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IN2012DN06562A - - Google Patents

Info

Publication number
IN2012DN06562A
IN2012DN06562A IN6562DEN2012A IN2012DN06562A IN 2012DN06562 A IN2012DN06562 A IN 2012DN06562A IN 6562DEN2012 A IN6562DEN2012 A IN 6562DEN2012A IN 2012DN06562 A IN2012DN06562 A IN 2012DN06562A
Authority
IN
India
Prior art keywords
synthesis
compounds
general formula
provides
present
Prior art date
Application number
Inventor
Vasselin David
Carly Nicolas
Ates Célal
Original Assignee
Ucb Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Gmbh filed Critical Ucb Pharma Gmbh
Publication of IN2012DN06562A publication Critical patent/IN2012DN06562A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A).
IN6562DEN2012 2010-02-05 2011-02-03 IN2012DN06562A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30174110P 2010-02-05 2010-02-05
PCT/EP2011/051549 WO2011095539A2 (en) 2010-02-05 2011-02-03 Novel process for the preparation of nitrogen substituted aminotetralins derivatives

Publications (1)

Publication Number Publication Date
IN2012DN06562A true IN2012DN06562A (en) 2015-10-23

Family

ID=44118859

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6562DEN2012 IN2012DN06562A (en) 2010-02-05 2011-02-03

Country Status (4)

Country Link
US (1) US8729306B2 (en)
EP (1) EP2531486B1 (en)
IN (1) IN2012DN06562A (en)
WO (1) WO2011095539A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109580792A (en) * 2017-09-28 2019-04-05 安徽省庆云医药股份有限公司 A kind of method of liquid chromatography for separating and determining rotigotine and its optical isomer
CN116359381B (en) * 2023-03-22 2025-11-07 四川青木制药有限公司 Separation method, detection method, rotigotine or pharmaceutical salt composition, pharmaceutical preparation and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018065A1 (en) 1997-10-03 1999-04-15 Chirotech Technology Limited Chiral amines
HK1049156B (en) 1999-11-23 2004-12-10 Ucb Manufacturing Ireland Limited Improved process for preparing nitrogen-substituted aminotetralins
CA2307390C (en) 2000-05-01 2005-06-28 Torcan Chemical Ltd. Enzymatic resolution of aminotetralins
EP1325742A1 (en) 2001-05-08 2003-07-09 Schwarz Pharma Ag Improved transdermal therapeutic system for the treatment of Parkinson's disease
DE10220230A1 (en) 2002-05-06 2003-11-27 Sanol Arznei Schwarz Gmbh Use of Rotigotine to treat restless leg syndrome
DE10334188B4 (en) 2003-07-26 2007-07-05 Schwarz Pharma Ag Use of rotigotine to treat depression
DE10361259A1 (en) 2003-12-24 2005-07-28 Schwarz Pharma Ag Use of Rotigotine in Early Stage Parkinson's Disease to Prevent Further Neuronal Loss
DE102004014841B4 (en) 2004-03-24 2006-07-06 Schwarz Pharma Ag Use of rotigotine for the treatment and prevention of Parkinson-Plus syndrome

Also Published As

Publication number Publication date
EP2531486B1 (en) 2017-06-21
US20120302790A1 (en) 2012-11-29
US8729306B2 (en) 2014-05-20
WO2011095539A2 (en) 2011-08-11
WO2011095539A3 (en) 2011-11-17
EP2531486A2 (en) 2012-12-12

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