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LT3575284T - Fenildifluormetil-pakeistas prolinamido junginys - Google Patents

Fenildifluormetil-pakeistas prolinamido junginys

Info

Publication number
LT3575284T
LT3575284T LTEPPCT/JP2018/001927T LT18744079T LT3575284T LT 3575284 T LT3575284 T LT 3575284T LT 18744079 T LT18744079 T LT 18744079T LT 3575284 T LT3575284 T LT 3575284T
Authority
LT
Lithuania
Prior art keywords
phenydifluormethyl
modified
prolinamide compound
prolinamide
compound
Prior art date
Application number
LTEPPCT/JP2018/001927T
Other languages
English (en)
Inventor
Yutaka Nakajima
Sunao Imada
Eriko YAMAMOTO
Kazuyuki Tsuchiya
Yu Harayama
Shunichiro Matsumoto
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of LT3575284T publication Critical patent/LT3575284T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEPPCT/JP2018/001927T 2017-01-24 2018-01-23 Fenildifluormetil-pakeistas prolinamido junginys LT3575284T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017010321 2017-01-24
PCT/JP2018/001927 WO2018139438A1 (ja) 2017-01-24 2018-01-23 フェニルジフルオロメチル置換プロリンアミド化合物

Publications (1)

Publication Number Publication Date
LT3575284T true LT3575284T (lt) 2021-10-25

Family

ID=62979051

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/JP2018/001927T LT3575284T (lt) 2017-01-24 2018-01-23 Fenildifluormetil-pakeistas prolinamido junginys

Country Status (31)

Country Link
US (2) US10322997B2 (lt)
EP (1) EP3575284B1 (lt)
JP (1) JP7001068B2 (lt)
KR (1) KR102553613B1 (lt)
CN (2) CN110248925B (lt)
AR (1) AR110767A1 (lt)
AU (1) AU2018211735B2 (lt)
BR (1) BR112019014788A2 (lt)
CA (1) CA3050224A1 (lt)
CO (1) CO2019009090A2 (lt)
CY (1) CY1124906T1 (lt)
DK (1) DK3575284T3 (lt)
ES (1) ES2892400T3 (lt)
HR (1) HRP20211613T1 (lt)
HU (1) HUE056920T2 (lt)
IL (1) IL268060B (lt)
JO (1) JOP20190181B1 (lt)
LT (1) LT3575284T (lt)
MA (1) MA47380A (lt)
MX (1) MX379651B (lt)
MY (1) MY195587A (lt)
PH (1) PH12019501645A1 (lt)
PL (1) PL3575284T3 (lt)
PT (1) PT3575284T (lt)
RS (1) RS62477B1 (lt)
SG (1) SG11201906777TA (lt)
SI (1) SI3575284T1 (lt)
TW (1) TWI764976B (lt)
UA (1) UA124036C2 (lt)
WO (1) WO2018139438A1 (lt)
ZA (1) ZA201904741B (lt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4467565A3 (en) 2016-12-21 2025-03-12 Amgen Inc. Anti-tnf alpha antibody formulations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ534583A (en) * 2002-03-05 2006-11-30 Axys Pharm Inc Leucinamide derivatives suitable as cathepsin cysteine protease inhibitors
JP2010121918A (ja) 2008-11-17 2010-06-03 Hiroyoshi Asada 鍋等の取っ手部分の焼き焦げ防止具。
PE20120911A1 (es) * 2009-04-20 2012-08-06 Hoffmann La Roche Derivados de prolina como inhibidores de catepsina
US7893099B2 (en) 2009-06-11 2011-02-22 Hoffman-La Roche Inc. Cyclopentane derivatives
JP2012059507A (ja) 2010-09-08 2012-03-22 Panasonic Corp 基板間接続コネクタ構造
US8524710B2 (en) * 2010-11-05 2013-09-03 Hoffmann-La Roche Inc. Pyrrolidine derivatives
WO2013068434A1 (en) * 2011-11-11 2013-05-16 F. Hoffmann-La Roche Ag Process for the preparation of 1-acyl-4-phenylsulfonylprolinamide derivatives and new intermediates
RU2014136573A (ru) * 2012-02-17 2016-04-10 Ф. Хоффманн-Ля Рош Аг Новые производные пирролидина
MX2015002026A (es) 2012-08-21 2015-06-05 Hoffmann La Roche Nuevos derivados de piridina.
JP6454335B2 (ja) * 2013-10-08 2019-01-16 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. カテプシンシステインプロテアーゼ阻害剤
WO2015051479A1 (en) * 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
SI3419970T1 (sl) 2016-02-26 2020-04-30 F. Hoffmann-La Roche Ag Novi pirolidinski derivati

Also Published As

Publication number Publication date
EP3575284A4 (en) 2020-08-12
TWI764976B (zh) 2022-05-21
MX2019008756A (es) 2019-09-11
RU2019122734A3 (lt) 2021-05-31
JOP20190181A1 (ar) 2019-07-22
SI3575284T1 (sl) 2021-11-30
RS62477B1 (sr) 2021-11-30
AR110767A1 (es) 2019-05-02
US20190071398A1 (en) 2019-03-07
JOP20190181B1 (ar) 2023-09-17
CN111574422A (zh) 2020-08-25
IL268060A (en) 2019-09-26
DK3575284T3 (da) 2021-10-18
ZA201904741B (en) 2020-12-23
AU2018211735B2 (en) 2021-08-12
PL3575284T3 (pl) 2021-12-27
US10532979B2 (en) 2020-01-14
MY195587A (en) 2023-02-02
SG11201906777TA (en) 2019-08-27
KR102553613B1 (ko) 2023-07-07
ES2892400T3 (es) 2022-02-04
KR20190110549A (ko) 2019-09-30
MA47380A (fr) 2021-03-17
BR112019014788A2 (pt) 2020-02-27
EP3575284A1 (en) 2019-12-04
IL268060B (en) 2021-09-30
HRP20211613T1 (hr) 2022-02-04
RU2019122734A (ru) 2021-02-26
AU2018211735A1 (en) 2019-08-01
CN110248925A (zh) 2019-09-17
CO2019009090A2 (es) 2019-08-30
EP3575284B1 (en) 2021-08-25
CY1124906T1 (el) 2023-01-05
WO2018139438A1 (ja) 2018-08-02
CN110248925B (zh) 2020-07-17
HUE056920T2 (hu) 2022-03-28
JPWO2018139438A1 (ja) 2019-11-07
MX379651B (es) 2025-03-11
PH12019501645A1 (en) 2020-03-09
CA3050224A1 (en) 2018-08-02
JP7001068B2 (ja) 2022-01-19
PT3575284T (pt) 2021-10-01
UA124036C2 (uk) 2021-07-07
US10322997B2 (en) 2019-06-18
TW201840531A (zh) 2018-11-16
CN111574422B (zh) 2023-09-08
US20190248738A1 (en) 2019-08-15

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