GR3034906T3 - Indoletetralins having dopaminergic activity - Google Patents
Indoletetralins having dopaminergic activityInfo
- Publication number
- GR3034906T3 GR3034906T3 GR20000402612T GR20000402612T GR3034906T3 GR 3034906 T3 GR3034906 T3 GR 3034906T3 GR 20000402612 T GR20000402612 T GR 20000402612T GR 20000402612 T GR20000402612 T GR 20000402612T GR 3034906 T3 GR3034906 T3 GR 3034906T3
- Authority
- GR
- Greece
- Prior art keywords
- alkyl
- halogen
- pct
- hydrogen
- phenyl
- Prior art date
Links
- 230000003291 dopaminomimetic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3756893A | 1993-03-25 | 1993-03-25 | |
| PCT/US1994/002800 WO1994021608A1 (en) | 1993-03-25 | 1994-03-21 | Indoletetralins having dopaminergic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3034906T3 true GR3034906T3 (en) | 2001-02-28 |
Family
ID=21895045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20000402612T GR3034906T3 (en) | 1993-03-25 | 2000-11-24 | Indoletetralins having dopaminergic activity |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5639778A (el) |
| EP (1) | EP0690843B1 (el) |
| JP (1) | JP3298885B2 (el) |
| AT (1) | ATE195935T1 (el) |
| AU (1) | AU679053B2 (el) |
| DE (1) | DE69425736T2 (el) |
| DK (1) | DK0690843T3 (el) |
| ES (1) | ES2149869T3 (el) |
| GR (1) | GR3034906T3 (el) |
| LV (1) | LV12792B (el) |
| NZ (1) | NZ263403A (el) |
| PT (1) | PT690843E (el) |
| WO (1) | WO1994021608A1 (el) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0923542B1 (en) * | 1996-05-31 | 2003-08-20 | PHARMACIA & UPJOHN COMPANY | Aryl substituted cyclic amines as selective dopamine d3 ligands |
| FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| IT1292155B1 (it) * | 1997-06-13 | 1999-01-25 | Zambon Spa | Derivati naftotiazolonici attivi sul recettore dopaminergico d 3 |
| JP2004518658A (ja) * | 2000-12-18 | 2004-06-24 | イーライ・リリー・アンド・カンパニー | 新規なｓＰＬＡ２インヒビター |
| AU2002238106A1 (en) * | 2001-02-13 | 2002-08-28 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
| EP1425029A4 (en) * | 2001-08-10 | 2006-06-07 | Palatin Technologies Inc | PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7053223B2 (en) * | 2003-02-14 | 2006-05-30 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US7227023B2 (en) | 2003-04-30 | 2007-06-05 | Wyeth | Quinoline 3-amino chroman derivatives |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7968548B2 (en) * | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| JP5193602B2 (ja) * | 2004-10-14 | 2013-05-08 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ドーパミンｄ３受容体の調節に応答する障害の治療に好適なアリールスルホニルメチルまたはアリールスルホンアミド置換芳香族化合物 |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| TW201040154A (en) * | 2009-02-13 | 2010-11-16 | Sanofi Aventis | Novel substituted indanes, process for preparation thereof and use thereof as a medicament |
| EP3636649B1 (en) | 2014-01-24 | 2024-02-14 | Turning Point Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| RU2732405C2 (ru) | 2015-07-02 | 2020-09-16 | Тёрнинг Поинт Терапьютикс, Инк. | Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ |
| WO2017007759A1 (en) | 2015-07-06 | 2017-01-12 | Tp Therapeutics, Inc. | Diaryl macrocycle polymorph |
| US20180325901A1 (en) | 2015-07-21 | 2018-11-15 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles and uses thereof |
| JP2019527230A (ja) | 2016-07-28 | 2019-09-26 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 大環状キナーゼ阻害剤 |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| WO2018151240A1 (ja) * | 2017-02-17 | 2018-08-23 | 第一三共株式会社 | ３，６，７，８－テトラヒドロシクロペンタ［ｅ］インドール化合物 |
| LT3658148T (lt) | 2017-07-28 | 2024-09-10 | Turning Point Therapeutics, Inc. | Makrocikliniai junginiai ir jų panaudojimas |
| EP3728270A4 (en) * | 2017-12-19 | 2021-06-23 | Turning Point Therapeutics, Inc. | MACROCYCLIC KINASE INHIBITORS AND THEIR USES |
| KR102814342B1 (ko) * | 2017-12-19 | 2025-05-29 | 터닝 포인트 테라퓨틱스, 인크. | 질병 치료용 대환식 화합물 |
| EP4192447A4 (en) * | 2020-08-06 | 2024-07-24 | Tactogen Inc. | 2-AMINOINDANE COMPOUNDS FOR IMPROVING MENTAL DISORDERS |
| CN112724068A (zh) * | 2020-12-30 | 2021-04-30 | 蔡桂坡 | 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4060626A (en) * | 1972-01-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Indole-carboxylic carbon compounds and pharmaceutical compositions containing them |
| DE2740836A1 (de) * | 1977-09-10 | 1979-03-22 | Troponwerke Gmbh & Co Kg | Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4110339A (en) * | 1977-11-25 | 1978-08-29 | Eli Lilly And Company | 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole |
| CA1159459A (en) * | 1980-12-11 | 1983-12-27 | Andre A. Asselin | 6,7,8,9-tetrahydro-3h-benz¬e| indolamine derivatives |
| US4510157A (en) * | 1982-12-27 | 1985-04-09 | Ayerst, Mckenna & Harrison, Inc. | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives |
| US4470990A (en) * | 1983-03-14 | 1984-09-11 | Ayerst, Mckenna & Harrison Inc. | 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants |
| FR2613364B1 (fr) * | 1987-04-01 | 1989-06-09 | Adir | Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2613365B1 (fr) * | 1987-04-01 | 1989-07-28 | Adir | Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| ATE178893T1 (de) * | 1990-01-11 | 1999-04-15 | Upjohn Co | 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem |
-
1994
- 1994-03-21 DK DK94911606T patent/DK0690843T3/da active
- 1994-03-21 NZ NZ263403A patent/NZ263403A/en not_active IP Right Cessation
- 1994-03-21 DE DE69425736T patent/DE69425736T2/de not_active Expired - Fee Related
- 1994-03-21 ES ES94911606T patent/ES2149869T3/es not_active Expired - Lifetime
- 1994-03-21 WO PCT/US1994/002800 patent/WO1994021608A1/en not_active Ceased
- 1994-03-21 AT AT94911606T patent/ATE195935T1/de not_active IP Right Cessation
- 1994-03-21 JP JP52118994A patent/JP3298885B2/ja not_active Expired - Fee Related
- 1994-03-21 AU AU64086/94A patent/AU679053B2/en not_active Ceased
- 1994-03-21 PT PT94911606T patent/PT690843E/pt unknown
- 1994-03-21 US US08/522,290 patent/US5639778A/en not_active Expired - Fee Related
- 1994-03-21 EP EP94911606A patent/EP0690843B1/en not_active Expired - Lifetime
-
2000
- 2000-11-24 GR GR20000402612T patent/GR3034906T3/el not_active IP Right Cessation
-
2001
- 2001-08-30 LV LVP-01-129A patent/LV12792B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LV12792A (en) | 2002-02-20 |
| WO1994021608A1 (en) | 1994-09-29 |
| DE69425736T2 (de) | 2001-04-12 |
| ES2149869T3 (es) | 2000-11-16 |
| US5639778A (en) | 1997-06-17 |
| LV12792B (en) | 2002-06-20 |
| ATE195935T1 (de) | 2000-09-15 |
| AU6408694A (en) | 1994-10-11 |
| EP0690843A1 (en) | 1996-01-10 |
| DK0690843T3 (da) | 2000-11-13 |
| DE69425736D1 (de) | 2000-10-05 |
| PT690843E (pt) | 2001-01-31 |
| JPH08508251A (ja) | 1996-09-03 |
| JP3298885B2 (ja) | 2002-07-08 |
| AU679053B2 (en) | 1997-06-19 |
| NZ263403A (en) | 1996-10-28 |
| EP0690843B1 (en) | 2000-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |