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PA8663501A1 - Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados - Google Patents

Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados

Info

Publication number
PA8663501A1
PA8663501A1 PA20068663501A PA8663501A PA8663501A1 PA 8663501 A1 PA8663501 A1 PA 8663501A1 PA 20068663501 A PA20068663501 A PA 20068663501A PA 8663501 A PA8663501 A PA 8663501A PA 8663501 A1 PA8663501 A1 PA 8663501A1
Authority
PA
Panama
Prior art keywords
benzotiofen
indeno
indol
benzofuran
derivatives
Prior art date
Application number
PA20068663501A
Other languages
English (en)
Inventor
Lalitha Krishnan
Gary Paul Stack
Annmarie Louise Sabb
Robert Lewis Vogel
Deborah Ann Evrard
Amedeo Arturo Failli
Anita Wai-Yin Chan
Jianxi Ren
Charles J Guinosso
Reinhardt Bernhard Baudy
Jean Yi-Ching
Yanfang Li
Iii Charles John Stanton
Antonia Nikitenko
Original Assignee
Wyeth Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Wyeth filed Critical Wyeth Wyeth
Publication of PA8663501A1 publication Critical patent/PA8663501A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA DERIVADOS DE INDOL, BENZOTIOFENO, BENZOFURANO, E INDENO CICLOALQUILCONDENSADOS, Y METODOS PARA USARLOS, POR EJEMPLO, PARA TRATAR, PREVENIR Y/O MEJORAR ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL ANTAGONIZANDO RECEPTORES 5-HT 1A Y MODULANDO LOS NIVELES DE SEROTONINA.
PA20068663501A 2005-02-17 2006-02-16 Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados PA8663501A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65366605P 2005-02-17 2005-02-17

Publications (1)

Publication Number Publication Date
PA8663501A1 true PA8663501A1 (es) 2006-11-09

Family

ID=36609274

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20068663501A PA8663501A1 (es) 2005-02-17 2006-02-16 Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados

Country Status (13)

Country Link
US (2) US7297704B2 (es)
EP (1) EP1856126A2 (es)
JP (1) JP2008530229A (es)
CN (1) CN101120002A (es)
AR (1) AR052674A1 (es)
AU (1) AU2006214233A1 (es)
BR (1) BRPI0608353A2 (es)
CA (1) CA2597616A1 (es)
GT (1) GT200600078A (es)
MX (1) MX2007009783A (es)
PA (1) PA8663501A1 (es)
TW (1) TW200640931A (es)
WO (1) WO2006089053A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006016885A1 (de) * 2006-04-11 2007-10-18 Bayer Cropscience Ag Mit bicyclischen Radikalen N-substituierte Diamino-1,3,5-triazine, Verfahren für ihre Herstellung, Zubereitungen davon und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
UA98777C2 (en) 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
HRP20120917T1 (hr) * 2008-05-16 2012-12-31 Eli Lilly & Company TETRAHIDROCIKLOPENTA[b]INDOLSKI MODULATORI ANDROGENOG RECEPTORA
JP5476305B2 (ja) 2008-08-07 2014-04-23 杏林製薬株式会社 ビシクロ［２．２．２］オクチルアミン誘導体の製造方法
WO2010032723A1 (ja) * 2008-09-16 2010-03-25 杏林製薬株式会社 アミノアセチルピロリジンカルボニトリル誘導体の精製方法およびその塩
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
NZ767139A (en) * 2009-12-04 2022-08-26 Sunovion Pharmaceuticals Inc Multicyclic compounds and methods of use thereof
BR112013011737A2 (pt) 2010-11-15 2016-08-09 Univ Leuven Kath composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv
AR088377A1 (es) * 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN105255887B (zh) * 2015-07-17 2018-05-18 四川大学 一种重组慢病毒及其在制备治疗可卡因成瘾的药物中的用途
KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
US10196403B2 (en) 2016-07-29 2019-02-05 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
WO2018151861A1 (en) 2017-02-16 2018-08-23 Sunovion Pharamaceuticials Inc. Methods of treating schizophrenia
JP7191085B2 (ja) 2017-08-02 2022-12-16 サノビオン ファーマシューティカルズ インク イソクロマン化合物およびその使用
EP3752508A1 (en) 2018-02-16 2020-12-23 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
JP2023510220A (ja) 2020-01-17 2023-03-13 テグ－キョンプク メディカル イノベーション ファウンデーション 新規化合物、その調製方法、及びその使用
WO2021211489A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders
CN113512427B (zh) * 2021-08-17 2023-04-28 烟台显华科技集团股份有限公司 具有负介电各向异性的液晶化合物、液晶组合物、液晶显示器件
CN113512430B (zh) * 2021-08-17 2023-05-02 烟台显华科技集团股份有限公司 负介电各向异性液晶组合物及液晶显示器件

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695294A (en) * 1952-12-19 1954-11-23 Mcneilab Inc N, n'-substituted diamine compounds and method of making the same
GB1005028A (en) 1964-03-13 1965-09-22 Charles E Frosst & Company Novel 1:4-benzodioxan derivatives
DE1913199C3 (de) 1969-03-15 1975-11-27 Beiersdorf Ag, 2000 Hamburg Mannichbasen aus alpha-Tetralon bzw. dessen Derivaten und Arylalkylaminen und deren Salze
CA924305A (en) 1969-09-23 1973-04-10 K. Wasson Burton (3-(1,4-benzodioxan-2-ylmethylamino)-propyl) polynuclear compounds
US3769298A (en) * 1971-04-02 1973-10-30 Pfizer Substituted aminomethylcarbazoles
US3868387A (en) * 1971-04-15 1975-02-25 Hoffmann La Roche 1,2,3,4-tetrahydrocarbazole-2-carboxylic acids and their derivatives
PT65342B (fr) * 1975-07-09 1978-01-06 Cortial Proces de preparation de nouvelles amino-3 3h-isobenzo-furanones n-substituees
GR71865B (es) 1978-03-20 1983-07-07 Ciba Geigy
US4396550A (en) 1980-04-22 1983-08-02 Kyowa Hakko Kogyo Co., Ltd. Dibenz [b,e] oxepin derivatives
US4684739A (en) 1980-12-15 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene derivatives and acid addition salts thereof
US4473586A (en) * 1982-05-03 1984-09-25 Abbott Laboratories Aminoalkyl dihydronaphthalenes
US4618683A (en) * 1982-06-01 1986-10-21 Abbott Laboratories Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives
JPS58219114A (ja) 1982-06-15 1983-12-20 Mitsubishi Chem Ind Ltd 血圧降下剤
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate
GB8511526D0 (en) 1985-05-07 1985-06-12 Hoechst Uk Ltd 1 4 benzodioxin & 1 4 benzoxazine derivatives
US4748182A (en) 1986-03-05 1988-05-31 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
US5049654A (en) 1986-12-04 1991-09-17 Toyo Jozo Kabushiki Kaisha Calcitonin gene related peptide derivatives
JPH01146876A (ja) 1987-12-03 1989-06-08 Dai Ichi Seiyaku Co Ltd アミノアルキルベンゾピラン誘導体
US5034381A (en) 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
DE68909253T2 (de) 1988-01-15 1994-02-24 Abbott Lab 1-Aminomethyl-1,2,3,4-tetrahydronaphthaline und -indane.
GT198900008A (es) * 1988-01-29 1990-07-17 Derivados de quinolina, quinazolina y cinolina.
CA1338625C (en) 1988-06-09 1996-10-01 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5049564A (en) * 1989-11-17 1991-09-17 Abbott Laboratories 5-HT selective agents
JPH0725785B2 (ja) 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US6432956B1 (en) * 1990-02-12 2002-08-13 William C. Dement Method for treatment of sleep apneas
EP0594593A1 (en) 1990-03-15 1994-05-04 PHARMACIA & UPJOHN COMPANY Therapeutically useful heterocyclic indole compounds
US5221879A (en) * 1990-09-21 1993-06-22 Bando Chemical Industries, Ltd. Method and apparatus for winding a cord continuously in dip treating apparatus
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
EP0492021A1 (en) 1990-12-24 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania
AU1752792A (en) 1991-03-08 1992-10-06 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5721237A (en) 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
CS164891A3 (en) 1991-05-31 1992-12-16 Vyzk Ustav Farm Biochem Sp N-arylalkyl derivatives of 2-aminomethyl-1,4-benzodioxan, and process forpreparing thereof
GB9112697D0 (en) 1991-06-13 1991-07-31 Shell Int Research Biocidal compounds
US5827871A (en) * 1991-06-26 1998-10-27 Smithkline Beecham Plc Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
EP0558245A1 (en) 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors
US5324743A (en) * 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226573D0 (en) 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
WO1994022846A1 (en) 1993-03-30 1994-10-13 Pfizer Inc. Compounds enhancing antitumor activity of other cytotoxic agents
FR2704857B1 (fr) * 1993-05-07 1995-06-23 Adir Nouvelles benzodioxines substituées, leur procédé de préparation et les compositions pharmaceutiques les contenant.
US5468767A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
DE4419973A1 (de) 1994-06-08 1995-12-14 Bayer Ag Monohydratform des (R)-2-Cycloheptylmethylaminomethyl-8-methoxy-chroman-hydrochlorids
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
FR2729141A1 (fr) 1995-01-06 1996-07-12 Smithkline Beecham Lab Nouveaux derives de carbazole, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
HU224067B1 (hu) 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
PL327617A1 (en) 1995-10-23 1998-12-21 Zymogenetics Inc Compositions for and methods of treating osseous insufficiency
US5756532A (en) 1995-11-06 1998-05-26 American Home Products Corporation Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
GB9526495D0 (en) 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
DE19604191A1 (de) * 1996-02-06 1997-08-07 Hoechst Schering Agrevo Gmbh 2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
EP0888324A1 (fr) * 1996-03-08 1999-01-07 Synthelabo Derives de 2-aminoethyl-benzofurane, leur preparation et leur application en therapeutique
PT842165E (pt) 1996-03-25 2001-08-30 Alcon Laboratoires Inc Derivados de acido tiazolidina-4-carboxilico como agentes citoprotectores
AU2980797A (en) 1996-06-11 1998-01-07 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and medicinal uses thereof
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5830911A (en) * 1996-08-14 1998-11-03 American Home Products Corporation Pyranoindole and tetrahydrocarbazole inhibitors of COX-2
US5846995A (en) * 1997-08-25 1998-12-08 Eli Lilly And Company Substituted 1, 2, 3, 4-tetrahydro-2-dibenzofuranamines and 2-amino-cyclohepta (6, 7-B) Benzofurans
US5750556A (en) * 1996-10-30 1998-05-12 American Home Products Corporation 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
DE19648384A1 (de) * 1996-11-22 1998-05-28 Merck Patent Gmbh Fluorene, Dibenzofurane und Dibenzothiophene
GB9704948D0 (en) 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
DE69807586T2 (de) 1997-05-20 2003-06-26 Mitsubishi Chemical Corp., Tokio/Tokyo Verwendung eines Alkylendioxybenzolderivats zur Behandlung von zirkadianen Schlafstörungen
US6221884B1 (en) * 1997-06-04 2001-04-24 Eli Lilly And Company Carboxamides useful as 5-HT1F agonists
EP0905136A1 (en) 1997-09-08 1999-03-31 Janssen Pharmaceutica N.V. Tetrahydro gamma-carbolines
UA58476C2 (uk) 1997-10-09 2003-08-15 Санофі-Сентелябо Похідні 8-азабіцикло[3.2.1]октан-3-метанаміну, фармацевтична композиція та лікарський засіб
FR2769912B1 (fr) * 1997-10-16 2000-03-10 Pf Medicament Nouveaux derives de la 3-oxo- (2h)-1,2,4 triazine leur preparation et leur application en therapeutique humaine
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
DE19754573A1 (de) 1997-12-09 1999-06-10 Bayer Ag Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma
US6051586A (en) * 1997-12-19 2000-04-18 Bayer Corporation Sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
SK9362000A3 (en) 1997-12-19 2001-09-11 Bayer Ag Carboxyl substituted chroman derivatives useful as beta-3-adrenoreceptor agonists
JPH11189536A (ja) 1997-12-25 1999-07-13 Toray Ind Inc 原発性糸球体腎炎治療または予防薬
GB9811879D0 (en) 1998-06-03 1998-07-29 Knoll Ag Therapeutic agents
RU2233841C2 (ru) 1998-06-12 2004-08-10 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик Сас Бета-карболиновые соединения, фармацевтические композиции на их основе и способы связывания, достижения агонистического/антагонистического эффекта
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
EP1119570B1 (en) 1998-10-06 2004-06-16 Janssen Pharmaceutica N.V. Tricyclic delta3-piperidines as pharmaceuticals
EP1044972A4 (en) * 1998-10-23 2003-03-12 Toray Industries 5,7,7-TRINOR-4,8-INTER-m-PHENYLENE PGI2 DERIVATIVE AND MEDICAMENTS CONTAINING SAID DERIVATIVE
AU2175500A (en) 1998-12-17 2000-07-03 Alcon Laboratories, Inc. Improved viscoelastic compositions and methods of use
FR2791675B1 (fr) 1999-03-30 2001-05-04 Synthelabo Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique
WO2000075136A1 (en) 1999-06-02 2000-12-14 Janssen Pharmaceutica N.V. Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
DE60023144T2 (de) 1999-08-05 2006-07-06 Teijin Ltd. Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten
MY125942A (en) * 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
IL149177A0 (en) * 1999-11-05 2002-11-10 Sod Conseils Rech Applic Novel heterocyclic compounds and their use as medicines
AU784211B2 (en) 1999-12-10 2006-02-23 Wyeth Combinations of (S)-2(benzylamino-methyl)-2,3,8,9,- tetrahydro-7H-1,4-dioxino(2,3)-E indol-8-one and neuroleptics
US6482862B1 (en) * 1999-12-20 2002-11-19 G.D. Searle & Co. Method of using substituted N-benzyl-N-phenyl aminoalcohols for inhibiting cholesteryl ester transfer protein activity
GB0007376D0 (en) 2000-03-28 2000-05-17 Knoll Ag Therapeutic agents
US20020016359A1 (en) * 2000-06-29 2002-02-07 Hellberg Mark R. Compositions and methods of treating neurodegenerative diseases
YU23503A (sh) 2000-09-29 2006-03-03 Neurogen Corporation Mali molekuli kao modulatori receptora c5a visokog afiniteta
ATE403647T1 (de) 2000-10-16 2008-08-15 Hoffmann La Roche Indolinderivate und deren verwendung als 5-ht2 rezeptor liganden
IT1317926B1 (it) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Derivati triciclici dell'indolo ad attivita' antiangiogenica.
DE10101917A1 (de) * 2001-01-16 2002-07-18 Bayer Ag Verwendung von Chromanen
IL156595A0 (en) 2001-01-16 2004-01-04 Astrazeneca Ab Therapeutic heterocyclic compounds
US6458802B1 (en) * 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
AR035858A1 (es) 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
US6803368B2 (en) 2001-04-25 2004-10-12 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene
US6800642B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
US6627639B2 (en) * 2001-04-26 2003-09-30 Wyeth Uses for indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino-[2,3-e]indole
US6821981B2 (en) * 2001-04-26 2004-11-23 Wyeth Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
AU2002256334A1 (en) * 2001-04-26 2002-11-11 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino(2,3-f)quinoxaline
US7008944B2 (en) * 2001-04-26 2006-03-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline
DK1381613T3 (da) 2001-04-26 2005-01-24 Wyeth Corp Antidepressive azaheterocyclylmethylderivater af oxaheterocyclokondenserede 1,4-benzodioxaner
US6861434B2 (en) 2001-04-26 2005-03-01 Wyeth Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one
DE10120619A1 (de) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
US6800641B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
US6861427B2 (en) * 2001-04-26 2005-03-01 Wyeth Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists
US6800648B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
US6555560B2 (en) 2001-04-30 2003-04-29 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
IL158879A0 (en) * 2001-05-17 2004-05-12 Wyeth Corp PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-(2,3-f) QUINOLINE
KR100397792B1 (ko) * 2001-06-28 2003-09-13 한국과학기술연구원 4-(페닐아미노)-[1,4]디옥사노[2,3-ｇ]퀴나졸린 유도체 및그의 제조방법
US6541502B1 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
WO2003010169A1 (en) * 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
ATE296628T1 (de) 2001-08-01 2005-06-15 Merck Patent Gmbh Integrinhemmer zur behandlung von augenkrankheiten
US6632371B2 (en) 2001-08-07 2003-10-14 Abbott Laboratories Method for controlling the proportion of fluid passing through a filter
US20040235920A1 (en) 2001-09-12 2004-11-25 Gerd Bartoszyk Novel use of substituted aminomethyl chromans for the treatment of movement disorders and of adverse effects induced by drugs administered to treat extrapyramidal movement disorders
MXPA04002492A (es) 2001-09-19 2004-05-31 Merck Patent Ges Mit Baschrank Uso novedoso de aminometil cromanos sustituidos.
DE10148425A1 (de) * 2001-10-01 2003-04-17 Bayer Ag Chromane
CA2461381A1 (en) 2001-10-04 2003-04-10 Wyeth Chroman derivatives as 5-hydroxytryptamine-6 ligands
WO2003029239A1 (en) 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
MXPA04003086A (es) 2001-10-05 2004-09-06 Wyeth Corp Proceso para sintesis estereoselectiva de 2-hidroximetil-cromanos.
JP2005508349A (ja) * 2001-10-09 2005-03-31 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー ５−ｈｔ６受容体リガンドとしてのアリールスルホニル置換されたテトラヒドロ−およびヘキサヒドロ−カルバゾール
AU2002364211A1 (en) 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
JP2003212872A (ja) 2002-01-23 2003-07-30 Japan Energy Corp 新規クロマン誘導体及びその医薬用途
EP1474162A1 (en) 2002-02-14 2004-11-10 MERCK PATENT GmbH Methods and compositions for the treatment of eye diseases
JP2003335669A (ja) 2002-05-17 2003-11-25 Mitsubishi Pharma Corp Ｐｅｒ遺伝子発現増強剤及び概日リズム障害治療薬
WO2003104216A1 (en) 2002-06-10 2003-12-18 Acadia Pharmaceuticals Inc. Urotensin ii receptor modulators
JP2004059538A (ja) 2002-07-31 2004-02-26 Sumitomo Pharmaceut Co Ltd 新規なイミダゾキノリノン誘導体
AR040962A1 (es) 2002-08-09 2005-04-27 Novartis Ag Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
EP1424337A1 (en) 2002-11-26 2004-06-02 Solvay Pharmaceuticals GmbH 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives

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AR052674A1 (es) 2007-03-28
MX2007009783A (es) 2007-08-22
WO2006089053A3 (en) 2007-01-11
CN101120002A (zh) 2008-02-06
US20060205759A1 (en) 2006-09-14
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WO2006089053A2 (en) 2006-08-24
US7297704B2 (en) 2007-11-20

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