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JP4991288B2 - 二本鎖ｉＲＮＡ剤、および二本鎖ｉＲＮＡ剤の対合の安定性を調節する方法。 - Google Patents

二本鎖ｉＲＮＡ剤、および二本鎖ｉＲＮＡ剤の対合の安定性を調節する方法。 Download PDF

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Publication number
JP4991288B2
JP4991288B2 JP2006513075A JP2006513075A JP4991288B2 JP 4991288 B2 JP4991288 B2 JP 4991288B2 JP 2006513075 A JP2006513075 A JP 2006513075A JP 2006513075 A JP2006513075 A JP 2006513075A JP 4991288 B2 JP4991288 B2 JP 4991288B2
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Japan
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hydrogen
alkyl
monomer
hydroxy
double
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Expired - Lifetime
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JP2006513075A
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Japanese (ja)
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JP2007525453A (ja
Inventor
マノハーラン、ムシア
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Priority claimed from PCT/US2004/007070 external-priority patent/WO2004080406A2/fr
Priority claimed from PCT/US2004/010586 external-priority patent/WO2004090108A2/fr
Priority claimed from PCT/US2004/011255 external-priority patent/WO2004091515A2/fr
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of JP2007525453A publication Critical patent/JP2007525453A/ja
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Publication of JP4991288B2 publication Critical patent/JP4991288B2/ja
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JP2006513075A 2003-04-17 2004-04-16 二本鎖ｉＲＮＡ剤、および二本鎖ｉＲＮＡ剤の対合の安定性を調節する方法。 Expired - Lifetime JP4991288B2 (ja)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US46377203P 2003-04-17 2003-04-17
US60/463,772 2003-04-17
US46566503P 2003-04-25 2003-04-25
US46580203P 2003-04-25 2003-04-25
US60/465,665 2003-04-25
US60/465,802 2003-04-25
US46961203P 2003-05-09 2003-05-09
US60/469,612 2003-05-09
US49398603P 2003-08-08 2003-08-08
US60/493,986 2003-08-08
US49459703P 2003-08-11 2003-08-11
US60/494,597 2003-08-11
US50634103P 2003-09-26 2003-09-26
US60/506,341 2003-09-26
US51024603P 2003-10-09 2003-10-09
US60/510,246 2003-10-09
US51031803P 2003-10-10 2003-10-10
US60/510,318 2003-10-10
US51845303P 2003-11-07 2003-11-07
US60/518,453 2003-11-07
USPCT/US04/07070 2004-03-08
PCT/US2004/007070 WO2004080406A2 (fr) 2003-03-07 2004-03-08 Compositions therapeutiques
USPCT/US04/10586 2004-04-05
PCT/US2004/010586 WO2004090108A2 (fr) 2003-04-03 2004-04-05 Conjugues d'arni
PCT/US2004/011255 WO2004091515A2 (fr) 2003-04-09 2004-04-09 Conjugues arni
USPCT/US04/11255 2004-04-09
PCT/US2004/011822 WO2004094345A2 (fr) 2003-04-17 2004-04-16 Monomeres proteges

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Publication Number Publication Date
JP2007525453A JP2007525453A (ja) 2007-09-06
JP4991288B2 true JP4991288B2 (ja) 2012-08-01

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JP2006513075A Expired - Lifetime JP4991288B2 (ja) 2003-04-17 2004-04-16 二本鎖ｉＲＮＡ剤、および二本鎖ｉＲＮＡ剤の対合の安定性を調節する方法。

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EP (1) EP1625138A4 (fr)
JP (1) JP4991288B2 (fr)
AU (1) AU2004232964B2 (fr)
CA (1) CA2522349A1 (fr)
WO (1) WO2004094345A2 (fr)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
US8796436B2 (en) 2003-04-17 2014-08-05 Alnylam Pharmaceuticals, Inc. Modified iRNA agents
US7723509B2 (en) 2003-04-17 2010-05-25 Alnylam Pharmaceuticals IRNA agents with biocleavable tethers
CA2522637C (fr) * 2003-04-17 2014-01-21 Alnylam Pharmaceuticals, Inc. Agents modifies d'arni
US8017762B2 (en) 2003-04-17 2011-09-13 Alnylam Pharmaceuticals, Inc. Modified iRNA agents
AU2005222902B2 (en) 2004-03-12 2010-06-10 Alnylam Pharmaceuticals, Inc. iRNA agents targeting VEGF
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EP1625138A2 (fr) 2006-02-15
WO2004094345A2 (fr) 2004-11-04
WO2004094345A8 (fr) 2016-06-30
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