KR900701735A - 2-아미노카르복실산 및 그의 유도체, 그의 제조방법 및 의약으로서의 그의 용도 - Google Patents
2-아미노카르복실산 및 그의 유도체, 그의 제조방법 및 의약으로서의 그의 용도Info
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- KR900701735A KR900701735A KR1019900701383A KR900701383A KR900701735A KR 900701735 A KR900701735 A KR 900701735A KR 1019900701383 A KR1019900701383 A KR 1019900701383A KR 900701383 A KR900701383 A KR 900701383A KR 900701735 A KR900701735 A KR 900701735A
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- octadecyloxy
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- 239000003814 drug Substances 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- -1 3-octadecyloxy-2-hydroxypropyl Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 230000003412 degenerative effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000006289 hydroxybenzyl group Chemical group 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061533 Myotonia Diseases 0.000 claims 1
- 102000003923 Protein Kinase C Human genes 0.000 claims 1
- 108090000315 Protein Kinase C Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000003636 chemical group Chemical group 0.000 claims 1
- 125000004803 chlorobenzyl group Chemical group 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000006178 methyl benzyl group Chemical group 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 다음 일반식 (Ⅰ)의 2-아미노카르복실산 및 유도체와 약리적으로 허용되는 그의 염 (단, DB-A 1 518362호에 개시될 화합물은 제외)상기식 중, R1은 직쇄 또는 분지쇄의, 탄소원자 20개이하의 포화 또는 불포화 알킬기이고, R2및 R3은 같거나 다르고, 수소 또는 단소원자 4개 이하의 직쇄 또는 분지쇄 알킬기이며, R4는 수소 메틸 히드록시메틸 벤질, 히드록시벤질, 탄소원자 4개 이하의 카르복실기, 히드록시알킬기 또는 알콕시카르보닐기이고, R5는 수소 또는 탄소원자 4개 이하의 전쇄 또는 분지쇄 알킬기임.
- 제1항에 있어서, R1이 옥틸-또는 옥타데실기, 서로 같거나 다른, R2및 R3은 수소 또는 메틸기, R4가 수소, 메틸, 히드록시메틸, 히드록시에틸, 벤질, 히드록시벤질, 시카르보닐기이고, R5는 수소 또는 에틸기인 것이 특징인 일반식(Ⅰ)의 화합물.
- 제1항에 있어서, 즉 2-〔N-메틸-N-(3-옥타데실옥시-2-히드록시프로필)〕-아미노-3-히드록시프로피온산 염산염; 2-〔N-메틸-N-(3-틸옥시-2-히드록시프로필)〕-아미노-3-히드록시프로피온산; 2-〔N-메틸-N-(3-옥타데실옥시-2-히드록시프로필)〕-아미노-3-히드록시프로피온산 에틸 에스테르;(±)-2-N-(3-옥타데실옥시-2-히드록시프로필)-아미노아세트산 염산염; 2-N-(3-옥타데실옥시-2-히드록시프로필)-아미노-3-히드록시프로피온산 염산염: 2-N-(3-옥타데실옥시-2-메톡시프로필)-아미노프로피온산 에틸 에스테르 옥살산염; 2-N-(3-옥타데실옥시-2-메톡시프로필)-아미노-3-히드록시부티르산; 2-N-(3-옥타데실옥시-2-히드록시프로필)-아미노말론산 디에틸 에스테르; 2-N-(3-옥타데실옥시-2-히드록시프로필)-아미노-3-페닐-프로피온산인 일반식(Ⅰ)의 화합물.
- a) 다음 일반식(Ⅱ)의 아미노 화합물을(상기 식중, R1, R2및 R3은 상기 정의와 같음) 다음 일반식(Ⅲ)의 화합물과 반응시켜 일반식 (Ⅰ)의 화합물로 만들거나 또는,(상기식중, R4및 R5는 상기 정의와 같고, Z는 예컨데 토실기 또는 할로겐 원자와 같이 쉽게 제거가능한 기임)b) 다음 일반식(Ⅳ)의 에폭사이드를(상기식증 R1은 상기 정의와 같음) 다음 일반식(Ⅴ)의 화합물과〔상기식중 R3및 R5는 상기 정의와 같고 R6는 수소, 메틸 벤질 또는 카르복실기 또는 다음 일반식(Ⅵ) 또는 (Ⅵa)의 화학기(상기식중, R7은 예컨대 벤질, 클로로벤질, 2,6-디클로로벤질 또는 3급-부틸과 같이 쉽게 분열될 수 있는 보호기임)임〕반응시켜 다음 일반식(Ⅶ)의 화합물을 생성시킨 다음(상기식중, R1, R3, R5및 R6은 상기 정의와 같음)R2가 수소가 아닌 경우에는, 이 화합물을 공지 방법으로 알킬화시켜 다음 일 반식 (Ⅷ) 의 화합물을 생성시키고(상기식중, R1, R2, R3, R5및 R6은 상기 정의와 같음) 이어서 일반식 (Ⅷ) 의 이 화합물들을 상기 정의한 보호기를 산분해시키거나 가수소분해시킴으로써 일반식 (Ⅰ) 의 화합물로 만드는 것을 특징으로하는 제1항에 따른 일반식 (Ⅰ)의 화학물의 제조방법.
- 다음 일반식 (Ⅰ)의 2-아미노카르복실산 및 유도체와 약리적으로 허용되는 그의 염의 단백질 카나아제 C의 저해 및 그에 따른 수축, 분리 및 증식과정의 조절용도.상기식 중, R1은 직쇄 또는 분지쇄의, 탄소원자 20개이하의 포화 또는 불포화 알킬기이고, R2및 R3은 같거나 다르고, 수소 또는 탄소원자 4개 이하의 직쇄 또는분지쇄 알킬기이며, R4는 수소, 메틸, 히드록시메틸, 벤질, 히드록시벤질, 탄소원자4개 이하의 카르복실기, 히드록시알킬기 또는 알콕시카르보닐기이고, R5는 수소 또는 탄소원자 4개 이하의 직쇄 또는 분지쇄 알킬기이다.
- 제5항에 있어서, 혈전병, 동맥경화증, 고혈압과 같은 심장 및 혈관계 질환, 염증성 경과, 알레르기, 암, 바이러스성 질병 및 중추신경계의 퇴행적 손상의 예방 및/또는 치료를 위한 일반식(Ⅰ)의 화합물의 용도.
- 제5항에 있어서, 혈전병, 동맥경화증, 근긴장항진과 같은 심장 및 혈관계 질환, 염증성 경과, 알레르기, 암, 바이러스성 질병 및 중추신경계의 퇴행적 손상의 예방 및/또는 치료하기 위한 의약을 제조하는데 있어서의 일반식(Ⅰ)의 화합물의 용도.
- 통상적인 보조제 및 첨가제 외에, 제1항에 따른 일반식(Ⅰ)의 화합물을 함유함을 특징으로 하는 의약.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3836987A DE3836987A1 (de) | 1988-10-31 | 1988-10-31 | 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| PCT/EP1989/001293 WO1990005130A1 (de) | 1988-10-31 | 1989-10-30 | 2-aminocarbonsäure-derivate, ihre herstellung und verwendung als arzneimittel |
| DEP3836987,7 | 1989-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR900701735A true KR900701735A (ko) | 1990-12-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900701383A Withdrawn KR900701735A (ko) | 1988-10-31 | 1989-10-30 | 2-아미노카르복실산 및 그의 유도체, 그의 제조방법 및 의약으로서의 그의 용도 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5401875A (ko) |
| EP (2) | EP0440731A1 (ko) |
| JP (1) | JPH04502149A (ko) |
| KR (1) | KR900701735A (ko) |
| CN (1) | CN1042347A (ko) |
| AT (1) | ATE99282T1 (ko) |
| AU (1) | AU635908B2 (ko) |
| DD (1) | DD289520A5 (ko) |
| DE (2) | DE3836987A1 (ko) |
| DK (1) | DK65691A (ko) |
| ES (1) | ES2060722T3 (ko) |
| HU (1) | HU896587D0 (ko) |
| PT (1) | PT92155B (ko) |
| WO (1) | WO1990005130A1 (ko) |
| ZA (1) | ZA898274B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3836987A1 (de) * | 1988-10-31 | 1990-05-23 | Goedecke Ag | 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
| TW328914B (en) * | 1996-02-06 | 1998-04-01 | Ajinomoto Kk | Surfactant, and toiletry or detergent composition containing the same |
| CN101906097B (zh) * | 2009-06-02 | 2012-06-27 | 首都医科大学 | 1,3-二氧六环类化合物及其合成方法和在医学中应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB727482A (en) * | 1952-03-11 | 1955-04-06 | Dow Chemical Co | Improvements in poly-valent metal ion chelating agents |
| DE1518362A1 (de) * | 1963-07-10 | 1969-06-26 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Hydroxylkylaminocarbonsaeuren |
| DD60382A (ko) * | 1967-04-13 | |||
| US3647868A (en) * | 1967-10-18 | 1972-03-07 | Textilana Corp | N-(2-hydroxyalkyl) sarcosine-n-oxides |
| DE1922003C3 (de) * | 1969-04-30 | 1979-10-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | N-(3-Aryloxy-2-hydroxypropyl)-aminocarbonsäuren, deren Ester, Amide und Salze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung von Herzinsuffizienz |
| JPS4835372B1 (ko) * | 1969-05-28 | 1973-10-27 | ||
| DE2940509C2 (de) * | 1978-10-06 | 1995-01-26 | Nippon Paint Co Ltd | Polymerisierbare Aminosäureverbindungen und ihre Verwendung |
| CA1146695A (en) * | 1979-03-01 | 1983-05-17 | Shinichi Ishikura | Polymeric resin and coating composition comprising same |
| EP0053434B1 (en) * | 1980-11-28 | 1986-08-27 | American Hospital Supply Corporation | Compounds and method for treatment or prophylaxis of cardiac disorders |
| US4450173A (en) * | 1980-11-28 | 1984-05-22 | American Hospital Supply Corporation | Compounds and method for treatment or prophylaxis of cardiac disorders |
| OA06199A (fr) * | 1981-05-13 | 1981-06-30 | Berol Kemi Ab | Procédé de flottation de minéraux phosphatés et composé destiné à ce procédé. |
| SE441740B (sv) * | 1983-05-27 | 1985-11-04 | Berol Kemi Ab | Forfarande for flotation av fosfatmalm |
| SE452120B (sv) * | 1984-04-04 | 1987-11-16 | Berol Kemi Ab | Forfarande for skumflotation samt flotationsmedel herfor |
| DE3625738A1 (de) * | 1986-07-30 | 1988-02-11 | Goedecke Ag | 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung |
| DE3836987A1 (de) * | 1988-10-31 | 1990-05-23 | Goedecke Ag | 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
-
1988
- 1988-10-31 DE DE3836987A patent/DE3836987A1/de not_active Withdrawn
-
1989
- 1989-10-30 US US07/681,500 patent/US5401875A/en not_active Expired - Fee Related
- 1989-10-30 AU AU45143/89A patent/AU635908B2/en not_active Ceased
- 1989-10-30 DE DE89120142T patent/DE58906571D1/de not_active Expired - Fee Related
- 1989-10-30 JP JP1511644A patent/JPH04502149A/ja active Pending
- 1989-10-30 KR KR1019900701383A patent/KR900701735A/ko not_active Withdrawn
- 1989-10-30 PT PT92155A patent/PT92155B/pt not_active IP Right Cessation
- 1989-10-30 HU HU896587A patent/HU896587D0/hu unknown
- 1989-10-30 AT AT89120142T patent/ATE99282T1/de not_active IP Right Cessation
- 1989-10-30 WO PCT/EP1989/001293 patent/WO1990005130A1/de not_active Ceased
- 1989-10-30 EP EP89912439A patent/EP0440731A1/de active Pending
- 1989-10-30 ES ES89120142T patent/ES2060722T3/es not_active Expired - Lifetime
- 1989-10-30 EP EP89120142A patent/EP0367205B1/de not_active Expired - Lifetime
- 1989-10-30 DD DD89334041A patent/DD289520A5/de not_active IP Right Cessation
- 1989-10-31 ZA ZA898274A patent/ZA898274B/xx unknown
- 1989-10-31 CN CN89108252A patent/CN1042347A/zh active Pending
-
1991
- 1991-04-11 DK DK065691A patent/DK65691A/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1042347A (zh) | 1990-05-23 |
| AU635908B2 (en) | 1993-04-08 |
| JPH04502149A (ja) | 1992-04-16 |
| DE58906571D1 (de) | 1994-02-10 |
| DD289520A5 (de) | 1991-05-02 |
| DE3836987A1 (de) | 1990-05-23 |
| PT92155B (pt) | 1995-07-18 |
| EP0367205A1 (de) | 1990-05-09 |
| DK65691D0 (da) | 1991-04-11 |
| WO1990005130A1 (de) | 1990-05-17 |
| HU896587D0 (en) | 1991-07-29 |
| EP0367205B1 (de) | 1993-12-29 |
| US5401875A (en) | 1995-03-28 |
| AU4514389A (en) | 1990-05-28 |
| EP0440731A1 (de) | 1991-08-14 |
| PT92155A (pt) | 1990-05-31 |
| DK65691A (da) | 1991-04-11 |
| ZA898274B (en) | 1990-07-25 |
| ATE99282T1 (de) | 1994-01-15 |
| ES2060722T3 (es) | 1994-12-01 |
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Legal Events
| Date | Code | Title | Description |
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| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19900628 |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |