PA8572001A1 - Derivados de isoquinolina - Google Patents
Derivados de isoquinolinaInfo
- Publication number
- PA8572001A1 PA8572001A1 PA20038572001A PA8572001A PA8572001A1 PA 8572001 A1 PA8572001 A1 PA 8572001A1 PA 20038572001 A PA20038572001 A PA 20038572001A PA 8572001 A PA8572001 A PA 8572001A PA 8572001 A1 PA8572001 A1 PA 8572001A1
- Authority
- PA
- Panama
- Prior art keywords
- isoquinoline derivatives
- preparation
- refers
- medicines
- mao
- Prior art date
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
ESTA INVENCION SE REFIERE A DERIVADOS DE ISOQUINOLINA DE FORMULA GENERAL EN DONDE Y ES >C=O O -CH2-, Z ES >C=O O -CH2-, Y R1, R2, Y M SON TAL COMO SE HAN DEFINIDO EN LA ESPECIFICACION, ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES. LA INVENCION ADEMAS SE REFIERE A MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS, UN PROCESO PARA SU PREPARACION ASI COMO SU USO PARA LA PREPARACION DE MEDICAMENTOS PARA EL TRATAMENTO O PREVENCION DE ENFERMEDADES EN QUE LOS INHIBIDORES DE LA MAO-B PUEDAN SER BENEFICIOSOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02009253 | 2002-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8572001A1 true PA8572001A1 (es) | 2003-12-10 |
Family
ID=29265896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20038572001A PA8572001A1 (es) | 2002-04-26 | 2003-04-23 | Derivados de isoquinolina |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6818774B2 (es) |
| EP (1) | EP1501804B1 (es) |
| JP (1) | JP4322685B2 (es) |
| KR (1) | KR100681585B1 (es) |
| CN (1) | CN1310890C (es) |
| AR (1) | AR039651A1 (es) |
| AT (1) | ATE440821T1 (es) |
| AU (1) | AU2003227614B2 (es) |
| BR (1) | BR0309562A (es) |
| CA (1) | CA2483461C (es) |
| DE (1) | DE60328978D1 (es) |
| DK (1) | DK1501804T3 (es) |
| ES (1) | ES2329354T3 (es) |
| GT (1) | GT200300095A (es) |
| HR (1) | HRP20040952A2 (es) |
| IL (1) | IL164677A0 (es) |
| MX (1) | MXPA04010537A (es) |
| MY (1) | MY133527A (es) |
| NO (1) | NO20044571L (es) |
| NZ (1) | NZ535885A (es) |
| PA (1) | PA8572001A1 (es) |
| PE (1) | PE20040594A1 (es) |
| PL (1) | PL373697A1 (es) |
| PT (1) | PT1501804E (es) |
| RU (1) | RU2318812C2 (es) |
| SI (1) | SI1501804T1 (es) |
| TW (1) | TWI278451B (es) |
| UY (1) | UY27786A1 (es) |
| WO (1) | WO2003091219A1 (es) |
| ZA (1) | ZA200408281B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| ATE537825T1 (de) * | 2003-05-19 | 2012-01-15 | Irm Llc | Immunosuppressive verbindungen und zusammensetzungen |
| WO2004113330A1 (en) * | 2003-05-19 | 2004-12-29 | Irm Llc | Immunosuppressant compounds and compositions |
| US7825109B2 (en) | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
| ES2754221T3 (es) * | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
| DE602004017206D1 (de) * | 2003-10-23 | 2008-11-27 | Hoffmann La Roche | Benzazepin-derivate als mao-b-hemmer |
| US7763638B2 (en) | 2004-03-01 | 2010-07-27 | Actelion Pharmaceuticals Ltd. | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
| EP2371811B1 (en) | 2004-12-13 | 2014-10-08 | Ono Pharmaceutical Co., Ltd. | Azetidinecarboxylic acid derivative and medicinal use thereof |
| JP4934055B2 (ja) * | 2005-01-28 | 2012-05-16 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | イソクロマンおよびその誘導体の製造方法 |
| EP2281556A1 (en) | 2005-02-25 | 2011-02-09 | F. Hoffmann-La Roche AG | Tablets with improved drugs substance dispersibility |
| SI1963280T1 (sl) | 2005-12-22 | 2016-02-29 | Newron Pharmaceuticals S.P.A. | 2-feniletilamino derivati kot modulatorji kalcijevih in/ali natrijevih kanalčkov |
| AU2007226203A1 (en) * | 2006-03-15 | 2007-09-20 | Actelion Pharmaceuticals Ltd | Tetrahydroisoquinoline derivatives to enhance memory function |
| EP2013209B1 (en) | 2006-04-26 | 2011-01-19 | Actelion Pharmaceuticals Ltd. | Pyrazolo-tetrahydropyridine derivatives as orexin receptor antagonists |
| KR101220182B1 (ko) * | 2009-02-25 | 2013-01-11 | 에스케이바이오팜 주식회사 | 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법 |
| CN105315204B (zh) * | 2014-07-04 | 2018-02-09 | 中南大学 | 7‑氨基‑1,4‑二氢异喹啉‑3(2h)‑酮衍生物及其合成方法和用途 |
| CN105585527B (zh) * | 2015-12-17 | 2018-06-26 | 浙江工业大学 | 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用 |
| CN105461626B (zh) * | 2015-12-17 | 2018-05-08 | 浙江工业大学 | 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用 |
| CN110461829B (zh) * | 2017-03-27 | 2023-02-28 | 百时美施贵宝公司 | 作为免疫调节剂的取代的异喹啉衍生物 |
| ES3029867T3 (en) * | 2019-12-18 | 2025-06-25 | Chdi Foundation Inc | Compounds and probes for imaging huntingtin protein |
| CN114591238B (zh) * | 2022-03-25 | 2022-11-15 | 邦恩泰(山东)生物医药科技集团股份有限公司 | 一种异喹啉类药物中间体的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| US6448269B1 (en) * | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicyclic compounds and pharmaceutical compositions containing them |
| US6137002A (en) * | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
| CN1116870C (zh) | 1996-03-15 | 2003-08-06 | 萨默塞特药品有限公司 | 司立吉林在制备用于预防或治疗外周神经病的药物中的应用 |
| AU1359801A (en) | 1999-11-05 | 2001-06-06 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
-
2003
- 2003-04-14 KR KR1020047017185A patent/KR100681585B1/ko not_active Expired - Fee Related
- 2003-04-14 PL PL03373697A patent/PL373697A1/xx unknown
- 2003-04-14 CA CA2483461A patent/CA2483461C/en not_active Expired - Fee Related
- 2003-04-14 EP EP03725018A patent/EP1501804B1/en not_active Expired - Lifetime
- 2003-04-14 HR HR20040952A patent/HRP20040952A2/hr not_active Application Discontinuation
- 2003-04-14 AT AT03725018T patent/ATE440821T1/de not_active IP Right Cessation
- 2003-04-14 RU RU2004134575/04A patent/RU2318812C2/ru not_active IP Right Cessation
- 2003-04-14 WO PCT/EP2003/003845 patent/WO2003091219A1/en not_active Ceased
- 2003-04-14 NZ NZ535885A patent/NZ535885A/en not_active IP Right Cessation
- 2003-04-14 AU AU2003227614A patent/AU2003227614B2/en not_active Ceased
- 2003-04-14 BR BR0309562-2A patent/BR0309562A/pt not_active IP Right Cessation
- 2003-04-14 DK DK03725018T patent/DK1501804T3/da active
- 2003-04-14 JP JP2003587782A patent/JP4322685B2/ja not_active Expired - Fee Related
- 2003-04-14 MX MXPA04010537A patent/MXPA04010537A/es active IP Right Grant
- 2003-04-14 ES ES03725018T patent/ES2329354T3/es not_active Expired - Lifetime
- 2003-04-14 PT PT03725018T patent/PT1501804E/pt unknown
- 2003-04-14 SI SI200331658T patent/SI1501804T1/sl unknown
- 2003-04-14 DE DE60328978T patent/DE60328978D1/de not_active Expired - Lifetime
- 2003-04-14 CN CNB038093766A patent/CN1310890C/zh not_active Expired - Fee Related
- 2003-04-16 US US10/417,378 patent/US6818774B2/en not_active Expired - Fee Related
- 2003-04-23 PA PA20038572001A patent/PA8572001A1/es unknown
- 2003-04-23 TW TW092109478A patent/TWI278451B/zh not_active IP Right Cessation
- 2003-04-24 GT GT200300095A patent/GT200300095A/es unknown
- 2003-04-24 AR ARP030101412A patent/AR039651A1/es unknown
- 2003-04-24 PE PE2003000408A patent/PE20040594A1/es not_active Application Discontinuation
- 2003-04-25 MY MYPI20031578A patent/MY133527A/en unknown
- 2003-04-28 UY UY27786A patent/UY27786A1/es not_active Application Discontinuation
-
2004
- 2004-10-13 ZA ZA200408281A patent/ZA200408281B/xx unknown
- 2004-10-18 IL IL16467704A patent/IL164677A0/xx not_active IP Right Cessation
- 2004-10-22 NO NO20044571A patent/NO20044571L/no not_active Application Discontinuation
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