CHOR-CH2O-[CH2CHOR-CH2O-]nCH2-CHOR-CH2OR; n ES 0-10; R ES H, CO.R"; R" ES ALQUILO C8-C22, AL MENOS UN R NO ES H; d)DE 5% A 50% DE ESTERES DE GLICEROL MACROGOL TRIGLICERIDO, GLICERIDOS PARCIALES O ACIDOS GRASOS O ESTERES MACROGOL DE ACIDOS GRASOS (ACEITE DE CASTOR HALOGENADO, LA CANTIDAD DE OXIDO DE ETILENO PARA LA SINTESIS DE ESTAS SUSTANCIAS OSCILA ENTRE 50 MOL A 150 MOL, SIENDO LA PROPORCION DE LOS COMPONENTES b Y d DE 0,1:1 A 10:1; DE a:c Y a:e ES DE 0,001:1 A 10:1, SE CARACTERIZA POR LA PREVIA DILUCION EN AGUA 1.1 POR VOLUMEN, LA VISCOSIDAD DE LA FORMULACION SE INCREMENTA EN AL MENOS 5 VECES EN COMPARACION CON LA FORMULACION NO DILUIDA; LA FORMULACION CREA UNA DISPERSION DE PARTICULAS DE GEL POLIMORFO CON UNA DIMENSION DE 0,2µm A 500µm
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9919288A GB2355656B (en) | 1999-08-17 | 1999-08-17 | Pharmaceutical compositions for oral and topical administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010636A1 true PE20010636A1 (es) | 2001-06-02 |
Family
ID=10859192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000842A PE20010636A1 (es) | 1999-08-17 | 2000-08-17 | Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topica |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US20070190132A1 (es) |
| EP (2) | EP1210119B1 (es) |
| JP (2) | JP2003507343A (es) |
| KR (2) | KR100828748B1 (es) |
| CN (2) | CN1382061A (es) |
| AR (2) | AR025324A1 (es) |
| AT (2) | ATE402691T1 (es) |
| AU (1) | AU777740B2 (es) |
| BR (1) | BR0013385A (es) |
| CA (2) | CA2452118A1 (es) |
| CO (1) | CO5380014A1 (es) |
| CY (1) | CY1105318T1 (es) |
| CZ (2) | CZ296170B6 (es) |
| DE (2) | DE60018081T2 (es) |
| DK (2) | DK1210119T3 (es) |
| EE (2) | EE04954B1 (es) |
| EG (1) | EG23994A (es) |
| ES (2) | ES2311077T3 (es) |
| GB (1) | GB2355656B (es) |
| HK (1) | HK1049629A1 (es) |
| HR (1) | HRP20020154B1 (es) |
| HU (1) | HUP0203236A3 (es) |
| IL (4) | IL148200A0 (es) |
| JO (1) | JO2324B1 (es) |
| MX (1) | MXPA02001631A (es) |
| NO (2) | NO20020760L (es) |
| NZ (1) | NZ517271A (es) |
| PE (1) | PE20010636A1 (es) |
| PL (1) | PL192769B1 (es) |
| PT (2) | PT1210119E (es) |
| RU (2) | RU2279894C2 (es) |
| SA (1) | SA00210487B1 (es) |
| SG (1) | SG143019A1 (es) |
| SI (1) | SI1210119T1 (es) |
| SK (2) | SK2482002A3 (es) |
| TN (1) | TNSN00173A1 (es) |
| UA (2) | UA72539C2 (es) |
| UY (1) | UY26303A1 (es) |
| WO (1) | WO2001012229A1 (es) |
| ZA (2) | ZA200308221B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2355656B (en) * | 1999-08-17 | 2004-04-07 | Galena As | Pharmaceutical compositions for oral and topical administration |
| FR2826261B1 (fr) * | 2001-06-26 | 2005-03-25 | Lmd | Composition a usage topique comprenant un produit cytotoxique et son utilisation dans le traitement de l'alopeche |
| DE10154464B4 (de) * | 2001-11-08 | 2005-10-20 | Max Delbrueck Centrum | Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol |
| KR20030065831A (ko) * | 2002-02-01 | 2003-08-09 | 주식회사 태평양 | 사이클로스포린을 함유한 지속 방출형 약학적 조성물 |
| US7101576B2 (en) * | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
| US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| EP1935407A1 (en) * | 2002-12-03 | 2008-06-25 | Elan Pharma International Limited | Low viscosity liquid dosage forms |
| US7470436B2 (en) | 2002-12-04 | 2008-12-30 | Nisshin Pharma Inc. | Water-soluble composition containing coenzyme Q10 |
| JP4518042B2 (ja) * | 2002-12-04 | 2010-08-04 | 日油株式会社 | コエンザイムｑ１０を含有する水溶性組成物の製造方法 |
| AU2003299590B8 (en) * | 2002-12-09 | 2010-04-08 | Abraxis Bioscience, Llc | Compositions and methods of delivery of pharmacological agents |
| US6979672B2 (en) | 2002-12-20 | 2005-12-27 | Polichem, S.A. | Cyclosporin-based pharmaceutical compositions |
| TW200616681A (en) * | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
| US8236286B2 (en) * | 2004-10-20 | 2012-08-07 | Kao Corporation | Liquid compositions for the oral cavity |
| EP1855659A2 (en) * | 2005-02-24 | 2007-11-21 | Elan Pharma International Limited | Nanoparticulate formulations of docetaxel and analogues thereof |
| KR20110091862A (ko) * | 2008-11-28 | 2011-08-16 | 어드밴스 홀딩스 리미티드 | 다이클로페낙과 하이드록시 지방산 폴리알킬렌 에스터를 포함하는 약학적 제제 |
| NZ594646A (en) * | 2009-03-12 | 2013-12-20 | Lectio Pharmaentwicklungs Und Verwertungs Gmbh | Pharmaceutical formulation comprising ketoprofen and a polyoxyalkylene ester of a hydroxy fatty acid |
| KR101100933B1 (ko) * | 2009-04-23 | 2012-01-02 | 한국기술교육대학교 산학협력단 | 솔더 볼 제거 장치 |
| JP6763939B2 (ja) | 2015-03-27 | 2020-09-30 | アーチ・パーソナル・ケア・プロダクツ・エルピー | パーソナルケア製品のための粘度増強組成物 |
| CN112426403B (zh) * | 2020-12-09 | 2021-09-17 | 南京天纵易康生物科技股份有限公司 | 一种口腔溃疡凝胶及其制备方法和应用 |
| WO2023214509A1 (ja) * | 2022-05-02 | 2023-11-09 | 中外製薬株式会社 | 界面活性剤と併用するためのペプチド化合物を含む組成物 |
| CN119770478A (zh) * | 2024-12-31 | 2025-04-08 | 美济生物医药(广州)有限公司 | 紫杉醇类药物口服药物组合物、制剂及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| CZ288631B6 (cs) * | 1996-01-18 | 2001-08-15 | Galena, A. S. | Léčivé přípravky s obsahem cyklosporinu |
| CZ288739B6 (cs) * | 1996-08-01 | 2001-08-15 | Galena, A. S. | Cyklosporin obsahující léčivé přípravky |
| CZ267796A3 (cs) * | 1996-09-12 | 1998-04-15 | Galena A.S. | Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů |
| DK0969856T3 (da) * | 1997-03-12 | 2005-05-02 | Abbott Lab | Hydrofile, binære systemer til administrering af cyclosporin |
| EP0973502A1 (en) * | 1997-03-12 | 2000-01-26 | Abbott Laboratories | Lipophilic binary systems for the administration of lipophilic compounds |
| DK0999826T3 (da) * | 1997-07-29 | 2004-07-26 | Upjohn Co | Selv-emulgerende formulering til lipofile forbindelser |
| US6063762A (en) * | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
| US20030216303A1 (en) * | 1998-03-06 | 2003-11-20 | Michael Ambuhl | Emulsion preconcentrates containing cyclosporin or a macrolide |
| GB2355656B (en) * | 1999-08-17 | 2004-04-07 | Galena As | Pharmaceutical compositions for oral and topical administration |
-
1999
- 1999-08-17 GB GB9919288A patent/GB2355656B/en not_active Revoked
-
2000
- 2000-08-17 CZ CZ20020575A patent/CZ296170B6/cs not_active IP Right Cessation
- 2000-08-17 ES ES03008447T patent/ES2311077T3/es not_active Expired - Lifetime
- 2000-08-17 JO JO2000302A patent/JO2324B1/en active
- 2000-08-17 CZ CZ20032302A patent/CZ296591B6/cs not_active IP Right Cessation
- 2000-08-17 IL IL14820000A patent/IL148200A0/xx active IP Right Grant
- 2000-08-17 HU HU0203236A patent/HUP0203236A3/hu unknown
- 2000-08-17 DE DE60018081T patent/DE60018081T2/de not_active Expired - Lifetime
- 2000-08-17 EE EEP200200075A patent/EE04954B1/xx not_active IP Right Cessation
- 2000-08-17 UY UY26303A patent/UY26303A1/es not_active Application Discontinuation
- 2000-08-17 EP EP00951765A patent/EP1210119B1/en not_active Expired - Lifetime
- 2000-08-17 PT PT00951765T patent/PT1210119E/pt unknown
- 2000-08-17 CO CO00061955A patent/CO5380014A1/es not_active Application Discontinuation
- 2000-08-17 ZA ZA200308221A patent/ZA200308221B/xx unknown
- 2000-08-17 AT AT03008447T patent/ATE402691T1/de active
- 2000-08-17 KR KR1020057015114A patent/KR100828748B1/ko not_active Expired - Fee Related
- 2000-08-17 SI SI200030614T patent/SI1210119T1/xx unknown
- 2000-08-17 MX MXPA02001631A patent/MXPA02001631A/es active IP Right Grant
- 2000-08-17 PL PL353445A patent/PL192769B1/pl unknown
- 2000-08-17 SG SG200305899-7A patent/SG143019A1/en unknown
- 2000-08-17 AT AT00951765T patent/ATE288766T1/de active
- 2000-08-17 SK SK248-2002A patent/SK2482002A3/sk unknown
- 2000-08-17 RU RU2002106825/15A patent/RU2279894C2/ru not_active IP Right Cessation
- 2000-08-17 CN CN00813185A patent/CN1382061A/zh active Pending
- 2000-08-17 DK DK00951765T patent/DK1210119T3/da active
- 2000-08-17 UA UA2002032078A patent/UA72539C2/uk unknown
- 2000-08-17 ES ES00951765T patent/ES2237443T3/es not_active Expired - Lifetime
- 2000-08-17 TN TNTNSN00173A patent/TNSN00173A1/en unknown
- 2000-08-17 BR BR0013385-0A patent/BR0013385A/pt not_active Application Discontinuation
- 2000-08-17 HR HR20020154A patent/HRP20020154B1/xx not_active IP Right Cessation
- 2000-08-17 EE EEP200300371A patent/EE04955B1/xx not_active IP Right Cessation
- 2000-08-17 CN CNA2008101094369A patent/CN101406453A/zh active Pending
- 2000-08-17 DK DK03008447T patent/DK1334717T3/da active
- 2000-08-17 IL IL15810800A patent/IL158108A0/xx unknown
- 2000-08-17 EP EP03008447A patent/EP1334717B1/en not_active Expired - Lifetime
- 2000-08-17 KR KR1020027002109A patent/KR100828747B1/ko not_active Expired - Fee Related
- 2000-08-17 JP JP2001516572A patent/JP2003507343A/ja active Pending
- 2000-08-17 WO PCT/GB2000/003161 patent/WO2001012229A1/en not_active Ceased
- 2000-08-17 AU AU64613/00A patent/AU777740B2/en not_active Ceased
- 2000-08-17 PE PE2000000842A patent/PE20010636A1/es not_active Application Discontinuation
- 2000-08-17 CA CA002452118A patent/CA2452118A1/en not_active Abandoned
- 2000-08-17 SK SK1023-2003A patent/SK286083B6/sk not_active IP Right Cessation
- 2000-08-17 NZ NZ517271A patent/NZ517271A/en unknown
- 2000-08-17 HK HK03101840.7A patent/HK1049629A1/zh unknown
- 2000-08-17 CA CA2380951A patent/CA2380951C/en not_active Expired - Fee Related
- 2000-08-18 AR ARP000104281A patent/AR025324A1/es unknown
- 2000-08-19 EG EG20001069A patent/EG23994A/xx active
- 2000-11-01 SA SA00210487A patent/SA00210487B1/ar unknown
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2002
- 2002-02-15 ZA ZA200201315A patent/ZA200201315B/en unknown
- 2002-02-15 NO NO20020760A patent/NO20020760L/no not_active Application Discontinuation
- 2002-02-17 IL IL148200A patent/IL148200A/en not_active IP Right Cessation
- 2002-02-17 IL IL158108A patent/IL158108A/en not_active IP Right Cessation
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2003
- 2003-04-26 PT PT03008447T patent/PT1334717E/pt unknown
- 2003-08-17 DE DE60322454T patent/DE60322454D1/de not_active Expired - Lifetime
- 2003-09-10 AR ARP030103268A patent/AR043106A2/es unknown
- 2003-10-24 NO NO20034778A patent/NO20034778D0/no not_active Application Discontinuation
- 2003-11-17 RU RU2003133451/15A patent/RU2279895C2/ru not_active IP Right Cessation
- 2003-12-24 UA UA20031212327A patent/UA75926C2/uk unknown
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2004
- 2004-03-31 JP JP2004106963A patent/JP2004238399A/ja active Pending
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2005
- 2005-05-05 CY CY20051100574T patent/CY1105318T1/el unknown
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2007
- 2007-04-13 US US11/786,846 patent/US20070190132A1/en not_active Abandoned
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