PE20000436A1 - PREPARACION DE ANTIBIOTICOS ß-LACTAMA EN PRESENCIA DE UREA O AMIDA - Google Patents
PREPARACION DE ANTIBIOTICOS ß-LACTAMA EN PRESENCIA DE UREA O AMIDAInfo
- Publication number
- PE20000436A1 PE20000436A1 PE1999000341A PE00034199A PE20000436A1 PE 20000436 A1 PE20000436 A1 PE 20000436A1 PE 1999000341 A PE1999000341 A PE 1999000341A PE 00034199 A PE00034199 A PE 00034199A PE 20000436 A1 PE20000436 A1 PE 20000436A1
- Authority
- PE
- Peru
- Prior art keywords
- acid
- solution
- compound
- glycine
- suspension
- Prior art date
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title abstract 2
- 239000004202 carbamide Substances 0.000 title abstract 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 title 1
- 239000002132 β-lactam antibiotic Substances 0.000 title 1
- 229940124586 β-lactam antibiotics Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 6
- -1 ß-LACTAM COMPOUND Chemical class 0.000 abstract 5
- 239000000725 suspension Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN PROCESO PARA PREPARAR UN COMPUESTO CRISTALINO ß-LACTAMA MEDIANTE LA ADICION DE UNA BASE A UNA SOLUCION O SUSPENSION ACIDA DE UN COMPUESTO ß-LACTAMA QUE SE OBTIENE MEDIANTE LA ADICION DE UN ACIDO A UNA SOLUCION O SUSPENSION DE UN COMPUESTO DE ß-LACTAMA QUE SE OBTIENE: a)MEDIANTE UNA REACCION DE ACILACION DE ACIDO 6-AMINOPENICILANICO, ACIDO 7-AMINOCEFALOSPORANICO, ACIDO 7-AMINO-3`-DESACETOXICEFOLASPORANICO, ACIDO 3-CLORO-7-AMINODESACETOXIDESMETILCEFOLASPORANICO, ENTRE OTROS; CON UN ANHIDRIDO MEZCLADO DE LA SAL DE DANE DE D-FENIL-GLICINA, D-PARA-HIDROXIFENIL-GLICINA, D-2-(1,4-CICLOHEXADIENO-1-ILO)GLICINA; ENTRE OTROS; EN UNO O MAS SOLVENTES; b)DISOLVER O SUSPENDER UN COMPUESTO CRUDO DE ß-LACTAMA EN UNA SOLUCION QUE CONTIENE AGUA Y/O UNO O MAS SOLVENTES ORGANICOS TAL COMO ALCANOL C1-C6, CETONA, ESTER DE UN CARBOXILATO C1-C6 CON ALCANOL C1-C6, CARACTERIZADO POR LA ADICION DE UREA O AMIDA O SUS DERIVADOS TAL COMO R4R3N-CO-NR1R2; R3-CO-NR1R2; R1, R2, R3, R4 SON H, ALQUILO, ALILO; O R1 Y R3 FORMAN -CH2-CH2-, -CH2-CH2-CH2-, -CH2-CO- Y CH=CH-CO JUNTO CON -N-CO-N FORMAN UN ANILLO CICLICO DE 5-6 MIEMBROS, ESTERES DE ALCANO C1-C6 DE ACIDO CARBOXILICO C1-C6, A LA SOLUCION O SUSPENSION DE UN COMPUESTO ß-LACTAMA, CARACTERIZADO PORQUE LA TEMPERATURA EN QUE SE AGREGA EL ACIDO ES ENTRE -50°C Y 10°C Y EL pH ES DE 0,1-3,5
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201399A EP0953569A1 (en) | 1998-04-29 | 1998-04-29 | Preparation of beta-lactam antibiotics in the presence of urea or amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000436A1 true PE20000436A1 (es) | 2000-05-20 |
Family
ID=8233664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000341A PE20000436A1 (es) | 1998-04-29 | 1999-04-26 | PREPARACION DE ANTIBIOTICOS ß-LACTAMA EN PRESENCIA DE UREA O AMIDA |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0953569A1 (es) |
| KR (1) | KR20010043039A (es) |
| CN (1) | CN1298407A (es) |
| AU (1) | AU3539699A (es) |
| BR (1) | BR9910576A (es) |
| ID (1) | ID26414A (es) |
| PE (1) | PE20000436A1 (es) |
| TR (1) | TR200003135T2 (es) |
| WO (1) | WO1999055709A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007002924A1 (de) * | 2007-01-19 | 2008-07-24 | Bayer Healthcare Ag | ß-Lactam-haltige Formulierungen mit erhöhter Stabilität in wässriger Lösung |
| CN102134250B (zh) * | 2011-01-19 | 2013-03-13 | 天津大学 | 一种头孢羟氨苄单水合物的结晶方法及结晶 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1104937A (en) * | 1964-05-28 | 1968-03-06 | Glaxo Lab Ltd | Improvements in or relating to the acylation of 7-aminocephalosporanic acid and derivatives thereof |
| US3954745A (en) * | 1974-09-12 | 1976-05-04 | Eli Lilly And Company | Process for preparing cefazolin |
| GB1459807A (en) * | 1975-05-27 | 1976-12-31 | Proter Spa | Process for the production of 7-d-a-amino-phenyl-acetamido-3- desacetoxy-cephalosporanic acid |
| IT1053312B (it) * | 1976-01-15 | 1981-08-31 | Ankerfarm Spa | Procedimento per la produzione di antibiotici di penicillina semisintetici |
| GB2034695B (en) * | 1978-10-06 | 1982-10-27 | Glaxo Group Ltd | Acylation of 6-apa via silyl intermediates |
| US4248780A (en) * | 1979-08-21 | 1981-02-03 | Canada Packers Limited | Process for preparing ampicillin |
| GB2240102B (en) * | 1990-01-22 | 1993-10-20 | Biochemie Gmbh | Improvements in or relating to beta lactam production |
-
1998
- 1998-04-29 EP EP98201399A patent/EP0953569A1/en not_active Withdrawn
-
1999
- 1999-04-26 PE PE1999000341A patent/PE20000436A1/es not_active Application Discontinuation
- 1999-04-27 CN CN99805526A patent/CN1298407A/zh active Pending
- 1999-04-27 EP EP99917237A patent/EP1073663A1/en not_active Withdrawn
- 1999-04-27 AU AU35396/99A patent/AU3539699A/en not_active Abandoned
- 1999-04-27 ID IDW20002182A patent/ID26414A/id unknown
- 1999-04-27 KR KR1020007011902A patent/KR20010043039A/ko not_active Withdrawn
- 1999-04-27 TR TR2000/03135T patent/TR200003135T2/xx unknown
- 1999-04-27 BR BR9910576-4A patent/BR9910576A/pt not_active Application Discontinuation
- 1999-04-27 WO PCT/NL1999/000247 patent/WO1999055709A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1073663A1 (en) | 2001-02-07 |
| CN1298407A (zh) | 2001-06-06 |
| KR20010043039A (ko) | 2001-05-25 |
| EP0953569A1 (en) | 1999-11-03 |
| AU3539699A (en) | 1999-11-16 |
| TR200003135T2 (tr) | 2001-03-21 |
| BR9910576A (pt) | 2001-01-09 |
| ID26414A (id) | 2000-12-21 |
| WO1999055709A1 (en) | 1999-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |