JP5288791B2 - 難水溶性物質含有微細化組成物 - Google Patents
難水溶性物質含有微細化組成物 Download PDFInfo
- Publication number
- JP5288791B2 JP5288791B2 JP2007503613A JP2007503613A JP5288791B2 JP 5288791 B2 JP5288791 B2 JP 5288791B2 JP 2007503613 A JP2007503613 A JP 2007503613A JP 2007503613 A JP2007503613 A JP 2007503613A JP 5288791 B2 JP5288791 B2 JP 5288791B2
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- JP
- Japan
- Prior art keywords
- soluble substance
- poorly water
- water
- composition
- melting point
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007503613A JP5288791B2 (ja) | 2005-01-28 | 2006-01-27 | 難水溶性物質含有微細化組成物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005022124 | 2005-01-28 | ||
| JP2005022124 | 2005-01-28 | ||
| JP2007503613A JP5288791B2 (ja) | 2005-01-28 | 2006-01-27 | 難水溶性物質含有微細化組成物 |
| PCT/JP2006/301816 WO2006087919A1 (fr) | 2005-01-28 | 2006-01-27 | Composition finement divisee contenant un substance peu hydrosoluble |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2006087919A1 JPWO2006087919A1 (ja) | 2008-07-03 |
| JP5288791B2 true JP5288791B2 (ja) | 2013-09-11 |
Family
ID=36916329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503613A Active JP5288791B2 (ja) | 2005-01-28 | 2006-01-27 | 難水溶性物質含有微細化組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8623405B2 (fr) |
| EP (1) | EP1849830B1 (fr) |
| JP (1) | JP5288791B2 (fr) |
| WO (1) | WO2006087919A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2611737A1 (fr) * | 2005-06-10 | 2007-06-28 | Combino Pharm, S.L. | Formulations contenant du glimepiride et/ou ses sels |
| TWI405590B (zh) * | 2007-04-06 | 2013-08-21 | Activus Pharma Co Ltd | 微粉碎化有機化合物粒子之製法 |
| JP5298941B2 (ja) * | 2008-02-26 | 2013-09-25 | 大正製薬株式会社 | 飲料 |
| JP5298942B2 (ja) * | 2008-02-26 | 2013-09-25 | 大正製薬株式会社 | 飲料 |
| WO2010032434A1 (fr) * | 2008-09-19 | 2010-03-25 | 株式会社アクティバスファーマ | Poudre composite de composés organiques à usage médical, procédé de production de ladite poudre et utilisation de celle-ci |
| EP2392354A4 (fr) * | 2009-01-30 | 2012-08-08 | Meiji Seika Pharma Co Ltd | Composition pharmaceutique finement pulvérisée |
| EP2525783A1 (fr) * | 2010-01-18 | 2012-11-28 | Cephalon France | Lyophilisats oraux améliorés contenant un copolymère de pvp/va |
| RU2015142279A (ru) * | 2010-03-19 | 2018-12-28 | Бостон Байомедикал, Инк. | Новые соединения и композиции для нацеливания на злокачественные стволовые клетки |
| CN103429224A (zh) * | 2011-03-24 | 2013-12-04 | 大塚制药株式会社 | 用于治疗口腔疾病的包含瑞巴派特的药物组合物 |
| US9180099B2 (en) * | 2011-07-07 | 2015-11-10 | Arqule Inc. | Pyrroloquinolinyl-pyrrolidine-2,5-dione formulations and methods for preparing and using same |
| WO2013072770A2 (fr) | 2011-11-15 | 2013-05-23 | Dr. Reddy's Laboratories Ltd. | Formulations pharmaceutiques comprenant de l'atorvastatine et du glimépiride |
| JP6018845B2 (ja) * | 2012-09-03 | 2016-11-02 | 三生医薬株式会社 | 超微粉末含有カプセル剤の製造方法 |
| CN104644557B (zh) * | 2013-11-22 | 2017-10-31 | 上海宣泰医药科技有限公司 | 卟啉铁固体分散体及其制备方法 |
| EP2913048A1 (fr) * | 2014-02-27 | 2015-09-02 | ratiopharm GmbH | Composition pharmaceutique comprenant de la trametinib |
| CA3091597A1 (fr) * | 2018-02-07 | 2019-08-15 | Smawa Gmbh | Formulations pharmaceutiques, procede de fabrication d'une formulation pharmaceutique et medicament comprenant une telle formulation pharmaceutique |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04295420A (ja) * | 1991-01-25 | 1992-10-20 | Sterling Winthrop Inc | 表面変性薬物微小粒子 |
| US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
| JPH09206000A (ja) * | 1996-02-08 | 1997-08-12 | Asahi Chem Ind Co Ltd | 水分散性組成物 |
| JP2004501183A (ja) * | 2000-06-27 | 2004-01-15 | ヴェクトゥラ リミテッド | 医薬組成物で使用するための粒子の製造法 |
| JP2004099442A (ja) * | 2002-09-04 | 2004-04-02 | Nisshin Pharma Inc | 難溶性薬物含有製剤およびその製造方法 |
| JP2005513037A (ja) * | 2001-11-20 | 2005-05-12 | スミスクライン ビーチャム パブリック リミテッド カンパニー | 5−[4−[2−(n−メチル−n−(2−ピリジル)アミノ)エトキシ]ベンジル]チアゾリジン−2,4−ジオンおよび当該化合物配合の医薬組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1179985A (ja) | 1997-09-01 | 1999-03-23 | Kyorin Pharmaceut Co Ltd | 喘息治療用の粉末吸入剤 |
| GB0008660D0 (en) * | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| DK1920763T3 (da) * | 2000-11-30 | 2014-07-07 | Vectura Ltd | Farrmaceutiske præparater til inhalation |
| JP2004518642A (ja) * | 2000-12-06 | 2004-06-24 | ファルマシア・コーポレーション | ラボラトリースケールの微粉砕化プロセス |
| US20020068641A1 (en) * | 2000-12-06 | 2002-06-06 | Dicicco Thomas | Roller coaster based simulator for amusement and flight training |
| HUP0400683A2 (hu) * | 2000-12-11 | 2004-06-28 | Takeda Chemical Industries, Ltd. | HER2 inhibitort tartalmazó fokozott felszívódású gyógyászati készítmény |
-
2006
- 2006-01-27 EP EP06712959A patent/EP1849830B1/fr active Active
- 2006-01-27 US US11/795,734 patent/US8623405B2/en active Active
- 2006-01-27 JP JP2007503613A patent/JP5288791B2/ja active Active
- 2006-01-27 WO PCT/JP2006/301816 patent/WO2006087919A1/fr not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04295420A (ja) * | 1991-01-25 | 1992-10-20 | Sterling Winthrop Inc | 表面変性薬物微小粒子 |
| US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
| US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| JPH09206000A (ja) * | 1996-02-08 | 1997-08-12 | Asahi Chem Ind Co Ltd | 水分散性組成物 |
| JP2004501183A (ja) * | 2000-06-27 | 2004-01-15 | ヴェクトゥラ リミテッド | 医薬組成物で使用するための粒子の製造法 |
| JP2005513037A (ja) * | 2001-11-20 | 2005-05-12 | スミスクライン ビーチャム パブリック リミテッド カンパニー | 5−[4−[2−(n−メチル−n−(2−ピリジル)アミノ)エトキシ]ベンジル]チアゾリジン−2,4−ジオンおよび当該化合物配合の医薬組成物 |
| JP2004099442A (ja) * | 2002-09-04 | 2004-04-02 | Nisshin Pharma Inc | 難溶性薬物含有製剤およびその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006087919A1 (fr) | 2006-08-24 |
| US8623405B2 (en) | 2014-01-07 |
| EP1849830A4 (fr) | 2009-03-04 |
| EP1849830B1 (fr) | 2012-02-29 |
| JPWO2006087919A1 (ja) | 2008-07-03 |
| EP1849830A1 (fr) | 2007-10-31 |
| US20080118552A1 (en) | 2008-05-22 |
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