LV12792B - Formyl- or cyano- substituted indole derivatives having dopaminergic activity - Google Patents
Formyl- or cyano- substituted indole derivatives having dopaminergic activityInfo
- Publication number
- LV12792B LV12792B LVP-01-129A LV010129A LV12792B LV 12792 B LV12792 B LV 12792B LV 010129 A LV010129 A LV 010129A LV 12792 B LV12792 B LV 12792B
- Authority
- LV
- Latvia
- Prior art keywords
- 6alkyl
- dopamine
- independently hydrogen
- formyl
- cyano
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- -1 cyano- substituted indole Chemical class 0.000 title 1
- 230000003291 dopaminomimetic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 102000015554 Dopamine receptor Human genes 0.000 abstract 2
- 108050004812 Dopamine receptor Proteins 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- DCLKZMQLRCOSOE-UHFFFAOYSA-N 6,7,8,9-tetrahydro-3h-benzo[e]indol-1-amine Chemical class C1CCCC2=C3C(N)=CNC3=CC=C21 DCLKZMQLRCOSOE-UHFFFAOYSA-N 0.000 abstract 1
- 206010000599 Acromegaly Diseases 0.000 abstract 1
- 201000000736 Amenorrhea Diseases 0.000 abstract 1
- 206010001928 Amenorrhoea Diseases 0.000 abstract 1
- 208000001287 Galactorrhea Diseases 0.000 abstract 1
- 206010017600 Galactorrhoea Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 231100000540 amenorrhea Toxicity 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000031424 hyperprolactinemia Diseases 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3756893A | 1993-03-25 | 1993-03-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV12792A LV12792A (en) | 2002-02-20 |
| LV12792B true LV12792B (en) | 2002-06-20 |
Family
ID=21895045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-01-129A LV12792B (en) | 1993-03-25 | 2001-08-30 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5639778A (xx) |
| EP (1) | EP0690843B1 (xx) |
| JP (1) | JP3298885B2 (xx) |
| AT (1) | ATE195935T1 (xx) |
| AU (1) | AU679053B2 (xx) |
| DE (1) | DE69425736T2 (xx) |
| DK (1) | DK0690843T3 (xx) |
| ES (1) | ES2149869T3 (xx) |
| GR (1) | GR3034906T3 (xx) |
| LV (1) | LV12792B (xx) |
| NZ (1) | NZ263403A (xx) |
| PT (1) | PT690843E (xx) |
| WO (1) | WO1994021608A1 (xx) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002064091A2 (en) * | 2001-02-13 | 2002-08-22 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
| CA2255612A1 (en) * | 1996-05-31 | 1997-12-04 | Pharmacia & Upjohn Company | Aryl substituted cyclic amines as selective dopamine d3 ligands |
| FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| IT1292155B1 (it) * | 1997-06-13 | 1999-01-25 | Zambon Spa | Derivati naftotiazolonici attivi sul recettore dopaminergico d 3 |
| EP1349834A2 (en) * | 2000-12-18 | 2003-10-08 | Eli Lilly And Company | Cycloalkyfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| JP2005504043A (ja) * | 2001-08-10 | 2005-02-10 | パラチン テクノロジーズ インク． | 生物学的に活性な金属ペプチド類のペプチド模倣体類 |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7053223B2 (en) * | 2003-02-14 | 2006-05-30 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US7227023B2 (en) | 2003-04-30 | 2007-06-05 | Wyeth | Quinoline 3-amino chroman derivatives |
| US7968548B2 (en) * | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| RU2442781C2 (ru) * | 2004-10-14 | 2012-02-20 | Абботт ГмбХ унд Ко. КГ | Арилсульфонилметильные или арилсульфонамидные производные ароматических соединений, фармацевтическая композиция на их основе и способ лечения расстройств, восприимчивых к лечению лигандами дофаминовых d3 рецепторов, с их помощью |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| UY32442A (es) * | 2009-02-13 | 2010-09-30 | Sanofi Aventis | Nuevos indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento |
| WO2015112806A2 (en) | 2014-01-24 | 2015-07-30 | Tp Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| ES2864839T3 (es) | 2015-07-02 | 2021-10-14 | Turning Point Therapeutics Inc | Macrociclos de diarilo quirales como moduladores de proteína quinasas |
| ES2979111T3 (es) | 2015-07-06 | 2024-09-24 | Turning Point Therapeutics Inc | Polimorfo de macrociclo de diarilo |
| MX383823B (es) | 2015-07-21 | 2025-03-14 | Turning Point Therapeutics Inc | Macrociclos de diarilo quirales y usos de los mismo. |
| CN109715165A (zh) | 2016-07-28 | 2019-05-03 | Tp生物医药公司 | 巨环激酶抑制剂 |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| WO2018151240A1 (ja) * | 2017-02-17 | 2018-08-23 | 第一三共株式会社 | ３，６，７，８－テトラヒドロシクロペンタ［ｅ］インドール化合物 |
| MY201925A (en) | 2017-07-28 | 2024-03-23 | Turning Point Therapeutics Inc | Macrocyclic compounds and uses thereof |
| EP3728270A4 (en) * | 2017-12-19 | 2021-06-23 | Turning Point Therapeutics, Inc. | MACROCYCLIC KINASE INHIBITORS AND THEIR USES |
| JP7194188B2 (ja) | 2017-12-19 | 2022-12-21 | ターニング・ポイント・セラピューティクス・インコーポレイテッド | 疾患を治療するための大環状化合物 |
| CA3187217A1 (en) | 2020-08-06 | 2022-02-10 | Matthew BAGGOTT | 2-aminoindane compounds for mental disorders or enhancement |
| CN112724068A (zh) * | 2020-12-30 | 2021-04-30 | 蔡桂坡 | 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4060626A (en) * | 1972-01-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Indole-carboxylic carbon compounds and pharmaceutical compositions containing them |
| DE2740836A1 (de) * | 1977-09-10 | 1979-03-22 | Troponwerke Gmbh & Co Kg | Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4110339A (en) * | 1977-11-25 | 1978-08-29 | Eli Lilly And Company | 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole |
| CA1159459A (en) * | 1980-12-11 | 1983-12-27 | Andre A. Asselin | 6,7,8,9-tetrahydro-3h-benz¬e| indolamine derivatives |
| US4510157A (en) * | 1982-12-27 | 1985-04-09 | Ayerst, Mckenna & Harrison, Inc. | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives |
| US4470990A (en) * | 1983-03-14 | 1984-09-11 | Ayerst, Mckenna & Harrison Inc. | 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants |
| FR2613364B1 (fr) * | 1987-04-01 | 1989-06-09 | Adir | Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2613365B1 (fr) * | 1987-04-01 | 1989-07-28 | Adir | Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| ATE178893T1 (de) * | 1990-01-11 | 1999-04-15 | Upjohn Co | 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem |
-
1994
- 1994-03-21 WO PCT/US1994/002800 patent/WO1994021608A1/en not_active Ceased
- 1994-03-21 DE DE69425736T patent/DE69425736T2/de not_active Expired - Fee Related
- 1994-03-21 US US08/522,290 patent/US5639778A/en not_active Expired - Fee Related
- 1994-03-21 ES ES94911606T patent/ES2149869T3/es not_active Expired - Lifetime
- 1994-03-21 PT PT94911606T patent/PT690843E/pt unknown
- 1994-03-21 AU AU64086/94A patent/AU679053B2/en not_active Ceased
- 1994-03-21 NZ NZ263403A patent/NZ263403A/en not_active IP Right Cessation
- 1994-03-21 JP JP52118994A patent/JP3298885B2/ja not_active Expired - Fee Related
- 1994-03-21 EP EP94911606A patent/EP0690843B1/en not_active Expired - Lifetime
- 1994-03-21 DK DK94911606T patent/DK0690843T3/da active
- 1994-03-21 AT AT94911606T patent/ATE195935T1/de not_active IP Right Cessation
-
2000
- 2000-11-24 GR GR20000402612T patent/GR3034906T3/el not_active IP Right Cessation
-
2001
- 2001-08-30 LV LVP-01-129A patent/LV12792B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LV12792A (en) | 2002-02-20 |
| AU679053B2 (en) | 1997-06-19 |
| AU6408694A (en) | 1994-10-11 |
| PT690843E (pt) | 2001-01-31 |
| GR3034906T3 (en) | 2001-02-28 |
| JP3298885B2 (ja) | 2002-07-08 |
| DE69425736T2 (de) | 2001-04-12 |
| DK0690843T3 (da) | 2000-11-13 |
| WO1994021608A1 (en) | 1994-09-29 |
| US5639778A (en) | 1997-06-17 |
| NZ263403A (en) | 1996-10-28 |
| ES2149869T3 (es) | 2000-11-16 |
| EP0690843A1 (en) | 1996-01-10 |
| DE69425736D1 (de) | 2000-10-05 |
| JPH08508251A (ja) | 1996-09-03 |
| EP0690843B1 (en) | 2000-08-30 |
| ATE195935T1 (de) | 2000-09-15 |
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