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IT1275433B - Derivati di diarildiammine - Google Patents

Derivati di diarildiammine

Info

Publication number
IT1275433B
IT1275433B ITMI951020A ITMI951020A IT1275433B IT 1275433 B IT1275433 B IT 1275433B IT MI951020 A ITMI951020 A IT MI951020A IT MI951020 A ITMI951020 A IT MI951020A IT 1275433 B IT1275433 B IT 1275433B
Authority
IT
Italy
Prior art keywords
alkyl
hydrogen
branched
pct
independently
Prior art date
Application number
ITMI951020A
Other languages
English (en)
Inventor
Giulio Dondio
Silvano Ronzoni
Original Assignee
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma
Publication of ITMI951020A0 publication Critical patent/ITMI951020A0/it
Priority to ITMI951020A priority Critical patent/IT1275433B/it
Priority to ZA963939A priority patent/ZA963939B/xx
Priority to PL96323385A priority patent/PL323385A1/xx
Priority to BR9608458A priority patent/BR9608458A/pt
Priority to US08/952,443 priority patent/US5922887A/en
Priority to PCT/EP1996/002152 priority patent/WO1996036620A1/en
Priority to TR97/01388T priority patent/TR199701388T1/xx
Priority to CA002221380A priority patent/CA2221380A1/en
Priority to JP53457496A priority patent/JP3205343B2/ja
Priority to DE69619512T priority patent/DE69619512T2/de
Priority to AT96916128T priority patent/ATE213735T1/de
Priority to KR1019970708252A priority patent/KR19990014907A/ko
Priority to AU58998/96A priority patent/AU5899896A/en
Priority to EP96916128A priority patent/EP0825991B1/en
Priority to ES96916128T priority patent/ES2171675T3/es
Priority to CZ973652A priority patent/CZ365297A3/cs
Priority to CN96195364A priority patent/CN1190393A/zh
Priority to HU9802222A priority patent/HUP9802222A3/hu
Publication of ITMI951020A1 publication Critical patent/ITMI951020A1/it
Application granted granted Critical
Publication of IT1275433B publication Critical patent/IT1275433B/it
Priority to MXPA/A/1997/008973A priority patent/MXPA97008973A/xx
Priority to NO975294A priority patent/NO975294L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C215/76—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring
    • C07C215/82—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of another six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/92—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the nitrogen atom of at least one of the amino groups being further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
ITMI951020A 1995-05-19 1995-05-19 Derivati di diarildiammine IT1275433B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITMI951020A IT1275433B (it) 1995-05-19 1995-05-19 Derivati di diarildiammine
ZA963939A ZA963939B (en) 1995-05-19 1996-05-17 Diaryldiamine derivatives
AT96916128T ATE213735T1 (de) 1995-05-19 1996-05-20 Diaryldiamin derivate und ihre verwendung als agonisten/antagonisten des delta opioid rezeptors
EP96916128A EP0825991B1 (en) 1995-05-19 1996-05-20 Diaryldiamine derivatives and their use as delta opioid (ant)-agonists
US08/952,443 US5922887A (en) 1995-05-19 1996-05-20 Diaryldiamine derivatives and their use as delta opiod (ANT)-agonists
PCT/EP1996/002152 WO1996036620A1 (en) 1995-05-19 1996-05-20 Diaryldiamine derivatives and their use as delta opioid (ant)-agonists
TR97/01388T TR199701388T1 (xx) 1995-05-19 1996-05-20 Di- arildiyamin t�revleri ve bunlar�n delta opiovit (ANT)-agonistleri olarak kullan�lmas�.
CA002221380A CA2221380A1 (en) 1995-05-19 1996-05-20 Diaryldiamine derivatives and their use as delta opioid (ant)-agonists
JP53457496A JP3205343B2 (ja) 1995-05-19 1996-05-20 ジアリールジアミン誘導体およびそれらのデルタオピオイド（アント）−アゴニストとしての使用
DE69619512T DE69619512T2 (de) 1995-05-19 1996-05-20 Diaryldiamin derivate und ihre verwendung als agonisten/antagonisten des delta opioid rezeptors
PL96323385A PL323385A1 (en) 1995-05-19 1996-05-20 Diarylamine derivatives and their application as delta opioidic (ant)-agonists
KR1019970708252A KR19990014907A (ko) 1995-05-19 1996-05-20 디아릴디아민 유도체 및 델타 오피오이드 작용 (또는 길항) 물질로서의 그의 용도
AU58998/96A AU5899896A (en) 1995-05-19 1996-05-20 Diaryldiamine derivatives and their use as delta opioid (ant)-agonists
BR9608458A BR9608458A (pt) 1995-05-19 1996-05-20 Derivados diaril diamina e seu uso como (ant) - agonistas delta opióide
ES96916128T ES2171675T3 (es) 1995-05-19 1996-05-20 Derivados de diarildiamina y su uso como (ant)agonistas de los receptores delta opioides.
CZ973652A CZ365297A3 (cs) 1995-05-19 1996-05-20 Diaryldiaminové deriváty a jejich použití jako delta opioidních (ant)-agonistů
CN96195364A CN1190393A (zh) 1995-05-19 1996-05-20 二芳基二胺衍生物及其作为δ－阿片样物质(拮抗)激动剂的用途
HU9802222A HUP9802222A3 (en) 1995-05-19 1996-05-20 Diaryldiamine derivatives, their use as delta opioid agonists/antagonists, and pharmaceuticals containing the same
MXPA/A/1997/008973A MXPA97008973A (en) 1995-05-19 1997-11-18 Diarildiamine erivates and their use as agonistasy delta-opioi antagonists
NO975294A NO975294L (no) 1995-05-19 1997-11-18 Diaryldiaminderivater og deres anvendelse som delta-opioid (ant)-agonister

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI951020A IT1275433B (it) 1995-05-19 1995-05-19 Derivati di diarildiammine

Publications (3)

Publication Number Publication Date
ITMI951020A0 ITMI951020A0 (it) 1995-05-19
ITMI951020A1 ITMI951020A1 (it) 1996-11-19
IT1275433B true IT1275433B (it) 1997-08-07

Family

ID=11371631

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI951020A IT1275433B (it) 1995-05-19 1995-05-19 Derivati di diarildiammine

Country Status (19)

Country Link
US (1) US5922887A (it)
EP (1) EP0825991B1 (it)
JP (1) JP3205343B2 (it)
KR (1) KR19990014907A (it)
CN (1) CN1190393A (it)
AT (1) ATE213735T1 (it)
AU (1) AU5899896A (it)
BR (1) BR9608458A (it)
CA (1) CA2221380A1 (it)
CZ (1) CZ365297A3 (it)
DE (1) DE69619512T2 (it)
ES (1) ES2171675T3 (it)
HU (1) HUP9802222A3 (it)
IT (1) IT1275433B (it)
NO (1) NO975294L (it)
PL (1) PL323385A1 (it)
TR (1) TR199701388T1 (it)
WO (1) WO1996036620A1 (it)
ZA (1) ZA963939B (it)

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US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
KR100559816B1 (ko) * 1996-12-24 2006-03-10 쥬가이 세이야쿠 가부시키가이샤 Ｎｏｓ 저해작용을 가진 방향족 아민 유도체
JPH10338658A (ja) * 1997-04-08 1998-12-22 Hoechst Marion Roussel Kk レチノイド作用調節剤
US6103722A (en) * 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
ZA9811842B (en) * 1997-12-24 2000-06-23 Ortho Mcneil Pharm Inc 4-[aryl(piperidin-4-yl)]aminobenzamides.
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
ES2248281T3 (es) * 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. Derivados de fenoxialquilamina utiles como agonistas del receptor opioide delta.
WO2001070689A1 (en) 2000-03-24 2001-09-27 Meiji Seika Kaisha, Ltd. DIPHENYLALKYLAMINE DERIVATIVES USEFUL AS OPIOID δ RECEPTOR AGONISTS
US20040120979A1 (en) * 2000-06-02 2004-06-24 Roessler Blake J. Delivery systems comprising biocompatible and bioerodable membranes
US6699890B2 (en) * 2000-12-22 2004-03-02 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
US7205320B2 (en) 2001-01-22 2007-04-17 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
RU2354648C2 (ru) 2002-07-19 2009-05-10 Мемори Фармасьютиклз Корпорейшн Соединения 6-амино-1н-индазола и 4-аминобензофурана в качестве ингибиторов фосфодиэстеразы 4
AU2003256616B2 (en) 2002-07-19 2009-08-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
DE10237722A1 (de) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
MXPA05002983A (es) * 2002-09-18 2005-06-22 Univ Missouri Analogos de opiato selectivos del receptor opioide d.
CN100513397C (zh) 2002-11-19 2009-07-15 记忆药物公司 磷酸二酯酶4抑制剂
WO2004080968A1 (en) * 2003-03-07 2004-09-23 Eli Lilly And Company 6-substituted nicotinamide derivatives as opioid receptor antagonists
AU2005287375B8 (en) * 2004-08-25 2009-11-12 The Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
AU2005286733B2 (en) * 2004-09-23 2009-11-05 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20070041934A1 (en) * 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
EP2137656A2 (en) * 2007-04-19 2009-12-30 The Regents of the University of Michigan Dendrimer based compositions and methods of using the same
WO2009151687A2 (en) 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010039861A2 (en) 2008-09-30 2010-04-08 The Regents Of The University Of Michigan Dendrimer conjugates
US9017644B2 (en) 2008-11-07 2015-04-28 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
CA2777682C (en) 2009-10-13 2015-02-24 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules

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US4217452A (en) * 1974-02-09 1980-08-12 Akzona Incorporated Synthesis for the preparation of tetracyclic compounds
FR2376123A1 (fr) * 1977-01-04 1978-07-28 Esteve Intercional Sa Prod Nouveaux derives de 4-tert.butyl-3'-chlorodiphenylamine a activite anti-histaminique, et leur procede de preparation
FR2646847B1 (fr) * 1989-05-12 1991-07-12 Rhone Poulenc Sante N-phenyl amides, leurs procedes de preparation et les medicaments les contenant
DK0613458T3 (da) * 1991-11-12 1998-02-09 Pfizer Acykliske ethylendiaminderivater som substans P receptorantagonister
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds

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CA2221380A1 (en) 1996-11-21
WO1996036620A1 (en) 1996-11-21
JPH11505237A (ja) 1999-05-18
CN1190393A (zh) 1998-08-12
ZA963939B (en) 1997-01-21
NO975294D0 (no) 1997-11-18
NO975294L (no) 1997-11-18
DE69619512D1 (de) 2002-04-04
PL323385A1 (en) 1998-03-30
EP0825991B1 (en) 2002-02-27
HUP9802222A3 (en) 1999-09-28
ATE213735T1 (de) 2002-03-15
EP0825991A1 (en) 1998-03-04
KR19990014907A (ko) 1999-02-25
CZ365297A3 (cs) 1998-06-17
TR199701388T1 (xx) 1998-03-21
JP3205343B2 (ja) 2001-09-04
ITMI951020A0 (it) 1995-05-19
DE69619512T2 (de) 2002-10-31
ITMI951020A1 (it) 1996-11-19
US5922887A (en) 1999-07-13
AU5899896A (en) 1996-11-29
BR9608458A (pt) 1999-01-05
MX9708973A (es) 1998-03-31
ES2171675T3 (es) 2002-09-16
HUP9802222A2 (hu) 1999-07-28

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