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IN2012DN03391A - - Google Patents

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Publication number
IN2012DN03391A
IN2012DN03391A IN3391DEN2012A IN2012DN03391A IN 2012DN03391 A IN2012DN03391 A IN 2012DN03391A IN 3391DEN2012 A IN3391DEN2012 A IN 3391DEN2012A IN 2012DN03391 A IN2012DN03391 A IN 2012DN03391A
Authority
IN
India
Prior art keywords
compound
methyl
processes
relates
luoro
Prior art date
Application number
Inventor
David Cantin Louis
Luo Xuehong
Jerzy Tomaszewski Miroslaw
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IN2012DN03391A publication Critical patent/IN2012DN03391A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This invention generally relates to substituted benzoimidazole compounds, particularly methyl 2-((2-(2,6-di£luoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate and salts thereof. This invention also relates to pharmaceutical compositions and kits comprising such a compound, uses of such a compound (including, for example, treatment methods and medicament preparations), processes for making such a compound, and intermediates used in such processes.
IN3391DEN2012 2009-11-18 2010-11-17 IN2012DN03391A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26226309P 2009-11-18 2009-11-18
PCT/SE2010/051269 WO2011062550A1 (en) 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof

Publications (1)

Publication Number Publication Date
IN2012DN03391A true IN2012DN03391A (en) 2015-10-23

Family

ID=44059844

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3391DEN2012 IN2012DN03391A (en) 2009-11-18 2010-11-17

Country Status (16)

Country Link
US (1) US8530467B2 (en)
EP (1) EP2501697B1 (en)
JP (1) JP5657018B2 (en)
KR (1) KR20120113709A (en)
CN (1) CN102741245B (en)
AR (1) AR079050A1 (en)
AU (1) AU2010322478B2 (en)
BR (1) BR112012011518B8 (en)
CA (1) CA2777746C (en)
ES (1) ES2442797T3 (en)
IN (1) IN2012DN03391A (en)
MX (1) MX2012005329A (en)
RU (1) RU2542582C2 (en)
TW (1) TW201121957A (en)
UY (1) UY33037A (en)
WO (1) WO2011062550A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012158117A1 (en) * 2011-05-17 2012-11-22 Astrazeneca Ab Combination therapies for treating pain
WO2014117274A1 (en) * 2013-01-31 2014-08-07 Neomed Institute Imidazopyridine compounds and uses thereof
JP6632127B2 (en) * 2013-12-20 2020-01-15 塩野義製薬株式会社 Method for producing optically active compound having thrombopoietin receptor agonistic activity and intermediate thereof
EP3981406A1 (en) * 2014-07-03 2022-04-13 Afferent Pharmaceuticals Inc. Methods and compositions for treating diseases and conditions
US10111883B1 (en) * 2017-09-18 2018-10-30 Bellus Health Cough Inc. Selective P2X3 modulators
CN108904507A (en) * 2018-02-11 2018-11-30 赖英杰 P2X3 receptor modulators benzimidazole compound is preparing the application in anti-respiratory disorder drug
SG11202106706TA (en) * 2018-12-29 2021-07-29 Wuhan Ll Science And Technology Development Co Ltd Heterocyclic compound intermediate, preparation method therefor and application thereof
CN113727716A (en) 2019-02-25 2021-11-30 贝卢斯医疗咳嗽病公司 Treatment with P2X3 modulators
WO2021161105A1 (en) * 2020-02-14 2021-08-19 Bellus Health Cough Inc. P2x3 modulators
WO2022033567A1 (en) * 2020-08-13 2022-02-17 上海拓界生物医药科技有限公司 Benzimidazole derivatives, preparation method therefor and medical use thereof
WO2022117062A1 (en) * 2020-12-04 2022-06-09 上海拓界生物医药科技有限公司 Fused tricyclic ring-containing compounds and pharmaceutical use thereof
CN114478508A (en) * 2021-12-31 2022-05-13 淮北师范大学 Crystalline form of a benzimidazole compound
WO2023151658A1 (en) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 Pharmaceutically acceptable salt of p2x3 receptor antagonist and preparation method therefor
CN118556054A (en) * 2022-02-11 2024-08-27 江苏恒瑞医药股份有限公司 Crystalline forms of P2X3 receptor antagonists and methods of making the same

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6026A (en) * 1849-01-09 Cast-iron car-wheel
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
WO1997030035A1 (en) 1996-02-13 1997-08-21 Zeneca Limited Quinazoline derivatives as vegf inhibitors
PT885198E (en) 1996-03-05 2002-06-28 Astrazeneca Ab 4-ANYLINOQUINAZOLINE DERIVATIVES
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
BRPI0017548B8 (en) 1999-02-10 2023-05-02 Astrazeneca Ab COMPOUND
JP4059671B2 (en) * 2000-01-17 2008-03-12 帝人株式会社 Benzimidazole derivatives
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (en) 2000-06-06 2005-10-17 Астразенека Аб Quinazoline derivatives for the treatment of tumours and a pharmaceutical composition
MXPA02012905A (en) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Colchinol derivatives as vascular damaging agents.
BR0112225A (en) 2000-07-07 2003-05-06 Angiogene Pharm Ltd Compound, pharmaceutical composition, use of a compound, and process for preparing a compound
BRPI0515897A (en) * 2004-09-24 2008-08-12 Astrazeneca Ab compound, use thereof, pharmaceutical composition, and method for pain therapy in a warm-blooded animal, and for the preparation of a compound
AR065495A1 (en) * 2007-03-02 2009-06-10 Schering Corp METHODS TO USE BENCIMIDAZOL DERIVATIVES TO TREAT OR PREVENT PAIN, DIABETES, DIABETIC COMPLICATION COMPOSITIONS.
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
JP2011502148A (en) * 2007-10-31 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション P2X3 receptor antagonist for the treatment of pain

Also Published As

Publication number Publication date
WO2011062550A1 (en) 2011-05-26
US8530467B2 (en) 2013-09-10
ES2442797T3 (en) 2014-02-13
AR079050A1 (en) 2011-12-21
JP2013511517A (en) 2013-04-04
BR112012011518B8 (en) 2023-01-10
MX2012005329A (en) 2012-05-29
CA2777746C (en) 2019-05-14
AU2010322478B2 (en) 2013-11-14
EP2501697A4 (en) 2013-04-24
RU2542582C2 (en) 2015-02-20
KR20120113709A (en) 2012-10-15
CN102741245A (en) 2012-10-17
US20120289504A1 (en) 2012-11-15
EP2501697B1 (en) 2013-10-23
AU2010322478A1 (en) 2012-05-31
TW201121957A (en) 2011-07-01
CA2777746A1 (en) 2011-05-26
JP5657018B2 (en) 2015-01-21
RU2012124268A (en) 2013-12-27
UY33037A (en) 2011-06-30
CN102741245B (en) 2014-11-05
BR112012011518A2 (en) 2016-06-28
BR112012011518B1 (en) 2020-03-10
EP2501697A1 (en) 2012-09-26

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