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IT1248032B - Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina. - Google Patents

Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina.

Info

Publication number
IT1248032B
IT1248032B ITMI911604A ITMI911604A IT1248032B IT 1248032 B IT1248032 B IT 1248032B IT MI911604 A ITMI911604 A IT MI911604A IT MI911604 A ITMI911604 A IT MI911604A IT 1248032 B IT1248032 B IT 1248032B
Authority
IT
Italy
Prior art keywords
chloroacetyl
amine
dichlorofenyl
fenyl
procedure
Prior art date
Application number
ITMI911604A
Other languages
English (en)
Inventor
Stefano Maiorana
Guido Galliani
Giorgio Chiodini
Original Assignee
Laboratorio Chimico Int Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Chimico Int Spa filed Critical Laboratorio Chimico Int Spa
Priority to ITMI911604A priority Critical patent/IT1248032B/it
Publication of ITMI911604A0 publication Critical patent/ITMI911604A0/it
Priority to AU19253/92A priority patent/AU1925392A/en
Priority to PCT/EP1992/001240 priority patent/WO1992022522A1/en
Priority to ZA924236A priority patent/ZA924236B/xx
Publication of ITMI911604A1 publication Critical patent/ITMI911604A1/it
Application granted granted Critical
Publication of IT1248032B publication Critical patent/IT1248032B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La N-(2,6-diclorofenil)-N-fenil-N-(cloroacetil)-ammina di formula (I): (FORMULA I) (intermedio per la sintesi del Diclofenac) viene preparata mediante trasposizione di N-(2,6-diclorofenossiacetil)-anilina a dare N-(2, 6 diclorofenil)-anilina che, a sua volta, viene trasformata nel prodotto finale per reazione con cloruro di cloroacetile.
ITMI911604A 1991-06-11 1991-06-11 Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina. IT1248032B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI911604A IT1248032B (it) 1991-06-11 1991-06-11 Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina.
AU19253/92A AU1925392A (en) 1991-06-11 1992-06-04 A process for the preparation of n-(2,6-dichlorophenyl)-n-phenyl-n-(chloroacetyl)-amine
PCT/EP1992/001240 WO1992022522A1 (en) 1991-06-11 1992-06-04 A process for the preparation of n-(2,6-dichlorophenyl)-n-phenyl-n-(chloroacetyl)-amine
ZA924236A ZA924236B (en) 1991-06-11 1992-06-10 A process for the preparation of n-(2,6-dichlorophenyl)-n-phenyl-n-(chloroacetyl)-amine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911604A IT1248032B (it) 1991-06-11 1991-06-11 Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina.

Publications (3)

Publication Number Publication Date
ITMI911604A0 ITMI911604A0 (it) 1991-06-11
ITMI911604A1 ITMI911604A1 (it) 1992-12-11
IT1248032B true IT1248032B (it) 1995-01-05

Family

ID=11360092

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911604A IT1248032B (it) 1991-06-11 1991-06-11 Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina.

Country Status (4)

Country Link
AU (1) AU1925392A (it)
IT (1) IT1248032B (it)
WO (1) WO1992022522A1 (it)
ZA (1) ZA924236B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922830D0 (en) * 1999-09-27 1999-11-24 Novartis Ag Processes
CN103130594A (zh) * 2012-07-30 2013-06-05 浙江大学 从酚类化合物出发制备n-芳基和n-烷基芳胺类化合物方法
CN103113236A (zh) * 2013-03-15 2013-05-22 河南东泰制药有限公司 一种2,6-二氯二苯胺的制备方法
CN106905178A (zh) * 2017-04-14 2017-06-30 吉林大学 一种双氯芬酸锌的合成方法
CN113402408A (zh) * 2021-05-31 2021-09-17 河南康达制药有限公司 一种双氯芬酸钠的合成方法
CN114516813B (zh) 2022-02-25 2024-05-28 复旦大学 一种双氯芬酸钠的连续流制备方法
CN114539086B (zh) * 2022-02-25 2023-10-03 复旦大学 一种双氯芬酸钠的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation

Also Published As

Publication number Publication date
WO1992022522A1 (en) 1992-12-23
ITMI911604A0 (it) 1991-06-11
ITMI911604A1 (it) 1992-12-11
AU1925392A (en) 1993-01-12
ZA924236B (en) 1993-03-31

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Legal Events

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0001 Granted