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PE20001520A1 - Composiciones farmaceuticas que comprenden derivados sustituidos de indazol como inhibidores de pde tipo iv y la produccion de tnf - Google Patents

Composiciones farmaceuticas que comprenden derivados sustituidos de indazol como inhibidores de pde tipo iv y la produccion de tnf

Info

Publication number
PE20001520A1
PE20001520A1 PE1999001052A PE00105299A PE20001520A1 PE 20001520 A1 PE20001520 A1 PE 20001520A1 PE 1999001052 A PE1999001052 A PE 1999001052A PE 00105299 A PE00105299 A PE 00105299A PE 20001520 A1 PE20001520 A1 PE 20001520A1
Authority
PE
Peru
Prior art keywords
alkyl
production
indazole
tnf
inhibitors
Prior art date
Application number
PE1999001052A
Other languages
English (en)
Inventor
Anthony Andrea Fossa
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20001520A1 publication Critical patent/PE20001520A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: a)UN COMPUESTO INDAZOL QUE INHIBE A LA FOSFODIESTERASA TIPO IV Y LA PRODUCCION DE FACTOR DE NECROSIS TUMORAL DE FORMULA I DONDE: R ES H, ALQUILO C1-C6, (Z`)b(Z'')c(ARILO C6-C10), ENTRE OTROS; b Y c SON 0-1; Z' ES ALQUILENO C1-C6, ALQUENILENO C2-C6, Z'' ES O, S, SO2, NR9; R1 ES H, ALQUILO C1-C7, ALQUENILO C2-C3, FENILO, ENTRE OTROS; R2 ES EL GRUPO Ia, Ib, ENTRE OTROS; m ES 0-4; R3 ES H, HALO, CIANO, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON HALO, CH2NHC(O)C(O)NH2, CICLOPROPILO SUSTITUIDO OPCIONALMENTE POR R11, R17, NR9R10, C(O)NR9R10, ENTRE OTROS; R4 ES H, C(Y)R14, C(Y)NR17R14, CN, ENTRE OTROS; R5 ES R9, OR9, CH2OR9, CIANO, C(O)R9, CO2R9, ENTRE OTROS; R4 Y R5 JUNTOS FORMAN =O, R8; O R5 ES H; R4 ES OR14, SR14, S(O)nR15, ENTRE OTROS; R6 ES METILO, ETILO; R7 ES OR14, SR14, SO2NR17R14, ENTRE OTROS; R8 ES =NR15, =NCR9R10(ALQUENILO C2-C6), =NOR14, ENTRE OTROS; R9 Y R10 SON H, ALQUILO C1-C4; R11 ES FLUOR, R10; R12 ES ALQUILO C1-C6, ALQUENILO C2-C3, ENTRE OTROS; R14 ES H, R15; R14 Y 17 JUNTO A N FORMAN UN ANILLO DE 5 A 7 MIEMBROS; R17 ES OR9, R10. UN COMPUESTO I PREFERIDO ES 1(1-CICLOPENTIL-3-ETIL)-1H-INDAZOL-6-IL)-4-OXO-CICLOHEXANOCARBONITRILO, ENTRE OTROS. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE LA INSUFICIENCIA CARDIACA CONGESTIVA (ICC)
PE1999001052A 1998-10-21 1999-10-19 Composiciones farmaceuticas que comprenden derivados sustituidos de indazol como inhibidores de pde tipo iv y la produccion de tnf PE20001520A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10510898P 1998-10-21 1998-10-21

Publications (1)

Publication Number Publication Date
PE20001520A1 true PE20001520A1 (es) 2001-01-08

Family

ID=22304064

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001052A PE20001520A1 (es) 1998-10-21 1999-10-19 Composiciones farmaceuticas que comprenden derivados sustituidos de indazol como inhibidores de pde tipo iv y la produccion de tnf

Country Status (12)

Country Link
US (1) US6265429B1 (es)
EP (1) EP0995439A1 (es)
JP (1) JP2000128785A (es)
KR (1) KR20000029221A (es)
AR (1) AR018692A1 (es)
AU (1) AU766780B2 (es)
CA (1) CA2287139A1 (es)
HU (1) HUP9903735A3 (es)
IL (1) IL132407A0 (es)
NZ (1) NZ500514A (es)
PE (1) PE20001520A1 (es)
ZA (1) ZA996625B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.

Also Published As

Publication number Publication date
JP2000128785A (ja) 2000-05-09
KR20000029221A (ko) 2000-05-25
US6265429B1 (en) 2001-07-24
CA2287139A1 (en) 2000-04-21
AU766780B2 (en) 2003-10-23
NZ500514A (en) 2001-11-30
HUP9903735A3 (en) 2001-02-28
AR018692A1 (es) 2001-11-28
ZA996625B (en) 2001-04-20
EP0995439A1 (en) 2000-04-26
IL132407A0 (en) 2001-03-19
AU5597699A (en) 2000-05-04
HU9903735D0 (en) 1999-12-28
HUP9903735A2 (hu) 2000-08-28

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