LV5264A3 - Panemiens guanina atvasinajumu vai to farmaceitiski pielietojamu skabju-aditivo saju iegusanai - Google Patents

Panemiens guanina atvasinajumu vai to farmaceitiski pielietojamu skabju-aditivo saju iegusanai

Info

Publication number: LV5264A3
Authority: LV; Latvia
Prior art keywords: additive; achievement; pharmaceutically usable; guanine derivatives; guanine
Prior art date: 1987-08-15

Application number

LV920335A

Other languages

English (en)

Inventor

Thomas Anthony Krenitsky

Lilia Marie Beauchamp

Original Assignee

Wellcome Foundation Limtied

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-15

Filing date

1992-12-18

Publication date

1993-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV5264(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-08-15 Priority claimed from GB878719367A external-priority patent/GB8719367D0/en

1987-11-05 Priority claimed from GB878725939A external-priority patent/GB8725939D0/en

1992-12-18 Application filed by Wellcome Foundation Limtied filed Critical Wellcome Foundation Limtied

1993-10-10 Publication of LV5264A3 publication Critical patent/LV5264A3/lv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)

LV920335A 1987-08-15 1992-12-18 Panemiens guanina atvasinajumu vai to farmaceitiski pielietojamu skabju-aditivo saju iegusanai LV5264A3 (lv)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB878719367A GB8719367D0 (en)	1987-08-15	1987-08-15	Therapeutic compounds
GB878725939A GB8725939D0 (en)	1987-11-05	1987-11-05	Therapeutic compounds
SU884356404A SU1634138A3 (ru)	1987-08-15	1988-08-12	Способ получени производных гуанина или их кислотно-аддитивных фармацевтически приемлемых солей

Publications (1)

Publication Number	Publication Date
LV5264A3 true LV5264A3 (lv)	1993-10-10

Family

ID=26292613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LV920335A LV5264A3 (lv)	1987-08-15	1992-12-18	Panemiens guanina atvasinajumu vai to farmaceitiski pielietojamu skabju-aditivo saju iegusanai

Country Status (30)

Country	Link
EP (2)	EP0308065B1 (lv)
JP (2)	JPH0662623B2 (lv)
KR (2)	KR960002849B1 (lv)
CN (1)	CN1033701C (lv)
AP (2)	AP160A (lv)
AT (1)	ATE138660T1 (lv)
AU (1)	AU612393C (lv)
CS (1)	CS276903B6 (lv)
CY (1)	CY1833A (lv)
DE (1)	DE3855333T2 (lv)
DK (2)	DK170045B1 (lv)
ES (1)	ES2087639T3 (lv)
FI (1)	FI89713C (lv)
GR (1)	GR3020372T3 (lv)
HU (1)	HU201071B (lv)
IE (1)	IE65551B1 (lv)
IL (1)	IL87434A (lv)
LU (1)	LU88746I2 (lv)
LV (1)	LV5264A3 (lv)
MC (1)	MC1968A1 (lv)
MX (1)	MX9203418A (lv)
MY (1)	MY103760A (lv)
NL (1)	NL960001I2 (lv)
NO (2)	NO167805C (lv)
NZ (1)	NZ225809A (lv)
PL (1)	PL158285B1 (lv)
PT (1)	PT88261B (lv)
SA (1)	SA95160244B1 (lv)
SG (1)	SG26346G (lv)
SU (1)	SU1634138A3 (lv)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
GB8816760D0 (en) *	1988-07-14	1988-08-17	Wellcome Found	Therapeutic compounds
ATE123285T1 (de) *	1988-12-19	1995-06-15	Wellcome Found	Antivirale pyrimidin- und purinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate.
GB8829571D0 (en) *	1988-12-19	1989-02-08	Wellcome Found	Antiviral compounds
DE4008858A1 (de) *	1990-03-20	1991-09-26	Hoechst Ag	Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
NZ266527A (en) *	1993-06-08	1999-10-28	Cancer Res Campaign Tech	Alkylguanine derivatives and pharmaceutical compositions
DE69426880T2 (de) *	1993-06-10	2001-10-31	Rolabo S.L., Zaragoza	Verfahren zur herstellung von aminosäureester von nukleosid analogen
GB9317146D0 (en) *	1993-08-18	1993-10-06	Wellcome Found	Therapeutic combinations
GB9320316D0 (en) *	1993-10-01	1993-11-17	Smithkline Beecham Plc	Pharmaceuticals
TW282470B (lv) *	1993-11-18	1996-08-01	Ajinomoto Kk
DE69513313T2 (de) *	1994-02-01	2000-07-13	Ajinomoto Co., Inc.	Verfahren zur Herstellung von Nukleinsäurebasenderivaten
US5543414A (en) *	1994-07-28	1996-08-06	Syntex (Usa) Inc.	Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) *	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5856481A (en) *	1994-07-28	1999-01-05	Syntex (U.S.A.) Inc.	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
GB9501142D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Compounds for use in medicine
GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative
GB9501127D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Tablet
DE19536164A1 (de) *	1995-09-28	1997-04-03	Boehringer Ingelheim Kg	Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
PT874631E (pt) *	1996-01-19	2004-04-30	Glaxo Group Ltd	Utilizacao de valaciclovir para a manufactura de um medicamento para o tratamento de herpes genital por aplicacao diaria unica
US6040446A (en)	1996-01-26	2000-03-21	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
KR100491941B1 (ko) *	1996-01-26	2005-08-05	에프. 호프만-라 로슈 아게	푸린유도체의제조방법
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
IT1283447B1 (it) *	1996-07-18	1998-04-21	Ind Chimica Srl	Processo di preparazione del valaciclovir e relativi intermedi
WO1998031683A1 (en) *	1997-01-17	1998-07-23	Ajinomoto Co., Inc.	Novel z-valacyclovir crystals
CA2332961A1 (en) *	1998-05-21	1999-11-25	Michael Zasloff	A method for stimulation of defensin production by exposure to isoleucine
SK1592004A3 (sk) *	2001-09-07	2005-03-04	Teva Pharmaceutical Industries Ltd.	Kryštalické formy valaciklovírus hydrochlóridu
WO2004000265A2 (en)	2002-06-24	2003-12-31	Ranbaxy Laboratories Limited	Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050043329A1 (en) *	2002-09-06	2005-02-24	Shlomit Wizel	Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) *	2002-10-28	2007-04-11	南京长澳医药科技有限公司	6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
WO2005000850A2 (en) *	2003-06-02	2005-01-06	Teva Pharmaceutical Industries, Ltd.	Novel crystalline forms of valacyclovir hydrochloride
CN1331471C (zh) *	2003-09-22	2007-08-15	陈云芳	盐酸万乃洛韦软胶囊组合物
WO2005073233A1 (en) *	2004-01-21	2005-08-11	Teva Pharmaceutical Industries Ltd.	Process for the preparation of valacyclovir hydrochloride
GB2413017A (en) *	2004-04-06	2005-10-12	Ford Global Tech Llc	An electrical connector for a vehicle
WO2006035452A1 (en) *	2004-09-27	2006-04-06	Matrix Laboratories Ltd	Novel pseudomorph of valaciclovir hydrochloride
ES2379804T3 (es)	2005-05-25	2012-05-03	Eli Lilly And Company	Ésteres de ciclopropanocarboxilato de aciclovir
EP1746098A1 (en)	2005-07-21	2007-01-24	SOLMAG S.p.A.	Valacyclovir polymorphs and a process for the preparation thereof
CN101456859B (zh) *	2009-01-06	2011-07-20	华南理工大学	抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (en)	2010-06-15	2011-12-22	Matrix Laboratories Ltd	Process for the preparation of valacyclovir hydrochloride polymorphic form ii
CN102850354B (zh) *	2012-10-10	2014-07-23	山东金城医药化工股份有限公司	高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) *	2016-12-27	2017-05-10	河南康达制药有限公司	一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) *	2020-05-18	2021-07-05	Александр Сергеевич Самойлов	Производные гуанина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) *	1985-09-24	1987-04-02	Hoechst Ag	In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3534774A1 (de) *	1985-09-30	1987-04-02	Robugen Gmbh	Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.

1988
- 1988-08-10 AP APAP/P/1991/000238A patent/AP160A/en active
- 1988-08-10 AP APAP/P/1988/000099A patent/AP55A/en active
- 1988-08-11 MC MC881999A patent/MC1968A1/fr unknown
- 1988-08-12 NO NO883612A patent/NO167805C/no not_active IP Right Cessation
- 1988-08-12 CS CS885594A patent/CS276903B6/cs not_active IP Right Cessation
- 1988-08-12 DK DK451388A patent/DK170045B1/da not_active IP Right Cessation
- 1988-08-12 CN CN88106535A patent/CN1033701C/zh not_active Expired - Lifetime
- 1988-08-12 EP EP88307512A patent/EP0308065B1/en not_active Expired - Lifetime
- 1988-08-12 LU LU88746C patent/LU88746I2/fr unknown
- 1988-08-12 ES ES93120604T patent/ES2087639T3/es not_active Expired - Lifetime
- 1988-08-12 PL PL1988274215A patent/PL158285B1/pl unknown
- 1988-08-12 FI FI883757A patent/FI89713C/fi not_active IP Right Cessation
- 1988-08-12 DE DE3855333T patent/DE3855333T2/de not_active Expired - Lifetime
- 1988-08-12 AT AT93120604T patent/ATE138660T1/de not_active IP Right Cessation
- 1988-08-12 SU SU884356404A patent/SU1634138A3/ru active
- 1988-08-12 JP JP63200320A patent/JPH0662623B2/ja not_active Expired - Lifetime
- 1988-08-12 KR KR1019880010298A patent/KR960002849B1/ko not_active Expired - Lifetime
- 1988-08-12 IE IE246388A patent/IE65551B1/en not_active IP Right Cessation
- 1988-08-12 EP EP93120604A patent/EP0596542B1/en not_active Expired - Lifetime
- 1988-08-12 IL IL87434A patent/IL87434A/xx not_active IP Right Cessation
- 1988-08-12 NZ NZ225809A patent/NZ225809A/en unknown
- 1988-08-12 MY MYPI88000934A patent/MY103760A/en unknown
- 1988-08-12 AU AU20978/88A patent/AU612393C/en not_active Expired
- 1988-08-12 PT PT88261A patent/PT88261B/pt not_active IP Right Cessation
- 1988-08-12 HU HU884332A patent/HU201071B/hu unknown
1990
- 1990-08-28 JP JP2226434A patent/JPH07113025B2/ja not_active Expired - Lifetime
1992
- 1992-06-25 MX MX9203418A patent/MX9203418A/es unknown
- 1992-12-18 LV LV920335A patent/LV5264A3/lv unknown
1994
- 1994-07-08 DK DK082694A patent/DK170803B1/da not_active IP Right Cessation
1995
- 1995-02-24 SG SG1995903373A patent/SG26346G/en unknown
- 1995-09-20 SA SA95160244A patent/SA95160244B1/ar unknown
- 1995-12-01 CY CY183395A patent/CY1833A/xx unknown
1996
- 1996-01-17 KR KR1019960000775A patent/KR960004940B1/ko not_active Expired - Lifetime
- 1996-01-18 NL NL960001C patent/NL960001I2/nl unknown
- 1996-06-27 GR GR960401743T patent/GR3020372T3/el unknown
- 1996-12-17 NO NO1996015C patent/NO1996015I1/no unknown

Also Published As

Publication number	Publication date
NO883612L (no)	1989-02-16
PL274215A1 (en)	1990-02-19
NL960001I2 (nl)	1996-11-01
JPS6468373A (en)	1989-03-14
FI89713B (fi)	1993-07-30
HUT47935A (en)	1989-04-28
MY103760A (en)	1993-09-30
DK82694A (da)	1994-07-08
AP8800099A0 (en)	1988-08-01
FI89713C (fi)	1993-11-10
EP0308065A2 (en)	1989-03-22
CS276903B6 (en)	1992-09-16
GR3020372T3 (en)	1996-09-30
CN1032538A (zh)	1989-04-26
NL960001I1 (nl)	1996-03-01
NZ225809A (en)	1991-07-26
HU201071B (en)	1990-09-28
PT88261B (pt)	1995-03-01
KR960004940B1 (ko)	1996-04-18
FI883757A0 (fi)	1988-08-12
JPH07113025B2 (ja)	1995-12-06
AU612393C (en)	2006-08-17
AU612393B2 (en)	1991-07-11
CY1833A (en)	1995-12-01
FI883757L (fi)	1989-02-16
AU2097888A (en)	1989-02-16
SU1634138A3 (ru)	1991-03-07
AP55A (en)	1989-09-26
NO883612D0 (no)	1988-08-12
NO167805C (no)	1991-12-11
DK451388A (da)	1989-02-16
EP0308065A3 (en)	1989-09-27
PT88261A (pt)	1989-06-30
MX9203418A (es)	1992-07-01
CN1033701C (zh)	1997-01-01
JPH03115284A (ja)	1991-05-16
NO1996015I1 (no)	1996-12-17
NO167805B (no)	1991-09-02
SG26346G (en)	1995-09-01
PL158285B1 (en)	1992-08-31
ES2087639T3 (es)	1996-07-16
IE882463L (en)	1989-02-15
IL87434A (en)	1993-06-10
DE3855333T2 (de)	1996-12-05
DK170045B1 (da)	1995-05-08
JPH0662623B2 (ja)	1994-08-17
LU88746I2 (fr)	1996-10-04
IE65551B1 (en)	1995-11-01
KR890003761A (ko)	1989-04-17
DK170803B1 (da)	1996-01-22
IL87434A0 (en)	1989-01-31
EP0596542A1 (en)	1994-05-11
MC1968A1 (fr)	1989-09-29
SA95160244B1 (ar)	2006-10-02
EP0596542B1 (en)	1996-05-29
ATE138660T1 (de)	1996-06-15
KR960002849B1 (ko)	1996-02-27
DK451388D0 (da)	1988-08-12
EP0308065B1 (en)	1995-01-04
DE3855333D1 (de)	1996-07-04
AP160A (en)	1991-11-18
CS8805594A2 (en)	1990-06-13

Publication	Publication Date	Title
LV5264A3 (lv)	1993-10-10	Panemiens guanina atvasinajumu vai to farmaceitiski pielietojamu skabju-aditivo saju iegusanai
LV10614A (lv)	1995-04-20	2-anilinopirimidina atvasinajumi
LV5624A3 (lv)	1994-05-10	Panemiens 5'-dezoksi-5-fluorcitidina atvasinajumu iegusanai
DE3856154D1 (de)	1998-05-07	Adenosin-Derivate
KR890002608U (ko)	1989-04-06	자동차의 전부차체구조
DK179388D0 (da)	1988-03-30	Acylderivater
KR880701730A (ko)	1988-11-04	아데노신의 복소방향족 유도체
FI895447A7 (fi)	1989-11-15	Substituoidut terapeuttisina aineina käytettävät adeniinijohdannaiset
FI884721A7 (fi)	1989-04-16	Fluorijohdannnaisten käyttö varjoaineina
NO178497C (no)	1996-04-10	Fremgangsmåte for fremstilling av 9-substituerte guaninderivater og mellomprodukter for anvendelse i fremgangsmåten
DK390986D0 (da)	1986-08-15	Guaninderivater
DK455288A (da)	1989-02-15	Acylderivater
IT8822760A0 (it)	1988-11-28	Ciclodestrinclatrati di derivati della 5-ciano-prostaciclina e loro impiego come medicinali
DK71187A (da)	1987-08-15	Purinderivater
DK170088D0 (da)	1988-03-28	Acylderivater
FI884960A7 (fi)	1989-05-01	2-pyrimidinyyli-1-piperatsiini-johdannaisten käyttö
PT87705A (pt)	1988-07-01	Process for the preparation of 6-deoxy guanine derivative
FI893648A7 (fi)	1989-08-01	Hydroksipyrimidiinien asyylijohdannaisia
DK316589D0 (da)	1989-06-26	Substituerede azacyclohexylderivater af rifamyciner
LV5499A3 (lv)	1994-03-10	2-Tieniloksietikskabes atvasinajumu vai to farmaceitiski pienemamu salu iegusanas panemiens
FR2618676B1 (fr)	1994-09-02	Compositions pharmaceutiques antivirales
DK323788A (da)	1988-12-17	Acylderivater
DK629387D0 (da)	1987-12-01	Fremgangsmaade
PT8008Y (pt)	1992-08-31	Canhao de brinquedo
LV5513A3 (lv)	1994-03-10	2-(2-Tienil)-imidazo(4,5-c)piridina atvasinajumu vai to farmaceitiski derigu skabes aditivo salu iegusanas panemiens