IN2014MU00203A - - Google Patents
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- Publication number
- IN2014MU00203A IN2014MU00203A IN203MU2014A IN2014MU00203A IN 2014MU00203 A IN2014MU00203 A IN 2014MU00203A IN 203MU2014 A IN203MU2014 A IN 203MU2014A IN 2014MU00203 A IN2014MU00203 A IN 2014MU00203A
- Authority
- IN
- India
- Prior art keywords
- compound
- trazodone
- preparation
- provides
- hydrochloride
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 5
- 238000002360 preparation method Methods 0.000 abstract 3
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 abstract 2
- 229960002301 trazodone hydrochloride Drugs 0.000 abstract 2
- OHHDIOKRWWOXMT-UHFFFAOYSA-N trazodone hydrochloride Chemical compound [H+].[Cl-].ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 OHHDIOKRWWOXMT-UHFFFAOYSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960003991 trazodone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The present invention provides an improved process for preparation of the substantially pure trazodone and its hydrochloride salt. The process comprises reaction of the compound-II (as described) with the compound-Ill (as described) optionally in the presence of an inorganic base, and a catalyst; wherein in the said process the trazodone free base and/or its hydrochloride salt are isolated by precipitation at lower temperature. The improved process for the preparation of trazodone hydrochloride (the compound I) provides the product with total amount of alkylating substances (as described herein) as impurity in less than 10 ppm. The improved process for the preparation of trazodone hydrochloride (the compound I) provides the product with total amount of l-(3-chlorophenyl)-4-(3-chloropropyl) piperazine as an impurity in less than 2.5 ppm.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14879353.2A EP3097099A4 (en) | 2014-01-21 | 2014-12-12 | An improved process for the preparation of trazodone and hydrochloride salt thereof |
| CA2937417A CA2937417C (en) | 2014-01-21 | 2014-12-12 | An improved process for the preparation of trazodone and hydrochloride salt thereof |
| IN203MU2014 IN2014MU00203A (en) | 2014-01-21 | 2014-12-12 | |
| JP2016547540A JP2017505302A (en) | 2014-01-21 | 2014-12-12 | Improved process for producing trazodone and its hydrochloride |
| PCT/IB2014/066841 WO2015110883A1 (en) | 2014-01-21 | 2014-12-12 | An improved process for the preparation of trazodone and hydrochloride salt thereof |
| IL246835A IL246835A0 (en) | 2014-01-21 | 2016-07-19 | An improved process for the preparation of trazodone and hydrochloride salt thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN203MU2014 IN2014MU00203A (en) | 2014-01-21 | 2014-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MU00203A true IN2014MU00203A (en) | 2015-09-25 |
Family
ID=53680891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN203MU2014 IN2014MU00203A (en) | 2014-01-21 | 2014-12-12 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3097099A4 (en) |
| JP (1) | JP2017505302A (en) |
| CA (1) | CA2937417C (en) |
| IL (1) | IL246835A0 (en) |
| IN (1) | IN2014MU00203A (en) |
| WO (1) | WO2015110883A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL234822B1 (en) | 2017-03-14 | 2020-04-30 | Politechnika Krakowska Im Tadeusza Kosciuszki | Method for obtaining trazodone |
| CN117517545A (en) * | 2023-12-08 | 2024-02-06 | 重庆锐恩医药有限公司 | Method for detecting trazodone hydrochloride related substances |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1066857B (en) * | 1965-12-15 | 1985-03-12 | Acraf | DERIVATIVES OF S IPIAZOLE 4.3 A PYRIDIN AND PROCESSES FOR THEIR PREPARATION |
| US4252806A (en) * | 1979-09-24 | 1981-02-24 | Mead Johnson & Company | Triazoloquinolones |
| HU201324B (en) * | 1988-07-29 | 1990-10-28 | Egyt Gyogyszervegyeszeti Gyar | New process for production of substituated 1,2,4-triasole (4,3-a)-piridin-2 (2h)-on |
| ITMI20071603A1 (en) * | 2007-08-03 | 2009-02-04 | Acraf | TRAZODONE AND CHLORIDATED TRAZODONE IN PURIFIED FORM |
| US20090209550A1 (en) * | 2008-02-20 | 2009-08-20 | Auspex Pharmaceuticals, Inc. | Substituted triazolopyridines |
-
2014
- 2014-12-12 WO PCT/IB2014/066841 patent/WO2015110883A1/en not_active Ceased
- 2014-12-12 EP EP14879353.2A patent/EP3097099A4/en not_active Ceased
- 2014-12-12 JP JP2016547540A patent/JP2017505302A/en active Pending
- 2014-12-12 IN IN203MU2014 patent/IN2014MU00203A/en unknown
- 2014-12-12 CA CA2937417A patent/CA2937417C/en active Active
-
2016
- 2016-07-19 IL IL246835A patent/IL246835A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3097099A4 (en) | 2017-08-23 |
| IL246835A0 (en) | 2016-08-31 |
| CA2937417A1 (en) | 2015-07-30 |
| CA2937417C (en) | 2022-04-12 |
| WO2015110883A1 (en) | 2015-07-30 |
| EP3097099A1 (en) | 2016-11-30 |
| JP2017505302A (en) | 2017-02-16 |
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