PE133899A1 - Antibioticos cefalosporinicos - Google Patents
Antibioticos cefalosporinicosInfo
- Publication number
- PE133899A1 PE133899A1 PE1998001191A PE00119198A PE133899A1 PE 133899 A1 PE133899 A1 PE 133899A1 PE 1998001191 A PE1998001191 A PE 1998001191A PE 00119198 A PE00119198 A PE 00119198A PE 133899 A1 PE133899 A1 PE 133899A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- refers
- replaced
- cephalosporinic
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000283707 Capra Species 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 241001494479 Pecora Species 0.000 abstract 1
- 241000282849 Ruminantia Species 0.000 abstract 1
- 241000191940 Staphylococcus Species 0.000 abstract 1
- 241000194017 Streptococcus Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 208000004396 mastitis Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A CEFALOSPORINAS FLUORADAS DE FORMULA I, DONDE Ra, Rb, Rc, Rd, Re SON H, F, (ALQUILO C1-C6)-(Z)n-, SUSTITUIDO POR LO MENOS POR UN FLUOR; X ES O o S; Y ES S, O o -CH2-; Z ES O, S, -SO-, -SO2-; m Yn SON 0-1; R ES UN GRUPO a; R1 ES H, ALQUILO C1-C6, FENILO O BENCILO OPCIONALMENTE SUSTITUIDO CON HALO, ALCOXI C1-C4, FENILO, NO2, ALCANOILO C1-C6, BENZOILO, ALCANOILOXI C1-C6; UNO DE Ra, Rb, Rc, Rd o Re NO ES H; CUANDO X E Y SON S Y Rb o Rc ES F, ENTONCES UNO DE Ra, Rb, Rc, Rd o Re NO ES H. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN ANTIBIOTICO Y PUEDE SER UTIL PARA EL TRATAMIENTO DE MASTITIS CAUSADA POR STAPHYLOCOCCUS Y STREPTOCOCCUS EN RUMIANTES TAL COMO VACAS, CABRAS, OVEJAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6965597P | 1997-12-12 | 1997-12-12 | |
| US8364698P | 1998-04-30 | 1998-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE133899A1 true PE133899A1 (es) | 2000-01-11 |
Family
ID=26750285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001191A PE133899A1 (es) | 1997-12-12 | 1998-12-07 | Antibioticos cefalosporinicos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6329363B1 (es) |
| EP (1) | EP0922705A1 (es) |
| JP (1) | JP2002508381A (es) |
| AR (1) | AR017837A1 (es) |
| AU (1) | AU1719099A (es) |
| CA (1) | CA2314139A1 (es) |
| CO (1) | CO4990947A1 (es) |
| PE (1) | PE133899A1 (es) |
| WO (1) | WO1999031110A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3056497B1 (en) | 2008-05-05 | 2018-08-29 | The General Hospital Corporation | Methods using bodipy-labelled enzyme substrates |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3335136A (en) | 1965-12-27 | 1967-08-08 | Lilly Co Eli | Halophenylmercaptomethyl cephalosporins |
| CA1017325A (en) | 1971-12-27 | 1977-09-13 | George W. Huffman | Halogenated phenylthioacetamidocephalosporin derivatives |
| BE793310A (fr) | 1971-12-27 | 1973-06-27 | Lilly Co Eli | Procede de lutte contre staphylococcus aureus resistant a la methicilline |
| GB1325846A (en) * | 1972-02-23 | 1973-08-08 | Lilly Co Eli | Process for the preparation of a 3-thiomethyl cephalosporin |
| US3907784A (en) * | 1972-09-11 | 1975-09-23 | Lilly Co Eli | 7-Halophenylthioacetamido cephalosporins |
| US4261991A (en) * | 1979-05-01 | 1981-04-14 | Eli Lilly And Company | Method of treating infections caused by Streptococcus faecalis |
| US4379739A (en) * | 1980-03-31 | 1983-04-12 | Eli Lilly And Company | Electrolytic reduction of cephalosporin p-nitrobenzyl esters |
| EP0308558A1 (en) | 1987-09-25 | 1989-03-29 | Mobil Oil Corporation | A process for preparing a macrostructural unit having a catalytically-active zeolite surface |
| GB8722477D0 (en) * | 1987-09-24 | 1987-10-28 | Beecham Group Plc | Compounds |
| MY106991A (en) | 1989-09-04 | 1995-08-30 | Pfizer | Novel cephalosporin derivatives or compounds |
| EP0416810B1 (en) * | 1989-09-04 | 1995-02-08 | Beecham Group p.l.c. | Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates |
| US5559108A (en) | 1994-09-02 | 1996-09-24 | Bristol-Myers Squibb Company | Cephalosporin derivatives |
| US5567698A (en) | 1995-02-15 | 1996-10-22 | Bristol-Myers Squibb Company | Pyridinium thiomethyl substituted chepholosporin derivatives |
-
1998
- 1998-11-06 US US09/188,783 patent/US6329363B1/en not_active Expired - Fee Related
- 1998-12-07 PE PE1998001191A patent/PE133899A1/es not_active Application Discontinuation
- 1998-12-08 WO PCT/US1998/026115 patent/WO1999031110A1/en not_active Ceased
- 1998-12-08 JP JP2000539033A patent/JP2002508381A/ja not_active Withdrawn
- 1998-12-08 CA CA002314139A patent/CA2314139A1/en not_active Abandoned
- 1998-12-08 AU AU17190/99A patent/AU1719099A/en not_active Abandoned
- 1998-12-10 EP EP98310126A patent/EP0922705A1/en not_active Withdrawn
- 1998-12-10 CO CO98073442A patent/CO4990947A1/es unknown
- 1998-12-10 AR ARP980106269A patent/AR017837A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002508381A (ja) | 2002-03-19 |
| CO4990947A1 (es) | 2000-12-26 |
| WO1999031110A1 (en) | 1999-06-24 |
| EP0922705A1 (en) | 1999-06-16 |
| AU1719099A (en) | 1999-07-05 |
| CA2314139A1 (en) | 1999-06-24 |
| AR017837A1 (es) | 2001-10-24 |
| US6329363B1 (en) | 2001-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |