ITMI20040164A1 - Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono - Google Patents
Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengonoInfo
- Publication number
- ITMI20040164A1 ITMI20040164A1 IT000164A ITMI20040164A ITMI20040164A1 IT MI20040164 A1 ITMI20040164 A1 IT MI20040164A1 IT 000164 A IT000164 A IT 000164A IT MI20040164 A ITMI20040164 A IT MI20040164A IT MI20040164 A1 ITMI20040164 A1 IT MI20040164A1
- Authority
- IT
- Italy
- Prior art keywords
- deacetylthiocolchicine
- derivatives
- contain
- pharmaceutical formulations
- linker
- Prior art date
Links
- NUNCOHUMTCDISK-AWEZNQCLSA-N (7s)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5h-benzo[a]heptalen-9-one Chemical compound C1([C@@H](N)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC NUNCOHUMTCDISK-AWEZNQCLSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 230000002456 anti-arthritic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/30—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000164A ITMI20040164A1 (it) | 2004-02-03 | 2004-02-03 | Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono |
| JP2006550141A JP4884983B2 (ja) | 2004-02-03 | 2005-02-01 | Ｎ−デアセチルチオコルヒチン誘導体、その使用およびそれを含有する医薬製剤 |
| US10/588,012 US7399788B2 (en) | 2004-02-03 | 2005-02-01 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| KR1020067015170A KR101163794B1 (ko) | 2004-02-03 | 2005-02-01 | Ｎ-데아세틸치오콜키신 유도체, 그의 용도 및 그를 함유한약제학적 제제 |
| EP05707124A EP1711461B1 (en) | 2004-02-03 | 2005-02-01 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| AU2005211501A AU2005211501B2 (en) | 2004-02-03 | 2005-02-01 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| PL05707124T PL1711461T3 (pl) | 2004-02-03 | 2005-02-01 | Pochodne N-deacetylotiokolchicyny, ich zastosowanie i kompozycje farmaceutyczne je zawierające |
| SI200530939T SI1711461T1 (sl) | 2004-02-03 | 2005-02-01 | Derivati n-deacetiltiokolhicina, njihova uporaba in farmacevtske formulacije, ki jih vsebujejo |
| PT05707124T PT1711461E (pt) | 2004-02-03 | 2005-02-01 | Derivados de n-desacetiltiocolchicina, sua utilização e formulações farmacêuticas que os contêm |
| CA2555058A CA2555058C (en) | 2004-02-03 | 2005-02-01 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| DK05707124.3T DK1711461T3 (da) | 2004-02-03 | 2005-02-01 | N-Deacetylthiocolchicinderivater, deres anvendelse og farmaceutiske formuleringer indeholdende dem |
| ES05707124T ES2336010T3 (es) | 2004-02-03 | 2005-02-01 | Derivados de n-desacetiltiocolchicina, su uso y formulaciones farmaceuticas que los contienen. |
| CNB200580003821XA CN100558705C (zh) | 2004-02-03 | 2005-02-01 | N-脱乙酰基硫代秋水仙碱、它们的用途和含有它们的药物制剂 |
| RU2006127967/04A RU2370486C2 (ru) | 2004-02-03 | 2005-02-01 | Производные n-деацетилтиоколхицина, их применение и содержащие их фармацевтические составы |
| PCT/EP2005/000987 WO2005075418A2 (en) | 2004-02-03 | 2005-02-01 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| DE602005019135T DE602005019135D1 (de) | 2004-02-03 | 2005-02-01 | N-desacetylthiocolchicinderivate, deren verwendung und pharmazeutische formulierungen, die diese enthalten |
| HK07108622.2A HK1100877B (en) | 2004-02-03 | 2005-02-01 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| AT05707124T ATE456554T1 (de) | 2004-02-03 | 2005-02-01 | N-desacetylthiocolchicinderivate, deren verwendung und pharmazeutische formulierungen, die diese enthalten |
| IL177196A IL177196A (en) | 2004-02-03 | 2006-08-01 | N-deacetylthiocolchicine derivatives and pharmaceutical formulations containing them |
| NO20063509A NO337208B1 (no) | 2004-02-03 | 2006-08-01 | N-deacetyltiokolchisinderivater, deres anvendelse samt farmasøytiske formuleringer inneholdende slike |
| US12/142,522 US7687545B2 (en) | 2004-02-03 | 2008-06-19 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| US12/142,485 US7579364B2 (en) | 2004-02-03 | 2008-06-19 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
| US12/142,502 US7582639B2 (en) | 2004-02-03 | 2008-06-19 | N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000164A ITMI20040164A1 (it) | 2004-02-03 | 2004-02-03 | Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20040164A1 true ITMI20040164A1 (it) | 2004-05-03 |
Family
ID=34835575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT000164A ITMI20040164A1 (it) | 2004-02-03 | 2004-02-03 | Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7399788B2 (it) |
| EP (1) | EP1711461B1 (it) |
| JP (1) | JP4884983B2 (it) |
| KR (1) | KR101163794B1 (it) |
| CN (1) | CN100558705C (it) |
| AT (1) | ATE456554T1 (it) |
| AU (1) | AU2005211501B2 (it) |
| CA (1) | CA2555058C (it) |
| DE (1) | DE602005019135D1 (it) |
| DK (1) | DK1711461T3 (it) |
| ES (1) | ES2336010T3 (it) |
| IL (1) | IL177196A (it) |
| IT (1) | ITMI20040164A1 (it) |
| NO (1) | NO337208B1 (it) |
| PL (1) | PL1711461T3 (it) |
| PT (1) | PT1711461E (it) |
| RU (1) | RU2370486C2 (it) |
| SI (1) | SI1711461T1 (it) |
| WO (1) | WO2005075418A2 (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105879114A (zh) * | 2005-02-18 | 2016-08-24 | 阿布拉西斯生物科学公司 | 用于整合入医疗装置的疏水性改善的药物 |
| CA2662140A1 (en) * | 2006-08-31 | 2008-03-06 | Abraxis Bioscience, Llc | Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases |
| KR101077609B1 (ko) * | 2009-07-08 | 2011-10-27 | 제일약품주식회사 | 트리사이클릭 유도체의 제조방법 |
| CN111182968A (zh) | 2017-10-05 | 2020-05-19 | 诺沃梅尔公司 | 异氰酸酯、其衍生物及它们的生产方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1344157A (fr) * | 1959-05-22 | 1963-11-29 | Roussel Uclaf | Nouvelles colchicines et leur procédé d'obtention |
| US4533675A (en) * | 1984-04-17 | 1985-08-06 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates of colchicine for treatment of gout |
| IT1276996B1 (it) * | 1995-06-27 | 1997-11-04 | Indena Spa | Derivati della colchicina, loro uso e formulazioni che li contengono |
| IT1283110B1 (it) * | 1996-06-07 | 1998-04-07 | Indena Spa | Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono |
| IT1318401B1 (it) * | 2000-03-17 | 2003-08-25 | Indena Spa | Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono. |
| US6825236B2 (en) * | 2003-04-14 | 2004-11-30 | California Pacific Medical Center | Colchicine derivatives |
-
2004
- 2004-02-03 IT IT000164A patent/ITMI20040164A1/it unknown
-
2005
- 2005-02-01 WO PCT/EP2005/000987 patent/WO2005075418A2/en not_active Ceased
- 2005-02-01 AT AT05707124T patent/ATE456554T1/de active
- 2005-02-01 PT PT05707124T patent/PT1711461E/pt unknown
- 2005-02-01 CN CNB200580003821XA patent/CN100558705C/zh not_active Expired - Fee Related
- 2005-02-01 US US10/588,012 patent/US7399788B2/en not_active Expired - Lifetime
- 2005-02-01 PL PL05707124T patent/PL1711461T3/pl unknown
- 2005-02-01 DE DE602005019135T patent/DE602005019135D1/de not_active Expired - Lifetime
- 2005-02-01 SI SI200530939T patent/SI1711461T1/sl unknown
- 2005-02-01 KR KR1020067015170A patent/KR101163794B1/ko not_active Expired - Fee Related
- 2005-02-01 EP EP05707124A patent/EP1711461B1/en not_active Expired - Lifetime
- 2005-02-01 JP JP2006550141A patent/JP4884983B2/ja not_active Expired - Fee Related
- 2005-02-01 DK DK05707124.3T patent/DK1711461T3/da active
- 2005-02-01 CA CA2555058A patent/CA2555058C/en not_active Expired - Lifetime
- 2005-02-01 AU AU2005211501A patent/AU2005211501B2/en not_active Ceased
- 2005-02-01 ES ES05707124T patent/ES2336010T3/es not_active Expired - Lifetime
- 2005-02-01 RU RU2006127967/04A patent/RU2370486C2/ru active
-
2006
- 2006-08-01 NO NO20063509A patent/NO337208B1/no not_active IP Right Cessation
- 2006-08-01 IL IL177196A patent/IL177196A/en active IP Right Grant
-
2008
- 2008-06-19 US US12/142,502 patent/US7582639B2/en not_active Expired - Lifetime
- 2008-06-19 US US12/142,522 patent/US7687545B2/en not_active Expired - Lifetime
- 2008-06-19 US US12/142,485 patent/US7579364B2/en not_active Expired - Lifetime
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