KR0162281B1 - Cosmetic composition containing taurine and aminopropane sulfonic acid or salts thereof - Google Patents
Cosmetic composition containing taurine and aminopropane sulfonic acid or salts thereof Download PDFInfo
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- KR0162281B1 KR0162281B1 KR1019950037610A KR19950037610A KR0162281B1 KR 0162281 B1 KR0162281 B1 KR 0162281B1 KR 1019950037610 A KR1019950037610 A KR 1019950037610A KR 19950037610 A KR19950037610 A KR 19950037610A KR 0162281 B1 KR0162281 B1 KR 0162281B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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Abstract
본 발명은 피부자극 없이 효과적으로 피부 탄력의 회복 및 피부 주름의 형성을 방지할 수 있는 화장료 조성물을 제공하는 것을 목적으로 하며, 본 발명에 따른 화장료 조성물은 타우린과, 하기 일반식의 구조를 갖는 아미노프로판 설폰산 또는 그의 염과의 배합물을 함유함을 특징으로 한다.An object of the present invention is to provide a cosmetic composition capable of effectively restoring skin elasticity and preventing the formation of skin wrinkles without skin irritation, the cosmetic composition according to the present invention is taurine, amino propane having a structure of the following general formula In combination with sulfonic acids or salts thereof.
Description
[발명의 명칭][Name of invention]
타우린 및 아미노프로판 설폰산 또는 그의 염을 함유하는 화장료 조성물Cosmetic composition containing taurine and aminopropane sulfonic acid or salts thereof
[발명의 상세한 설명]Detailed description of the invention
본 발명은 타우린 및 아미노프로판 설폰산(Amino Propane Sulfonic acid; 이하 APS산이라 한다) 또는 그의 염을 함유하는 화장료 조성물에 관한 것으로, 더욱 상세하게는 타우린과 APS산 또는 그의 염을 동시에 함유함으로써, 이들의 복합작용으로 피부에서 세포의 산소소비를 촉진시켜 피부 호흡을 도우며, 피부 혈액을 촉진시키고, 또 피부에서의 주름의 생성을 효과적으로 감소시켜주어 피부의 노화를 지연시킬 수 있는 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition containing taurine and amino propane sulfonic acid (hereinafter referred to as APS acid) or salts thereof, and more particularly, by simultaneously containing taurine and APS acid or salts thereof, It relates to a cosmetic composition that can delay the aging of the skin by promoting the oxygen consumption of the cells in the complex action of the skin to help skin respiration, promote skin blood, and effectively reduce the production of wrinkles in the skin.
타우린은 포유동물에 있어서, 해독작용(detoxyfying action), 신경조절작용(neuromodulating role), 레타나(retina)의 구조유지 등의 중요한 역할을 수행하는 매우 유용한 물질이다. 또한, 안정성 시험에서, 쥐에 대한 실험결과로서 TDL0값이 87mg/kg으로 매우 안정한 물질로 보고된 바 있으며, 또한 약용제로서 피로회복, 자양강장 효과 등의 약효가 입증되어 있는 드링크제로 음용되고 있을 정도로 인체 안정성이 매우 높은 물질이다.Taurine is a very useful substance that plays an important role in mammals such as detoxyfying action, neuromodulating role, and retina structure maintenance. In addition, in the stability test, as a test result for rats, the TDL 0 value was reported as a very stable substance (87 mg / kg), and it is also drinking as a drinking agent that has been proved as a medicinal agent such as fatigue recovery and nourishing tonic effect. It is a substance with very high human stability.
이러한 유효한 약효를 갖고 있는 타우린을 화장료로 사용하는 경우, 피부 혈행 촉진작용으로 피부 보호 효과를 기대할 수 있으나, 충분한 효과를 얻기 위해서는 화장료 중량에 대해 1중량% 이상의 양으로 사용하여야 한다. 그러나, 이런 경우 피부 자극을 유발하는 문제가 있다.When taurine having such an effective effect is used as a cosmetic, it can be expected to protect the skin by promoting blood circulation, but in order to obtain a sufficient effect, it should be used in an amount of 1% by weight or more based on the weight of the cosmetic. However, in this case, there is a problem of causing skin irritation.
이에, 본 발명자는 상기한 유효한 약효를 갖는 타우린을 화장료로서 효과적으로 작용할 수 있는 방법을 모색하던 중, 본 출원인의 1995년 2월 17일자 특허출원 제1995-3013호에 개시된 아미노프로판 설폰산(APS산)을 타우린과 베합하여 사용하는 경우, 타우린의 사용량을 감소시킬 수 있고, 따라서 피부자극을 저하시킬 수 있음을 발견하고 본 발명을 완성하기에 이르렀다.Accordingly, the inventors of the present invention, while searching for a method of effectively acting as a cosmetic to the taurine having the above-mentioned effective efficacy, the amino propane sulfonic acid (APS acid) disclosed in the patent application No. 1995-3013 dated February 17, 1995 of the applicant When used in conjunction with taurine, the present inventors have found that the amount of taurine used can be reduced, and thus can reduce skin irritation.
따라서, 본 발명의 목적은 피부자극 없이 효과적으로 피부 탄력의 회복 및 피부 주름의 형성을 방지할 수 있는 화장료 조성물을 제공하는 것이다.Accordingly, an object of the present invention is to provide a cosmetic composition that can effectively prevent the recovery of skin elasticity and the formation of skin wrinkles without skin irritation.
본 발명은 상기한 목적을 달성하기 위하여, 타우린과, 하기 일반식의 구조를 갖는 아미노프로판 설폰산 또는 그의 염을 동시에 함유량을 특징으로 하는 화장료 조성물을 제공한다.In order to achieve the above object, the present invention provides a cosmetic composition characterized by simultaneously containing taurine and aminopropane sulfonic acid having a structure of the following general formula or a salt thereof.
본 발명의 다른 목적 및 적용은 하기 발명의 상세한 설명으로부터 당업자에게 명백하게 드러날 것이다.Other objects and applications of the present invention will become apparent to those skilled in the art from the following detailed description.
이하, 본 발명을 보다 상세하게 설명한다.Hereinafter, the present invention will be described in more detail.
본 발명에 따른 화장료 조성물에 사용되는 타우린(Tanurine ; 아미노메탄 설폰산)은, 피부의 혈류량을 증가시켜 주며, 피부세포를 활성화시켜 세포 재생을 효과적으로 촉진하는 기능을 제공한다. 즉, 피부 주름의 예방 및 개선을 목적으로 사용될 수 있다.Taurine (Tanurine; aminomethane sulfonic acid) used in the cosmetic composition according to the present invention increases the blood flow of the skin and provides a function of effectively promoting cell regeneration by activating skin cells. That is, it can be used for the purpose of preventing and improving skin wrinkles.
본 발명에 따른 화장료 조성물에서는 타우린을, 타우린과 유사한 구조를 갖는 APS산과 혼용하며, 따라서 타우린을 단독으로 사용하는 종래의 화장료와 비교하여, 동일한 효과를 목적으로 그 사용량을 감소시킬 수 있으며, 피부 자극을 현저히 감소시킬 수 있다. 또한, 피부세포 활성화 및 피부노화 방지 효과에 있어서도 APS산과 혼용함으로써 상승된 효과를 얻얼 수 있다.In the cosmetic composition according to the present invention, taurine is mixed with APS acid having a structure similar to taurine, and thus, compared with conventional cosmetics using taurine alone, the amount of its use can be reduced for the same effect, and skin irritation Can be significantly reduced. In addition, in the skin cell activation and skin aging prevention effects, an increased effect can be obtained by mixing with APS acid.
본 발명에 따르면, 타우린은 화장료 조성물에 0.01~0.5중량%의 양으로 함유된다. 후술하는 실험예를 통해 입증되는 바와 같이, 타우린의 함량이 0.5중량%를 초과하는 경우에는 APS산의 함량에 관계없이 피부자극이 나타나며, 따라서 0.5중량% 이하로 사용하는 것이 바람직하다.According to the invention, taurine is contained in the cosmetic composition in an amount of 0.01 to 0.5% by weight. As demonstrated by the experimental example described below, when the content of taurine exceeds 0.5% by weight, irritation of the skin appears regardless of the content of APS acid, and therefore, it is preferable to use it at 0.5% by weight or less.
본 발명에 따르면, 타우린은 그 사용의 용이성을 위하여 약 10%의 용액으로 만들어 화장료 조성물에 사용하며, 이때 그 기제로는 정제수 65%, 글리세린 10%, 글리세릴 폴미레타크릴레이트 15% 를 사용하여 전체 100이 되도록 한다.According to the present invention, taurine is used in the cosmetic composition by making a solution of about 10% for ease of use, wherein the base is purified water 65%, glycerin 10%, glyceryl polymy acrylate 15% To 100 total.
또한, 본 발명에서, 타우린을 함유하는 화장료 조성물에 있어서 피부자극을 감소시키고, 상승된 피부노화 방지효과를 제공할 목적으로 사용하는 APS산은 아미노프로판올의 설폰산반응에 의해 얻어지며, 구조는 타우린의 구조 NH2-CH2-CH2-SO3H와 메우 유사하다. 또한, APS산은 JP 3-63211A, JP 2-62810A, JP 1-22810A, JPU 62-19511A, JP 61-207312A, JP 60-199810A, JP 58-26726A 등에 피부의 노화를 억제하고 미백기능이 있는 것으로 기재된 γ-아미노부티르산(GABA)의 구조 NH2-CH2-CH2-CH2-COOH와도 유사한 구조를 갖는다.In addition, in the present invention, in the cosmetic composition containing taurine, APS acid used for the purpose of reducing skin irritation and providing an enhanced anti-aging effect is obtained by sulfonic acid reaction of aminopropanol, and the structure of taurine The structure is very similar to NH 2 -CH 2 -CH 2 -SO 3 H. In addition, APS acid inhibits skin aging and whitening function in JP 3-63211A, JP 2-62810A, JP 1-22810A, JPU 62-19511A, JP 61-207312A, JP 60-199810A, and JP 58-26726A. The structure of γ-aminobutyric acid (GABA) described has a structure similar to NH 2 -CH 2 -CH 2 -CH 2 -COOH.
본 발명자의 연구에 따르면, APS산은 피부에서의 노화 억제작용, 변형에 대한 회복력 및 피부 강도의 증가작용에 있어서, 타우린이나 GABA와 비교하여 우수한 효능을 나타낼 뿐만 아니라, 피부 안정성에서도 우수하며, 나아가 일반적인 화장료 조성물에서 요구되는 피부의 보습 및 유연효과 역시 우수한 것으로 확인되었다.According to the research of the present inventors, APS acid not only shows excellent efficacy in comparison with taurine or GABA, but also in skin stability, and in general, in aging inhibitory effect on skin, recovery ability against deformation and increase in skin strength. The moisturizing and softening effect of the skin required in the cosmetic composition was also confirmed to be excellent.
본 발명에 따르면, APS산 또는 그의 염은 통상의 화장료 조성물에 0.01~1.0중량%, 바람직하게는 0.01~0.5중량%의 양으로 함유된다. 후술하는 실험예를 통해 입증되는 바와 같이, APS산의 함량이 증가함에 따라 피부자극이 나타나며, 따라서 1.0중량% 이하로 사용하는 것이 바람직하며, 더욱 바람직하게는 0.5중량% 이하의 양으로 사용하는 것이 바람직하다.According to the present invention, APS acid or a salt thereof is contained in a conventional cosmetic composition in an amount of 0.01 to 1.0% by weight, preferably 0.01 to 0.5% by weight. As demonstrated through the experimental example described below, the skin irritation appears as the content of APS acid increases, so it is preferable to use it in an amount of 1.0% by weight or less, and more preferably in an amount of 0.5% by weight or less. desirable.
본 발명에 따른 APS산의 염으로는 화장품 제제학적으로 허용되는 것이면 제한없이 있어할 수 있지만, 일반적으로 나트륨, 칼륨 등의 알칼리 금속염류, 칼슘, 마그네슘 등의 알칼리토금속염류, 리신, 아르기닌, 히스티딘 등의 염기성 아미노산에 의한 염류, 트리에탄올아민 등의 아민 또는 암모니아에 의한 염류, 폴리쿼터늄 -4,-6,-7,-10,-11,-16 등의 양이온성 폴리머에 의한 염류, 및 라우릴디메틸렌암모니아클로라이드, 스테아릴메틸벤질암모니움클로라이드, 비헤닐트리메틸암모니아클로라이드 등의 양이온성 계면활성제에 의한 염류를 예시할 수 있다.The salt of the APS acid according to the present invention may be any cosmetically acceptable salt, but alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, lysine, arginine, histidine and the like. Salts with basic amino acids, salts with amines such as triethanolamine or ammonia, salts with cationic polymers such as polyquaternium-4, -6, -7, -10, -11, -16, and lauryl Salts by cationic surfactants, such as dimethylene ammonia chloride, stearylmethylbenzyl ammonium chloride, and bihenyl trimethyl ammonia chloride, can be illustrated.
본 발명에 따르면, APS산이나 그의 염은 그 사용의 용이성을 위하여 약 10%의 용액으로 만들어 화장료 조성물에 사용하며, 이때 그 기제서는 정제수 65%, 글리세린 10%, 글리세릴 폴리메타크릴레이트 15% 를 사용하여 전체 100이 되도록 한다.According to the present invention, APS acid or a salt thereof is made into a solution of about 10% for ease of use and used in the cosmetic composition, where the base is purified water 65%, glycerin 10%, glyceryl polymethacrylate 15% Use to make a total of 100.
이하에 각종 예를 들어 본 발명을 보다 상세하게 설명하지만, 본 발명이 이들 예에만 한정되는 것은 아니다.Although various examples are given to the following and this invention is demonstrated in detail, this invention is not limited only to these examples.
[처방예 1~6 및 비교처방예 1~9 : 크림류][Prescription Examples 1-6 and Comparative Prescription Examples 1-9: Cream]
수상 성분과 유상 성분을 각각 가열 용해한 후 혼합하여 교반후 실온으로 냉각하여 크림 제품을 제조하였다.The aqueous phase and oil phase components were each dissolved by heating, mixed, stirred and cooled to room temperature to prepare a cream product.
[처방예 7~12 및 비교처방예 10~18 : 영양화장수류][Prescription Examples 7-12 and Comparative Prescription Examples 10-18: Nutritious Cosmetics]
정세수에 카르복시메틸셀룰로스나트륨을 가열 용해후 실온으로 냉각한 다음 나머지 수용성 성분을 첨가하고, 에탄올 파트를 가하여 혼합함으로써 영양화장수를 제조하였다.After dissolving sodium carboxymethyl cellulose in the cleansing water and cooling it to room temperature, the remaining water-soluble component was added, and ethanol parts were added and mixed to prepare nutrient cosmetic water.
[실시예]EXAMPLE
상기 각 처방예 및 비교처방예의 제품 각각의 피부안정성 실험 및 피부의 노화와 관련된 피부의 보습효과(Hydration), 유연도(Extensibility), 변형예 대한 회복력(Tonicity), 피부의 강도(Firmness) 등을 측정하여 사용전과 사용후, 그리고 APS산과 타우린 각각을 단독 사용하였을 때와 혼용하였을 때를 비교하였다.Skin stability test and skin hydration effect (Extensibility), tonicity for modification, skin strength (Firmness), etc. of each product of each prescription and comparative prescription examples Measurements were made before and after use, and when APS acid and taurine were used alone or in combination.
[실시예 1]Example 1
[피부안전성][Skin Safety]
피부의 안전성을 측정하기 위해서는 통상의 패취테스트를 실시하였으며, 25~40세의 여성 10명의 양쪽 하박 안쪽에 상기한 처방예 1~6, 비교처방예 1~9의 첩포를 부착한 후, 24시간이 지난 후에 첩포를 떼어내고, 떼어낸지 30분이 지난 후에 다음과 같은 판정에 따라 피부자극이 정도를 점수화하고, 10개의 점수의 평균을 표3에 나타내었다.In order to measure the safety of the skin, a normal patch test was conducted, and the patch of Formulations 1 to 6 and Comparative Prescriptions 1 to 9 was attached to the inside of both lower chests of 10 women aged 25 to 40, 24 hours. After this time, the patch was removed, and after 30 minutes, the skin irritation was scored according to the following judgment, and the average of the ten scores was shown in Table 3.
[실시예 2]Example 2
[피부 보습효과][Skin moisturizing effect]
보습효과는 Corneometer를 사용하여 처방예 7~12, 비교처방예 10~18의 제품의 도포전과 도포후의 피부 수분을 측정하여 피부 수화의 증감을 확인하였다.The moisturizing effect was measured by using a corneometer to measure skin moisture before and after application of the products of Formulation Examples 7-12 and Comparative Formulation Examples 10-18 to confirm the increase and decrease of skin hydration.
[실시예 3]Example 3
[피부 유연도][Skin smoothness]
본 시험예의 피부의 유연도 및 후술하는 시험예 4과 5에 있어서의 변형에 대한 회복력 및 피부의 강도는 25-40세의 여성 150명에게 10명씩 1조를 이루어 동일 제품을 4주간 사용하게 하고 사용전과 사용 2주후, 사용 4주후, 사용 4주후의 피부상태를 Fermometer를 사용하여 측정하였으며, 이때의 수치는 증감의 백분율로 나타내었고, 그 평균값으로 나타내었다.The softness of the skin of the present test and the recovery of the deformation and the strength of the skin in the test examples 4 and 5 to be described later were made to 150 women of 25 to 40 years old 10 people each to use the same product for 4 weeks Skin conditions before and after 2 weeks, 4 weeks after use, and 4 weeks after use were measured using a Fermometer, and the numerical values were expressed as a percentage of increase and decrease, and the average value.
[실시예 4]Example 4
[변형에 대한 회복력][Resilience to deformation]
[실시예 5]Example 5
[피부의 강도][Strength of skin]
상기 표 3 내지 표 7에 나타낸 결과로부터 알 수 있는 바와 같이, 각각의 시험 결과에 대하여 실험 오차를 인정해야 하지만, 전반적으로 타우린을 단독사용하는 경우에는 만족스러운 효과를 위해서는 1중량% 이상의 양으로 사용하여야 하며, 이 경우에는 표 3에서 보는 바와 같이 피부자극이 심하게 나타난다. 한편, 타우린과 APS산을 동시에 함유함으로써, 피부자극을 현저히 감소시킬 수 있으며, 타우린이나, APS산을 단독으로 사용했을 때와 비교하여, 보습, 유연도, 변형에 대한 회복력 및 피부강도에서 우수한 효과를 얻을 수 있다.As can be seen from the results shown in Tables 3 to 7, the experimental error should be acknowledged for each test result, but when using taurine alone, it is used in an amount of 1% by weight or more for satisfactory effects. In this case, skin irritation is severe as shown in Table 3. On the other hand, by simultaneously containing taurine and APS acid, skin irritation can be significantly reduced, and compared with taurine or APS acid alone, it has excellent effects on moisturizing, softness, recovery against deformation and skin strength. Can be obtained.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019950037610A KR0162281B1 (en) | 1995-10-27 | 1995-10-27 | Cosmetic composition containing taurine and aminopropane sulfonic acid or salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019950037610A KR0162281B1 (en) | 1995-10-27 | 1995-10-27 | Cosmetic composition containing taurine and aminopropane sulfonic acid or salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR970020084A KR970020084A (en) | 1997-05-28 |
| KR0162281B1 true KR0162281B1 (en) | 1998-12-01 |
Family
ID=19431596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950037610A Expired - Fee Related KR0162281B1 (en) | 1995-10-27 | 1995-10-27 | Cosmetic composition containing taurine and aminopropane sulfonic acid or salts thereof |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR0162281B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2920967A1 (en) * | 2007-09-14 | 2009-03-20 | Sederma Soc Par Actions Simpli | USE OF HYDROXYMETHIONINE AS ANTI-AGING AGENT |
| US11992471B2 (en) | 2021-11-29 | 2024-05-28 | Amorepacific Corporation | Reelin/VEGF-C production/activation promoter and skin external composition using the same |
-
1995
- 1995-10-27 KR KR1019950037610A patent/KR0162281B1/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2920967A1 (en) * | 2007-09-14 | 2009-03-20 | Sederma Soc Par Actions Simpli | USE OF HYDROXYMETHIONINE AS ANTI-AGING AGENT |
| WO2009034537A3 (en) * | 2007-09-14 | 2010-02-25 | Sederma | Cosmetic composition comprising hydroxymethionine and 3-aminopropanesulfonic acid |
| US8377663B2 (en) | 2007-09-14 | 2013-02-19 | Sederma, S.A.S. | Cosmetic composition comprising hydroxymethionine and 3-aminopropanesulfonic acid |
| US11992471B2 (en) | 2021-11-29 | 2024-05-28 | Amorepacific Corporation | Reelin/VEGF-C production/activation promoter and skin external composition using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| KR970020084A (en) | 1997-05-28 |
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