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PE20001243A1 - Sintesis de intermediarios utiles para preparar compuestos triciclicos - Google Patents

Sintesis de intermediarios utiles para preparar compuestos triciclicos

Info

Publication number
PE20001243A1
PE20001243A1 PE1999001170A PE00117099A PE20001243A1 PE 20001243 A1 PE20001243 A1 PE 20001243A1 PE 1999001170 A PE1999001170 A PE 1999001170A PE 00117099 A PE00117099 A PE 00117099A PE 20001243 A1 PE20001243 A1 PE 20001243A1
Authority
PE
Peru
Prior art keywords
compound
prepare
imine
synthesis
tricyclic compounds
Prior art date
Application number
PE1999001170A
Other languages
English (en)
Inventor
Charles F Bernard
Michael Casey
Frank Xing Chen
George G Wu
Marc Poirier
Robert P Williams
Yee-Shing Wong
Denise C Grogan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20001243A1 publication Critical patent/PE20001243A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UN PROCESO PARA PREPARAR UN COMPUESTO TRICICLICO DE FORMULA I, DONDE: R, R1, R2, R3 Y R4 SON H, Br, Cl, F, ALQUILO, ALCOXI; QUE COMPRENDE A)REACCIONAR UN COMPUESTO II, DONDE RA, RB, RC, RD Y RE SON H, HALO, ALQUILO, ALCOXI; R5 ES ARILO, HETEROARILO; CON UN DESHIDRATANTE PARA PRODUCIR UNA IMINA DE FORMULA III; LA MEZCLA DE REACCION SE PONE EN CONTACTO CON UN AGENTE ADICIONAL; B)HIDROLIZAR LA IMINA PARA PRODUCIR EL COMPUESTO I; EL DESHIDRATANTE PUEDE SER P2O5, P2O3, P2O3Cl4, POCl3, PCl3, PCl5, C6H6P(O)Cl2, PBr3, PBr5, SOCl2, SOBr2, COCl2 Y H2SO4; EL AGENTE ADICIONAL PUEDE SER AlCl3, FeCl3, ZnCl2, AlBr3, ZnBr2, TiCl4, SnCl4, CF3SO3H, HFSO3, HF/BF3, ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTOS INTERMEDIOS Y A LA IMINA DE FORMULA III. EL COMPUESTO I PUEDE SER UTIL COMO INTERMEDIARIO PARA PREPARAR COMPUESTOS ANTIHISTAMINICOS O INHIBIDORES DE FARNESIL TRANSFERASA
PE1999001170A 1998-11-20 1999-11-19 Sintesis de intermediarios utiles para preparar compuestos triciclicos PE20001243A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19700398A 1998-11-20 1998-11-20

Publications (1)

Publication Number Publication Date
PE20001243A1 true PE20001243A1 (es) 2000-11-15

Family

ID=22727622

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001170A PE20001243A1 (es) 1998-11-20 1999-11-19 Sintesis de intermediarios utiles para preparar compuestos triciclicos

Country Status (13)

Country Link
EP (1) EP1131296A2 (es)
JP (2) JP4663122B2 (es)
CN (1) CN1162404C (es)
AR (1) AR028138A1 (es)
AU (1) AU3790200A (es)
CA (1) CA2351693C (es)
CO (1) CO5150169A1 (es)
HK (1) HK1038698A1 (es)
MY (1) MY121795A (es)
PE (1) PE20001243A1 (es)
TW (1) TW509680B (es)
WO (1) WO2000030589A2 (es)
ZA (1) ZA200103246B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1274688T3 (da) 2000-04-18 2007-02-05 Schering Corp Syntese af mellemprodukter, der er nyttige ved fremstilling af tricykliske forbindelser
AU2002368506A1 (en) * 2002-12-26 2004-07-22 Cadila Healthcare Limited A process for preparing benzocyclohetapyridin-11-ones
CN108218773A (zh) * 2018-02-28 2018-06-29 朱路英 一种制备抗过敏性鼻炎药物氯雷他定中间体的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
EP0208855B1 (en) * 1985-05-13 1991-03-06 Schering Corporation process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
US5089496A (en) 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
CA2245055C (en) * 1989-02-28 2003-03-25 F. Hoffmann-La Roche Ag Amidation of pyridines
US5672750A (en) * 1994-12-16 1997-09-30 Eastman Chemical Company Preparation of aromatic amides from carbon monoxide, an amine and an aromatic chloride
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
EP1380581A1 (en) 1995-12-22 2004-01-14 Schering Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases
EP0806415B1 (de) * 1996-05-09 2000-02-16 Lonza Ag Verfahren zur Herstellung von Arylamiden heteroaromatischer Carbonsäuren
US5958890A (en) * 1996-09-13 1999-09-28 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
ES2209121T3 (es) * 1997-03-25 2004-06-16 Schering Corporation Sintesis de intermedios utiles en la preparacion de compuestos triciclicos.

Also Published As

Publication number Publication date
CA2351693C (en) 2009-01-20
EP1131296A2 (en) 2001-09-12
WO2000030589A3 (en) 2001-01-04
JP2002530307A (ja) 2002-09-17
CA2351693A1 (en) 2000-06-02
AR028138A1 (es) 2003-04-30
MY121795A (en) 2006-02-28
HK1038698A1 (zh) 2002-03-28
CO5150169A1 (es) 2002-04-29
TW509680B (en) 2002-11-11
ZA200103246B (en) 2002-07-22
CN1162404C (zh) 2004-08-18
AU3790200A (en) 2000-06-13
JP2010132701A (ja) 2010-06-17
JP4663122B2 (ja) 2011-03-30
CN1326444A (zh) 2001-12-12
WO2000030589A2 (en) 2000-06-02

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed