LT3214083T - Kvinolono junginių gamybos būdas - Google Patents

Kvinolono junginių gamybos būdas

Info

Publication number: LT3214083T
Authority: LT; Lithuania
Prior art keywords: manufacture; quinolone compounds; quinolone; compounds
Prior art date: 2008-09-24

Application number

LTEP17163383.7T

Other languages

English (en)

Inventor

Roger Hanselmann

Maxwell Reeve

Graham Johnson

Original Assignee

Melinta Subsidiary Corp.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-24

Filing date

2009-09-23

Publication date

2021-01-25

2009-09-23 Application filed by Melinta Subsidiary Corp. filed Critical Melinta Subsidiary Corp.

2021-01-25 Publication of LT3214083T publication Critical patent/LT3214083T/lt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/02—Gearboxes; Mounting gearing therein
- F16H57/027—Gearboxes; Mounting gearing therein characterised by means for venting gearboxes, e.g. air breathers
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/02—Gearboxes; Mounting gearing therein
- F16H57/037—Gearboxes for accommodating differential gearings
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H48/00—Differential gearings
- F16H48/06—Differential gearings with gears having orbital motion
- F16H48/08—Differential gearings with gears having orbital motion comprising bevel gears
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/04—Features relating to lubrication or cooling or heating
- F16H57/0457—Splash lubrication
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/04—Features relating to lubrication or cooling or heating
- F16H57/048—Type of gearings to be lubricated, cooled or heated
- F16H57/0482—Gearings with gears having orbital motion
- F16H57/0483—Axle or inter-axle differentials
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/19—Gearing
- Y10T74/19642—Directly cooperating gears
- Y10T74/19688—Bevel
- Y10T74/19693—Motor vehicle drive
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/21—Elements
- Y10T74/2186—Gear casings
- Y10T74/2188—Axle and torque tubes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Mechanical Engineering (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

LTEP17163383.7T 2008-09-24 2009-09-23 Kvinolono junginių gamybos būdas LT3214083T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US19408308P	2008-09-24	2008-09-24

Publications (1)

Publication Number	Publication Date
LT3214083T true LT3214083T (lt)	2021-01-25

Family

ID=42060333

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
LTEP17163383.7T LT3214083T (lt)	2008-09-24	2009-09-23	Kvinolono junginių gamybos būdas
LTEP20191961.0T LT3766876T (lt)	2008-09-24	2009-09-23	Farmacinė vaisto forma, turinti chinolono darinį
LTPA2021002C LTC3214083I2 (lt)	2008-09-24	2021-02-17	Kvinolono junginių gamybos būdas

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
LTEP20191961.0T LT3766876T (lt)	2008-09-24	2009-09-23	Farmacinė vaisto forma, turinti chinolono darinį
LTPA2021002C LTC3214083I2 (lt)	2008-09-24	2021-02-17	Kvinolono junginių gamybos būdas

Country Status (28)

Country	Link
US (3)	US8497378B2 (lt)
EP (3)	EP2346855B1 (lt)
JP (2)	JP6013734B2 (lt)
KR (3)	KR20110091504A (lt)
CN (2)	CN102164912B (lt)
AU (1)	AU2009297085B2 (lt)
BR (1)	BRPI0919241B8 (lt)
CA (1)	CA2738236C (lt)
CY (2)	CY1123658T1 (lt)
DK (2)	DK3214083T3 (lt)
ES (3)	ES2966093T3 (lt)
FI (2)	FI3766876T3 (lt)
HK (1)	HK1214243A1 (lt)
HR (1)	HRP20201879T1 (lt)
HU (2)	HUE052219T2 (lt)
IL (1)	IL211845A (lt)
LT (3)	LT3214083T (lt)
MX (3)	MX2011003122A (lt)
NL (1)	NL301091I2 (lt)
NO (1)	NO2021006I1 (lt)
PL (2)	PL3766876T3 (lt)
PT (1)	PT3214083T (lt)
RS (1)	RS61194B1 (lt)
RU (1)	RU2546667C2 (lt)
SG (1)	SG10201605492YA (lt)
SI (1)	SI3214083T1 (lt)
SM (1)	SMT202000690T1 (lt)
WO (1)	WO2010036329A2 (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7576216B2 (en) *	2004-07-30	2009-08-18	Abbott Laboratories	Preparation of pyridonecarboxylic acid antibacterials
AU2009297085B2 (en) *	2008-09-24	2015-07-09	Melinta Subsidiary Corp.	Process for making quinolone compounds
WO2014152317A2 (en) *	2013-03-15	2014-09-25	Melinta Therapeutics, Inc.	Methods of treating gonorrhea infections using quinolone antibiotics
CN104098548B (zh) *	2013-04-11	2017-07-18	上海医药工业研究院	一种Delafloxacin的精制方法
CN103709100A (zh) *	2013-12-31	2014-04-09	南京工业大学	一种8-氯代喹诺酮衍生物的制备方法
TW201605447A (zh) *	2014-06-20	2016-02-16	美林塔治療學有限公司	處理感染的方法
CN106256824B (zh) *	2015-06-18	2020-10-27	重庆医药工业研究院有限责任公司	一种高纯度德拉沙星葡甲胺盐的制备方法
CN105017224A (zh) *	2015-07-10	2015-11-04	扬子江药业集团有限公司	一种德拉沙星葡甲胺晶型的制备方法
CN107778293B (zh) *	2016-08-29	2023-06-16	鲁南制药集团股份有限公司	一种改进的德拉沙星的制备方法
RU2019130519A (ru)	2017-03-31	2021-04-30	Фуджифилм Корпорэйшн	4-пиридоновое соединение или его соль, фармацевтическая композиция и содержащий их состав
WO2022240897A1 (en)	2021-05-10	2022-11-17	Sepelo Therapeutics, Llc	Pharmaceutical composition comprising delafloxacin for administration into the lung
CN113527262B (zh) *	2021-06-22	2022-07-15	安徽普利药业有限公司	一种德拉沙星及其葡甲胺盐的精制方法
CN114031607B (zh) *	2021-11-16	2023-01-10	海南普利制药股份有限公司	一种德拉沙星及其中间体的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4522811A (en)	1982-07-08	1985-06-11	Syntex (U.S.A.) Inc.	Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
DE69628466T2 (de)	1995-09-22	2004-04-01	Wakunaga Pharmaceutical Co., Ltd.	Zwischenverbindungen zur Herstellung von neunen Pyridoncarbonsäurederivate oder deren Salzen
MXPA02000103A (es) *	1999-07-01	2003-07-21	Wakunaga Pharma Co Ltd	Derivado de acido quinolin carboxilico o sales del mismo.
JP2005097116A (ja)	1999-11-11	2005-04-14	Wakunaga Pharmaceut Co Ltd	キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法
JP5274012B2 (ja) *	2004-07-30	2013-08-28	アボット・ラボラトリーズ	ピリドンカルボン酸抗菌薬の調製
LT3056492T (lt)	2004-10-08	2022-01-25	Abbvie Inc.	Meglumino druska ir atitinkamos vaisto (delafloksacino) kristalinės formos
US20060228411A1 (en) *	2005-04-11	2006-10-12	Huailiang Wu	Pharmaceutical compositions having improved dissolution profiles for poorly soluble drugs
AU2009297085B2 (en)	2008-09-24	2015-07-09	Melinta Subsidiary Corp.	Process for making quinolone compounds

2009
- 2009-09-23 AU AU2009297085A patent/AU2009297085B2/en active Active
- 2009-09-23 PL PL20191961.0T patent/PL3766876T3/pl unknown
- 2009-09-23 US US13/120,278 patent/US8497378B2/en not_active Ceased
- 2009-09-23 DK DK17163383.7T patent/DK3214083T3/da active
- 2009-09-23 PL PL17163383T patent/PL3214083T3/pl unknown
- 2009-09-23 EP EP09816565.7A patent/EP2346855B1/en active Active
- 2009-09-23 EP EP20191961.0A patent/EP3766876B8/en active Active
- 2009-09-23 FI FIEP20191961.0T patent/FI3766876T3/fi active
- 2009-09-23 DK DK09816565.7T patent/DK2346855T3/en active
- 2009-09-23 ES ES20191961T patent/ES2966093T3/es active Active
- 2009-09-23 PT PT171633837T patent/PT3214083T/pt unknown
- 2009-09-23 LT LTEP17163383.7T patent/LT3214083T/lt unknown
- 2009-09-23 SI SI200932102T patent/SI3214083T1/sl unknown
- 2009-09-23 SM SM20200690T patent/SMT202000690T1/it unknown
- 2009-09-23 US US14/743,365 patent/USRE46617E1/en active Active
- 2009-09-23 SG SG10201605492YA patent/SG10201605492YA/en unknown
- 2009-09-23 BR BRPI0919241A patent/BRPI0919241B8/pt active IP Right Grant
- 2009-09-23 WO PCT/US2009/005276 patent/WO2010036329A2/en not_active Ceased
- 2009-09-23 EP EP17163383.7A patent/EP3214083B1/en active Active
- 2009-09-23 LT LTEP20191961.0T patent/LT3766876T/lt unknown
- 2009-09-23 CN CN200980138280.XA patent/CN102164912B/zh active Active
- 2009-09-23 KR KR1020117009326A patent/KR20110091504A/ko not_active Ceased
- 2009-09-23 ES ES09816565.7T patent/ES2629466T3/es active Active
- 2009-09-23 JP JP2011529013A patent/JP6013734B2/ja active Active
- 2009-09-23 MX MX2011003122A patent/MX2011003122A/es active IP Right Grant
- 2009-09-23 RS RS20201519A patent/RS61194B1/sr unknown
- 2009-09-23 HU HUE17163383A patent/HUE052219T2/hu unknown
- 2009-09-23 KR KR1020167026280A patent/KR101775304B1/ko active Active
- 2009-09-23 ES ES17163383T patent/ES2826273T3/es active Active
- 2009-09-23 CA CA2738236A patent/CA2738236C/en active Active
- 2009-09-23 KR KR1020177008707A patent/KR20170039758A/ko not_active Ceased
- 2009-09-23 RU RU2011116052/04A patent/RU2546667C2/ru active
- 2009-09-23 MX MX2015000081A patent/MX377930B/es unknown
- 2009-09-23 CN CN201510401546.2A patent/CN105001207A/zh active Pending
2011
- 2011-03-22 IL IL211845A patent/IL211845A/en active IP Right Grant
- 2011-03-23 MX MX2020009790A patent/MX2020009790A/es unknown
2013
- 2013-07-09 US US13/937,488 patent/US8871938B2/en active Active
2015
- 2015-05-19 JP JP2015101828A patent/JP2015178515A/ja active Pending
2016
- 2016-02-23 HK HK16101979.5A patent/HK1214243A1/zh unknown
2020
- 2020-11-25 HR HRP20201879TT patent/HRP20201879T1/hr unknown
- 2020-12-09 CY CY20201101168T patent/CY1123658T1/el unknown
2021
- 2021-02-04 NL NL301091C patent/NL301091I2/nl unknown
- 2021-02-10 HU HUS2100004C patent/HUS2100004I1/hu unknown
- 2021-02-10 CY CY2021004C patent/CY2021004I1/el unknown
- 2021-02-15 NO NO2021006C patent/NO2021006I1/no unknown
- 2021-02-16 FI FIC20210002C patent/FIC20210002I1/fi unknown
- 2021-02-17 LT LTPA2021002C patent/LTC3214083I2/lt unknown

Also Published As

Publication number	Publication date
BRPI0919241A2 (pt)	2016-06-21
HUE052219T2 (hu)	2021-04-28
US8871938B2 (en)	2014-10-28
NL301091I1 (nl)	2021-02-10
MX377930B (es)	2025-03-10
MX2020009790A (es)	2020-10-12
CN102164912A (zh)	2011-08-24
PL3214083T3 (pl)	2021-04-06
US20120041208A1 (en)	2012-02-16
EP3214083A1 (en)	2017-09-06
EP3766876A1 (en)	2021-01-20
LTPA2021002I1 (lt)	2021-03-10
KR20170039758A (ko)	2017-04-11
EP3766876B8 (en)	2023-10-18
USRE46617E1 (en)	2017-11-28
IL211845A0 (en)	2011-06-30
PT3214083T (pt)	2020-12-04
ES2826273T3 (es)	2021-05-17
BRPI0919241B8 (pt)	2021-05-25
JP6013734B2 (ja)	2016-10-25
EP2346855B1 (en)	2017-04-05
CN102164912B (zh)	2015-08-19
US8497378B2 (en)	2013-07-30
CY2021004I2 (el)	2021-05-05
RU2011116052A (ru)	2012-10-27
JP2015178515A (ja)	2015-10-08
FI3766876T3 (fi)	2023-12-05
BRPI0919241A8 (pt)	2017-10-17
DK3214083T3 (da)	2020-12-07
ES2629466T3 (es)	2017-08-09
EP3214083B1 (en)	2020-09-16
CY2021004I1 (el)	2021-05-05
HUS2100004I1 (hu)	2021-03-01
US20140171648A1 (en)	2014-06-19
BRPI0919241B1 (pt)	2020-05-12
WO2010036329A2 (en)	2010-04-01
IL211845A (en)	2017-03-30
CY1123658T1 (el)	2021-05-05
JP2012508161A (ja)	2012-04-05
EP3766876B1 (en)	2023-09-13
PL3766876T3 (pl)	2024-04-02
CA2738236A1 (en)	2010-04-01
MX2011003122A (es)	2011-07-20
LTC3214083I2 (lt)	2022-06-27
SG10201605492YA (en)	2016-09-29
CA2738236C (en)	2016-11-15
CN105001207A (zh)	2015-10-28
LT3766876T (lt)	2023-12-11
KR101775304B1 (ko)	2017-09-05
EP2346855A4 (en)	2012-07-04
SI3214083T1 (sl)	2021-02-26
RS61194B1 (sr)	2021-01-29
DK2346855T3 (en)	2017-07-24
HK1244481A1 (en)	2018-08-10
SMT202000690T1 (it)	2021-01-05
KR20160116020A (ko)	2016-10-06
FIC20210002I1 (fi)	2021-02-16
ES2966093T3 (es)	2024-04-18
NL301091I2 (nl)	2021-08-03
AU2009297085A1 (en)	2010-04-01
AU2009297085B2 (en)	2015-07-09
NO2021006I1 (no)	2021-02-15
EP2346855A2 (en)	2011-07-27
WO2010036329A3 (en)	2010-07-01
HK1214243A1 (zh)	2016-07-22
HRP20201879T1 (hr)	2021-01-22
KR20110091504A (ko)	2011-08-11
RU2546667C2 (ru)	2015-04-10

Publication	Publication Date	Title
LTPA2021002I1 (lt)	2021-03-10	Kvinolono junginių gamybos būdas
FI20090389L (fi)	2011-04-24	Menetelmä hissin valmistamisessa
EP2262922A4 (en)	2011-08-17	PREPARATION OF TUBES
BRPI0919116A2 (pt)	2015-12-08	método
BR112012004707A2 (pt)	2016-04-12	método
BR112012000624A2 (pt)	2016-02-10	método
SMT201400023B (it)	2014-05-07	Analoghi di buprenorfina
EP2456440A4 (en)	2012-12-19	Quinolinone PDE2 INHIBITORS
PL3299356T3 (pl)	2022-04-04	Sposób wytwarzania pleuromutylin
DK2313489T3 (da)	2015-06-22	Fremstillingsmetode
BRPI1012526A2 (pt)	2016-03-29	método
EP2349335A4 (en)	2012-02-08	LEVETIRACETAM IMMUNOASSAYS
PL2493466T3 (pl)	2021-11-15	Nowe przeciwguzowe zastosowanie kabazytakselu
DK2452189T3 (da)	2014-01-20	Fremgangsmåde til identifikation af forbindelser til behandling af cancer
BRPI1010705A2 (pt)	2015-09-15	método
DK2358714T3 (da)	2012-08-20	Alkylcyclohexylethere af dihydrotetraazabenzoazulener
FI20095644A0 (fi)	2009-06-10	Ulokkeen muodostaminen
DK2346661T3 (da)	2020-03-02	Dannelsesfremgangsmåder
BRPI1012532A2 (pt)	2016-03-29	método
PL2358641T3 (pl)	2014-11-28	Sposób wytwarzania tytanianów
PT2492266E (pt)	2015-11-18	Derivado de 5-hidroxipirimidino-4-carboxamida
DK2554174T3 (da)	2015-12-07	Fremgangsmåde til behandling af sygdomme
BRPI0916597A2 (pt)	2015-08-04	Método
BRPI1009350A2 (pt)	2016-03-08	método
CU23884B1 (es)	2013-04-19	Derivados de dibenzotiazepina