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IT1248032B - PROCEDURE FOR THE PREPARATION OF N- (2,6-DICHLOROFENYL) -N-FENYL-N- (CHLOROACETYL) -AMINE. - Google Patents

PROCEDURE FOR THE PREPARATION OF N- (2,6-DICHLOROFENYL) -N-FENYL-N- (CHLOROACETYL) -AMINE.

Info

Publication number
IT1248032B
IT1248032B ITMI911604A ITMI911604A IT1248032B IT 1248032 B IT1248032 B IT 1248032B IT MI911604 A ITMI911604 A IT MI911604A IT MI911604 A ITMI911604 A IT MI911604A IT 1248032 B IT1248032 B IT 1248032B
Authority
IT
Italy
Prior art keywords
chloroacetyl
amine
dichlorofenyl
fenyl
procedure
Prior art date
Application number
ITMI911604A
Other languages
Italian (it)
Inventor
Stefano Maiorana
Guido Galliani
Giorgio Chiodini
Original Assignee
Laboratorio Chimico Int Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Chimico Int Spa filed Critical Laboratorio Chimico Int Spa
Priority to ITMI911604A priority Critical patent/IT1248032B/en
Publication of ITMI911604A0 publication Critical patent/ITMI911604A0/en
Priority to AU19253/92A priority patent/AU1925392A/en
Priority to PCT/EP1992/001240 priority patent/WO1992022522A1/en
Priority to ZA924236A priority patent/ZA924236B/en
Publication of ITMI911604A1 publication Critical patent/ITMI911604A1/en
Application granted granted Critical
Publication of IT1248032B publication Critical patent/IT1248032B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La N-(2,6-diclorofenil)-N-fenil-N-(cloroacetil)-ammina di formula (I): (FORMULA I) (intermedio per la sintesi del Diclofenac) viene preparata mediante trasposizione di N-(2,6-diclorofenossiacetil)-anilina a dare N-(2, 6 diclorofenil)-anilina che, a sua volta, viene trasformata nel prodotto finale per reazione con cloruro di cloroacetile.The N- (2,6-dichlorophenyl) -N-phenyl-N- (chloroacetyl) -amine of formula (I): (FORMULA I) (intermediate for the synthesis of Diclofenac) is prepared by transposition of N- (2, 6-dichlorophenoxyacetyl) -aniline to give N- (2, 6 dichlorophenyl) -aniline which, in turn, is transformed into the final product by reaction with chloroacetyl chloride.

ITMI911604A 1991-06-11 1991-06-11 PROCEDURE FOR THE PREPARATION OF N- (2,6-DICHLOROFENYL) -N-FENYL-N- (CHLOROACETYL) -AMINE. IT1248032B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI911604A IT1248032B (en) 1991-06-11 1991-06-11 PROCEDURE FOR THE PREPARATION OF N- (2,6-DICHLOROFENYL) -N-FENYL-N- (CHLOROACETYL) -AMINE.
AU19253/92A AU1925392A (en) 1991-06-11 1992-06-04 A process for the preparation of n-(2,6-dichlorophenyl)-n-phenyl-n-(chloroacetyl)-amine
PCT/EP1992/001240 WO1992022522A1 (en) 1991-06-11 1992-06-04 A process for the preparation of n-(2,6-dichlorophenyl)-n-phenyl-n-(chloroacetyl)-amine
ZA924236A ZA924236B (en) 1991-06-11 1992-06-10 A process for the preparation of n-(2,6-dichlorophenyl)-n-phenyl-n-(chloroacetyl)-amine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911604A IT1248032B (en) 1991-06-11 1991-06-11 PROCEDURE FOR THE PREPARATION OF N- (2,6-DICHLOROFENYL) -N-FENYL-N- (CHLOROACETYL) -AMINE.

Publications (3)

Publication Number Publication Date
ITMI911604A0 ITMI911604A0 (en) 1991-06-11
ITMI911604A1 ITMI911604A1 (en) 1992-12-11
IT1248032B true IT1248032B (en) 1995-01-05

Family

ID=11360092

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911604A IT1248032B (en) 1991-06-11 1991-06-11 PROCEDURE FOR THE PREPARATION OF N- (2,6-DICHLOROFENYL) -N-FENYL-N- (CHLOROACETYL) -AMINE.

Country Status (4)

Country Link
AU (1) AU1925392A (en)
IT (1) IT1248032B (en)
WO (1) WO1992022522A1 (en)
ZA (1) ZA924236B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922830D0 (en) * 1999-09-27 1999-11-24 Novartis Ag Processes
CN103130594A (en) * 2012-07-30 2013-06-05 浙江大学 Method preparing N-aryl and N-alkyl aromatic amine type compound from phenol type compound
CN103113236A (en) * 2013-03-15 2013-05-22 河南东泰制药有限公司 Preparation method of 2,6-dichlorodiphenylamine
CN106905178A (en) * 2017-04-14 2017-06-30 吉林大学 A kind of synthetic method of Dic Zn
CN113402408A (en) * 2021-05-31 2021-09-17 河南康达制药有限公司 Method for synthesizing diclofenac sodium
CN114516813B (en) 2022-02-25 2024-05-28 复旦大学 A continuous flow preparation method of diclofenac sodium
CN114539086B (en) * 2022-02-25 2023-10-03 复旦大学 A kind of synthesis method of diclofenac sodium

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation

Also Published As

Publication number Publication date
WO1992022522A1 (en) 1992-12-23
ITMI911604A0 (en) 1991-06-11
ITMI911604A1 (en) 1992-12-11
AU1925392A (en) 1993-01-12
ZA924236B (en) 1993-03-31

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Legal Events

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