IT1321321B1 - Bio-material for use in patches, packaging materials and in implants and prosthesis, especially cardiac valve, comprises tissues obtained from animal cornea - Google Patents
Bio-material for use in patches, packaging materials and in implants and prosthesis, especially cardiac valve, comprises tissues obtained from animal corneaInfo
- Publication number
- IT1321321B1 IT1321321B1 ITBO20000430A IT1321321B1 IT 1321321 B1 IT1321321 B1 IT 1321321B1 IT BO20000430 A ITBO20000430 A IT BO20000430A IT 1321321 B1 IT1321321 B1 IT 1321321B1
- Authority
- IT
- Italy
- Prior art keywords
- tissue
- prosthesis
- bio
- animal
- cardiac valve
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 3
- 239000012620 biological material Substances 0.000 title abstract 2
- 210000004087 cornea Anatomy 0.000 title abstract 2
- 210000003709 heart valve Anatomy 0.000 title abstract 2
- 239000007943 implant Substances 0.000 title abstract 2
- 239000005022 packaging material Substances 0.000 title 1
- 241000251468 Actinopterygii Species 0.000 abstract 1
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000582 anti-calcifiying effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 210000005252 bulbus oculi Anatomy 0.000 abstract 1
- 230000002308 calcification Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000012856 packing Methods 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 210000001835 viscera Anatomy 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Prostheses (AREA)
Abstract
A bio-material (I) comprises tissues basically obtained from an animal cornea. Independent claims are also included for the following: (1) patch suitable for application in blood vessels, cavity organs or viscera, containing (I); (2) treatment of (I), which involves explantation of the tissue from the eyeball of an animal (particularly fish), washing the tissue with sterile physiological solution, fixing the tissue with glutaraldehyde solution at variable concentrations (0.1%-5%, preferably 0.4%), fixing in phosphate buffer saline solution at pH 7.4 for variable periods (preferably three months, so as to cause an increase in the cruciform bonds of the tissular collagen) and treating the tissue with bioactive substances, such as heparin, antibiotics, anticalcifying agents and drugs, to give the tissue additional potentially favorable characteristics, such as prevention of calcification phenomena and increased antithrombogenicity; (3) packing including (I) and a support frame containing (I); (4) prosthesis or implant partially made with (I); and (5) cardiac valve (10) including a support frame (11), some covering units (12,13) of the frame, some fasteners (14) to the patient's heart, and at least one cusp (15) containing (I), to open and close blood flow during systole and diastole. ACTIVITY : Cardiant. MECHANISM OF ACTION : None given in source material.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000BO000430 IT1321321B1 (en) | 2000-07-14 | 2000-07-14 | Bio-material for use in patches, packaging materials and in implants and prosthesis, especially cardiac valve, comprises tissues obtained from animal cornea |
| EP01955510A EP1307246B1 (en) | 2000-07-11 | 2001-07-10 | Biomaterial including animal corneal tissue |
| BR0112565-6A BR0112565A (en) | 2000-07-11 | 2001-07-10 | Biomaterial that includes animal corneal tissue |
| PCT/IT2001/000363 WO2002004037A1 (en) | 2000-07-11 | 2001-07-10 | Biomaterial including animal corneal tissue |
| ES01955510T ES2249459T3 (en) | 2000-07-11 | 2001-07-10 | BIOMATERIAL THAT INCLUDES ANIMAL CORNEA FABRIC. |
| AU2001277669A AU2001277669A1 (en) | 2000-07-11 | 2001-07-10 | Biomaterial including animal corneal tissue |
| JP2002508491A JP2004502499A (en) | 2000-07-11 | 2001-07-10 | Biomaterials containing animal corneal tissue |
| US10/332,554 US7323010B2 (en) | 2000-07-11 | 2001-07-10 | Biomaterial including animal corneal tissue |
| DE60113550T DE60113550T2 (en) | 2000-07-11 | 2001-07-10 | BIOMATERIAL WITH ANIMAL HORN SKIN FABRIC |
| AT01955510T ATE304871T1 (en) | 2000-07-11 | 2001-07-10 | ORGANIC MATERIAL WITH ANIMAL CORNEAL TISSUE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000BO000430 IT1321321B1 (en) | 2000-07-14 | 2000-07-14 | Bio-material for use in patches, packaging materials and in implants and prosthesis, especially cardiac valve, comprises tissues obtained from animal cornea |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITBO20000430A0 ITBO20000430A0 (en) | 2000-07-14 |
| ITBO20000430A1 ITBO20000430A1 (en) | 2002-01-14 |
| IT1321321B1 true IT1321321B1 (en) | 2004-01-08 |
Family
ID=11438622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2000BO000430 IT1321321B1 (en) | 2000-07-11 | 2000-07-14 | Bio-material for use in patches, packaging materials and in implants and prosthesis, especially cardiac valve, comprises tissues obtained from animal cornea |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1321321B1 (en) |
-
2000
- 2000-07-14 IT IT2000BO000430 patent/IT1321321B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ITBO20000430A1 (en) | 2002-01-14 |
| ITBO20000430A0 (en) | 2000-07-14 |
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