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IN2012DN02000A - - Google Patents

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Publication number
IN2012DN02000A
IN2012DN02000A IN2000DEN2012A IN2012DN02000A IN 2012DN02000 A IN2012DN02000 A IN 2012DN02000A IN 2000DEN2012 A IN2000DEN2012 A IN 2000DEN2012A IN 2012DN02000 A IN2012DN02000 A IN 2012DN02000A
Authority
IN
India
Prior art keywords
preparing
salt
formula
intermediates useful
provides processes
Prior art date
Application number
Inventor
Zhang Weijiang
Colson Pierre-Jean
Fass Timothy
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of IN2012DN02000A publication Critical patent/IN2012DN02000A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

The invention provides processes for preparing intermediates useful for preparing compounds of the formula: or a salt thereof, where R1-3 are as defined in the specification.
IN2000DEN2012 2009-09-29 2010-09-28 IN2012DN02000A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24660809P 2009-09-29 2009-09-29
PCT/US2010/050481 WO2011041284A1 (en) 2009-09-29 2010-09-28 Process for preparing biphenyl imidazole compounds

Publications (1)

Publication Number Publication Date
IN2012DN02000A true IN2012DN02000A (en) 2015-07-24

Family

ID=43383440

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2000DEN2012 IN2012DN02000A (en) 2009-09-29 2010-09-28

Country Status (19)

Country Link
US (4) US8188294B2 (en)
EP (1) EP2483246B1 (en)
JP (3) JP5787893B2 (en)
KR (1) KR101750977B1 (en)
CN (2) CN105837511A (en)
AU (1) AU2010300788B2 (en)
BR (1) BR112012007145A8 (en)
CA (1) CA2771160A1 (en)
ES (1) ES2656820T3 (en)
IL (1) IL218003A (en)
IN (1) IN2012DN02000A (en)
MX (1) MX2012003616A (en)
MY (1) MY160382A (en)
NZ (1) NZ598278A (en)
PH (1) PH12012500617A1 (en)
RU (1) RU2552350C2 (en)
TW (1) TWI545114B (en)
WO (1) WO2011041284A1 (en)
ZA (1) ZA201202218B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (en) 2007-04-24 2014-08-11 Theravance Inc Dual-acting antihypertensive agents
RU2013126403A (en) * 2010-11-10 2014-12-20 ТЕРЕВАНС БАЙОФАРМА Р энд Д ИП,ЛЛС CRYSTAL FORMS OF ALCOXYIMIDAZOLE-1-ILMETHYLBIPHENYL CARBOXYLIC ACIDS
CN103664431B (en) * 2013-12-06 2016-11-16 德州学院 A kind of preparation method of aryl-aryl biphenyl compound
CN103664747A (en) * 2013-12-06 2014-03-26 刘雷芳 Preparation method for heterocyclic biphenyl compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
RU2104272C1 (en) * 1991-01-04 1998-02-10 Хехст АГ Imidazole derivatives, method of their synthesis and pharmaceutical composition decreasing blood pressure
CA2058198A1 (en) 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
WO2005023758A2 (en) * 2003-09-04 2005-03-17 Bakulesh Mafatlal Khamar Process for the preparation of losartan potassium form i
WO2007026375A1 (en) * 2005-08-31 2007-03-08 Suven Life Sciences Process for the preparation of losartan
TWI448284B (en) 2007-04-24 2014-08-11 Theravance Inc Dual-acting antihypertensive agents
TW201014830A (en) * 2008-09-30 2010-04-16 Theravance Inc Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid
WO2010045420A1 (en) * 2008-10-16 2010-04-22 Theravance, Inc. Methods for detecting sulfhydryl-containing compounds in a biological test sample

Also Published As

Publication number Publication date
IL218003A0 (en) 2012-04-30
WO2011041284A1 (en) 2011-04-07
EP2483246A1 (en) 2012-08-08
AU2010300788B2 (en) 2014-11-13
NZ598278A (en) 2014-02-28
CN102482229A (en) 2012-05-30
JP2013505961A (en) 2013-02-21
US20110077411A1 (en) 2011-03-31
ZA201202218B (en) 2012-12-27
ES2656820T3 (en) 2018-02-28
MX2012003616A (en) 2012-04-20
TW201124383A (en) 2011-07-16
US9221763B2 (en) 2015-12-29
JP2015042683A (en) 2015-03-05
JP2015044856A (en) 2015-03-12
CN105837511A (en) 2016-08-10
US8188294B2 (en) 2012-05-29
US20130345437A1 (en) 2013-12-26
KR20120093237A (en) 2012-08-22
IL218003A (en) 2016-06-30
TWI545114B (en) 2016-08-11
BR112012007145A8 (en) 2018-02-06
AU2010300788A1 (en) 2012-03-15
US20150038725A1 (en) 2015-02-05
RU2012117812A (en) 2013-11-10
US8889882B2 (en) 2014-11-18
MY160382A (en) 2017-03-15
EP2483246B1 (en) 2017-11-15
PH12012500617A1 (en) 2012-10-22
BR112012007145A2 (en) 2016-08-23
RU2552350C2 (en) 2015-06-10
US20120209008A1 (en) 2012-08-16
CA2771160A1 (en) 2011-04-07
US8541597B2 (en) 2013-09-24
KR101750977B1 (en) 2017-06-26
JP5787893B2 (en) 2015-09-30

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