[go: up one dir, main page]

LTIP187A - 4,13-dioksabiciklo[8.2.1]tridekanono dariniai, jų gavimo būdas, tarpiniai produktai jiems gauti ir juos turinčios farmacinės kompozicijos - Google Patents

4,13-dioksabiciklo[8.2.1]tridekanono dariniai, jų gavimo būdas, tarpiniai produktai jiems gauti ir juos turinčios farmacinės kompozicijos

Info

Publication number
LTIP187A
LTIP187A LTIP187A LTIP187A LTIP187A LT IP187 A LTIP187 A LT IP187A LT IP187 A LTIP187 A LT IP187A LT IP187 A LTIP187 A LT IP187A LT IP187 A LTIP187 A LT IP187A
Authority
LT
Lithuania
Prior art keywords
derivatives
dioxabicyclo
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
LTIP187A
Other languages
English (en)
Inventor
Dagmar Hoeltje
Ulf Preuschoff
Christian Eeckhout
Original Assignee
Solvay Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals Gmbh filed Critical Solvay Pharmaceuticals Gmbh
Publication of LTIP187A publication Critical patent/LTIP187A/lt
Publication of LT3015B publication Critical patent/LT3015B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

4.13-Dioksabiciklo[8.2.1]tridekanono dariniai jų gavimo būdas, tarpiniai produktai jiems gauti ir juos turinčios farmacinės kompozicijos.@Aprašyti ciklu susiaurinti N-demetil-N-izopropil-eritromicinoA dariniai, pasižymintys virškinimo traktui efektyviomis motilin-agonistinėmis savybėmis, ir jų gavimas.
LTIP187A 1992-01-07 1992-12-22 4,13-dioksabiciklo£8.2.1|tridekanono dariniai, ju gavimo budas, tarpiniai produktai jiems gauti ir juos turincios farmacines kompozicijos LT3015B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4200145A DE4200145A1 (de) 1992-01-07 1992-01-07 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
LTIP187A true LTIP187A (lt) 1994-03-25
LT3015B LT3015B (lt) 1994-08-25

Family

ID=6449136

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP187A LT3015B (lt) 1992-01-07 1992-12-22 4,13-dioksabiciklo£8.2.1|tridekanono dariniai, ju gavimo budas, tarpiniai produktai jiems gauti ir juos turincios farmacines kompozicijos

Country Status (27)

Country Link
US (1) US5418224A (lt)
EP (1) EP0550895B1 (lt)
JP (1) JP3300084B2 (lt)
KR (1) KR100273937B1 (lt)
CN (1) CN1033646C (lt)
AT (1) ATE155478T1 (lt)
AU (1) AU667699B2 (lt)
CA (1) CA2086811C (lt)
CZ (1) CZ281773B6 (lt)
DE (2) DE4200145A1 (lt)
DK (1) DK0550895T3 (lt)
DZ (1) DZ1652A1 (lt)
ES (1) ES2104808T3 (lt)
FI (1) FI106862B (lt)
GR (1) GR3024859T3 (lt)
HU (2) HU212272B (lt)
IL (1) IL104158A (lt)
LT (1) LT3015B (lt)
LV (1) LV10458B (lt)
MX (1) MX9300045A (lt)
NO (1) NO179586C (lt)
PH (1) PH30098A (lt)
RU (1) RU2107070C1 (lt)
SK (1) SK279251B6 (lt)
TW (1) TW238308B (lt)
UA (1) UA29393C2 (lt)
ZA (1) ZA9339B (lt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0859777B1 (en) * 1995-10-13 2007-05-23 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene derivatives, their preparation and use
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
WO1997031930A1 (fr) * 1996-03-01 1997-09-04 Takeda Chemical Industries, Ltd. Processus de preparation de derives d'erythromycine
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
HRP980496B1 (en) * 1998-09-10 2007-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. New thilozine hydroxy derivatives and a process for the preparation thereof
ES2257720T3 (es) * 2000-08-17 2006-08-01 The Kitasato Institute Nuevos derivados de pseudoeritromicina.
CA2420847C (en) * 2000-09-01 2008-02-05 Chugai Seiyaku Kabushiki Kaisha Process for producing erythromycin derivative
WO2002092592A1 (de) * 2001-05-10 2002-11-21 Solvay Pharmaceuticals Gmbh Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US20040067896A1 (en) * 2002-07-25 2004-04-08 The Kitasato Institute Novel pseudoerythromycin derivatives
ATE457995T1 (de) 2003-06-18 2010-03-15 Tranzyme Pharma Inc Makrozyklische motilin rezeptorantagonisten
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
US20070135362A1 (en) * 2005-12-08 2007-06-14 Yaoquan Liu Method for demethylating the 3'-dimethylamino group of erythromycin compounds
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
AU2007330456B2 (en) * 2006-12-05 2011-03-03 Pfizer Inc. Motilide polymorphs
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
TWI662967B (zh) * 2013-03-25 2019-06-21 日商志瑞亞新藥工業股份有限公司 食後期之胃運動亢進劑

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
CA1321581C (en) * 1987-05-26 1993-08-24 Herbert A. Kirst Ring-contracted macrolides
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders

Also Published As

Publication number Publication date
DK0550895T3 (da) 1997-08-25
HUT66234A (en) 1994-10-28
CZ281773B6 (cs) 1997-01-15
LT3015B (lt) 1994-08-25
LV10458A (lv) 1995-02-20
FI106862B (fi) 2001-04-30
CA2086811A1 (en) 1993-07-08
SK279251B6 (sk) 1998-08-05
EP0550895B1 (de) 1997-07-16
CA2086811C (en) 2003-12-09
KR930016436A (ko) 1993-08-26
IL104158A (en) 1997-07-13
IL104158A0 (en) 1993-05-13
FI930051L (fi) 1993-07-08
NO179586C (no) 1996-11-06
RU2107070C1 (ru) 1998-03-20
DE4200145A1 (de) 1993-07-08
MX9300045A (es) 1993-12-01
ATE155478T1 (de) 1997-08-15
PH30098A (en) 1996-12-27
HU210216A9 (en) 1995-02-28
KR100273937B1 (ko) 2000-12-15
US5418224A (en) 1995-05-23
NO930029D0 (no) 1993-01-06
EP0550895A1 (de) 1993-07-14
AU667699B2 (en) 1996-04-04
NO930029L (no) 1993-07-08
LV10458B (en) 1996-02-20
TW238308B (lt) 1995-01-11
FI930051A0 (fi) 1993-01-07
ES2104808T3 (es) 1997-10-16
UA29393C2 (uk) 2000-11-15
ZA9339B (en) 1993-08-05
DE59208710D1 (de) 1997-08-21
HU212272B (en) 1996-04-29
CN1075320A (zh) 1993-08-18
AU3103693A (en) 1993-07-08
SK341492A3 (en) 1995-05-10
JPH07247299A (ja) 1995-09-26
CN1033646C (zh) 1996-12-25
NO179586B (no) 1996-07-29
DZ1652A1 (fr) 2002-02-17
GR3024859T3 (en) 1998-01-30
HK1014003A1 (en) 1999-09-17
CZ341492A3 (en) 1993-07-14
JP3300084B2 (ja) 2002-07-08
HU9204076D0 (en) 1993-04-28

Similar Documents

Publication Publication Date Title
LTIP187A (lt) 4,13-dioksabiciklo[8.2.1]tridekanono dariniai, jų gavimo būdas, tarpiniai produktai jiems gauti ir juos turinčios farmacinės kompozicijos
FR2680512B1 (fr) Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU1914092A (en) Novel derivatives of thiopyranopyrrole, their preparation and pharmaceutical compositions containing them
NO951198L (no) Lipopeptidderivater, fremgangsmåte for fremstilling derav og anvendelse av derivatene
CS257491A3 (en) 3-amidopyrazole derivatives, process of their preparation and pharmaceutical compositions comprising them
HUT71594A (en) Process to prepare 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines and pharmaceutical compns. contg. them
AU5669398A (en) Novel cyclosporin derivatives, method of preparation and pharmaceutical compositions containing them
IL99437A0 (en) Mometasone furoate monohydrate,process for making same and pharmaceutical compositions
IL136088A0 (en) 6-0-alkyl erythromycin b oxime
AU1161292A (en) Azabicydic and azatricydic derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
CZ95895A3 (en) Novel taxan derivatives, process of their preparation and pharmaceutical compositions containing thereof
MY120683A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
AU4352193A (en) Novel aminopropanol derivatives, pharmaceutical compositions containing them and process for preparing same
FI954931A7 (fi) Uusia piperidinyylitioindolin johdannaisia, niiden valmistusmenetelmä, niitä sisältäviä farmaseuttisia koostumuksia, jotka ovat käyttökelpoi sia erityisesti kivun lievittäjinä
FR2685325B1 (fr) Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU4075693A (en) Novel dihydroxybenzylamine derivatives, their preparation and pharmaceutical compositions containing same
FI951561A7 (fi) Uudet 17 -substituoidut 4-androstaanijohdannaiset, niitä sisältävät farmaseuttiset koostumukset ja menetelmä niiden valmistamiseksi
AU8917891A (en) Poly-aminopyrrolecarboxamido derivatives, processes for their preparation and pharmaceutical compositions containing them
AP2002002572A0 (en) Novel substituted pyrazol(4,3-e) diazepines, pharmaceutical compositions containing them, as medical products and processes for preparing them
EP0443957A3 (en) New 17-spiro substituted steroid compounds, process for their preparation and intermediates of this process, their use as medicines and pharmaceutical preparations containing them
HUP9601712A3 (en) Substituted benzothiazine derivatives, intermediates of them, process for their preparation and pharmaceutical compositions containing the same
EP0386920A3 (en) 2-hydroxy-3-thienyloxypropylamino derivatives
AU4756693A (en) 1-heteroarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them
FI942675A7 (fi) Uudet substituoidut oksatsinoisokinoliinijohdannaiset, niitä sisältävät farmaseuttiset koostumukset sekä menetelmä niiden valmistamiseksi
AU4504893A (en) Novel 10-diacetyl baccatine iii derivatives, preparation thereof and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PD9A Change of patent owner

Free format text: SOLVAY PHARMACEUTICALS GMBH,HANS-BOECKLER-ALLEE 20, D-30173 HANNOVER,DE,19970725

MM9A Lapsed patents

Effective date: 20081222