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Publication number
JP2017037014A5
JP2017037014A5 JP2015158726A JP2015158726A JP2017037014A5 JP 2017037014 A5 JP2017037014 A5 JP 2017037014A5 JP 2015158726 A JP2015158726 A JP 2015158726A JP 2015158726 A JP2015158726 A JP 2015158726A JP 2017037014 A5 JP2017037014 A5 JP 2017037014A5
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JP
Japan
Prior art keywords
amino acid
acid sequence
sequence consisting
metal
protein
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JP2015158726A
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Japanese (ja)
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JP2017037014A (en
JP6623406B2 (en
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Publication date
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Priority to JP2015158726A priority Critical patent/JP6623406B2/en
Priority claimed from JP2015158726A external-priority patent/JP6623406B2/en
Priority to PCT/JP2016/073537 priority patent/WO2017026505A1/en
Publication of JP2017037014A publication Critical patent/JP2017037014A/en
Publication of JP2017037014A5 publication Critical patent/JP2017037014A5/ja
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Publication of JP6623406B2 publication Critical patent/JP6623406B2/en
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Claims (10)

以下の（ａ）又は（ｂ）のアミノ酸配列を有するペプチドからなり、かつ金属への結合能を有する、結合剤：
（ａ）以下の（１）〜（１７）の何れかに記載のアミノ酸配列；
（１）Ｋ、Ｋ、Ｒ、Ｅ、Ｖ及びＲからなるアミノ酸配列、
（２）Ｖ、Ｙ、Ｎ、Ｋ、Ｒ及びＫからなるアミノ酸配列、
（３）Ｓ、Ｒ、Ａ、Ａ、Ｋ及びＹからなるアミノ酸配列、
（４）Ｑ、Ｋ、Ｒ、Ｋ、Ｖ及びＶからなるアミノ酸配列、
（５）Ｋ、Ｇ、Ｒ、Ｇ、Ｒ及びＶからなるアミノ酸配列、
（６）Ｋ、Ｒ、Ｋ、Ａ、Ａ及びＭからなるアミノ酸配列、
（７）Ｋ、Ｔ、Ｒ、Ｇ、Ｖ及びＫからなるアミノ酸配列、
（８）Ｋ、Ｑ、Ｋ、Ｋ、Ｔ及びＴからなるアミノ酸配列、
（９）Ｒ、Ｔ、Ｒ、Ｎ、Ｒ及びＳからなるアミノ酸配列、
（１０）Ｔ、Ｑ、Ｋ、Ｇ、Ｒ及びＫからなるアミノ酸配列、
（１１）Ｋ、Ｇ、Ａ、Ｋ、Ｋ及びＶからなるアミノ酸配列、
（１２）Ｋ、Ｋ、Ｔ、Ｓ、Ｋ及びＧからなるアミノ酸配列、
（１３）Ｋ、Ｔ、Ｒ、Ｍ、Ｒ及びＧからなるアミノ酸配列、
（１４）Ｌ、Ｋ、Ｄ、Ｋ、Ｋ及びＫからなるアミノ酸配列、
（１５）Ｒ、Ｇ、Ｙ、Ｋ、Ｋ及びＧからなるアミノ酸配列、
（１６）Ｒ、Ｋ、Ｇ、Ｎ、Ｋ及びＡからなるアミノ酸配列、
（１７）Ｒ、Ｖ、Ｇ、Ｒ、Ｋ及びＧからなるアミノ酸配列
（ｂ）（ａ）に記載のアミノ酸配列において１又は数個のアミノ酸が欠失、置換もしくは付加されたアミノ酸配列。 A binding agent comprising a peptide having the following amino acid sequence (a) or (b) and having a binding ability to a metal:
(A) the amino acid sequence according to any one of (1) to (17) below:
(1) an amino acid sequence consisting of K, K, R, E, V and R;
(2) an amino acid sequence consisting of V, Y, N, K, R and K;
(3) an amino acid sequence consisting of S, R, A, A, K and Y,
(4) an amino acid sequence consisting of Q, K, R, K, V and V;
(5) an amino acid sequence consisting of K, G, R, G, R and V;
(6) an amino acid sequence consisting of K, R, K, A, A and M;
(7) an amino acid sequence consisting of K, T, R, G, V and K;
(8) an amino acid sequence consisting of K, Q, K, K, T and T;
(9) an amino acid sequence consisting of R, T, R, N, R and S,
(10) an amino acid sequence consisting of T, Q, K, G, R and K;
(11) an amino acid sequence consisting of K, G, A, K, K and V,
(12) an amino acid sequence consisting of K, K, T, S, K and G;
(13) an amino acid sequence consisting of K, T, R, M, R and G;
(14) an amino acid sequence consisting of L, K, D, K, K and K;
(15) an amino acid sequence consisting of R, G, Y, K, K and G;
(16) an amino acid sequence consisting of R, K, G, N, K and A,
(17) Amino acid sequence consisting of R, V, G, R, K, and G, wherein one or several amino acids are deleted, substituted, or added in the amino acid sequence described in (b) (a). 以下の（ｃ）、（ｄ）又は（ｅ）のアミノ酸配列を有するペプチドからなり、かつ金属への結合能を有する、請求項１に記載の結合剤：
（ｃ）配列番号１〜１７の何れかに記載のアミノ酸配列；
（ｄ）（ｃ）に記載のアミノ酸配列の逆配列；
（ｅ）（ｃ）又は（ｄ）に記載のアミノ酸配列において１又は数個のアミノ酸が欠失、置換もしくは付加されたアミノ酸配列。 The binding agent according to claim 1, comprising a peptide having the following amino acid sequence (c), (d) or (e) and having a binding ability to a metal:
(C) the amino acid sequence according to any one of SEQ ID NOs: 1 to 17;
(D) a reverse sequence of the amino acid sequence described in (c);
(E) An amino acid sequence in which one or several amino acids are deleted, substituted or added in the amino acid sequence described in (c) or (d). Ｋ、Ｒ、Ｇ、Ｖ、Ｔ、Ａ、Ｑ、Ｓ、Ｙ、Ｎ、Ｍ、Ｌ、Ｄ又はＥから選ばれるアミノ酸からなる、請求項１又は２に記載の結合剤。   The binder according to claim 1 or 2, comprising an amino acid selected from K, R, G, V, T, A, Q, S, Y, N, M, L, D or E. 蛋白質に請求項１〜３の何れか１項に記載の結合剤を連結した、金属結合性蛋白質。   A metal-binding protein obtained by linking the binding agent according to any one of claims 1 to 3 to a protein. 蛋白質のＮ末端及び／又はＣ末端に結合剤を連結した、請求項４記載の金属結合性蛋白質。   The metal-binding protein according to claim 4, wherein a binder is linked to the N-terminus and / or C-terminus of the protein. 蛋白質が抗体又は酵素である、請求項４又は５記載の金属結合性蛋白質。   The metal binding protein according to claim 4 or 5, wherein the protein is an antibody or an enzyme. 蛋白質が酸化還元酵素である、請求項４〜６の何れか１項に記載の金属結合性蛋白質。   The metal-binding protein according to any one of claims 4 to 6, wherein the protein is an oxidoreductase. 請求項４〜７の何れか１項に記載の金属結合性蛋白質を含む、測定試薬組成物。   A measurement reagent composition comprising the metal binding protein according to any one of claims 4 to 7. 請求項４〜７の何れか１項に記載の金属結合性蛋白質を使用する、試料中の測定対象物の測定方法。   The measuring method of the measuring object in a sample which uses the metal binding protein of any one of Claims 4-7. 測定対象物がグルコースである、請求項９記載の測定方法。   The measurement method according to claim 9, wherein the measurement object is glucose.
JP2015158726A 2015-08-11 2015-08-11 Binder Active JP6623406B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2015158726A JP6623406B2 (en) 2015-08-11 2015-08-11 Binder
PCT/JP2016/073537 WO2017026505A1 (en) 2015-08-11 2016-08-10 Binding agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015158726A JP6623406B2 (en) 2015-08-11 2015-08-11 Binder

Publications (3)

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JP2017037014A JP2017037014A (en) 2017-02-16
JP2017037014A5 true JP2017037014A5 (en) 2018-10-04
JP6623406B2 JP6623406B2 (en) 2019-12-25

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101970327B1 (en) * 2017-04-13 2019-04-18 고려대학교 산학협력단 A Method for Accurate, Rapid, and Convenient One-Step-Diagnosis of Disease Based on Signal Self-Enhancement
JPWO2024024517A1 (en) 2022-07-26 2024-02-01
JPWO2024024518A1 (en) 2022-07-26 2024-02-01

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060246426A1 (en) * 2003-09-26 2006-11-02 Biohesion, Inc. Recombinant fusion proteins with high affinity binding to gold and applications thereof
CA2785376A1 (en) * 2009-11-20 2011-05-26 Tokyo Metropolitan Institute Of Medical Science Pharmaceutical composition
WO2013143026A1 (en) * 2012-03-31 2013-10-03 Abmart (Shanghai) Co., Ltd Peptide and antibody libraries and uses thereof
JP2014205626A (en) * 2013-04-11 2014-10-30 学校法人東京薬科大学 Platinum binder, and use thereof

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