KR20060033247A - Composition for preventing and eliminating hangover, including magnesium compound and / or magnesium salt and salviae, and functional liquor - Google Patents

Abstract

The present invention relates to a composition for preventing and eliminating hangovers, and functional liquor comprising one or more components selected from the group consisting of magnesium compounds and magnesium salts and salvia extract.

The composition for preventing and eliminating hangover promotes alcohol and acetaldehyde metabolism and protects hepatocytes and gastric parietal cells, thereby minimizing side effects of alcohol, and the functional alcoholic beverage provides an excellent effect of minimizing hangover when drinking alcoholic beverages. do.

Magnesium, Salvia, Hangover, Alcohol, Acetaldehyde

Description

Composition for prevention and relief of alcoholic hangover, and alcoholic liquors containing magnesium compound and / or magnesium salt and Salvia miltorrhiza Bunge}             

Figure 1 shows the effect on the blood alcohol concentration when compared to the other administration group when the composition containing magnesium oxide and dansam mixed with alcohol orally administered to the rat.

Figure 2 shows a change in blood alcohol concentration over time when orally administered to mice mixed with a composition comprising magnesium oxide and dansam (M1: magnesium oxide 2 mg / kg + 2 mg / kg salvia extract; M2 : Magnesium oxide 10 mg / kg + salvia extract 2 mg / kg).

Figure 3 shows the change in acetaldehyde concentration of blood with time when orally administered to mice mixed with a composition containing magnesium oxide and salvia (M1: magnesium oxide 2 mg / kg + salvia extract 2 mg / kg M2: magnesium oxide 10 mg / kg + salvia extract 2 mg / kg).

Figure 4 shows a change in the blood alcohol concentration with time when orally administered to mice mixed with a composition containing magnesium gluconate and salvia (M: magnesium gluconate 10 mg / kg + 2 mg / salvia extract kg).

The present invention relates to a composition for preventing and eliminating hangovers, and functional liquor comprising one or more components selected from the group consisting of magnesium compounds and magnesium salts and salvia extract.

Alcohol has been used for a long time by humans, and it is effective in promoting relationships, relieving stress, promoting sleep, and promoting metabolism, but if excessive drinking continues, it causes fatal diseases in the liver, and excessive alcohol is easily absorbed and broken down by the body. It doesn't work, leading to headaches and heartburn.

The main component of alcohol is ethanol. When ingested, it is mainly metabolized by alcohol dehydrogenase in the liver and converted to acetaldehyde.As further metabolism progresses, acetaldehyde dehydrogenase causes Decomposes into water. Usually, when the appropriate amount of drinking these enzymes work smoothly and side effects do not appear very much, but when excessive drinking, acetaldehyde accumulates, causing side effects such as vomiting and headache.                         

Lovers take various drinks and medicines to avoid and worry about the aftereffects of drinking, but they do not have enough to relieve the hangover.

Many of the hangovers developed in the past have been aimed at reducing blood alcohol levels only. Therefore, the development of drugs that can effectively alleviate and resolve hangovers caused by acetaldehyde, a major substance causing excessive side effects, has yet to be developed. to be. Accordingly, the present inventors have completed the present invention by confirming that the composition including magnesium compound and / or magnesium salt and salvia extract reduces blood acetaldehyde and alcohol concentration simultaneously, as well as hepatocellular and gastric parietal cell protection.

The present invention promotes alcohol and acetaldehyde metabolism and protects hepatocytes and gastric parietal cells, thereby providing a composition for the prevention and resolution of hangover that can minimize the side effects of alcohol and a functional liquor having an excellent effect of minimizing hangover when taken. For the purpose of

The present invention relates to a composition for preventing and eliminating hangovers, and functional liquor comprising one or more components selected from the group consisting of magnesium compounds and magnesium salts and salvia extract.                     

The composition for preventing and eliminating hangover of the present invention, and the functional liquor may further include one or more components selected from the group consisting of vitamin B1, methionine, L-alanine, and hawthorn fruit extract.

Representative examples of the composition for preventing and eliminating hangovers of the present invention, and magnesium compounds used in the functional liquor include magnesium oxide, magnesium hydroxide, and the like; Representative examples of magnesium salts include magnesium chloride, magnesium sulfate, magnesium citrate, magnesium lactate, magnesium stearate, magnesium gluconate and the like. In particular, magnesium oxide, magnesium gluconate, and the like exhibit more favorable effects.

In the present invention, the composition for preventing and eliminating hangover is a concept including a pharmaceutical formulation, food, beverage, food additives and the like for such use.

The composition for preventing and eliminating hangover of the present invention can be administered 1-3 times a day, 1-2400 mg / 1 times based on the magnesium compound and / or magnesium salt contained in the composition in terms of magnesium content Preferably, 10-1000 mg / 1.

The composition for preventing and eliminating hangover of the present invention may include 0.01-95% by weight of one or more components selected from the group consisting of magnesium compounds and magnesium salts and 0.001-80% by weight of salvia extract have.

In addition , if the vitamin B1, methionine, L-alanine, and the barberry fruit extract further comprises one or more components selected from the group may be included in 0.001-80% by weight.

Excessive alcohol consumption not only causes gastrointestinal disorders (Mach, T. Protective effect of alkalies on ethyl alcohol-damaged gastric mucosa.Folia Med. Cracov. 30 (3-4): 93-101,1989) Cardiovascular disease by promoting the excretion of magnesium, reducing the concentration of magnesium in the blood (Chakraborti et al. Protective role of magnesium in cardiova scula diseases: a review.Mol Cell Biochem. Sep; 238 (1-2): 163-79, 2002) (Vamvakas et al. Acohl abuse: potential role in electrolyte disturbances and kidney diseases.Clin Nephrol. Apr: 49 (4) 205-13, 1998) and nervous system diseases (Thomson. Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome.Alcohol Alchol. 2000).

The present inventors, by ingesting an appropriate amount of one or more components selected from the group consisting of magnesium compounds and magnesium salts before and after ingestion of alcohol, may induce enzyme activities such as alcohol dehydrogenase and acetaldehyde dehydrogenase, which are involved in alcohol metabolism in vivo. (Thomasson et al. Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism.Behavioral Genetics. 23 (2): 131-136, 1993) and supplement the loss of blood magnesium by alcohol, which is effective in preventing and eliminating hangovers. Was found.

Furthermore, by ingesting at least one ingredient selected from the group consisting of magnesium compounds and magnesium salts before and after the alcohol intake and the salvia extract, the synergy of these ingredients prevents the better hangover than when magnesium alone is ingested. And it was confirmed through experiments that the effect of resolving.

Salviae used in the present invention ( Salviae miltiorrhizae Bunge) is the root of the perennial herb, the taste is bitter, known as a non-toxic medicine with a slightly cold nature, the components of the dansam is tanshionine (tanshionine), millionone ( miltionone), salvianolic acid, etc., and pharmacological actions include cerebral ischemic action, antihypertensive action, cisplatin-induced acute renal impairment, hepatic fibrosis inhibitory action, and allergy suppression effect by IgE. , Cancer cell proliferation inhibitory effect has been reported.

In addition to the present invention, methionine can be added to the active adenosylmethionine (adenosylmethionine) in the body by introducing a methyl group to the choline (methyl) to synthesize the choline (choline) component of lecithin Help to give As a result, methionine has a liver protective effect of inhibiting fatty liver. In addition, L-alanine promotes the regeneration of NAD and activates alcohol dehydrogenase, thereby increasing the decomposition of alcohol. The barn tree is also known as earth tree, sesame tree or barberry. The use of the barn tree in the treatment of addiction by drinking too much alcohol is introduced in old medical books such as Seonghyebang and Jinnam Herb. It has been reported that the bark tree has an excellent alcohol degrading effect, and when administered to rats, alcohol concentration is reduced by 50% or more after 4 hours, and has a liver protection effect.

In the compositions for the prevention and resolution of hangovers of the present invention, pharmaceutical preparations for this use can be formulated in a variety of forms when they include pharmaceutically acceptable carriers, excipients and / or additives. That is, the composition according to the present invention can be formulated in the form of parenteral formulations such as oral formulations, injections, transdermal administrations, etc., such as conventional tablets, capsules, solutions, powders.

In the composition for preventing and eliminating hangover of the present invention, the food composition for this use can be applied to various foods. For example, drinks, tea, soups, health supplements and the like.

In addition, the composition for preventing and eliminating hangover of the present invention can also be used in the form of food additives for this purpose. For example, the composition of the present invention may be prepared in an additive form and added to various foods.

In the present invention, the functional liquor composition, which is another use, includes 0.01-100 g / L in terms of magnesium content of one or more components selected from the group consisting of magnesium compounds and magnesium salts and 0.001-100 g of salvia extract. Can be included with / L. This content can be appropriately adjusted according to the alcohol concentration of the liquor.

In addition , in the case of further comprising at least one component selected from the group consisting of vitamin B1, methionine, L-alanine and hollyhock extract 0.001-100 g / L wt%.

Functional liquor in the above means a liquor with a minimum hangover that occurs after drinking.

Hereinafter, the present invention will be described through Examples and Experimental Examples. However, the content of the present invention is not limited to the following experimental examples.

Example 1 Preparation of Salvia Extract

1 kg 70% ethanol 3L ethanol was extracted for 24 hours at 50 ℃. The extract was filtered, and the residual crude was extracted three times with 3 L of 70% ethanol again, and the extract was mixed. Concentrated under reduced pressure and lyophilized to obtain 216 g of Salvia extract.

Example 2 Preparation of Functional Liquor

60 g of magnesium gluconate and 6 g of salvia extract were dissolved in 1,000 ml of sterilized distilled water, and then mixed with 40% ethanol at a ratio of 1: 1 to prepare 20% (v / v) ethanol.

Experimental Example 1: Effect of Magnesium Compound and / or Magnesium Salt and Salmon Extract on Composition of Blood Alcohol and Acetaldehyde

(1) Experimental method

Six male rats (Sprague-Dawley) weighing 200-250 g were divided into one group and used for the experiment. As the control group, the animal test group was the alcohol-administered group, the alcohol-administered group with magnesium compound and / or magnesium salt, the alcohol-administered group with salviae extract, the alcohol-administered group with mixed magnesium compound and / or magnesium salt and salviae extract and the same use. It consisted of the product (RU-21) administration group on sale.

The alcohol group was orally administered with 40% ethanol at 2 g / kg;

The alcohol-administered group to which the magnesium compound and / or magnesium salt was added may have the following doses (magnesium oxide 2, 5, 10 mg / kg; magnesium gluconate 20 mg / kg; magnesium oxide 10 mg / kg and magnesium gluconate 10 mg / kg each) and orally administered in 40% ethanol, respectively.

In the alcohol-administered group to which salvia extract was added, 2 mg / kg of salvia extract was mixed orally administered with 40% ethanol,

The alcohol-administered group in which the magnesium compound and / or the magnesium salt and the salviae extract were mixed was added to the following doses (magnesium oxide 2 mg / kg + salvia extract 2 mg / kg, magnesium oxide 5 mg / kg + salvia extract 2 mg / kg, Magnesium oxide 10 mg / kg + salvia extract 2 mg / kg) and orally administered in 40% ethanol, respectively, and

The product sold for the same purpose (RU-21) was orally administered with 20 mg / kg mixed in 40% ethanol.

After 2 hours after administration, suffocated with CO ₂ gas, blood was collected to measure blood alcohol and acetaldehyde concentration.

Blood alcohol concentration was measured by gas chromatography, and acetaldehyde was measured by HPLC. Blood acetaldehyde concentration was measured by adding 1 ml of 0.01 M dinitrophenylhydrazine (DNPH) dissolved in 3.6 M HCl to 1 ml of blood, mixing at room temperature for 30 minutes, and then adding 20 ml pentane. Then centrifuged for 20 minutes at 3,500rpm. The pentane layer was washed three times with 10 ml of distilled water, followed by centrifugation and mixed with a small amount of anhydrous sodium sulfate (Na ₂ SO ₄ anhydrous) in the pentane layer, followed by centrifugation to separate the pentane layer and concentrated by an evaporator. 0.5 ml of acetonitrile and distilled water were quantified by HPLC with a solvent mixed 1: 1. HPLC column was used Novapak C18 (Waters Co.), the developing solvent was a mixture of acetonitrile and distilled water in a 1: 1. The retention time of acetaldehyde was 4.95 minutes.

(2) Experiment result

As shown in FIG. 1, blood alcohol concentrations of the magnesium oxide 10 mg / kg + salvia extract 2 mg / kg and the magnesium gluconate 20 mg / kg were most significantly reduced among the experimental groups. Magnesium oxide 10 mg / kg + Salviae extract 2 mg / kg administration group is similar in effect compared to the magnesium gluconate 20 mg administration group, but is much easier to manufacture in total. In addition, in the RU-21 (20 mg / kg) administration group developed as a conventional hangover relievers, there was no significant difference in blood alcohol concentration compared to the control group.

Experimental Example 2: Effect of the composition of magnesium oxide salt and salvia extract on blood alcohol concentration and acetaldehyde concentration

(1) Experimental method

For the control group and the alcohol-administered group to which magnesium oxide salt and salvia extract (magnesium oxide 2 mg / kg + salvia extract 2 mg / kg (M1), magnesium oxide 10 mg / kg + salvia extract 2 mg / kg (M2)) were added. Only the experiment was carried out, and after choking with CO ₂ gas after 1, 2 and 4 hours after administration, respectively, the experiment was performed in the same manner as in Experiment 1 except that the blood alcohol and acetaldehyde concentrations were measured.

(2) Experiment result

As can be seen in Figure 2, in the alcohol-administered group to which magnesium oxide 10 mg / kg + salvia extract 2 mg / kg (M2) was added, the blood alcohol concentration was significantly reduced from 2 hours, magnesium oxide 2 mg / kg + There was no significant difference in the alcohol-administered group with 2 mg / kg (M1) of salvia extract compared to the alcohol-administered group.

In addition, as shown in FIG. 3, in the alcohol-administered group to which magnesium oxide 10 mg / kg + salvia extract 2 mg / kg (M2) was added, blood acetaldehyde concentration was significantly decreased from 1 hour, but magnesium oxide 2 mg There was no significant difference in the alcohol-administered group with / kg + 2 mg / kg (M1) of salvia extract compared to the alcohol-administered group.

Experimental Example 3. Effect of the composition of magnesium gluconate and salvia extract on blood alcohol concentration

(1) Experimental method

Only the control group and the alcohol-administered group to which 10 mg / kg magnesium gluconate + 2 mg / kg (M) of salvia extract were added to the test group were suffocated with CO ₂ gas after 1, 2 and 4 hours, respectively. Blood was collected and tested in the same manner as in Experiment 1 except that blood alcohol and acetaldehyde concentrations were measured.

(2) Experiment result

As can be seen in Figure 4, in the alcohol administration group to which magnesium magnesium gluconate 10 mg / kg + 2 mg / kg (M) was added to the alcohol concentration of blood significantly decreased from 1 hour.

The present invention promotes alcohol and acetaldehyde metabolism and protects hepatocytes and gastric parietal cells, thereby providing a composition for preventing and eliminating hangovers that can minimize side effects of alcohol and a functional liquor having an excellent effect of minimizing hangovers when taken. do.

Claims (12)

Magnesium compound and magnesium salt composition for the prevention and resolution of hangover comprising one or more components selected from the group consisting of salviaeul extract. According to claim 1, Vitamin B1, methionine, L-alanine, and the composition of the hangover fruit further comprises at least one component selected from the group consisting of a hangover fruit. The method of claim 1, wherein the administration of 1-2400 mg / 1 times, usually 1-3 times a day, based on the magnesium content of one or more components selected from the group consisting of magnesium compounds and magnesium salts A composition for preventing and eliminating hangovers, characterized by the above. The hangover according to claim 1, comprising at least 0.01-95% by weight of at least one component selected from the group consisting of magnesium compounds and magnesium salts in terms of magnesium content, and 0.001-80% by weight of Salvia extract. Composition for the prevention and remedy. According to claim 2, Vitamin B1, methionine, L-alanine and the composition of the hangberry fruit extract for preventing and eliminating hangover, characterized in that it comprises 0.001-80% by weight of one or more components. The magnesium compound is selected from magnesium oxide and magnesium hydroxide, and the magnesium salt is selected from the group consisting of magnesium chloride, magnesium sulfate, magnesium citrate, magnesium lactate, magnesium stearate and magnesium gluconate. Composition for preventing and eliminating hangovers. The method for preventing and alleviating hangovers according to claim 1, which is prepared in the form of a pharmaceutical preparation, food, beverage or food additive. Functional liquor comprising one or more components selected from the group consisting of magnesium compounds and magnesium salts and salvia extract. The functional liquor according to claim 8, further comprising at least one component selected from the group consisting of vitamin B1, methionine, L-alanine and hollyhock extract. The method according to claim 8, wherein the magnesium compound and one or more components selected from the group consisting of magnesium salts in terms of magnesium content containing 0.01-100 mg / L and containing the salviae extract in 0.001-100g / L weight% Functional liquor characterized by. 10. The functional liquor according to claim 9, which comprises at least 0.001-100 g / L wt% of at least one component selected from the group consisting of vitamin B1, methionine, L-alanine and hollyhock extract. The magnesium compound is selected from magnesium oxide and magnesium hydroxide, and the magnesium salt is selected from the group consisting of magnesium chloride, magnesium sulfate, magnesium citrate, magnesium lactate, magnesium stearate and magnesium gluconate. Composition for the prevention and treatment of gastric ulcers.

Images