IT1266571B1 - Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari - Google Patents

Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Info

Publication number: IT1266571B1
Authority: IT; Italy
Prior art keywords: useful; treatment; cardiovascular diseases; propanamide; mercapto
Prior art date: 1993-07-30

Application number

IT93MI001723A

Other languages

English (en)

Inventor

Gabriele Norcini

Francesco Santangelo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-30

Filing date

1993-07-30

Publication date

1997-01-09

1993-07-30 Application filed by Zambon Spa filed Critical Zambon Spa

1993-07-30 Priority to IT93MI001723A priority Critical patent/IT1266571B1/it

1993-07-30 Publication of ITMI931723A0 publication Critical patent/ITMI931723A0/it

1994-07-25 Priority to DE69402004T priority patent/DE69402004T2/de

1994-07-25 Priority to AT94111584T priority patent/ATE150019T1/de

1994-07-25 Priority to EP94111584A priority patent/EP0636621B1/en

1994-07-27 Priority to US08/281,105 priority patent/US5506259A/en

1995-01-30 Publication of ITMI931723A1 publication Critical patent/ITMI931723A1/it

1997-01-09 Application granted granted Critical

1997-01-09 Publication of IT1266571B1 publication Critical patent/IT1266571B1/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IT93MI001723A 1993-07-30 1993-07-30 Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari IT1266571B1 (it)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
IT93MI001723A IT1266571B1 (it)	1993-07-30	1993-07-30	Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari
DE69402004T DE69402004T2 (de)	1993-07-30	1994-07-25	Beta-mercapto-propanamidderivate verwendbar zur Behandlung kardiovaskularer Krankheiten oder Erkrankungen
AT94111584T ATE150019T1 (de)	1993-07-30	1994-07-25	Beta-mercapto-propanamidderivate verwendbar zur behandlung kardiovaskularer krankheiten oder erkrankungen
EP94111584A EP0636621B1 (en)	1993-07-30	1994-07-25	Beta-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases
US08/281,105 US5506259A (en)	1993-07-30	1994-07-27	β-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT93MI001723A IT1266571B1 (it)	1993-07-30	1993-07-30	Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Publications (3)

Publication Number	Publication Date
ITMI931723A0 ITMI931723A0 (it)	1993-07-30
ITMI931723A1 ITMI931723A1 (it)	1995-01-30
IT1266571B1 true IT1266571B1 (it)	1997-01-09

Family

ID=11366739

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT93MI001723A IT1266571B1 (it)	1993-07-30	1993-07-30	Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Country Status (5)

Country	Link
US (1)	US5506259A (it)
EP (1)	EP0636621B1 (it)
AT (1)	ATE150019T1 (it)
DE (1)	DE69402004T2 (it)
IT (1)	IT1266571B1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19510566A1 (de) *	1995-03-23	1996-09-26	Kali Chemie Pharma Gmbh	Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2745570B1 (fr) *	1996-03-04	1998-06-19	Roussel Uclaf	Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
SE9901573D0 (sv) *	1999-05-03	1999-05-03	Astra Ab	New compounds
US7468390B2 (en)	2002-01-17	2008-12-23	Novartis Ag	Methods of treatment and pharmaceutical composition
AR057882A1 (es)	2005-11-09	2007-12-26	Novartis Ag	Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
EP3943084A1 (en)	2012-08-24	2022-01-26	Novartis AG	Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling
WO2017033128A1 (en)	2015-08-25	2017-03-02	Novartis Ag	Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
US20180311241A1 (en)	2015-10-29	2018-11-01	Cadila Healthcare Limited	Pharmaceutical synergistic combination

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1191109B (it) *	1982-12-03	1988-02-24	Simes	Derivati di acidi aminopiridincarbossilici,loro metodo di sintesi e composizioni farmaceutiche che li contengono
FR2540495B1 (fr) *	1983-02-07	1986-02-14	Roussel Uclaf	Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0136883B1 (en) *	1983-10-03	1987-11-25	E.R. Squibb & Sons, Inc.	Enkephalinase inhibitors
FR2611712B1 (fr) *	1987-02-26	1989-06-23	Roussel Uclaf	Nouveaux derives n-substitues de l'alpha-mercaptomethyl benzene propanamide, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
EP0318859A3 (en) *	1987-12-03	1990-08-16	Dainippon Pharmaceutical Co., Ltd.	N-substituted mercaptopropanamide derivatives
US4879309A (en) *	1988-09-27	1989-11-07	Schering Corporation	Mercapto-acylamino acids as antihypertensives
EP0361365A1 (en) *	1988-09-30	1990-04-04	E.R. SQUIBB & SONS, INC.	Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use
GB9123353D0 (en) *	1991-11-04	1991-12-18	Fujisawa Pharmaceutical Co	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB2272435A (en) *	1992-11-16	1994-05-18	Fujisawa Pharmaceutical Co	WS75624 substances from saccharothrix strain

1993
- 1993-07-30 IT IT93MI001723A patent/IT1266571B1/it active IP Right Grant
1994
- 1994-07-25 EP EP94111584A patent/EP0636621B1/en not_active Expired - Lifetime
- 1994-07-25 DE DE69402004T patent/DE69402004T2/de not_active Expired - Fee Related
- 1994-07-25 AT AT94111584T patent/ATE150019T1/de not_active IP Right Cessation
- 1994-07-27 US US08/281,105 patent/US5506259A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0636621B1 (en)	1997-03-12
ITMI931723A1 (it)	1995-01-30
ATE150019T1 (de)	1997-03-15
US5506259A (en)	1996-04-09
ITMI931723A0 (it)	1993-07-30
DE69402004T2 (de)	1997-06-19
DE69402004D1 (de)	1997-04-17
EP0636621A1 (en)	1995-02-01

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ES2055860T3 (es)	1994-09-01	Derivados 2-aminopirimidinona.
FI920023A0 (fi)	1992-01-03	Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
DK0539204T3 (da)	1998-09-07	Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre
DE68906609D1 (de)	1993-06-24	Dopamin-vorlaeufer.
ATE106403T1 (de)	1994-06-15	Isoxazol-derivate mit anti-serotonin-aktivität, deren herstellungsverfahren und diese enthaltende zusammensetzungen.
SE8404065D0 (sv)	1984-08-10	Novel biologically active compounds
FI944823A0 (fi)	1994-10-13	Galantamiinijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineissa
DE69210091D1 (de)	1996-05-30	Leukotrien-B4-Antagonisten
IT1266571B1 (it)	1997-01-09	Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari
ATE92036T1 (de)	1993-08-15	Kardiovaskulaer aktive verbindungen.
ITMI910456A1 (it)	1992-08-21	Composizione farmaceutica per il trattamento della cataratta
ATE260252T1 (de)	2004-03-15	Thiocolchicin-derivate mit entzündungshemmender und muskelrelaxierender wirkung
IT1266570B1 (it)	1997-01-09	Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari
SE8600658D0 (sv)	1986-02-14	Novel composition of matter
IL108997A0 (en)	1994-06-24	Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
IL89538A0 (en)	1989-09-10	Peptides,their preparation and pharmaceutical compositions containing them
ATE88176T1 (de)	1993-04-15	2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung.
ES2104295T3 (es)	1997-10-01	Derivados ciclopeptidicos de la angiopeptina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ITMI950132A1 (it)	1996-07-29	Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
DE69222143D1 (de)	1997-10-16	Indanderivate
ITMI920082A1 (it)	1993-07-17	Derivati solforati di acidi biliari
IL89537A0 (en)	1989-09-10	Peptides,their preparation and pharmaceutical compositions containing them
IT1277736B1 (it)	1997-11-12	Derivati tiolici ad attivita' inibitrice delle metallopeptidasi

Legal Events

Date	Code	Title	Description
1997-01-09	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970311