KR20100120332A - Hair growth agent from plant complex and its applicant - Google Patents

Abstract

The present invention is decolorized and treated after ultra-high frequency treatment under reduced pressure using a solvent such as water, ethanol aqueous solution, 1,3-butylene glycol, dipropylene glycol, isopropanol, etc. The present invention relates to a hair regrowth composition using the extract obtained by removing the odor, and a method for preparing the same. According to the present invention, hair cell reactivation and blood promoting activity have high cheongung, baekryeop, licorice, red ginseng, and donkey. , Rheum vinegar, ginseng mixed extract 0.01-20 parts by weight, benzophenone, licorice acid, polyoxymethylene nonylphenyl ether, polyoxyethylene lauryl ether sulfate sodium sulfate, polyoxyethylene stearyl ether selected from the group consisting of 5.0 to 10.0 parts by weight of at least one selected from the group of humectants consisting of 0.1 to 5.0 parts by weight, glycerin, dipropylene glycol, mineral concentrate, snail extract, sesame leaf Hair regrowth agent manufactured by mixing 5.0-15.0 parts by weight and additives such as moisture, oil, activator, preservative, fragrance, and refreshing agent with at least one selected from the group of hair promoters composed of extracts. It is to provide a composition of a hair regrowth agent having a hair growth promoting, hair loss prevention and hair growth effect and a method for producing the same.

Description

Hair growth agent composition containing a plant mixture extract and a method for producing the same {Hair growth agent from plant complex and its applicant.}

The present invention relates to a hair-repellent composition containing cheongung, baekbaekbyeon, licorice, ginseng, donkey, lactic acid vinegar, ginseng mixed extract, and a method for preparing the same, and more specifically, cheongung, baekbaekbyeon, licorice, ginseng, donkey, vulgaris, ginseng The mixture is harmless to the human body using an extract obtained by ultra-high frequency treatment under reduced pressure using a solvent such as water, ethanol aqueous solution, 1,3-butylene glycol, dipropylene glycol, isopropanol, decolorization and odor removal. It relates to an excellent hair growth and hair loss prevention, hair growth action, and a hair regrowth composition prepared in various forms such as solution, sol-gel, emulsion or ointment and a method for producing the same. The present inventors refer to the cheonsugung, baekbaekbyeon, licorice, red ginseng, Angelica, Lactobacillus, ginseng mixed extract is called the JS hair complex.

According to a recent study by Kyung Hee University, a professor of dermatology Shim Woo-young, who surveyed 1,132 patients with alopecia who visited Kyung Hee Medical Center's East-West Health Diagnosis Center for two years from 1997 to 1999 (Mariday Economy, March 31, 2000). 14.1% and 5.6% of women showed alopecia. In modern society, side effects due to various stresses and overwork, pollution of the environment and misuse of addictive drugs, blood flow disorders of the scalp due to the use of perm, dyeing, mousse, spray, etc. For this reason, as the occurrence of hair loss becomes more serious, there is an increasing interest in hair growth, but the medical knowledge and physiological mechanisms of hair growth have not yet made progress, and especially the composition for promoting hair growth and There are no particular developments in the preparation method thereof. Conventional hair growth components include, for example, hormones such as follicle hormones, minerals such as mineral E, B2, B6, biotin, and pantothenic acid, and other peptide substituents. Phosphorus amino acids, anti-inflammatory agents such as diphenhydramine, hydrochloride, wetting agents such as glycerin, bactericides such as hinokithiol, and refreshing agents such as ethanol, All of these have been claimed to promote hair growth. Further, hair growth promoting drugs include Minoxidil of Upjohn Co., Ltd., disclosed in US Pat. No. 4,596,812. 411/1985 discloses an alcohol having an odd carbon number and a derivative thereof, and Japanese Unexamined Patent Publication No. 20732/1986 describes higher fatty acid alcohols having 22 to 34 carbon atoms. The issue describes the use of glycyl-L-histidyl-L-lysine: copper (II) (GHL-Cu) derivative as a cosmetic composition and the promotion of hair growth in warm-blooded animals. This easy-to-produce and active ingredient has a problem in its stability as a synthetic compound in the human body, and does not have sufficient effects on hair growth and hair growth. Accordingly, the present inventors have found a hair growth agent having excellent hair growth promotion, hair loss prevention, and hair growth effect that are safe to the human body and do not cause side effects in consideration of various problems of existing hair regrowth agents, and completed the present invention based on these findings.

In this regard, the inventors of the present invention have been intensively researched to develop a hair regrowth that is harmless to the human body and has excellent hair growth, hair loss prevention, hair growth effects, and the like. Extract obtained by treatment of ultra-high frequency under reduced pressure using a solvent such as water, ethanol aqueous solution, 1,3-butylene glycol, dipropylene glycol, isopropanol, etc. It has been successful to prepare a hair restorer containing.

And it is confirmed that the hair growth, hair growth state and the like as a method of confirming the state of hair growth by applying a hair regrowth containing the cheongung, baekbaekbyeon, licorice, red ginseng, donkey, harpoon, ginseng mixed extract of the present invention to the hair loss part of alopecia patients This invention was completed. After all, it is an object of the present invention to provide a hair regrowth containing harmless to the human body, hair growth promotion and hair loss prevention, hair growth effect excellent cheongung, baekryeop, licorice, red ginseng, Angelica, Lactobacillus, ginseng mixed extract. In addition, another object of the present invention is to provide a method for preparing a hair restorer containing cheongung, side white leaf, licorice, red ginseng, donkey, lactic acid herb, ginseng mixed extract.

Hereinafter, the present invention will be described in more detail.

In order to manufacture a hair-repellent agent containing cheongung, baekryeop, licorice, red ginseng, donkey, lactic acid vinegar, ginseng mixed extract for achieving the object of the present invention, (a) cheongung, baekryeop, licorice, red ginseng, sugar ear, vulgaris, 0.01-20 parts by weight of ginseng mixed extract, (b) selected from the group of hair promoters consisting of oxymethoxycinnamate, licorice acid, polyoxymethylenenonylphenyl ether, polyoxyethylene lauryl ether sulfate, polyoxyethylene stearyl ether Hair promoter comprising at least one selected from the group consisting of 0.1 to 5.0 parts by weight, (c) glycerin and dipropylene glycol, at least one selected from the group consisting of 5.0 to 10.0 parts by weight, (d) mineral concentrate, licorice extract and sesame leaf extract. It is characterized by blending at least one selected from the group by 5.0 to 15.0 parts by weight, but the hair regrowth agent of the present invention, in addition to these components, the base and moisture, oil, bow, and the like formulated into ordinary hair regrowth and hair growth agents First prepared by mixing an additive such as, a preservative, flavoring and refreshing agent.

First, among these (a) look at the method of extracting the cheongung, side white leaf, licorice, red ginseng, donkey, lactic acid vinegar, ginseng mixture, dried until there is no change in weight of the leaves of each plant and then pulverized by a pulverizer Mixing the same amount of hot water with distilled water and injecting nitrogen gas into the reactor for a predetermined time at a high temperature of 60 ~ 80 ℃ using an organic solvent such as ethanol aqueous solution, 1,3-butylene glycol, dipropylene glycol, isopropanol After stirring and eluting, ultra-high frequency treatment under reduced pressure, filtered through an activated carbon column, and the solvent was removed under reduced pressure to obtain off-flavored and decolorized cheongyo, white leaf, licorice, red ginseng, donkey, vigorous herb and ginseng mixed extract.

The cheongung, side white leaf, licorice, red ginseng, donkey, lactic acid herb, ginseng mixed extract (a) extracted by the above method is not toxic to the human body, so the amount of hair growth and hair growth agent is not limited and is widely used. It is possible, but when the amount of the effluent is 0.1 parts by weight or less, there is no hair growth and hair growth effect, and when the amount is more than 10 parts by weight, there is no significant difference in the effect and economically disadvantageous disadvantages, since the high concentration extract is 0.01-20 to the total amount. It is suitable to use in the range of a weight part, Preferably it is more effective to carry out in the range of 0.1-10 weight part.

In addition, (b) oxymethoxy cinnamate, (c) glycerin and (d) mineral concentrates may be blended one or two or more, but is not limited thereto, and (b) oxymethoxy cinnamate is blended 5.0 parts by weight or more This raises a problem in the usability and safety of the hair regrowth.

The hair growth and hair growth agent of the present invention may be formulated with conventional excipients such as hair tonic, hair cream, hair lotion, hair shampoo, hair rinse, hair spray, hair aerosol, hair oil, powder, jelly, and the like solution, sol gel, emulsion, oil, It may be prepared in various forms such as wax, aerosol, and the like.

Hereinafter, the present invention will be described in more detail with reference to the following examples.

These examples are only for illustrating the present invention, and it will be apparent to those skilled in the art that the scope of the present invention is not limited to these examples according to the gist of the present invention.

It is harmless to human body and is excellent in hair regrowth, hair loss prevention, hair growth effect, etc.

Example 1

After drying the mixture of Cheongung, Siegyeop, Licorice, Ginseng, Angelica, Lactobacillus, and Ginseng until there is no change in weight, 400g of distilled water was added to 100g of the mixture of crushed with a grinder. Ultra high frequency treatment for 24 hours while boiling in water, filtered through 0.45㎛ sterile filter paper, and extracted by odor removal and decolorization by passing through an activated carbon column.

[Example 2]

After drying the mixture of Cheongung, Siegyeop, Licorice, Ginseng, Angelica, Lactobacillus, and Ginseng until there is no change in weight, 100 g of the same amount of the mixture crushed with a grinder was added to 300 g of 30% ethanol aqueous solution and left for 5 days. 2 After evaporation of ethanol at 60 ° C. under reduced pressure, the mixture was filtered through a 0.45 μm sterile filter paper for 24 hours, followed by ultra-high frequency treatment, and extracted by odor removal and decolorization through an activated carbon column.

Example 3

Extraction was carried out in the same manner as in Example 2, except that the mixture was left for 48 hours using 300 g of a 30% 1,3 butylene glycol aqueous solution.

Example 4

Extraction was carried out in the same manner as in Example 2, except that 30 g of 30% dipropylene glycol aqueous solution or 300 g of isopropanol was used.

Example 5

2,0 parts by weight of oxymethoxycinnamate, polyoxyethylene curing in 10.0 parts by weight of cheongung, side white leaf, licorice, red ginseng, Angelica, vulgaris and ginseng extract extracted in the reaction mixture tank in one of Examples 1 to 4 Castor oil 2.0 parts by weight, glycerin 4.0 parts by weight, dipropylene glycol glycol 2.0 parts by weight, mineral concentrate 5.0 parts by weight snail extract 5.0 parts by weight, ethanol 10.0 parts by weight, purified water 57.0 parts by weight, mineral oil 2.4 parts by weight, fragrance 0.3 parts by weight , 0.3 parts by weight of the antioxidant was mixed and stirred to prepare a hair regrowth in the form of a solution.

Example 6

0.5 parts by weight of polyoxyethylene lauryl ether sulfate sodium sulfate, polyoxyethylene lauryl ether sulfate in 10.0 parts by weight of cheongung, baekryeop, licorice, red ginseng, Angelica, Lactobacillus, ginseng extract extracted in one of the methods in Examples 1 to 4 in a reaction mixture tank Aryl ether 0.2 parts by weight, glycerin 5.0 parts by weight, dipropylene glycol 3.0 parts by weight, mineral concentrate 5.0 parts by weight, snail extract 5.0 parts by weight, sesame leaf extract 2.0 parts by weight, liquid paraffin 20.0 parts, solid paraffin 5.0 parts by weight, ethanol 10.0 parts by weight, mineral oil 1.7 parts by weight, purified water 32.0 parts by weight, fragrance 0.3 parts by weight, and mixed with 0.3 parts by weight of antioxidant to prepare a sol-gel hair regrowth.

Example 7

1.0 parts by weight of polyoxyethylene lauryl ether sulfate sodium sulfate, polyoxyethylene curing in 10.0 parts by weight of cheongung, side white leaf, licorice, red ginseng, Angelica, Lactobacillus, ginseng mixed extract extracted in the reaction mixture tank in one of Examples 1 to 4 Castor oil 1.0 parts by weight, glycerin 8.0 parts by weight, mineral concentrate 8.0 parts by weight, snail extract 3.0 parts by weight, purified water 58.0 parts by weight, menthol 0.2 parts by weight, ethanol 8.0 parts by weight, mineral oil 2.2 parts by weight, fragrance 0.3 parts by weight, antioxidant 0.3 parts by weight of the mixing and stirring to prepare a hair emulsion in the form of a hair emulsion.

Example 8

2.0 parts by weight of licorice acid and 1.0 weight of polyoxyethylene hydrogenated castor oil in 10.0 parts by weight of Cheongung, Cucumber, Licorice, Red Ginseng, Angelica, Lactobacillus, and Ginseng mixed extract extracted by the method in Examples 1 to 4 in the reaction mixture tank. Part, a glycerin 6.0 parts by weight, mineral concentrate 4.0 parts by weight, snail extract 4.0 parts by weight, petrolatum 70.0 parts by weight, mineral oil 2.2 parts by weight, flavoring 0.4 parts by weight, antioxidant 0.4 parts by weight of the ointment was prepared in the form of an ointment.

Example 9

Hair growth test method: 10 males (20-60 years old) and 10 females (ages 32-62) male hair loss patients randomly landed in the country 1 day 3 hair regrowth prepared in Example 5 The method of applying to every corner of the hair root area where the hair loss was 5 ml each time and once was applied. This was evaluated 3, 6, 9, 12 months after the start of the test and observed the hair growth state of the coating site and the results are shown in Table 1.

(Table 1)

As described above, according to the present invention, there are excellent hair growth, hair loss prevention, and hair growth effects on the cheonggung, baekbaekbyeon, licorice, ginseng, donkey, lactic acid herb, ginseng mixed extract, and especially effective for female hair loss patients than male hair loss patients It is effective for hair loss patients younger than older people.

Example 10

Skin irritation test: The degree of irritation to the skin of the rabbit was measured for the hair regrowth prepared in Example 5, and for this purpose, rabbit hair was removed 24 hours before the application of the hair regrowth to treat treatment of normal skin and wound skin. And control compartments.

The coating method was applied once to the application site 1g per rabbit.

Untreated control compartments were applied in equal amounts of sterile physiological saline and covered with gauze.

In order to prevent evaporation of the sample, it was covered with a solid paper that was not permeable and reactive, and fixed with a tape and then applied for 24 hours, 72 hours, and 120 hours.

Then, after the end of the application time using the saline solution was lightly cleaned with the application site. In addition, the appearance, feed and beverage consumption and clinical symptoms were observed daily for one week after the administration of the sample material. Evaluation of skin reaction was judged using 'toxicity test criteria' of medicines. In addition, the degree of irritation to the skin was evaluated by the method of calculating the P.I.I. (Primary Irritation Index) of Draize which is commonly used, and the results are shown in Table 2 below.

Table 2

As described in the above skin irritation test, it was confirmed that the hair regrowth agent according to the present invention had safety and stability without irritation to the skin.

As described above, according to the present invention, hair cell reactivation and blood promotion are highly effective as a hair repellent containing cheongung, baekbaekbyeon, licorice, red ginseng, donkey, harpoon, ginseng mixed extract, It is safe and stable, and if this hair regrowth is continuously applied to the hair loss part, it will have excellent hair growth, hair loss prevention, hair growth effect, and thus hair growth and hair growth effects.

Claims (6)

Benzophenone, licorice acid, polyoxymethylenenonylphenyl ether, polyoxyethylene lauryl ether sulfate, polyoxy 0.1 to 5.0 parts by weight of hair promoter catalyst group consisting of ethylene stearyl ether, 5.0 to 10.0 parts by weight of wetting agent group consisting of glycerin and dipropylene glycol, 5.0 to 15.0 parts by weight of hair promoter group consisting of mineral concentrate, snail extract and sesame leaf extract A hair restorer composition characterized by blending. The oxymethoxycinnamate, licorice acid, polyoxymethylenenonylphenyl ether, polyoxyethylene lauryl ether according to claim 1, based on 10 parts by weight of cheonggung, side white leaf, licorice, red ginseng, donkey, lactic acid herb and ginseng mixed extract. A hair regrowth agent composition comprising 0.7 to 4.0 parts by weight of at least one selected from the group of hair promoting catalysts consisting of sodium sulfate and polyoxyethylene stearyl ether. The method according to claim 1, wherein 6.0 to 8.0 parts by weight of one or more selected from the group of humectants consisting of glycerin and dipropylene glycol is blended with 10 parts by weight of cheongung, side white leaf, licorice, red ginseng, donkey, lactic acid vinegar and ginseng mixed extract. Hair regrowth composition, characterized in that. According to claim 1, at least one selected from the group of hair promoters consisting of mineral concentrate, snail extract, sesame leaf extract for 10 parts by weight of cheongung, side white leaf, licorice, red ginseng, donkey, lactic acid vinegar, ginseng mixed extract 8.0 ~ A hair restorer composition, characterized in that blending at 12.0 parts by weight. Benzophenone, licorice acid, polyoxymethylenenonylphenyl ether, polyoxyethylene lauryl ether sulfate, polyoxy 0.1 to 5.0 parts by weight of hair promoter catalyst group consisting of ethylene stearyl ether, 5.0 to 10.0 parts by weight of wetting agent group consisting of glycerin and dipropylene glycol, 5.0 to 15.0 parts by weight of hair promoter group consisting of mineral concentrate, snail extract and sesame leaf extract In the manufacturing method of the hair regrowth composition characterized in that the mixing, the solvent extracting the cheongung, baekbaekbyeon, licorice, red ginseng, Angelica, Lactobacillus, ginseng mixed extract, water, ethanol aqueous solution, 1,3-butylene glycol, dipropylene Using at least one selected from the group consisting of glycol and isopropanol, and leaving for 1 to 5 days under a reduced pressure of 20-40 kg / cm 2 and seconds for 24 hours Method of producing a hair restorer composition was processed through a frequency passing through the activated carbon column, and then filtered through a sterilizing filter, characterized in that to eliminate odor and discoloration. In blending the hair regrowth composition of claim 1 or 5, the hair repellent composition is formulated in the form of a solution, a sol-gel, an emulsion or an ointment.