ITRM20010456A1 - Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati. - Google Patents
Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati.Info
- Publication number
- ITRM20010456A1 ITRM20010456A1 IT2001RM000456A ITRM20010456A ITRM20010456A1 IT RM20010456 A1 ITRM20010456 A1 IT RM20010456A1 IT 2001RM000456 A IT2001RM000456 A IT 2001RM000456A IT RM20010456 A ITRM20010456 A IT RM20010456A IT RM20010456 A1 ITRM20010456 A1 IT RM20010456A1
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- salts
- preparation
- aminocarnitine
- amminocarnitine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- DAWBGYHPBBDHMQ-LURJTMIESA-N (3s)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@@H](N)CC([O-])=O DAWBGYHPBBDHMQ-LURJTMIESA-N 0.000 abstract 2
- DAWBGYHPBBDHMQ-ZCFIWIBFSA-N (3r)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](N)CC([O-])=O DAWBGYHPBBDHMQ-ZCFIWIBFSA-N 0.000 abstract 1
- WPWLZCVABVFBGW-UHFFFAOYSA-N 3-azido-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)CC(O)(CC([O-])=O)N=[N+]=[N-] WPWLZCVABVFBGW-UHFFFAOYSA-N 0.000 abstract 1
- SKMSOHALMZCXFM-ZETCQYMHSA-N N[C@@](O)(C[N+](C)(C)C)CC([O-])=O Chemical class N[C@@](O)(C[N+](C)(C)C)CC([O-])=O SKMSOHALMZCXFM-ZETCQYMHSA-N 0.000 abstract 1
- JTARPNWGYOTOQV-ZETCQYMHSA-N [N+](=O)([O-])O[C@](O)(C[N+](C)(C)C)CC([O-])=O Chemical compound [N+](=O)([O-])O[C@](O)(C[N+](C)(C)C)CC([O-])=O JTARPNWGYOTOQV-ZETCQYMHSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000456A ITRM20010456A1 (it) | 2001-07-26 | 2001-07-26 | Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati. |
| AT02767834T ATE346837T1 (de) | 2001-07-26 | 2002-07-17 | Verfahren zur herstellung des inneren salzes von (r)- or (s)-aminocarnitin, salze und derivate davon |
| HK05100341.1A HK1068327B (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
| ES02767834T ES2280570T3 (es) | 2001-07-26 | 2002-07-17 | Proceso de preparacion de (r)- o (s)-aminocarnitina sal interna, sus sales y derivados. |
| DE60216466T DE60216466T2 (de) | 2001-07-26 | 2002-07-17 | Verfahren zur herstellung des inneren salzes von (r)- or (s)-aminocarnitin, salze und derivate davon |
| PCT/IT2002/000468 WO2003010129A1 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
| AU2002330738A AU2002330738B2 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (R)- or (S)-Aminocarnitine inner salt, the salts and derivatives thereof |
| CNB028140222A CN1231460C (zh) | 2001-07-26 | 2002-07-17 | 制备(r)－或(s)－氨基肉碱内盐及其盐和衍生物的方法 |
| MXPA04000676A MXPA04000676A (es) | 2001-07-26 | 2002-07-17 | Proceso para preparacion de sal interna de (r)- o (s) aminocarnitina, sales y derivados de las mismas. |
| CA002453019A CA2453019A1 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
| JP2003515489A JP4212473B2 (ja) | 2001-07-26 | 2002-07-17 | （ｒ）−または（ｓ）−アミノカルニチン分子内塩、その塩および誘導体の調製方法 |
| DK02767834T DK1409448T3 (da) | 2001-07-26 | 2002-07-17 | Fremgangsmåde til fremstilling af det indre salt af (R)- eller (S)-aminocarnitin, salte og derivater deraf |
| US10/482,729 US6953865B2 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
| PT02767834T PT1409448E (pt) | 2001-07-26 | 2002-07-17 | Processo para a preparação do sal interno de ( r ) - ou ( s )- aminocarnitina, dos seus sais e derivados |
| PL02367614A PL367614A1 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
| EP02767834A EP1409448B1 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
| HU0401617A HUP0401617A3 (en) | 2001-07-26 | 2002-07-17 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof |
| KR1020037017244A KR100879125B1 (ko) | 2001-07-26 | 2002-07-17 | （ｒ）－ 또는 （ｓ）－아미노카르니틴 내염, 그의 염 및유도체의 제조 방법 |
| CY20071100269T CY1107567T1 (el) | 2001-07-26 | 2007-02-26 | Μεθοδος για την παρασκευη του εσωτepικου αλατος της (r)-ή (s) αμινοκαρνιτινης, των αλατων και των παραγωγων της |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000456A ITRM20010456A1 (it) | 2001-07-26 | 2001-07-26 | Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITRM20010456A0 ITRM20010456A0 (it) | 2001-07-26 |
| ITRM20010456A1 true ITRM20010456A1 (it) | 2003-01-27 |
Family
ID=11455694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001RM000456A ITRM20010456A1 (it) | 2001-07-26 | 2001-07-26 | Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6953865B2 (it) |
| EP (1) | EP1409448B1 (it) |
| JP (1) | JP4212473B2 (it) |
| KR (1) | KR100879125B1 (it) |
| CN (1) | CN1231460C (it) |
| AT (1) | ATE346837T1 (it) |
| AU (1) | AU2002330738B2 (it) |
| CA (1) | CA2453019A1 (it) |
| CY (1) | CY1107567T1 (it) |
| DE (1) | DE60216466T2 (it) |
| DK (1) | DK1409448T3 (it) |
| ES (1) | ES2280570T3 (it) |
| HU (1) | HUP0401617A3 (it) |
| IT (1) | ITRM20010456A1 (it) |
| MX (1) | MXPA04000676A (it) |
| PL (1) | PL367614A1 (it) |
| PT (1) | PT1409448E (it) |
| WO (1) | WO2003010129A1 (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1299266B1 (it) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
| US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
| US8410150B2 (en) | 2007-03-09 | 2013-04-02 | University Health Network | Inhibitors of carnitine palmitoyltransferase and treating cancer |
| CA2694724C (en) | 2007-08-01 | 2017-09-12 | University Health Network | Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer |
| CN111621541B (zh) * | 2019-02-27 | 2025-10-31 | 广安摩珈生物科技有限公司 | 使用电渗析技术拆分光学异构体的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767781A (en) * | 1981-11-26 | 1988-08-30 | Takeda Chemical Industries, Ltd. | Derivatives of beta-amino-gamma-trimethylammonio-butyrate and their production and use |
| IT1261489B (it) * | 1993-07-29 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r amminocarnitina e s amminocarnitina. |
| IT1299266B1 (it) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
| IT1306184B1 (it) * | 1999-08-05 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Nitrilossi derivati della (r) e (s)-carnitina. |
-
2001
- 2001-07-26 IT IT2001RM000456A patent/ITRM20010456A1/it unknown
-
2002
- 2002-07-17 EP EP02767834A patent/EP1409448B1/en not_active Expired - Lifetime
- 2002-07-17 US US10/482,729 patent/US6953865B2/en not_active Expired - Fee Related
- 2002-07-17 DE DE60216466T patent/DE60216466T2/de not_active Expired - Lifetime
- 2002-07-17 CN CNB028140222A patent/CN1231460C/zh not_active Expired - Fee Related
- 2002-07-17 DK DK02767834T patent/DK1409448T3/da active
- 2002-07-17 PL PL02367614A patent/PL367614A1/xx unknown
- 2002-07-17 WO PCT/IT2002/000468 patent/WO2003010129A1/en not_active Ceased
- 2002-07-17 ES ES02767834T patent/ES2280570T3/es not_active Expired - Lifetime
- 2002-07-17 KR KR1020037017244A patent/KR100879125B1/ko not_active Expired - Fee Related
- 2002-07-17 MX MXPA04000676A patent/MXPA04000676A/es active IP Right Grant
- 2002-07-17 PT PT02767834T patent/PT1409448E/pt unknown
- 2002-07-17 AU AU2002330738A patent/AU2002330738B2/en not_active Ceased
- 2002-07-17 CA CA002453019A patent/CA2453019A1/en not_active Abandoned
- 2002-07-17 JP JP2003515489A patent/JP4212473B2/ja not_active Expired - Fee Related
- 2002-07-17 HU HU0401617A patent/HUP0401617A3/hu unknown
- 2002-07-17 AT AT02767834T patent/ATE346837T1/de not_active IP Right Cessation
-
2007
- 2007-02-26 CY CY20071100269T patent/CY1107567T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1409448E (pt) | 2007-02-28 |
| WO2003010129A1 (en) | 2003-02-06 |
| EP1409448A1 (en) | 2004-04-21 |
| HUP0401617A3 (en) | 2008-05-28 |
| DE60216466D1 (de) | 2007-01-11 |
| HK1068327A1 (en) | 2005-04-29 |
| JP2004536867A (ja) | 2004-12-09 |
| ITRM20010456A0 (it) | 2001-07-26 |
| JP4212473B2 (ja) | 2009-01-21 |
| MXPA04000676A (es) | 2004-04-05 |
| ES2280570T3 (es) | 2007-09-16 |
| CN1527811A (zh) | 2004-09-08 |
| CY1107567T1 (el) | 2013-03-13 |
| PL367614A1 (en) | 2005-03-07 |
| EP1409448B1 (en) | 2006-11-29 |
| DE60216466T2 (de) | 2007-09-20 |
| CA2453019A1 (en) | 2003-02-06 |
| US6953865B2 (en) | 2005-10-11 |
| DK1409448T3 (da) | 2007-04-02 |
| CN1231460C (zh) | 2005-12-14 |
| US20040171875A1 (en) | 2004-09-02 |
| KR100879125B1 (ko) | 2009-01-19 |
| KR20040032116A (ko) | 2004-04-14 |
| ATE346837T1 (de) | 2006-12-15 |
| HUP0401617A2 (hu) | 2004-12-28 |
| AU2002330738B2 (en) | 2008-05-08 |
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