LT5284B - Kompozicija, skirta neurocerebrovaskuliarinių sutrikimų gydymui - Google Patents

Kompozicija, skirta neurocerebrovaskuliarinių sutrikimų gydymui Download PDF

Info

Publication number: LT5284B
Authority: LT; Lithuania
Prior art keywords: composition; fraction; another embodiment; present; effective amount
Prior art date: 2001-12-14

Application number

LT2004060A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT2004060A (en

Inventor

Madhur Ray

Raghwendra Pal

Satyawan Singh

Nandoo M. Khanna

Original Assignee

Council Of Scientific And Industrial Research

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-14

Filing date

2004-07-02

Publication date

2005-11-25

2004-07-02 Application filed by Council Of Scientific And Industrial Research filed Critical Council Of Scientific And Industrial Research

2005-06-27 Publication of LT2004060A publication Critical patent/LT2004060A/xx

2005-11-25 Publication of LT5284B publication Critical patent/LT5284B/lt

Links

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LT2004060A 2001-12-14 2004-07-02 Kompozicija, skirta neurocerebrovaskuliarinių sutrikimų gydymui LT5284B (lt)

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JP (1)	JP4695839B2 (fr)
KR (1)	KR101001815B1 (fr)
CN (1)	CN100528149C (fr)
AU (2)	AU2002348802A1 (fr)
BR (1)	BR0214962A (fr)
CA (1)	CA2473874C (fr)
DE (1)	DE60233069D1 (fr)
EA (1)	EA007067B1 (fr)
EE (1)	EE05374B1 (fr)
GE (1)	GEP20084442B (fr)
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1752144A4 (fr) *	2004-05-31	2007-07-11	Kaneka Corp	Agent pour prévenir/améliorer les maladies liées au mode de vie contenant un composant d'huile essentielle de curcuma
WO2006118079A1 (fr) *	2005-04-28	2006-11-09	Arata Yamasaki	Agent anti-vieillissement pour la peau
US9492402B2 (en)	2005-05-30	2016-11-15	Benny Antony	Formulation of curcuminoids with enhanced bioavailability of curcumin, demethoxycurcumin, bisdemethoxycurcumin and method of preparation and uses thereof
US12053438B2 (en)	2005-05-30	2024-08-06	Arjuna Natural Private Limited	Formulation of curcuminoids with enhanced bioavailability of curcumin, demethoxycurcumin, bisdemethoxycurcumin and method of preparation and uses thereof
US10286027B2 (en)	2005-05-30	2019-05-14	Arjuna Natural Extracts, Ltd.	Sustained release formulations of curcuminoids and method of preparation thereof
US10543277B2 (en)	2005-05-30	2020-01-28	Arjuna Natural Private Limited	Formulation of curcumin with enhanced bioavailability of curcumin and method of preparation and treatment thereof
PL1890546T3 (pl)	2005-05-30	2019-04-30	Benny Antony	Sposób poprawiania biodostępności kurkuminy
US7883728B2 (en)	2005-05-30	2011-02-08	Arjuna Natural Extracts, Ltd.	Composition to enhance the bioavailability of curcumin
US8859020B2 (en)	2005-05-30	2014-10-14	Benny Antony	Treatment of alzheimer's with a curcuminoid mixture and essential oil of turmeric having 45% Ar-turmerone
JP4980626B2 (ja) *	2006-02-28	2012-07-18	ポーラ化成工業株式会社	プラスミノーゲンアクチベーターインヒビターｉ阻害剤及びそれを配合してなる食品組成物
JP5207341B2 (ja) *	2006-10-26	2013-06-12	独立行政法人産業技術総合研究所	炎症性サイトカイン産生抑制剤
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US9332753B2 (en) *	2009-03-05	2016-05-10	Keygene N.V.	Plant volatiles based on R-curcumene
CN102595884B (zh)	2009-07-31	2014-12-03	考格尼申治疗股份有限公司	认知衰退的抑制剂
JP5764288B2 (ja) *	2009-09-24	2015-08-19	ハウス食品グループ本社株式会社	ウコン抽出物とガジュツ抽出物とを含有する組成物
JP5578822B2 (ja) *	2009-09-25	2014-08-27	株式会社ピカソ美化学研究所	アセチルコリンエステラーゼ阻害剤
AU2012212219B2 (en)	2011-02-02	2017-03-23	Cognition Therapeutics, Inc.	Isolated compounds from turmeric oil and methods of use
EP2690969B1 (fr) *	2011-03-29	2018-10-03	Council of Scientific & Industrial Research	Procédé de modification d'huile essentielle de curcuma aromatica
GB201111319D0 (en)	2011-07-04	2011-08-17	Univ Leuven Kath	Anticonvulsant activity of tumeric oil and bisabolene sesquiterpenoids of curcuma longa
KR101792031B1 (ko) *	2012-01-13	2017-10-31	주식회사 엘지생활건강	피부 주름 개선 및 탄력 증진용 조성물
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JP2014201528A (ja) *	2013-04-02	2014-10-27	クラシエ製薬株式会社	抗酸化剤
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CN112351790A (zh) *	2018-06-29	2021-02-09	好侍健康食品株式会社	用于治疗、预防或改善阿尔茨海默氏症的组合物、用于抑制脑神经细胞死亡的组合物、用于抑制由β淀粉样蛋白诱导的小胶质细胞激活的组合物、及用于抑制由β淀粉样蛋白诱导的PGE2、TNF-α或IL-1β产生的组合物
CN111617060A (zh) *	2020-05-29	2020-09-04	广东工业大学	吉马酮的应用
CN111617059B (zh) *	2020-05-29	2023-07-25	广东工业大学	莪术二酮的应用
JP7637357B2 (ja) *	2020-09-29	2025-02-28	学校法人近畿大学	血管保護のためのターメリックオイルを含有する組成物、ならびにこのような組成物を含む飲食品および香料

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN162441B (fr)	1984-12-26	1988-05-28	Council Scient Ind Res
US4842849A (en)	1981-05-08	1989-06-27	L'oreal	Composition intended for the treatment of keratin fibres, based on a cationic polymer and an anionic polymer containing vinylsulphonic groups

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4842859A (en) *	1986-09-08	1989-06-27	Yaguang Liu	Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation
US5120538A (en) *	1990-02-05	1992-06-09	Pt Darya-Varia Laboratoria	Combinations of compounds isolated from curcuma spp as anti-inflammatory agents
US5863938A (en) *	1991-03-01	1999-01-26	Warner Lambert Company	Antibacterial-wound healing compositions and methods for preparing and using same
CN1100321A (zh) *	1994-03-27	1995-03-22	叶启智	灵猫香或其复方药用针剂
WO2001030335A2 (fr) *	1999-10-22	2001-05-03	The Board Of Trustees Of The University Of Illinois	Compositions pharmaceutiques utiles dans la prevention et le traitement d'une maladie induite par la proteine beta-amyloide
DE10029770A1 (de) *	2000-06-16	2001-12-20	Transmit Technologietransfer	Verwendung von Curcuminen zur Behandlung von soliden Tumoren,insbesondere von Hirntumoren
JP2002030081A (ja) *	2000-07-13	2002-01-29	Shiseido Co Ltd	ジアリールヘプタノイド誘導体及びマトリックスメタロプロテアーゼ活性阻害剤
KR20020073847A (ko) *	2001-03-16	2002-09-28	주식회사 바이오시너젠	쿠르쿠민 또는 울금 추출물을 포함하는 치매 예방 및치료용 조성물

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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4842849A (en)	1981-05-08	1989-06-27	L'oreal	Composition intended for the treatment of keratin fibres, based on a cationic polymer and an anionic polymer containing vinylsulphonic groups
IN162441B (fr)	1984-12-26	1988-05-28	Council Scient Ind Res

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHOPRA RN, GUPTA JC, CHOPRA GS: "Pharmacological action of the essential oil of Curcuma longa", INDIAN J MED RES, 1941, pages 769 - 772
E. SCHRAUFSTÃ„TTER, H. BERNT: "Antibacterial Action of Curcumin and Related Compounds", NATURE, 1949, pages 456
LUTOMSKI J, KEDZIA B, DEBSKA W.: "Effect of an alcohol extract and of active ingredients from Curcuma longa on bacteria and fungi", PLANTA MED., 1974, pages 9
ONODA M, INANO H: "Effect of curcumin on the production of nitric oxide by cultured rat mammary gland", NITRIC OXIDE : BIOLOGY AND CHEMISTRY / OFFICIAL JOURNAL OF THE NITRIC OXIDE SOCIETY, 2000, pages 505 - 515, XP001133827, DOI: doi:10.1006/niox.2000.0305
RAMASWAMY TS, BANERJEE BN: "Vegetable dyes as antioxidants for vegetable oils", ANN BIOCHEM EXP MED, 1948, pages 55
SHARMA, S.C. ET AL.: "Lipid peroxide formation inexperimental inflammation", BIOCHEM. PHARMACOL., 1972, pages 1210 - 1214
SRIMAL, R.C. ET AL.: "A preliminary report on anti-inflammatory activity of curcumin", INDIAN J. PHARMACOL., 1971, pages 10
T. SAWADA ET AL.: "Evaluation of crude drugs by bioassay. III. Comparison with local variation of contents and the fungistatic action of essential oil from the root of Curcuma longa", SHOYAKUGAKU ZASSHI, 1971, pages 11 - 16

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Publication number	Publication date
UA82057C2 (en)	2008-03-11
CN100528149C (zh)	2009-08-19
CN1615144A (zh)	2005-05-11
EA200400807A1 (ru)	2004-12-30
NO332066B1 (no)	2012-06-18
EP1453528B1 (fr)	2009-07-22
LT2004060A (en)	2005-06-27
WO2003051380A3 (fr)	2004-06-17
CA2473874A1 (fr)	2003-06-26
KR101001815B1 (ko)	2010-12-15
WO2003051380A2 (fr)	2003-06-26
DE60233069D1 (de)	2009-09-03
EA007067B1 (ru)	2006-06-30
AU2002348802A1 (en)	2003-06-30
GEP20084442B (en)	2008-08-10
JP2005516930A (ja)	2005-06-09
AU2009212969B2 (en)	2011-06-02
NO20043000L (no)	2004-07-13
US20100093870A1 (en)	2010-04-15
KR20040073478A (ko)	2004-08-19
CA2473874C (fr)	2011-11-22
EE05374B1 (et)	2011-02-15
BR0214962A (pt)	2004-12-14
ZA200404648B (en)	2005-11-30
MXPA04005680A (es)	2004-10-15
EE200400097A (et)	2004-10-15
US20060051438A1 (en)	2006-03-09
EP1453528A2 (fr)	2004-09-08
JP4695839B2 (ja)	2011-06-08
LV13250B (en)	2006-02-20
AU2009212969A1 (en)	2009-10-01

Publication	Publication Date	Title
LT5284B (lt)	2005-11-25	Kompozicija, skirta neurocerebrovaskuliarinių sutrikimų gydymui
US6991814B2 (en)	2006-01-31	Herbal medicaments for the treatment of neurocerebrovascular disorders
Khanna	1999	Turmeric–Nature's precious gift
AU2021204271B2 (en)	2024-12-12	Synergistic composition for osteoarthritis
KR101317668B1 (ko)	2013-10-15	멀꿀 잎 추출물을 유효성분으로 포함하는 관절염 치료 또는 예방용 약학 조성물
KR101991929B1 (ko)	2019-06-21	참당귀 추출물을 포함하는 항혈전 조성물
KR100595735B1 (ko)	2006-06-30	연골 재생 및 골관절염 치료용 생약 조성물
KR20050097614A (ko)	2005-10-10	대황추출물을 포함하는 혈관질환의 예방 또는 치료제
KR100541424B1 (ko)	2006-01-11	항염증성 생약 조성물 및 이의 제조방법
KR100526436B1 (ko)	2005-11-08	화살나무 수용성 추출물 및 이의 용도
Kavitha et al.	2022	Antirheumatic Potential of Justicia gendarussa Root Extract on Chronic Arthritic Models
US20220409691A1 (en)	2022-12-29	Natural drugs for the treatment of inflammation and melanoma
KR101785096B1 (ko)	2017-10-12	호로파 추출물을 포함하는 뇌암 치료용 조성물 및 미백 기능성 화장품
KR100491439B1 (ko)	2005-05-24	혈소판 응집 억제활성이 우수한 필발 나무 추출물 및 이의용도
KR100829596B1 (ko)	2008-05-14	항산화 활성을 갖는 오이 초본 추출물
KR102142060B1 (ko)	2020-08-07	소목 초단파 추출물을 포함하는 항염증제
PT1508334E (pt)	2010-05-04	Extracto solúvel em água a partir de planta do género solanum e o seu processo de preparação, e composição farmacêutica contendo o extracto solúvel em água
JP2007230882A (ja)	2007-09-13	プラスミノーゲンアクチベーターインヒビターｉ阻害剤及びそれを配合してなる食品組成物
MXPA00010424A (en)	2002-07-25	Antithrombotic agents

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