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LT3665173T - Naujas amanitinų sintezės būdas - Google Patents

Naujas amanitinų sintezės būdas

Info

Publication number
LT3665173T
LT3665173T LTEPPCT/EP2018/071268T LTEP2018071268T LT3665173T LT 3665173 T LT3665173 T LT 3665173T LT EP2018071268 T LTEP2018071268 T LT EP2018071268T LT 3665173 T LT3665173 T LT 3665173T
Authority
LT
Lithuania
Prior art keywords
amanitins
synthesizing
novel method
novel
synthesizing amanitins
Prior art date
Application number
LTEPPCT/EP2018/071268T
Other languages
English (en)
Inventor
Christian Lutz
Werner Simon
Susanne Werner-Simon
Christoph Müller
Torsten HECHLER
Michael Kulke
Original Assignee
Heidelberg Pharma Research Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Research Gmbh filed Critical Heidelberg Pharma Research Gmbh
Publication of LT3665173T publication Critical patent/LT3665173T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817Toxins
    • A61K47/6831Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LTEPPCT/EP2018/071268T 2017-08-07 2018-08-06 Naujas amanitinų sintezės būdas LT3665173T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17185182 2017-08-07
PCT/EP2018/071268 WO2019030173A1 (en) 2017-08-07 2018-08-06 NOVEL METHOD FOR SYNTHESIZING AMANITINES

Publications (1)

Publication Number Publication Date
LT3665173T true LT3665173T (lt) 2025-06-25

Family

ID=59579417

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2018/071268T LT3665173T (lt) 2017-08-07 2018-08-06 Naujas amanitinų sintezės būdas

Country Status (24)

Country Link
US (2) US10961277B2 (lt)
EP (1) EP3665173B1 (lt)
JP (1) JP7165720B2 (lt)
KR (1) KR102674750B1 (lt)
CN (1) CN111051310B (lt)
AU (1) AU2018314668B2 (lt)
BR (1) BR112020001345A2 (lt)
CA (1) CA3066867A1 (lt)
CL (1) CL2020000304A1 (lt)
CO (1) CO2020001259A2 (lt)
DK (1) DK3665173T3 (lt)
ES (1) ES3033917T3 (lt)
FI (1) FI3665173T3 (lt)
HR (1) HRP20250655T1 (lt)
HU (1) HUE072299T2 (lt)
LT (1) LT3665173T (lt)
MX (1) MX2020001472A (lt)
PL (1) PL3665173T3 (lt)
PT (1) PT3665173T (lt)
RS (1) RS66987B1 (lt)
SG (1) SG11201912224PA (lt)
SI (1) SI3665173T1 (lt)
WO (1) WO2019030173A1 (lt)
ZA (1) ZA201908158B (lt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110997676B (zh) 2017-08-07 2022-12-20 海德堡医药研究有限责任公司 合成鹅膏蕈碱的新方法
CN114191564A (zh) * 2017-08-18 2022-03-18 四川百利药业有限责任公司 一种非天然鹅膏毒肽类抗体偶联物
EP3773740A1 (en) * 2018-04-13 2021-02-17 Heidelberg Pharma Research GmbH Targeted amatoxin conjugate for the treatment of solid tumors
AR117958A1 (es) * 2018-12-11 2021-09-08 Heidelberg Pharma Res Gmbh Síntesis del (s)-6-hidroxitriptófano y derivados del mismo
JP2022530026A (ja) 2019-04-24 2022-06-27 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング アマトキシン抗体薬物複合体及びその使用
JP7654662B2 (ja) * 2019-12-16 2025-04-01 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング アマニンおよびその誘導体の合成
JP2023529455A (ja) * 2020-06-09 2023-07-10 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング チオエーテル含有ペプチドの合成方法
EP4308169A2 (en) 2021-03-19 2024-01-24 Heidelberg Pharma Research GmbH B-lymphocyte specific amatoxin antibody conjugates
CN115385916B (zh) * 2021-07-01 2023-08-15 江苏师范大学 一种手性吲哚啉并吡咯化合物及其合成方法
AR130916A1 (es) 2022-11-01 2025-01-29 Heidelberg Pharma Res Gmbh Anticuerpo anti-gucy2c y usos del mismo
EP4629980A1 (en) * 2022-12-06 2025-10-15 SRI International Antimicrobial compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
EP1859811B1 (en) 2006-05-27 2011-08-24 Faulstich, Heinz, Dr. Use of conjugates of amatoxins or phallotoxins with macromolecules for tumor and inflammation therapy
EP3485912A1 (en) 2009-04-08 2019-05-22 Faulstich, Heinz, Dr. Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
JP2012523383A (ja) 2009-04-08 2012-10-04 ファウルシュティヒ,ハインツ がんの治療のためのアマトキシンと複合体形成した標的結合部分
DK2549276T3 (en) 2009-08-10 2015-06-08 Ucl Business Plc Reversible, covalent bonding of functional molecules
ES2402254T3 (es) 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
EP2497499A1 (en) * 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
EP2684865A1 (en) 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins
WO2014043403A1 (en) 2012-09-12 2014-03-20 Agensys, Inc. Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
US20160220687A1 (en) 2015-02-02 2016-08-04 National Guard Health Affairs Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer
SI3268047T1 (sl) * 2015-03-09 2024-02-29 Heidelberg Pharma Research Gmbh Konjugati amatoksin-protitelo
AU2016360828B2 (en) 2015-11-27 2021-06-24 Heidelberg Pharma Research Gmbh Derivatives of gamma-amanitin

Also Published As

Publication number Publication date
US11702451B2 (en) 2023-07-18
CN111051310B (zh) 2022-11-08
CA3066867A1 (en) 2019-02-14
SI3665173T1 (sl) 2025-07-31
RU2020105484A (ru) 2021-08-05
PT3665173T (pt) 2025-06-11
KR102674750B1 (ko) 2024-06-13
RS66987B1 (sr) 2025-07-31
US20200181200A1 (en) 2020-06-11
KR20200037207A (ko) 2020-04-08
RU2020105484A3 (lt) 2021-09-13
CN111051310A (zh) 2020-04-21
NZ760113A (en) 2024-07-05
FI3665173T3 (fi) 2025-07-14
BR112020001345A2 (pt) 2020-08-11
JP2020529452A (ja) 2020-10-08
AU2018314668B2 (en) 2022-06-02
ES3033917T3 (en) 2025-08-11
WO2019030173A1 (en) 2019-02-14
MX2020001472A (es) 2020-10-19
PL3665173T3 (pl) 2025-08-18
CL2020000304A1 (es) 2020-08-07
US20210130412A1 (en) 2021-05-06
HUE072299T2 (hu) 2025-11-28
SG11201912224PA (en) 2020-01-30
ZA201908158B (en) 2022-12-21
EP3665173A1 (en) 2020-06-17
DK3665173T3 (da) 2025-08-04
CO2020001259A2 (es) 2020-02-18
AU2018314668A1 (en) 2020-01-16
US10961277B2 (en) 2021-03-30
EP3665173B1 (en) 2025-04-23
HRP20250655T1 (hr) 2025-08-01
JP7165720B2 (ja) 2022-11-04

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