PE20000428A1 - Nuevas dihidropirimidinas 2 heterociclicamente sustituidas - Google Patents
Nuevas dihidropirimidinas 2 heterociclicamente sustituidasInfo
- Publication number
- PE20000428A1 PE20000428A1 PE1999000310A PE00031099A PE20000428A1 PE 20000428 A1 PE20000428 A1 PE 20000428A1 PE 1999000310 A PE1999000310 A PE 1999000310A PE 00031099 A PE00031099 A PE 00031099A PE 20000428 A1 PE20000428 A1 PE 20000428A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- optionally substituted
- trifluoromethyl
- alkyl
- phenyl optionally
- Prior art date
Links
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000002430 hydrocarbons Chemical group 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 206010059193 Acute hepatitis B Diseases 0.000 abstract 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 abstract 1
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical class C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 abstract 1
- 208000037628 acute hepatitis B virus infection Diseases 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DIHIDROPIRIMIDINAS DE FORMULA I, DONDE R1 ES FENILO, FURILO, TIENILO, PIRIDILO, CICLOALQUILO C3-C6, ANILLO a, b, c OPCIONALMENTE SUSTITUIDOS CON HALOGENO, TRIFLUOROMETILO, NITRO, CIANO, -S-R6, NR7R8, CO-NR9R10, SO2-CF3, -A-CH2-R11, ENTRE OTROS; R6 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO; R7, R8, R9 Y R10 SON H, FENILO OPCIONALMENTE SUSTITUIDO CON HIDROXI, ACILO C1-C6, ALQUILO C1-C6; A ES O, S, SO, SO2; R11 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, NITRO, TRIFLUOROMETILO, ENTRE OTROS; R2 ES -OR12, NR13R14; R12 ES H, ALCOXI C1-C6(CARBONILO), UN GRUPO HIDROCARBONADO C1-C8; R3 ES H, AMINO, -C-(OCH3)2-, FORMILO, CIANO, TRIFLUOROMETILO, UN RESTO HIDROCARBURO; R4 ES H, ALQUILO C1-C4, ACETILO, BENZOILO; D ES O o S; R5 ES H, HALOGENO, ALQUILO C1-C6. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I TIENE ACTIVIDAD ANTIVIRAL CONTRA EL VIRUS DE LA HEPATITIS B (HBV), POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO Y PROFILAXIS DE INFECCIONES CRONICAS Y AGUDAS POR HEPATITIS B
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19817262A DE19817262A1 (de) | 1998-04-18 | 1998-04-18 | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000428A1 true PE20000428A1 (es) | 2000-06-25 |
Family
ID=7864971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000310A PE20000428A1 (es) | 1998-04-18 | 1999-04-15 | Nuevas dihidropirimidinas 2 heterociclicamente sustituidas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6503913B1 (es) |
| EP (1) | EP1073653B1 (es) |
| JP (1) | JP2002512244A (es) |
| KR (1) | KR20010042787A (es) |
| CN (1) | CN1134434C (es) |
| AR (1) | AR015765A1 (es) |
| AU (1) | AU3420599A (es) |
| CA (1) | CA2328876A1 (es) |
| DE (2) | DE19817262A1 (es) |
| ES (1) | ES2181413T3 (es) |
| GT (1) | GT199900055A (es) |
| ID (1) | ID26308A (es) |
| PE (1) | PE20000428A1 (es) |
| SV (1) | SV1999000049A (es) |
| WO (1) | WO1999054329A1 (es) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000058302A1 (de) * | 1999-03-25 | 2000-10-05 | Bayer Aktiengesellschaft | Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b |
| EP1193259A4 (en) | 1999-06-23 | 2003-01-29 | Ajinomoto Kk | dihydropyrimidine |
| AU3009801A (en) * | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
| DE10012549A1 (de) * | 2000-03-15 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10012824A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10013125A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| EP2004649B1 (en) * | 2006-03-24 | 2012-07-04 | The Feinstein Institute for Medical Research | Phenolic hydrazone macrophage migration inhibitory factor inhibitors |
| CN101104617B (zh) * | 2006-07-10 | 2010-06-23 | 北京摩力克科技有限公司 | 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途 |
| CN101104604B (zh) | 2006-07-10 | 2011-03-02 | 北京摩力克科技有限公司 | 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途 |
| CN100453542C (zh) * | 2007-04-30 | 2009-01-21 | 广东东阳光药业有限公司 | 2-杂环取代的二氢嘧啶消旋化合物的拆分方法 |
| CN101328170B (zh) * | 2007-06-18 | 2011-09-14 | 张中能 | 一种氟苯基-取代噻唑二氢嘧啶 |
| CN101328168B (zh) * | 2007-06-18 | 2011-09-07 | 张中能 | 一种乙氧碳酰基-取代噻唑二氢嘧啶 |
| BRPI0813237B8 (pt) | 2007-06-18 | 2021-05-25 | Sunshine Lake Pharma Co Ltd | composto, método para preparar o composto, medicamento, e, uso do composto |
| WO2010069147A1 (zh) * | 2008-12-17 | 2010-06-24 | 张中能 | 二氢嘧啶类化合物、其组合物及其应用 |
| EA026977B1 (ru) * | 2012-01-06 | 2017-06-30 | Янссен Сайенсиз Айрлэнд Юси | 4,4-дизамещенные 1,4-дигидропиримидины и их применение в качестве лекарственных препаратов для лечения гепатита b |
| JP6250561B2 (ja) * | 2012-02-08 | 2017-12-20 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ヘテロアリール化合物およびそれらの使用方法 |
| EP2831060B1 (en) * | 2012-03-31 | 2016-05-04 | F.Hoffmann-La Roche Ag | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| RU2655914C9 (ru) | 2012-08-24 | 2018-07-24 | Саншайн Лейк Фарма Ко., Лтд. | Соединения дигидропиримидина и их применение в фармацевтических препаратах |
| CN103664925B (zh) * | 2012-09-07 | 2018-01-23 | 广东东阳光药业有限公司 | 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用 |
| KR20150054795A (ko) | 2012-09-10 | 2015-05-20 | 에프. 호프만-라 로슈 아게 | B형 간염 바이러스 감염의 치료 및 예방을 위한 6-아미노산 헤테로아릴다이하이드로피리미딘 |
| RU2678990C1 (ru) | 2013-11-19 | 2019-02-05 | Саншайн Лейк Фарма Ко., Лтд. | Соединения дигидропиримидина и их применение в фармацевтических препаратах |
| AU2014356986B2 (en) | 2013-11-27 | 2018-01-04 | Sunshine Lake Pharma Co., Ltd. | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
| WO2015144093A1 (en) | 2014-03-28 | 2015-10-01 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
| CN105859708B (zh) | 2015-02-07 | 2020-01-21 | 广东东阳光药业有限公司 | 二氢嘧啶衍生物的盐及其在药物中的应用 |
| WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| EA201890767A1 (ru) | 2015-09-23 | 2019-09-30 | Рита Фармасьютикалз, Инк. | C4-модифицированные производные олеаноловой кислоты для ингибирования il-17 и других применений |
| CN108368113B (zh) * | 2015-11-04 | 2020-11-24 | 齐鲁制药有限公司 | 二氢吡啶并环化合物的晶型、制备方法和中间体 |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| MX384836B (es) | 2016-03-07 | 2025-03-14 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis b |
| KR20190027814A (ko) * | 2016-06-10 | 2019-03-15 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
| JP7187437B2 (ja) | 2016-07-29 | 2022-12-12 | サノビオン ファーマシューティカルズ インク | 化合物および組成物ならびにそれらの使用 |
| EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
| SG11202000669VA (en) | 2017-08-02 | 2020-02-27 | Sunovion Pharmaceuticals Inc | Isochroman compounds and uses thereof |
| CN107501257B (zh) * | 2017-08-17 | 2020-05-29 | 山东大学 | 二氢嘧啶-三氮唑类衍生物及其制备方法与应用 |
| NZ762994A (en) | 2017-08-28 | 2025-11-28 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| JP7202373B2 (ja) * | 2017-10-18 | 2023-01-11 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | ジヒドロピリミジン化合物、及び医薬におけるその使用 |
| WO2019113173A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2019191166A1 (en) | 2018-03-29 | 2019-10-03 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| EP3810141A1 (en) | 2018-06-20 | 2021-04-28 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| AR116474A1 (es) | 2018-09-21 | 2021-05-12 | Enanta Pharm Inc | DERIVADOS DEL ÁCIDO 6,7-DIHIDRO-2H-BENZOFURO[2,3-a]QUINOLIZIN-3-CARBOXÍLICO COMO AGENTES ANTIVIRALES PARA EL TRATAMIENTO O PREVENCIÓN DE UNA INFECCIÓN POR HBV |
| SG11202105007TA (en) | 2018-11-21 | 2021-06-29 | Enanta Pharm Inc | Functionalized heterocycles as antiviral agents |
| KR20210139376A (ko) | 2019-03-14 | 2021-11-22 | 선오비온 파마슈티컬스 인코포레이티드 | 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물 |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| KR102891865B1 (ko) | 2019-07-19 | 2025-11-26 | 리아타 파마슈티컬즈, 아이엔씨. | C17 극성-치환된 헤테로방향족 합성 트리터페노이드 및 그의 사용 방법 |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2021078221A1 (zh) * | 2019-10-24 | 2021-04-29 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| CN113512035B (zh) * | 2021-04-26 | 2023-11-24 | 山东大学 | 二氢嘧啶-泊马度胺缀合物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH550189A (de) | 1971-01-08 | 1974-06-14 | Ciba Geigy Ag | Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren. |
| CH569043A5 (es) | 1973-01-23 | 1975-11-14 | Ciba Geigy Ag | |
| DE3234684A1 (de) | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
-
1998
- 1998-04-18 DE DE19817262A patent/DE19817262A1/de not_active Withdrawn
-
1999
- 1999-04-07 ES ES99915743T patent/ES2181413T3/es not_active Expired - Lifetime
- 1999-04-07 WO PCT/EP1999/002345 patent/WO1999054329A1/de not_active Ceased
- 1999-04-07 CA CA002328876A patent/CA2328876A1/en not_active Abandoned
- 1999-04-07 DE DE59902470T patent/DE59902470D1/de not_active Expired - Fee Related
- 1999-04-07 US US09/673,597 patent/US6503913B1/en not_active Expired - Fee Related
- 1999-04-07 CN CNB998051705A patent/CN1134434C/zh not_active Expired - Fee Related
- 1999-04-07 EP EP99915743A patent/EP1073653B1/de not_active Expired - Lifetime
- 1999-04-07 ID IDW20002114A patent/ID26308A/id unknown
- 1999-04-07 JP JP2000544668A patent/JP2002512244A/ja active Pending
- 1999-04-07 KR KR1020007011526A patent/KR20010042787A/ko not_active Ceased
- 1999-04-07 AU AU34205/99A patent/AU3420599A/en not_active Abandoned
- 1999-04-15 AR ARP990101748A patent/AR015765A1/es unknown
- 1999-04-15 PE PE1999000310A patent/PE20000428A1/es not_active Application Discontinuation
- 1999-04-16 SV SV1999000049A patent/SV1999000049A/es unknown
- 1999-04-16 GT GT199900055A patent/GT199900055A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59902470D1 (de) | 2002-10-02 |
| KR20010042787A (ko) | 2001-05-25 |
| HK1037188A1 (en) | 2002-02-01 |
| CN1134434C (zh) | 2004-01-14 |
| DE19817262A1 (de) | 1999-10-21 |
| CN1297449A (zh) | 2001-05-30 |
| US6503913B1 (en) | 2003-01-07 |
| ES2181413T3 (es) | 2003-02-16 |
| AR015765A1 (es) | 2001-05-16 |
| CA2328876A1 (en) | 1999-10-28 |
| EP1073653A1 (de) | 2001-02-07 |
| WO1999054329A1 (de) | 1999-10-28 |
| GT199900055A (es) | 2000-10-07 |
| JP2002512244A (ja) | 2002-04-23 |
| EP1073653B1 (de) | 2002-08-28 |
| ID26308A (id) | 2000-12-14 |
| AU3420599A (en) | 1999-11-08 |
| SV1999000049A (es) | 2000-07-04 |
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