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PE20000703A1 - 2-amino-1-[2,7-dicloro-9-(aril)-9h-fluoren-4-il]-etanoles n-sustituidos - Google Patents

2-amino-1-[2,7-dicloro-9-(aril)-9h-fluoren-4-il]-etanoles n-sustituidos

Info

Publication number
PE20000703A1
PE20000703A1 PE1999000560A PE00056099A PE20000703A1 PE 20000703 A1 PE20000703 A1 PE 20000703A1 PE 1999000560 A PE1999000560 A PE 1999000560A PE 00056099 A PE00056099 A PE 00056099A PE 20000703 A1 PE20000703 A1 PE 20000703A1
Authority
PE
Peru
Prior art keywords
aril
ethanols
fluoren
dichloro
substitutes
Prior art date
Application number
PE1999000560A
Other languages
English (en)
Inventor
Thomas Allmendinger
Walther Helmut Wernsdorfer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20000703A1 publication Critical patent/PE20000703A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A 2-AMINO-1-[2,7-DICLORO-9-(ARIL)-9H-FLUOREN-4-IL]-ETANOLES-N-SUSTITUIDO DE FORMULA I, DONDE R ES ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDOS CON AMINO, HIDROXI, GUANIDINO; ALQUENILO, X ES ARILO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS; QUE COMPRENDE a)CONDENSAR UN COMPUESTO II CON UN ALDEHIDO X-CHO; b)ADICIONAR A UNA OXARINA DE FORMULA IV; UNA AMINA R-NH2. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDAD POR PROTOZOOS, TREMATODOS, EN CASOS GRAVES DE MALARIA, QUISTOSOMIASIS, MALARIA POTENCIALMENTE MULTIRESISTENTE
PE1999000560A 1998-06-25 1999-06-23 2-amino-1-[2,7-dicloro-9-(aril)-9h-fluoren-4-il]-etanoles n-sustituidos PE20000703A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH135198 1998-06-25

Publications (1)

Publication Number Publication Date
PE20000703A1 true PE20000703A1 (es) 2000-08-23

Family

ID=4208448

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000560A PE20000703A1 (es) 1998-06-25 1999-06-23 2-amino-1-[2,7-dicloro-9-(aril)-9h-fluoren-4-il]-etanoles n-sustituidos

Country Status (16)

Country Link
US (1) US6329552B2 (es)
EP (1) EP1089961B1 (es)
JP (1) JP4355450B2 (es)
CN (1) CN1183097C (es)
AT (1) ATE259346T1 (es)
AU (1) AU4776399A (es)
BR (1) BRPI9912208B8 (es)
CA (1) CA2335685C (es)
CO (1) CO5040050A1 (es)
ES (1) ES2216528T3 (es)
ID (1) ID27500A (es)
MY (1) MY117662A (es)
PE (1) PE20000703A1 (es)
PT (1) PT1089961E (es)
TW (2) TW200528419A (es)
WO (1) WO1999067197A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108148186A (zh) * 2012-01-31 2018-06-12 剑桥显示技术有限公司 聚合物
CN111320547B (zh) * 2020-04-03 2022-05-20 南京昊绿生物科技有限公司 一种苯芴醇-d9的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1029680C (zh) * 1988-11-10 1995-09-06 军事医学科学院微生物流行病研究所 抗疟新药苯芴醇的合成新工艺
CN1058717A (zh) * 1990-08-08 1992-02-19 中国人民解放军军事医学科学院微生物流行病研究所 抗疟新药—复方蒿甲醚及其制备方法

Also Published As

Publication number Publication date
CN1312794A (zh) 2001-09-12
CO5040050A1 (es) 2001-05-29
PT1089961E (pt) 2004-06-30
ATE259346T1 (de) 2004-02-15
AU4776399A (en) 2000-01-10
CA2335685A1 (en) 1999-12-29
US20010014699A1 (en) 2001-08-16
WO1999067197A1 (en) 1999-12-29
ES2216528T3 (es) 2004-10-16
BRPI9912208B1 (pt) 2016-04-19
TW200528419A (en) 2005-09-01
TWI250141B (en) 2006-03-01
EP1089961B1 (en) 2004-02-11
ID27500A (id) 2001-04-12
BR9912208A (pt) 2001-04-10
BRPI9912208B8 (pt) 2021-05-25
MY117662A (en) 2004-07-31
JP4355450B2 (ja) 2009-11-04
EP1089961A1 (en) 2001-04-11
JP2002518467A (ja) 2002-06-25
US6329552B2 (en) 2001-12-11
HK1035712A1 (en) 2001-12-07
CA2335685C (en) 2009-08-11
CN1183097C (zh) 2005-01-05

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