LT2014117A - Porous three dimensional cellulose based scaffold and method - Google Patents
Porous three dimensional cellulose based scaffold and methodInfo
- Publication number
- LT2014117A LT2014117A LT2014117A LT2014117A LT2014117A LT 2014117 A LT2014117 A LT 2014117A LT 2014117 A LT2014117 A LT 2014117A LT 2014117 A LT2014117 A LT 2014117A LT 2014117 A LT2014117 A LT 2014117A
- Authority
- LT
- Lithuania
- Prior art keywords
- bone
- scaffold
- cellulose
- biogenic
- porous
- Prior art date
Links
- 229920002678 cellulose Polymers 0.000 title abstract 3
- 239000001913 cellulose Substances 0.000 title abstract 3
- 210000000988 bone and bone Anatomy 0.000 abstract 7
- 230000000035 biogenic effect Effects 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 abstract 1
- 229920002101 Chitin Polymers 0.000 abstract 1
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 150000002484 inorganic compounds Chemical class 0.000 abstract 1
- 229910010272 inorganic material Inorganic materials 0.000 abstract 1
- 230000000278 osteoconductive effect Effects 0.000 abstract 1
- 235000015927 pasta Nutrition 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to material engineering and could be applied in odontology or other kind of surgery for bone tissue regeneration in a defect site.The aim of this invention is to prepare a porous three dimensional cellulose-based biocompatible scaffold of good osteoconductive and mechanical properties with the structure like that of a natural bone.To achieve the above object, the present invention provides a composite comprising cellulose and biogenic bone particles at a ratio (w/w) 1:0.12-6.0, wherein the diameter of the particles is 0.01-2000 microns. In a separate case a bone material which comprises inorganic compounds and polysaccharide chitin could be used as a biogenic bone. In a separate case the surface of the scaffold could be coated with collagen, platelet-rich fibrin, various growth factors, therapeutic additives, stem cells. The three dimensional porous scaffold of the natural bone morphology is prepared by inserting biogenic bone particles into a cellulose gel during its formation from cellulose acetate at a ratio 1:0.12-6.0, afterwards loading the gel with an aqueous 10-30 % ethanol solution and freeze-dried or extracted with carbon dioxide at supercritical conditions at 24-70 MPa and 35-80oC temperature. The resulting scaffold could be ground to granules of a desired size and/or the pasta could be prepared.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LT2014117A LT6309B (en) | 2014-10-13 | 2014-10-13 | Porous three dimensional cellulose based scaffold and method |
| PCT/IB2015/057597 WO2016059508A1 (en) | 2014-10-13 | 2015-10-05 | A 3d porous cellulose scaffold for bone tissue engineering and the method for its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LT2014117A LT6309B (en) | 2014-10-13 | 2014-10-13 | Porous three dimensional cellulose based scaffold and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT2014117A true LT2014117A (en) | 2016-05-10 |
| LT6309B LT6309B (en) | 2016-08-25 |
Family
ID=54345553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT2014117A LT6309B (en) | 2014-10-13 | 2014-10-13 | Porous three dimensional cellulose based scaffold and method |
Country Status (2)
| Country | Link |
|---|---|
| LT (1) | LT6309B (en) |
| WO (1) | WO2016059508A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2660588C1 (en) * | 2017-07-18 | 2018-07-06 | Федеральное государственное учреждение "Федеральный научно-исследовательский центр "Кристаллография и фотоника" Российской академии наук" | Method of hydrogel hardening |
| CN114904052A (en) * | 2022-05-06 | 2022-08-16 | 南京友德邦医疗科技有限公司 | Novel degradable magnesium alloy intravascular stent and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6340477B1 (en) * | 2000-04-27 | 2002-01-22 | Lifenet | Bone matrix composition and methods for making and using same |
| US6730252B1 (en) | 2000-09-20 | 2004-05-04 | Swee Hin Teoh | Methods for fabricating a filament for use in tissue engineering |
| US6478825B1 (en) | 2001-11-28 | 2002-11-12 | Osteotech, Inc. | Implant, method of making same and use of the implant for the treatment of bone defects |
| CA2680586A1 (en) | 2007-03-26 | 2008-10-02 | Mei Wei | Electrospun apatite/polymer nano-composite scaffolds |
| US9005286B2 (en) | 2012-02-21 | 2015-04-14 | Thierry Giorno | PLGA/HA hydroxyapatite composite bone grafts and method of making |
-
2014
- 2014-10-13 LT LT2014117A patent/LT6309B/en not_active IP Right Cessation
-
2015
- 2015-10-05 WO PCT/IB2015/057597 patent/WO2016059508A1/en not_active Ceased
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2660588C1 (en) * | 2017-07-18 | 2018-07-06 | Федеральное государственное учреждение "Федеральный научно-исследовательский центр "Кристаллография и фотоника" Российской академии наук" | Method of hydrogel hardening |
| CN114904052A (en) * | 2022-05-06 | 2022-08-16 | 南京友德邦医疗科技有限公司 | Novel degradable magnesium alloy intravascular stent and preparation method thereof |
| CN114904052B (en) * | 2022-05-06 | 2024-02-02 | 南京友德邦医疗科技有限公司 | A new type of degradable magnesium alloy vascular stent and its preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| LT6309B (en) | 2016-08-25 |
| WO2016059508A1 (en) | 2016-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Patent application published |
Effective date: 20160510 |
|
| FG9A | Patent granted |
Effective date: 20160825 |
|
| MM9A | Lapsed patents |
Effective date: 20171013 |