IN2012DN03391A - - Google Patents
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- Publication number
- IN2012DN03391A IN2012DN03391A IN3391DEN2012A IN2012DN03391A IN 2012DN03391 A IN2012DN03391 A IN 2012DN03391A IN 3391DEN2012 A IN3391DEN2012 A IN 3391DEN2012A IN 2012DN03391 A IN2012DN03391 A IN 2012DN03391A
- Authority
- IN
- India
- Prior art keywords
- compound
- methyl
- processes
- relates
- luoro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- -1 methyl 2-((2-(2 Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26226309P | 2009-11-18 | 2009-11-18 | |
| PCT/SE2010/051269 WO2011062550A1 (fr) | 2009-11-18 | 2010-11-17 | Composés de benzoimidazole et utilisations de ceux-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN03391A true IN2012DN03391A (fr) | 2015-10-23 |
Family
ID=44059844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3391DEN2012 IN2012DN03391A (fr) | 2009-11-18 | 2010-11-17 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8530467B2 (fr) |
| EP (1) | EP2501697B1 (fr) |
| JP (1) | JP5657018B2 (fr) |
| KR (1) | KR20120113709A (fr) |
| CN (1) | CN102741245B (fr) |
| AR (1) | AR079050A1 (fr) |
| AU (1) | AU2010322478B2 (fr) |
| BR (1) | BR112012011518B8 (fr) |
| CA (1) | CA2777746C (fr) |
| ES (1) | ES2442797T3 (fr) |
| IN (1) | IN2012DN03391A (fr) |
| MX (1) | MX2012005329A (fr) |
| RU (1) | RU2542582C2 (fr) |
| TW (1) | TW201121957A (fr) |
| UY (1) | UY33037A (fr) |
| WO (1) | WO2011062550A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012158117A1 (fr) * | 2011-05-17 | 2012-11-22 | Astrazeneca Ab | Traitements combinés pour le traitement de la douleur |
| WO2014117274A1 (fr) * | 2013-01-31 | 2014-08-07 | Neomed Institute | Composés imidazopyridine et leurs utilisations |
| JP6632127B2 (ja) * | 2013-12-20 | 2020-01-15 | 塩野義製薬株式会社 | トロンボポエチン受容体アゴニスト作用を有する光学活性な化合物およびその中間体の製造方法 |
| EP3981406A1 (fr) * | 2014-07-03 | 2022-04-13 | Afferent Pharmaceuticals Inc. | Procédés et compositions pour traiter les maladies et les affections |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| CN108904507A (zh) * | 2018-02-11 | 2018-11-30 | 赖英杰 | P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用 |
| SG11202106706TA (en) * | 2018-12-29 | 2021-07-29 | Wuhan Ll Science And Technology Development Co Ltd | Heterocyclic compound intermediate, preparation method therefor and application thereof |
| CN113727716A (zh) | 2019-02-25 | 2021-11-30 | 贝卢斯医疗咳嗽病公司 | 采用p2x3调节剂的治疗 |
| WO2021161105A1 (fr) * | 2020-02-14 | 2021-08-19 | Bellus Health Cough Inc. | Modulateurs de p2x3 |
| WO2022033567A1 (fr) * | 2020-08-13 | 2022-02-17 | 上海拓界生物医药科技有限公司 | Dérivés de benzimidazole, leur procédé de préparation et leur utilisation médicale |
| WO2022117062A1 (fr) * | 2020-12-04 | 2022-06-09 | 上海拓界生物医药科技有限公司 | Composés contenant un noyau tricyclique condensé et leur utilisation pharmaceutique |
| CN114478508A (zh) * | 2021-12-31 | 2022-05-13 | 淮北师范大学 | 一种苯并咪唑化合物的结晶形式 |
| WO2023151658A1 (fr) * | 2022-02-11 | 2023-08-17 | 江苏恒瑞医药股份有限公司 | Sel pharmaceutiquement acceptable d'un antagoniste du récepteur p2x3 et son procédé de préparation |
| CN118556054A (zh) * | 2022-02-11 | 2024-08-27 | 江苏恒瑞医药股份有限公司 | 一种p2x3受体拮抗剂的结晶形式及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6026A (en) * | 1849-01-09 | Cast-iron car-wheel | ||
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| WO1997030035A1 (fr) | 1996-02-13 | 1997-08-21 | Zeneca Limited | Derives de la quinazoline utilises comme inhibiteurs du vegf |
| PT885198E (pt) | 1996-03-05 | 2002-06-28 | Astrazeneca Ab | Derivados de 4-anilinoquinazolina |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| BRPI0017548B8 (pt) | 1999-02-10 | 2023-05-02 | Astrazeneca Ab | Composto |
| JP4059671B2 (ja) * | 2000-01-17 | 2008-03-12 | 帝人株式会社 | ベンズイミダゾール誘導体 |
| AU2001258628A1 (en) | 2000-05-31 | 2001-12-11 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| BR0112225A (pt) | 2000-07-07 | 2003-05-06 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto |
| BRPI0515897A (pt) * | 2004-09-24 | 2008-08-12 | Astrazeneca Ab | composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto |
| AR065495A1 (es) * | 2007-03-02 | 2009-06-10 | Schering Corp | Metodos para usar derivados de bencimidazol para tratar o prevenir dolor, diabetes, complicacion diabetica composiciones. |
| US20090099195A1 (en) | 2007-05-08 | 2009-04-16 | Astrazeneca Ab | Therapeutic Compounds 570 |
| JP2011502148A (ja) * | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト |
-
2010
- 2010-11-17 BR BR112012011518A patent/BR112012011518B8/pt active IP Right Grant
- 2010-11-17 CN CN201080061596.6A patent/CN102741245B/zh active Active
- 2010-11-17 ES ES10831876.7T patent/ES2442797T3/es active Active
- 2010-11-17 AU AU2010322478A patent/AU2010322478B2/en active Active
- 2010-11-17 TW TW099139607A patent/TW201121957A/zh unknown
- 2010-11-17 JP JP2012539853A patent/JP5657018B2/ja active Active
- 2010-11-17 AR ARP100104240A patent/AR079050A1/es unknown
- 2010-11-17 WO PCT/SE2010/051269 patent/WO2011062550A1/fr not_active Ceased
- 2010-11-17 IN IN3391DEN2012 patent/IN2012DN03391A/en unknown
- 2010-11-17 MX MX2012005329A patent/MX2012005329A/es active IP Right Grant
- 2010-11-17 KR KR1020127012726A patent/KR20120113709A/ko not_active Withdrawn
- 2010-11-17 CA CA2777746A patent/CA2777746C/fr active Active
- 2010-11-17 EP EP10831876.7A patent/EP2501697B1/fr active Active
- 2010-11-17 RU RU2012124268/04A patent/RU2542582C2/ru active
- 2010-11-18 UY UY0001033037A patent/UY33037A/es not_active Application Discontinuation
-
2012
- 2012-05-16 US US13/472,825 patent/US8530467B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011062550A1 (fr) | 2011-05-26 |
| US8530467B2 (en) | 2013-09-10 |
| ES2442797T3 (es) | 2014-02-13 |
| AR079050A1 (es) | 2011-12-21 |
| JP2013511517A (ja) | 2013-04-04 |
| BR112012011518B8 (pt) | 2023-01-10 |
| MX2012005329A (es) | 2012-05-29 |
| CA2777746C (fr) | 2019-05-14 |
| AU2010322478B2 (en) | 2013-11-14 |
| EP2501697A4 (fr) | 2013-04-24 |
| RU2542582C2 (ru) | 2015-02-20 |
| KR20120113709A (ko) | 2012-10-15 |
| CN102741245A (zh) | 2012-10-17 |
| US20120289504A1 (en) | 2012-11-15 |
| EP2501697B1 (fr) | 2013-10-23 |
| AU2010322478A1 (en) | 2012-05-31 |
| TW201121957A (en) | 2011-07-01 |
| CA2777746A1 (fr) | 2011-05-26 |
| JP5657018B2 (ja) | 2015-01-21 |
| RU2012124268A (ru) | 2013-12-27 |
| UY33037A (es) | 2011-06-30 |
| CN102741245B (zh) | 2014-11-05 |
| BR112012011518A2 (pt) | 2016-06-28 |
| BR112012011518B1 (pt) | 2020-03-10 |
| EP2501697A1 (fr) | 2012-09-26 |
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