KR20060120321A - Health food composition with hypoglycemic effect - Google Patents

Abstract

The present invention relates to a health food composition having a hypoglycemic effect, and more specifically, 5 to 15% by weight of mulberry leaf extract (solid content of 20% or more), and 5 to 15% by weight persimmon leaf extract (solid content of 20% or more). ), 0.5 to 5% by weight of red ginseng extract (solid content of 60% or more), 10 to 20% by weight of barberry extract (solid content of 20% or more), and 6 to 12% by weight pine needle extract (solid content of 15% or more) And, 4-7 wt% chicory fiber, 0.1-1 wt% vitamin C, 0.1-1 wt% vitamin E, 0.1-2 wt% terpene and 25-70 wt% purified water. It is done.

The present invention not only has excellent therapeutic efficacy with regard to insulin-dependent type 1 diabetes as well as insulin-independent type 2 diabetes resulting from obesity, stress, and dietary faults from the above-described configuration, By solving the technical problems of the to be able to have a significant effect, such as to have a body immunity by taking a temporary dose.

Description

Health care Food Composites for Decreasing BloodGlucose Level}

1 is a view showing an experimental example according to the present invention.

The present invention relates to a health food composition having a hypoglycemic effect, and more specifically, mulberry leaf extract, persimmon leaf extract, red ginseng extract, barberry extract, pine needle extract, chicory dietary fiber, vitamin C, vitamin E and terpene mixed It relates to a health food composition having efficacy.

Korea has traditionally focused on grains and vegetables, but as the national income improves, the patterns of life have changed, and Western and Western foods are becoming more and more westernized. As time goes by, the amount of walking time and exercise is absolutely insufficient due to the dissemination of cars, and as the information society, including computers, has changed, obesity, diabetes, high blood pressure, and various cancer patients have increased rapidly. This is a problem because diabetics currently represent one in ten of the population.

The diabetes may include a lack of insulin secreted from beta cells of the island of Langerhans in the pancreas, endocrine gland function such as the anterior pituitary gland, adrenal gland, and thyroid gland, and lesions of the central nervous system, especially the hypothalamus. .

In addition, there are two types of diabetes. Type 1 diabetes occurs in childhood and is called insulin-dependent diabetes, and type 2 diabetes begins in adulthood and is called insulin-independent.

Type 1 diabetes, on the other hand, is due to an absolute lack of insulin. The majority of diabetes in children and adolescents is due to autoimmune destruction of beta cells of the pancreas. Type 2 diabetes is also a combination of insulin resistance and relative insulin deficiency. The cause of type 2 diabetes is not known, but it is estimated to be caused by obesity, stress, poor diet, or drugs that antagonize insulin and the like. In fact, more than 95% of all diabetic patients belong to type 2 diabetes.

In particular, diabetes is urgently needed because it causes macrovascular complications such as myocardial infarction, angina pectoris or stroke (stroke).

The present invention provides a health food composition with excellent efficacy in lowering blood sugar in order to improve the social problems as described above, insulin-dependent type 2 diabetes as well as insulin-dependent type 1 diabetes, which develops from obesity, stress, and dietary errors. The purpose is to provide a health food that is effective in the treatment and prevention of type diabetes.

In order to achieve the above object, the present invention is 5-15% by weight of mulberry leaf extract (solid content of 20% or more), 5-15% by weight of persimmon leaf extract (solid content of 20% or more), 0.5-5 weight % Red ginseng extract (solid content of 60% or more), 10-20% by weight of thorny oak extract (solid content 20% or more), 6-12% by weight pine needle extract (solid content 15% or more), 4-7% by weight The chicory dietary fiber, 0.1 to 1% by weight of vitamin C, 0.1 to 1% by weight of vitamin E, 0.1 to 2% by weight terpene and 25 to 70% by weight of purified water.

Here, the mulberry leaf extract, persimmon leaf extract and thorny opi extract are obtained through hot water extraction, the red ginseng extract and pine needle extract is preferably obtained by alcohol (alcohol) extraction.

On the other hand, when explaining the action on the raw material composition is as follows.

First, mulberry leaves contain a large amount of GABA (γ-butyric acid) components, which are not found in other plantings to inhibit the process of changing glucose after eating a role to lower blood sugar levels.

In addition, red ginseng is composed only of a substance which is very beneficial to humans in various aspects, and is known to be particularly associated with diabetes. Among the components in the red ginseng, a component called "routine" increases the glucose concentration in the blood after eating (that is, when the concentration in the blood vessel is high and the concentration outside the blood vessel is low). It plays a role. In other words, the high concentration of glucose (Glucose) is pushed to the cells outside the blood vessels, and then to convert the glucose into glycogen form.

Prickly Ogai is an Ogai plant in Siberia and the Korean Peninsula. Unlike ordinary Ogapi, Prickly Pear has downward thorns and contains a glycoside called Acantoside. Play a role.

In addition, pine needles contain a variety of ingredients, among which polyphenols and terpenes, which contain various aromatic substances that clean peripheral hair and clear the head. The components of these pine needles prevent diabetic blood circulation of the limbs and the symptoms causing sensory paralysis and rotting symptoms when wounded.

Chicory dietary fiber is a water-soluble fiber that acts as an energy source other than glucose in the human body. As a result, diabetics can become healthier by increasing dietary fiber, which is one of the ingredients doctors highly recommend.

Vitamin C has the effect of lowering blood sugar levels, and acts to create and maintain various substances that support the organisms (cells). In addition, vitamin C provides antioxidant activity (anti-aging), enhances the ability of white blood cells to ensure optimal immune defense, lowers cholesterol levels and detoxifies the liver (chitochrome) to synthesize nitrosamines (carcinogens). By preventing the production of cancer, cerebral hemorrhage and heart disease can reduce the risk of features.

Vitamin E is a natural antioxidant (Anti-Aging) that facilitates platelet function, protects cell membranes, and facilitates blood circulation in peripheral blood vessels. Vitamin E also acts on the cardiovascular system to prevent cell membrane damage in the arterial vessel walls, to prevent cell damage from ischemia, to control endocrine function, to prevent infertility, to promote placental function, to increase sperm count. In addition, it protects cell membranes and protects skeletal muscle from damage, which is very effective for muscle pain, and it is also effective for cancer prevention (especially breast and lung cancer).

Terpene has various functions such as antibacterial and antifungal performance, promoting metabolism, enhancing immune function, improving blood circulation, stabilizing autonomic nervous system, improving physiological function, lowering blood sugar, controlling blood pressure, anticancer, capillary expansion and foreign body decomposition, and maintaining body equilibrium function. Efficacy, and when the function is reduced due to the virus infection of the pancreas acts to normalize the pancreas function by antibacterial action, and also serves to mix the various components well to help the human absorption.

Hereinafter, the efficacy of the present invention will be described in detail with reference to the following table and drawings.

Experimental Example

1. Selection of experimental animals and experimental methods

end. Laboratory animals

120 animals of S.D rat (Sprague-Dawley) (hereinafter referred to as "experimental rat") (weight 200 g ± 10 g) were purchased from a laboratory animal supplier (Biogenomeics).

I. Selection of hyperglycemia-inducing animals

1,2160 mg of streptozotocin was dissolved in 32 ml of 0.01 M citric acid buffer (pH = 4.0), injected into the abdominal cavity at 0.2 ml per rat (number of experimental rats). Blood glucose was measured using a blood glucose meter (Medisense Precision QID USA), and then a rat with high blood sugar level was selected and used as an experimental animal.

All. Experiment Animal Treatment Arrangement and Experiment Method

Rats selected as experimental rats were placed in treatment groups of 20 water, including 3 ml / 1 day / water, 2.5 ml / 1 day / water, 2.0 ml / 1, including the control group which is not fed the present invention (hereinafter referred to as "control"). A total of four treatment groups (hereinafter referred to as "3ml treatment", "2.5ml treatment", "2.0ml treatment"), and the like, and the present invention was orally administered daily using Sonde (Sonde) ).

The experiment was conducted for a total of four weeks, but the administration of the present invention was performed only for three weeks, and not for the remaining one week.

On the other hand, blood glucose was measured by ocular blood collection five times a week apart from blood glucose measurement before the start of the experiment.

2. Blood glucose measurement result

In the parking lot 0, the control group showed the highest level of 434.90 ml / dL, which was significantly higher than the treatment group (p <0.001). In addition, all treatments were lower than control, 3mL treatment was 333.20ml / dL, 2.0ml treatment was 293.70ml / dL, and 2.5ml treatment was the lowest (263.90ml / dL) (p <0.001). .

In addition, the control group was significantly higher than the control group at the level of 434.40 ml / dL (p <0.001), and the 3 ml treatment group was 204.90 ml / dL, and the 2.5 ml treatment group was 149.90 ml / dL and 2.0 ml. The treatment was found to be 212.70 ml / dL (p <0.001).

In the case of parking 2, the control group showed the highest level of 241.10 ml / dL, which was significantly higher than the treatment group (p <0.001), and the 3 ml treatment group was 100.80 ml / dL and 2.5 ml treatment group, 94.80 ml / dL and 2.0 ml, respectively. Treatments were found to be 132.80 ml / dL (p <0.001).

In the case of parking lot 3, the control group showed the highest level of 347.89 ml / dL, which was significantly higher than the treatment group (p <0.001), and the 3 ml treatment group was 152.60 ml / dL, and 2.5 ml treatment group was 101.78 ml / dL and 2.0 ml. The treatment was found to be 112.70 ml / dL (p <0.001).

Finally, the control group was significantly higher than the control group at the level of 396.44 ㎖ / dL (p <0.001), and the control group was 98.43 ㎖ / dL, 2.5ml and 106.00 ㎖ / dL and 2.0ml, respectively. Was 189.00 mL / dL (p <0.001).

As a result, the treatment group including the experimental rat to which the present invention was administered showed a significant difference compared to the control group, but no significant difference was found between the treatment groups (p> 0.01).

 0 (Weeks)  One  2  3  4  Control  434.90  340.40  241.10  347.89  396.44  2.0ml treatment slot  293.70  212.70  132.80  112.70  189.00  2.5ml treatment slot  263.90  149.90  94.80  101.78  106.00  3.0ml treatment slot  333.20  204.90  100.80  152.60  98.43

(Unit ml / dL)

On the other hand, the health food with hypoglycemic efficacy according to the present invention was tested in the culture of beta cells (beta cells) of the pancreatic cells extracted from the actual human cells.

As a result, when the health food composition having a hypoglycemic effect according to the present invention can be confirmed that the number of beta cells increased by about 2.5 times.

The present invention not only shows that insulin-dependent type 2 diabetes as well as insulin-dependent type 1 diabetes, which develop from obesity, stress, and dietary error, are excellent therapeutic effects, and are steadily long-term. By solving the conventional technical problem to be taken is to be an invention that can produce a remarkable effect, such as to have a body immunity by temporary administration.

In addition, the present invention promotes insulin secretion, promotes insulin secretion, and lowers blood cholesterol by the control effect of high and low blood pressure, prevents cerebrovascular disorders, and inhibits platelet aggregation by promoting blood circulation. Efficacy and increase blood flow, relieve numbness of hands and feet, very effective in the recovery of fatigue due to exercise load, improve sexual dysfunction, diabetic complications, etc. has various effects.

In the above, the present invention has been illustrated and described with respect to certain preferred embodiments. However, the present invention is not limited only to the above-described embodiments, and those skilled in the art may vary without departing from the spirit of the technical idea of the present invention described in the claims below. It may be changed.

Claims (1)

5-15 wt% mulberry leaf extract (more than 20% solids), 5-15 wt% persimmon leaf extract (more than 20% solids), 0.5-5 wt% red ginseng extract (more than 60% solids) , 10-20% by weight of Prickly Pear Extract (more than 20% solids), 6-12% by weight pine needle extract (more than 15% solids), 4-7% by weight of chicory dietary fiber, 0.1-1% by weight vitamin C and 0.1-1% by weight of vitamin E, 0.1-2% by weight terpene and 25-70% by weight of purified water comprising a hypoglycemic effect health food composition.

Images