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JP2007510677A - 調節性の物質の放出に影響を及ぼすマトリックスを有する多層の剤形 - Google Patents

調節性の物質の放出に影響を及ぼすマトリックスを有する多層の剤形 Download PDF

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Publication number
JP2007510677A
JP2007510677A JP2006538672A JP2006538672A JP2007510677A JP 2007510677 A JP2007510677 A JP 2007510677A JP 2006538672 A JP2006538672 A JP 2006538672A JP 2006538672 A JP2006538672 A JP 2006538672A JP 2007510677 A JP2007510677 A JP 2007510677A
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JP
Japan
Prior art keywords
substance
acid
copolymer
dosage form
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006538672A
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English (en)
Japanese (ja)
Inventor
リツィオ ロザリオ
ペーテライト ハンス−ウルリヒ
アスムス マンフレート
ラヴィシャンカール ヘマ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm GmbH Darmstadt
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Roehm GmbH Darmstadt
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Application filed by Roehm GmbH Darmstadt filed Critical Roehm GmbH Darmstadt
Publication of JP2007510677A publication Critical patent/JP2007510677A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2006538672A 2003-11-13 2004-09-15 調節性の物質の放出に影響を及ぼすマトリックスを有する多層の剤形 Pending JP2007510677A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353196A DE10353196A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
PCT/EP2004/010300 WO2005046561A2 (fr) 2003-11-13 2004-09-15 Forme galenique a couches multiples comportant une matrice influant sur la liberation d'une substance a effet modulateur

Publications (1)

Publication Number Publication Date
JP2007510677A true JP2007510677A (ja) 2007-04-26

Family

ID=34585091

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006538672A Pending JP2007510677A (ja) 2003-11-13 2004-09-15 調節性の物質の放出に影響を及ぼすマトリックスを有する多層の剤形

Country Status (10)

Country Link
US (1) US20070042045A1 (fr)
EP (1) EP1682094A2 (fr)
JP (1) JP2007510677A (fr)
KR (1) KR20060113728A (fr)
CN (1) CN1863516A (fr)
BR (1) BRPI0416492A (fr)
CA (1) CA2544487A1 (fr)
DE (1) DE10353196A1 (fr)
IL (1) IL175562A0 (fr)
WO (1) WO2005046561A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011509265A (ja) * 2008-01-10 2011-03-24 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 活性物質のパルス放出が強化された、コーティングされた医薬製剤もしくはニュートラシューティカル製剤
JP2016504349A (ja) * 2012-12-31 2016-02-12 サムヤン バイオファーマシューティカルズ コーポレイション 溶融押出された放出制御用薬学組成物、およびこれを含む経口用製剤
JP2018090601A (ja) * 2012-02-08 2018-06-14 スパーナス ファーマシューティカルズ インコーポレイテッド ビロキサジンの緩和放出製剤
US12121523B2 (en) 2008-09-05 2024-10-22 Supernus Pharmaceuticals, Inc. Method of treatment of attention deficit/hyperactivity disorder (ADHD)

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US6696088B2 (en) 2000-02-08 2004-02-24 Euro-Celtique, S.A. Tamper-resistant oral opioid agonist formulations
HUE038446T2 (hu) * 2002-09-20 2018-10-29 Alpharma Pharmaceuticals Llc Szekvesztráló alegység és releváns kompozíciók és módszerek
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
DE102004036437A1 (de) 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004059792A1 (de) * 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102005007059A1 (de) 2005-02-15 2006-08-24 Röhm GmbH & Co. KG Teilneutralisiertes anionisches (Meth)acrylat-Copolymer
BRPI0609598A2 (pt) * 2005-03-29 2010-04-20 Roehm Gmbh forma farmacêutica multiparticulada compreendendo péletes com uma substáncia possuindo um efeito modular em relação à liberação de ingrediente ativo
JP2008534531A (ja) * 2005-03-29 2008-08-28 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 調節物質の送達に影響を及ぼすマトリックスを有するペレットを有する多粒子の医薬剤形
KR101320016B1 (ko) * 2005-12-14 2013-10-29 주식회사 대웅 안정화된 코엔자임ｑ10, 종합 비타민 및 미네랄 성분을함유하는 복합제제
DE102006006532B4 (de) 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
ITMI20061024A1 (it) * 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
DK2526932T3 (en) * 2006-06-19 2017-07-17 Alpharma Pharmaceuticals Llc Pharmaceutical composition
DE102006035549A1 (de) * 2006-07-27 2008-01-31 Evonik Röhm Gmbh Arzneiform mit mindestens zweischichtiger Trennschicht
GB0618879D0 (en) 2006-09-26 2006-11-01 Zysis Ltd Pharmaceutical compositions
NZ579811A (en) * 2007-03-29 2012-02-24 Panacea Biotec Ltd Modified dosage forms of tacrolimus
CA2615137A1 (fr) * 2007-12-17 2009-06-17 Pharmascience Inc. Dispositif therapeutique monocouche a liberation controlee
AU2008346870A1 (en) * 2007-12-17 2009-07-16 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8623418B2 (en) * 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
EP2231122A1 (fr) * 2008-01-10 2010-09-29 Evonik Röhm GmbH Préparation pharmaceutique ou nutraceutique enrobée ayant une libération de substance active contrôlée accélérée
PL2230932T3 (pl) 2008-01-10 2017-09-29 Evonik Röhm Gmbh Powlekany preparat farmaceutyczny lub nutraceutyczny o zwiększonym uwalnianiu substancji aktywnej w jelicie grubym
US20100159009A1 (en) * 2008-12-24 2010-06-24 Zhongshui Yu Controlled-release formulations
US20100172979A1 (en) * 2008-12-24 2010-07-08 Zhongshui Yu Controlled-release formulations
WO2010096732A1 (fr) * 2009-02-20 2010-08-26 University Of Medicine And Dentistry Of New Jersey Polythérapie pour améliorer l'efficacité des médicaments
KR101317592B1 (ko) 2009-10-28 2013-10-15 씨제이제일제당 (주) 프레가발린, 폴리에틸렌옥사이드 및 폴리비닐알코올-폴리에틸렌글리콜 그라프트 공중합체를 함유하는 위체류형 서방성 제제
KR101137467B1 (ko) * 2009-11-02 2012-04-20 안국약품 주식회사 테오브로민 함유 서방성 정제
WO2011107855A2 (fr) * 2010-03-04 2011-09-09 Torrent Pharmaceuticals Limited Forme dosifiée sous forme de suspension liquide à libération prolongée pour une administration par voie orale
US20140004223A1 (en) * 2010-08-18 2014-01-02 Three Parkway North Mouth-moistening gum compositions and products containing the same
KR101220830B1 (ko) * 2010-08-18 2013-01-10 안국약품 주식회사 테오브로민의 서방성 과립제 및 그 제조방법
US20140141090A1 (en) 2011-02-02 2014-05-22 Edward S. Wilson Pharmaceutical Composition Comprising Opioid Agonist And Sequestered Antagonist
US8859005B2 (en) 2012-12-03 2014-10-14 Intercontinental Great Brands Llc Enteric delivery of functional ingredients suitable for hot comestible applications
KR102241487B1 (ko) 2013-02-20 2021-04-16 주식회사 종근당 제어방출 펠릿으로 된 약제학적 조성물
BR112020000084A2 (pt) 2017-07-07 2020-07-07 Dsm Ip Assets B.V. comprimidos compactados
ES2938609T3 (es) 2017-09-20 2023-04-13 Tillotts Pharma Ag Preparación de formas farmacéuticas sólidas que comprenden anticuerpos mediante estratificación de solución/suspensión
AU2024241638A1 (en) 2023-03-28 2025-10-09 Tillotts Pharma Ag Solid oral dosage form comprising antibodies for sustained release in the lower gastrointestinal tract
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06507903A (ja) * 1991-05-20 1994-09-08 アベンティス・ファーマスーティカルズ・インコーポレイテッド 複数層の制御放出処方剤
JP2002526401A (ja) * 1998-10-02 2002-08-20 レーム ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト 制御された作用物質放出性を有する被覆された医薬品形
WO2003030869A1 (fr) * 2001-10-09 2003-04-17 Apogepha Arzneimittel Gmbh Formes d'administration orale de propiverine ou de ses sels pharmaceutiquement acceptables, a liberation prolongee des agents actifs

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DE3483335D1 (de) * 1983-03-18 1990-11-08 Matsushita Electric Industrial Co Ltd Videosignalverarbeitungseinrichtung fuer videobandaufzeichnungsgeraete.
IE55745B1 (en) * 1983-04-06 1991-01-02 Elan Corp Plc Sustained absorption pharmaceutical composition
JPH04360826A (ja) * 1991-06-07 1992-12-14 Bayer Yakuhin Kk 放出制御製剤
US5260068A (en) * 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
DE10250543A1 (de) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Mehrschichtige Arzneiform

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JPH06507903A (ja) * 1991-05-20 1994-09-08 アベンティス・ファーマスーティカルズ・インコーポレイテッド 複数層の制御放出処方剤
JP2002526401A (ja) * 1998-10-02 2002-08-20 レーム ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト 制御された作用物質放出性を有する被覆された医薬品形
WO2003030869A1 (fr) * 2001-10-09 2003-04-17 Apogepha Arzneimittel Gmbh Formes d'administration orale de propiverine ou de ses sels pharmaceutiquement acceptables, a liberation prolongee des agents actifs

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011509265A (ja) * 2008-01-10 2011-03-24 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 活性物質のパルス放出が強化された、コーティングされた医薬製剤もしくはニュートラシューティカル製剤
US9011907B2 (en) 2008-01-10 2015-04-21 Evonik Röhm Gmbh Coated pharmaceutical or nutraceutical preparation with enhanced pulsed active substance release
US12121523B2 (en) 2008-09-05 2024-10-22 Supernus Pharmaceuticals, Inc. Method of treatment of attention deficit/hyperactivity disorder (ADHD)
JP2018090601A (ja) * 2012-02-08 2018-06-14 スパーナス ファーマシューティカルズ インコーポレイテッド ビロキサジンの緩和放出製剤
US10265319B2 (en) 2012-02-08 2019-04-23 Supernus Pharmaceuticals, Inc. Formulations of viloxazine
JP2016504349A (ja) * 2012-12-31 2016-02-12 サムヤン バイオファーマシューティカルズ コーポレイション 溶融押出された放出制御用薬学組成物、およびこれを含む経口用製剤
US10143659B2 (en) 2012-12-31 2018-12-04 Samyang Biopharmaceutical Corporation Melt-extruded release controlled pharmaceutical composition and oral dosage form comprising the same

Also Published As

Publication number Publication date
CN1863516A (zh) 2006-11-15
CA2544487A1 (fr) 2005-05-26
BRPI0416492A (pt) 2007-03-13
DE10353196A1 (de) 2005-06-16
US20070042045A1 (en) 2007-02-22
WO2005046561A2 (fr) 2005-05-26
IL175562A0 (en) 2008-04-13
EP1682094A2 (fr) 2006-07-26
KR20060113728A (ko) 2006-11-02
WO2005046561A3 (fr) 2006-03-16

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