LV10951B - 4-quinolinyl derivatives with anti-helicobacter activity - Google Patents

4-quinolinyl derivatives with anti-helicobacter activity Download PDF

Info

Publication number: LV10951B
Authority: LV; Latvia
Prior art keywords: formula; compounds; compound; vvas; acid
Prior art date: 1992-10-27

Application number

LVP-95-143A

Other languages

English (en)

Latvian (lv)

Other versions

LV10951A (lv

Inventor

Marc Gaston Venet

Jerome Emiles Georges Guillemont

Daniel Franck Jean Vernier

Franck Christopher Odds

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-27

Filing date

1995-05-26

Publication date

1996-08-20

1995-05-26 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1995-12-20 Publication of LV10951A publication Critical patent/LV10951A/xx

1996-08-20 Publication of LV10951B publication Critical patent/LV10951B/en

Links

230000000694 effects Effects 0.000 title abstract description 13
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150000001875 compounds Chemical class 0.000 claims abstract description 115
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239000002253 acid Substances 0.000 claims abstract description 46
150000003839 salts Chemical class 0.000 claims abstract description 28
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238000000034 method Methods 0.000 claims abstract description 25
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 22
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 21
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 17
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 10
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TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
150000004965 peroxy acids Chemical class 0.000 description 1
NHKJPPKXDNZFBJ-UHFFFAOYSA-N phenyllithium Chemical compound [Li]C1=CC=CC=C1 NHKJPPKXDNZFBJ-UHFFFAOYSA-N 0.000 description 1
IPNPIHIZVLFAFP-UHFFFAOYSA-N phosphorus tribromide Chemical compound BrP(Br)Br IPNPIHIZVLFAFP-UHFFFAOYSA-N 0.000 description 1
229960005235 piperonyl butoxide Drugs 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
239000008213 purified water Substances 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
WPYJKGWLDJECQD-UHFFFAOYSA-N quinoline-2-carbaldehyde Chemical class C1=CC=CC2=NC(C=O)=CC=C21 WPYJKGWLDJECQD-UHFFFAOYSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000006268 reductive amination reaction Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
150000004508 retinoic acid derivatives Chemical class 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
238000009097 single-agent therapy Methods 0.000 description 1
ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
201000011549 stomach cancer Diseases 0.000 description 1
239000000126 substance Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000004114 suspension culture Methods 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)

LVP-95-143A 1992-10-27 1995-05-26 4-quinolinyl derivatives with anti-helicobacter activity LV10951B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US96700892A	1992-10-27	1992-10-27
US6980493A	1993-06-01	1993-06-01
PCT/EP1993/002884 WO1994010164A1 (fr)	1992-10-27	1993-10-19	Derives de la 4-quinoleinyle a activite anti-helicobacter

Publications (2)

Publication Number	Publication Date
LV10951A LV10951A (lv)	1995-12-20
LV10951B true LV10951B (en)	1996-08-20

Family

ID=26750446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-95-143A LV10951B (en)	1992-10-27	1995-05-26	4-quinolinyl derivatives with anti-helicobacter activity

Country Status (22)

Country	Link
US (1)	US5589484A (fr)
EP (1)	EP0666855B1 (fr)
JP (1)	JPH08502503A (fr)
KR (1)	KR100239003B1 (fr)
AT (1)	ATE143013T1 (fr)
AU (1)	AU675087B2 (fr)
BG (1)	BG99566A (fr)
CA (1)	CA2146651A1 (fr)
CZ (1)	CZ287159B6 (fr)
DE (1)	DE69304930T2 (fr)
DK (1)	DK0666855T3 (fr)
ES (1)	ES2094567T3 (fr)
FI (1)	FI951996A0 (fr)
GR (1)	GR3021690T3 (fr)
HU (1)	HUT71895A (fr)
LV (1)	LV10951B (fr)
NO (1)	NO951588L (fr)
NZ (1)	NZ256871A (fr)
PL (1)	PL175679B1 (fr)
RU (1)	RU2130933C1 (fr)
SK (1)	SK53495A3 (fr)
WO (1)	WO1994010164A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6479514B1 (en)	1998-05-23	2002-11-12	Altana Pharma Ag	Quinoline-aminomethyl-pyridyl derivatives with anti-helicobacter activity
GB9819382D0 (en)	1998-09-04	1998-10-28	Cerebrus Ltd	Chemical compounds I
TW200803855A (en) *	2006-02-24	2008-01-16	Kalypsys Inc	Quinolones useful as inducible nitric oxide synthase inhibitors
US8987315B2 (en)	2009-12-31	2015-03-24	Innocrin Pharmaceuticals, Inc.	Metalloenzyme inhibitor compounds
US9302992B2 (en)	2013-04-02	2016-04-05	Annji Pharmaceutical Co., Ltd.	Multifunctional quinoline derivatives as anti-neurodegenerative agents
EP2981525A4 (fr) *	2013-04-02	2016-12-21	Annji Pharm Co Ltd	Dérivés de quinoléine multifonctionnels en tant qu'agents anti-neurodégénératifs
JP6254239B2 (ja)	2016-02-29	2017-12-27	大日精化工業株式会社	ポリマーの製造方法
JP6245719B1 (ja)	2017-03-24	2017-12-13	大日精化工業株式会社	ポリマーの製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT294090B (de) *	1969-04-22	1971-11-10	Degussa	Verfahren zur Herstellung von neuen Aminopyridinen, von deren optisch aktiven bzw. diastereomeren Formen, deren Salzen und deren quartären Verbindungen
CH679582A5 (fr) *	1988-07-18	1992-03-13	Glaxo Group Ltd
CA2002864C (fr) *	1988-11-29	1999-11-16	Eddy J. E. Freyne	Derives de quinoline, quinazoline ou quinoxaline (1h-azol-1-ylmethyl) substitues
GB8827820D0 (en) *	1988-11-29	1988-12-29	Janssen Pharmaceutica Nv	(1h-azol-1-ylmethyl)substituted quinoline derivatives
US5185346A (en) *	1988-11-29	1993-02-09	Hanssen Pharmaceutica	(1H-azol-1-ylmethyl)substituted quinoline derivatives
GB8827822D0 (en) *	1988-11-29	1988-12-29	Janssen Pharmaceutica Nv	(1h-azol-1-ylmethyl)substituted quinoline derivatives
US5128140A (en) *	1991-01-14	1992-07-07	The Procter & Gamble Company	Swallowable pharmaceutical compositions

1993
- 1993-10-19 EP EP93922961A patent/EP0666855B1/fr not_active Expired - Lifetime
- 1993-10-19 ES ES93922961T patent/ES2094567T3/es not_active Expired - Lifetime
- 1993-10-19 WO PCT/EP1993/002884 patent/WO1994010164A1/fr not_active Ceased
- 1993-10-19 CA CA002146651A patent/CA2146651A1/fr not_active Abandoned
- 1993-10-19 AU AU51782/93A patent/AU675087B2/en not_active Ceased
- 1993-10-19 KR KR1019950701501A patent/KR100239003B1/ko not_active Expired - Fee Related
- 1993-10-19 RU RU95109440A patent/RU2130933C1/ru active
- 1993-10-19 PL PL93308550A patent/PL175679B1/pl unknown
- 1993-10-19 DE DE69304930T patent/DE69304930T2/de not_active Expired - Fee Related
- 1993-10-19 HU HU9501207A patent/HUT71895A/hu unknown
- 1993-10-19 DK DK93922961.3T patent/DK0666855T3/da active
- 1993-10-19 JP JP6510636A patent/JPH08502503A/ja active Pending
- 1993-10-19 SK SK534-95A patent/SK53495A3/sk unknown
- 1993-10-19 CZ CZ1995837A patent/CZ287159B6/cs not_active IP Right Cessation
- 1993-10-19 AT AT93922961T patent/ATE143013T1/de not_active IP Right Cessation
- 1993-10-19 US US08/428,176 patent/US5589484A/en not_active Expired - Fee Related
- 1993-10-19 NZ NZ256871A patent/NZ256871A/en unknown
1995
- 1995-04-12 BG BG99566A patent/BG99566A/xx unknown
- 1995-04-26 FI FI951996A patent/FI951996A0/fi unknown
- 1995-04-26 NO NO951588A patent/NO951588L/no unknown
- 1995-05-26 LV LVP-95-143A patent/LV10951B/en unknown
1996
- 1996-11-18 GR GR960403075T patent/GR3021690T3/el unknown

Also Published As

Publication number	Publication date
JPH08502503A (ja)	1996-03-19
HU9501207D0 (en)	1995-06-28
NO951588D0 (no)	1995-04-26
AU675087B2 (en)	1997-01-23
RU2130933C1 (ru)	1999-05-27
PL308550A1 (en)	1995-08-21
DE69304930T2 (de)	1997-02-27
CZ83795A3 (en)	1995-09-13
BG99566A (en)	1996-01-31
LV10951A (lv)	1995-12-20
ES2094567T3 (es)	1997-01-16
FI951996A7 (fi)	1995-04-26
NO951588L (no)	1995-06-27
SK53495A3 (en)	1995-09-13
DK0666855T3 (da)	1996-10-07
AU5178293A (en)	1994-05-24
CA2146651A1 (fr)	1994-05-11
US5589484A (en)	1996-12-31
WO1994010164A1 (fr)	1994-05-11
ATE143013T1 (de)	1996-10-15
RU95109440A (ru)	1997-03-10
GR3021690T3 (en)	1997-02-28
KR950704297A (ko)	1995-11-17
CZ287159B6 (en)	2000-10-11
FI951996A0 (fi)	1995-04-26
KR100239003B1 (ko)	2000-02-01
HUT71895A (en)	1996-02-28
PL175679B1 (pl)	1999-01-29
NZ256871A (en)	1995-09-26
EP0666855B1 (fr)	1996-09-18
DE69304930D1 (de)	1996-10-24
EP0666855A1 (fr)	1995-08-16

Publication	Publication Date	Title
RU2152392C1 (ru)	2000-07-10	Ацильные производные азолонов, способ их получения, фармацевтическая композиция на их основе и способ ее получения
DE69620445T2 (de)	2002-12-12	(imidazol-5-yl)methyl-2-chinolinoderivate als farnesyl protein transferase inhibitoren
US5571811A (en)	1996-11-05	Sulfonamide derivatives of azolones
US5811426A (en)	1998-09-22	Urea and thiourea derivatives of azolones
EP0232937B1 (fr)	1992-08-19	Compositions anti-histaminiques contenant des N-hétérocyclyl-4-pipéridinamines
AP435A (en)	1995-11-17	Substituted azolone derivatives.
IL175512A (en)	2014-11-30	A pure crystalline form of aripiprazole
AU2002233706C1 (en)	2005-12-22	Pyridopyrimidine or naphthyridine derivative
KR100593395B1 (ko)	2006-06-28	광범위-스펙트럼 항진균제로서의 수용성 아졸
LV10951B (en)	1996-08-20	4-quinolinyl derivatives with anti-helicobacter activity
EP0398426A1 (fr)	1990-11-22	Ethers (thio)morpholinyl- et pipérazinylalkyliques du phénol doués d'une activité antirhinovirale
NO310289B1 (no)	2001-06-18	Heterocykliske azolonderivater med anti-Helicobacteraktivitet
US5710156A (en)	1998-01-20	Ester and carbamate derivatives of azolones
EP0364943B1 (fr)	1994-06-08	Composés benzohétérocycliques
CN118666764A (zh)	2024-09-20	一种三氮唑酰胺类化合物、其制备方法和其应用
HK1189384A1 (zh)	2014-06-06	吲哚、吲唑衍生物或其盐