[go: up one dir, main page]

PA8799401A1 - Uso de un beta bloqueante para la fabricacion de un medicamento para el tratamiento de los hemangiomas - Google Patents

Uso de un beta bloqueante para la fabricacion de un medicamento para el tratamiento de los hemangiomas

Info

Publication number
PA8799401A1
PA8799401A1 PA20088799401A PA8799401A PA8799401A1 PA 8799401 A1 PA8799401 A1 PA 8799401A1 PA 20088799401 A PA20088799401 A PA 20088799401A PA 8799401 A PA8799401 A PA 8799401A PA 8799401 A1 PA8799401 A1 PA 8799401A1
Authority
PA
Panama
Prior art keywords
hemangioms
treatment
manufacture
medicinal product
blocking beta
Prior art date
Application number
PA20088799401A
Other languages
English (en)
Inventor
Christine Leaute-Labreze
De La Roque Eric Dumas
Alain Taieb
Jean-Benoit Thambo
Original Assignee
Univ Victor Segalen Bordeaux 2
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39156667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8799401(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Victor Segalen Bordeaux 2 filed Critical Univ Victor Segalen Bordeaux 2
Publication of PA8799401A1 publication Critical patent/PA8799401A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE AL USO DE UN BETA BLOQUEANTE PARA LA FABRICACIÓN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE LOS HEMANGIOMAS, POR EJEMPLO DE UN LOS HEMANGIOMAS INFANTILES. EL BETA BLOQUEANTE PUEDE SER UN BETA BLOQUEANTE NO SELECTIVO, POR EJEMPLO PROPANOLOL. LA PRESENTE INVENCIÓN PROPORCIONA UNA ALTERNATIVA A LOS COMPUESTOS CONOCIDOS, POR EJ., CORTICOIDES, INTERFERÓN O VINCRISTINA, QUE SE USAN GENERALMENTE PARA EL TRATAMIENTO DE LOS HEMANGIOMAS.
PA20088799401A 2007-10-19 2008-10-16 Uso de un beta bloqueante para la fabricacion de un medicamento para el tratamiento de los hemangiomas PA8799401A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291273A EP2050441A1 (en) 2007-10-19 2007-10-19 Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas
US98950707P 2007-11-21 2007-11-21

Publications (1)

Publication Number Publication Date
PA8799401A1 true PA8799401A1 (es) 2009-05-15

Family

ID=39156667

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088799401A PA8799401A1 (es) 2007-10-19 2008-10-16 Uso de un beta bloqueante para la fabricacion de un medicamento para el tratamiento de los hemangiomas

Country Status (29)

Country Link
US (2) US8338489B2 (es)
EP (3) EP2050441A1 (es)
JP (1) JP5552700B2 (es)
KR (2) KR20150110827A (es)
CN (2) CN103169971A (es)
AR (1) AR068927A1 (es)
AT (1) ATE512661T1 (es)
AU (1) AU2008313405B2 (es)
CA (1) CA2701953C (es)
CL (1) CL2008003083A1 (es)
CO (1) CO6270209A2 (es)
CY (1) CY1112604T1 (es)
DE (1) DE08838691T1 (es)
DK (2) DK2187878T3 (es)
ES (2) ES2390534T3 (es)
HR (2) HRP20110659T1 (es)
IL (1) IL205129A (es)
MA (1) MA31843B1 (es)
MX (1) MX2010004295A (es)
MY (1) MY156750A (es)
NZ (1) NZ584307A (es)
PA (1) PA8799401A1 (es)
PL (2) PL2233135T3 (es)
PT (2) PT2187878E (es)
RU (1) RU2471500C2 (es)
SI (2) SI2233135T1 (es)
TN (1) TN2010000170A1 (es)
TW (1) TWI531365B (es)
WO (1) WO2009050567A2 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2050441A1 (en) 2007-10-19 2009-04-22 Université Victor Segalen Bordeaux 2 Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas
US8987262B2 (en) 2007-10-19 2015-03-24 Universite de Bordeaux Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas
US8633181B2 (en) * 2009-04-09 2014-01-21 Rutgers, The State University Of New Jersey Treatment of cutaneous hemangioma
EP2246044A1 (en) 2009-04-21 2010-11-03 Pierre Fabre Dermo-Cosmétique Paediatric solutions comprising a beta-blocker
WO2012125413A2 (en) * 2011-03-12 2012-09-20 Vicus Therapeutics, Llc Compositions for ameliorating systemic inflammation and methods for making and using them
CN102579412A (zh) * 2012-02-16 2012-07-18 山东省立医院 一种治疗婴幼儿血管瘤的外用药物及其制备方法
CN103536607A (zh) * 2012-07-10 2014-01-29 邵金辉 土霉素，普罗帕酮和安乃近的抗肿瘤作用
CN103054793B (zh) * 2013-01-05 2015-01-21 广州军区广州总医院 一种用于治疗婴幼儿血管瘤的盐酸普萘洛尔乳膏及其制备方法
WO2014150899A1 (en) * 2013-03-15 2014-09-25 Chapin Matthew J Topical ophthalmic formulations for treating migraine
CN104274390B (zh) * 2014-09-04 2017-06-13 郑家伟 一种噻吗洛尔长效透皮制剂及其在血管瘤中的应用
RU2584082C1 (ru) * 2015-01-21 2016-05-20 Ильдар Наилевич Нурмеев Способ лечения гемангиом
CN105434337B (zh) * 2015-04-03 2019-08-16 武汉科福新药有限责任公司 盐酸普萘洛尔亚微乳凝胶及其制备方法和用途
CN105106105A (zh) * 2015-08-14 2015-12-02 天津市聚星康华医药科技有限公司 噻吗洛尔外用制剂治疗婴幼儿血管瘤的应用及其制备方法
US20170360829A1 (en) * 2016-01-27 2017-12-21 Gillies Mcindoe Research Institute Treatment of vascular anomalies
RU2617516C1 (ru) * 2016-03-24 2017-04-25 Государственное бюджетное учреждение здравоохранения города Москвы Научно-исследовательский институт неотложной детской хирургии и травматологии Департамента здравоохранения города Москвы Способ лечения младенческих гемангиом
CN106474061B (zh) * 2016-12-08 2019-01-22 黑龙江童医生儿童生物制药有限公司 一种盐酸普萘洛尔口服乳剂及其制备方法
CN108261411B (zh) * 2016-12-30 2021-04-30 武汉科福新药有限责任公司 用于婴幼儿血管瘤治疗的口腔膜剂及其制备方法
EP3664788B1 (en) * 2017-08-07 2023-06-07 Consejo Superior de Investigaciones Cientificas M.P. Compounds for treating von hippel-lindau disease
US20190133974A1 (en) 2017-11-07 2019-05-09 University Of South Florida Methods for detecting and treating propranolol sensitive tumors
CN108299279B (zh) * 2018-02-09 2021-03-23 北京梅尔森医药技术开发有限公司 取代芳基胺醇化合物及其制备方法和用途
CN110314154A (zh) * 2018-03-28 2019-10-11 武汉恒信源药业有限公司 左旋普萘洛尔在制备治疗血管病变药物中的应用
WO2020072311A1 (en) * 2018-10-04 2020-04-09 Emory University Pharmaceutical compositions of r-(+)-propranolol in enantiomeric excess and therapeutic uses related thereto
RU2701213C1 (ru) * 2018-12-27 2019-09-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Способ лечения инфантильных гемангиом
US11154518B2 (en) * 2018-12-28 2021-10-26 Chang Gung Memorial Hospital, Linkou Methods and apparatus for treating a wound
US20220218716A1 (en) * 2019-05-24 2022-07-14 Pediatric Derm Developement Llc Treatment of infantile hemangioma
CN111773226A (zh) * 2019-06-26 2020-10-16 首都医科大学附属北京儿童医院 噻吗洛尔或其盐在制备预防和/或治疗丛状血管瘤的药物中的用途
AU2021212568B2 (en) * 2020-01-29 2024-12-12 Gillies Mcindoe Research Institute Methods and compositions for the treatment of hemangioma
CN116056693A (zh) * 2020-07-10 2023-05-02 长庚医疗财团法人林口长庚纪念医院 β-1肾上腺素受体拮抗剂用于制备减少表皮生长因子受体抑制剂诱导的上皮细胞损伤以及抑制癌细胞的组合物的用途
JPWO2022071481A1 (es) * 2020-09-30 2022-04-07
CN113274348A (zh) * 2021-06-11 2021-08-20 四川大学华西医院 用于治疗婴幼儿血管瘤的阿替洛尔凝胶、制备方法及应用
PL244294B1 (pl) * 2022-09-20 2024-01-03 Univ Medyczny W Lodzi Kompozycja farmaceutyczna do stosowania miejscowego oraz jej zastosowanie w leczeniu naczyniaków krwionośnych u dzieci
US12257255B1 (en) 2024-01-23 2025-03-25 Auson Pharmaceuticals Inc. Timolol maleate gel for topical administration
AU2024202561B1 (en) * 2024-04-18 2025-03-06 Aft Pharmaceuticals Limited Treatment of Hemangioma

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301580A (es) * 1962-12-11
US3466325A (en) * 1965-04-30 1969-09-09 Haessle Ab 1-(ortho-alkenyl phenoxy) - 2-hydroxy-3-isopropylaminopropanes and the salts thereof
US3657237A (en) * 1968-05-22 1972-04-18 Frosst & Co Charles E Process for making 1 2 5-thiadiazoles in the sinister configuration
GB1253709A (en) 1968-05-22 1971-11-17 Frosst & Co Charles E Thiadiazole derivatives
US3655663A (en) * 1969-04-21 1972-04-11 Burton K Wasson 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles
SE354851B (es) * 1970-02-18 1973-03-26 Haessle Ab
AT334385B (de) * 1973-12-20 1976-01-10 Chemie Linz Ag Verfahren zur herstellung von neuen phenoxypropylaminderivaten und deren salzen
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
US5116867A (en) * 1989-06-30 1992-05-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services D-propranolol as a selective adenosine antagonist
US5182102A (en) * 1991-07-12 1993-01-26 Alcon Laboratories, Inc. Anti-glaucoma compositions
PT1155689E (pt) * 1993-07-19 2007-01-31 Angiotech Pharm Inc Composições anti-angiogenicas e metodos de utilização
US6232299B1 (en) * 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
PL329851A1 (en) * 1996-05-01 1999-04-12 Lilly Co Eli Treatment of diseases associated with vegf
GB9616672D0 (en) * 1996-08-08 1996-09-25 Scherer Ltd R P Pharmaceutical compositions
WO2002090349A1 (de) * 2001-05-08 2002-11-14 Schering Aktiengesellschaft N-oxidanthranylamid-derivate und deren verwendung als arzneimittel
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20080221203A1 (en) * 2004-08-09 2008-09-11 University Catholique De Louvain Use of Agonists and Antagonists of Beta Adrenoceptors for Treating Arterial Disease
TW200716141A (en) * 2005-05-05 2007-05-01 Combinatorx Inc Compositions and methods for treatment for neoplasms
US8987262B2 (en) 2007-10-19 2015-03-24 Universite de Bordeaux Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas
EP2050441A1 (en) 2007-10-19 2009-04-22 Université Victor Segalen Bordeaux 2 Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas

Also Published As

Publication number Publication date
AU2008313405B2 (en) 2013-12-19
SI2233135T1 (sl) 2012-10-30
TWI531365B (zh) 2016-05-01
WO2009050567A2 (en) 2009-04-23
DE08838691T1 (de) 2010-08-26
HRP20120765T1 (hr) 2012-10-31
DK2187878T3 (da) 2011-09-19
CL2008003083A1 (es) 2009-03-06
TN2010000170A1 (en) 2011-11-11
CY1112604T1 (el) 2016-02-10
US9173858B2 (en) 2015-11-03
PL2233135T3 (pl) 2012-11-30
EP2233135B1 (en) 2012-06-27
PT2187878E (pt) 2011-09-07
KR20100087012A (ko) 2010-08-02
AU2008313405A1 (en) 2009-04-23
US20100273889A1 (en) 2010-10-28
MA31843B1 (fr) 2010-11-01
KR101562627B1 (ko) 2015-10-22
JP2011500661A (ja) 2011-01-06
MX2010004295A (es) 2010-08-02
RU2471500C2 (ru) 2013-01-10
WO2009050567A3 (en) 2009-06-18
DK2233135T3 (da) 2012-10-01
US8338489B2 (en) 2012-12-25
HRP20110659T1 (hr) 2011-10-31
NZ584307A (en) 2012-03-30
CO6270209A2 (es) 2011-04-20
EP2050441A1 (en) 2009-04-22
IL205129A (en) 2015-05-31
MY156750A (en) 2016-03-31
CA2701953A1 (en) 2009-04-23
IL205129A0 (en) 2010-11-30
RU2010112816A (ru) 2011-11-27
US20130072551A1 (en) 2013-03-21
CN102006864B (zh) 2013-01-16
ES2368299T3 (es) 2011-11-16
AR068927A1 (es) 2009-12-16
EP2187878B1 (en) 2011-06-15
CN103169971A (zh) 2013-06-26
EP2233135A1 (en) 2010-09-29
SI2187878T1 (sl) 2011-10-28
HK1148940A1 (en) 2011-09-23
ES2390534T3 (es) 2012-11-13
BRPI0816536A2 (pt) 2017-06-06
CN102006864A (zh) 2011-04-06
ATE512661T1 (de) 2011-07-15
PL2187878T3 (pl) 2012-01-31
EP2233135B8 (en) 2013-07-10
JP5552700B2 (ja) 2014-07-16
CA2701953C (en) 2015-05-19
KR20150110827A (ko) 2015-10-02
TW200932207A (en) 2009-08-01
PT2233135E (pt) 2012-09-06
EP2187878A2 (en) 2010-05-26

Similar Documents

Publication Publication Date Title
PA8799401A1 (es) Uso de un beta bloqueante para la fabricacion de un medicamento para el tratamiento de los hemangiomas
CL2018002703A1 (es) Agentes de iarn, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr). (divisional solicitud 201401291)
MX2023009205A (es) Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente.
ECSP099445A (es) Quinazolinas para la inhibición de pdk1
DOP2013000267A (es) Hidroximetil pirrolidinas como agonistas del receptor adrenérgico beta 3
CR20110103A (es) Heteroarilos sustituidos
MX2014001717A (es) Composiciones inmunoterapeuticas de levadura-mucina 1 (muc1) y usos de las mismas.
MX2018011992A (es) Compuestos de aminopurina sustituida, composiciones de estos y metodos de tratamiento con estos.
ECSP099620A (es) Derivados de ciclohexano espirociclico
ECSP11011054A (es) Péptidos antivirales terapéuticos
MX2009008347A (es) Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.
CL2013002517A1 (es) Compuestos derivados de fosforoamidato de 5-fluoro-2'-desoxiuridina; procedimiento de preparacion; composicion farmaceutica que los comprende; su uso en el tratamiento o profilaxis del cancer.
CL2012000921A1 (es) Compuestos derivados de espiropiperidina-metilbenciloxifenil, activadores del receptor rpg-40; composicion farmaceutica que los comprende; y uso del compuesto para tratar diabetes.
CR20140223A (es) Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a
ECSP088749A (es) Compuestos de tetrahidropiridotienopirimidina y procedimientos de uso de los mismos
CL2011000691A1 (es) Compuestos derivados de nicotinamida sustituida; composicion farmaceutica que los comprende; uso para el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias.
ECSP10010548A (es) Composiciones y metodos de preparacion y uso de las mismas
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
CL2011002494A1 (es) Compuestos derivados de 7-aza-di-espiro-[3.0.4.1]-decan-8-carboxamida; composición farmacéutica que los comprenden; y uso para el tratamiento de un trastorno asociado con el virus de la hepatitis c (hcv) y el virus de inmunodeficiencia humana (vih).
UY35129A (es) Compuestos heteroaromáticos y su uso como ligandos d1 de dopamina
CO6341625A2 (es) Derivados de indol como agentes anticáncer
ECSP12011658A (es) Ligandos sigma para la prevención o el tratamiento de dolor inducido por quimioterapia
UY30451A1 (es) 18-metil-19-nor-androst-4-en-17,17-espiroéteres (18-metil-19-nor-20-espirox-4-en-3-onas),ase como preparaciones farmacéuticas que lo contienen.
CL2012001031A1 (es) Compuestos derivados de 2-oxo-1-pirrolidinil-imidazotiadiazol; composición farmacéutica que los comprende; útiles para el tratamiento de la epilepsia, transtornos neurológicos, entre otros.
CL2017001539A1 (es) Compuestos indenil, composiciones farmacéuticas y sus usos médicos de los mismos