IN2012DN00302A - - Google Patents
Info
- Publication number
- IN2012DN00302A IN2012DN00302A IN302DEN2012A IN2012DN00302A IN 2012DN00302 A IN2012DN00302 A IN 2012DN00302A IN 302DEN2012 A IN302DEN2012 A IN 302DEN2012A IN 2012DN00302 A IN2012DN00302 A IN 2012DN00302A
- Authority
- IN
- India
- Prior art keywords
- enzyme
- mgs
- methylglyoxal synthase
- mutant
- biochemical
- Prior art date
Links
- 102100033598 Triosephosphate isomerase Human genes 0.000 abstract 7
- 108010083856 methylglyoxal synthase Proteins 0.000 abstract 7
- 102000004190 Enzymes Human genes 0.000 abstract 5
- 108090000790 Enzymes Proteins 0.000 abstract 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- XLSMFKSTNGKWQX-UHFFFAOYSA-N hydroxyacetone Chemical compound CC(=O)CO XLSMFKSTNGKWQX-UHFFFAOYSA-N 0.000 abstract 2
- 235000014655 lactic acid Nutrition 0.000 abstract 2
- 239000004310 lactic acid Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 235000013772 propylene glycol Nutrition 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03003—Methylglyoxal synthase (4.2.3.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23007609P | 2009-07-30 | 2009-07-30 | |
| EP09166815 | 2009-07-30 | ||
| PCT/EP2010/061094 WO2011012693A1 (fr) | 2009-07-30 | 2010-07-30 | Méthylglyoxal synthétase (mgs) mutante pour la production d'un agent biochimique par fermentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00302A true IN2012DN00302A (fr) | 2015-05-08 |
Family
ID=41014566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN302DEN2012 IN2012DN00302A (fr) | 2009-07-30 | 2010-07-30 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8497102B2 (fr) |
| EP (1) | EP2459710B1 (fr) |
| JP (1) | JP5913099B2 (fr) |
| KR (1) | KR101771266B1 (fr) |
| CN (1) | CN102575235B (fr) |
| BR (1) | BR112012002153A2 (fr) |
| CA (1) | CA2767962C (fr) |
| IN (1) | IN2012DN00302A (fr) |
| WO (1) | WO2011012693A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2532751A1 (fr) | 2011-06-10 | 2012-12-12 | Metabolic Explorer | Utilisation de promoteurs inductibles dans la production fermentative de 1,2-propanediol |
| AU2012268965A1 (en) | 2011-06-15 | 2013-12-19 | B.R.A.I.N. Biotechnology Research And Information Network Ag | New means and methods for producing propanediol |
| CN104204197A (zh) * | 2011-10-04 | 2014-12-10 | 美国佛罗里达大学研究基金会公司 | 具有d-乳酸脱氢酶活性的甘油脱氢酶变体及其用途 |
| CN104812889B (zh) * | 2012-09-14 | 2018-08-28 | 麦兰特公司 | 通过在低ph下发酵产生有机酸 |
| CN102994577B (zh) * | 2012-10-26 | 2015-01-21 | 上海交通大学 | 微生物细胞转化法生产丙酮醇的方法 |
| JP6446807B2 (ja) * | 2014-03-26 | 2019-01-09 | 三菱ケミカル株式会社 | 微生物を用いた有機化合物の製造方法 |
| US10731137B2 (en) | 2015-09-10 | 2020-08-04 | Metabolic Explorer | Lactaldehyde reductases for the production of 1,2-propanediol |
| EP3342873A1 (fr) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Conversion de méthylglyoxale en hydroxyacétone utilisant des enzymes et applications associées |
| KR102488646B1 (ko) * | 2020-04-02 | 2023-01-16 | 서강대학교산학협력단 | 스트렙-태그를 포함하는 오셔니써머스 프로펀더스 dsm 14977 균주 유래 초고내열성 메틸글라이옥살 합성효소 및 이를 이용한 메틸글라이옥살의 제조 방법 |
| KR102489629B1 (ko) * | 2020-04-02 | 2023-01-18 | 서강대학교산학협력단 | 스트렙-태그를 포함하는 클로스트리디움 디피실리 630 균주 유래 메틸글라이옥살 합성효소 및 이를 이용한 메틸글라이옥살의 제조 방법 |
| CN119709808B (zh) * | 2025-03-03 | 2025-07-25 | 天津科技大学 | 一种以蔗糖为原料合成乳酸单体的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3336051A1 (de) | 1983-10-04 | 1985-04-25 | Maizena Gmbh, 2000 Hamburg | Verfahren zur herstellung von 1,2-propandiol, insbesondere d(-)-1,2-propandiol |
| DE3820040A1 (de) | 1988-06-13 | 1989-12-14 | Henkel Kgaa | Verfahren und vorrichtung zum abtrennen von propylenglykol |
| DE4128692A1 (de) | 1991-08-29 | 1993-03-04 | Henkel Kgaa | Verfahren zum herstellen von acetol |
| US6087140A (en) | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
| WO1999028481A1 (fr) | 1997-02-19 | 1999-06-10 | Wisconsin Alumni Research Foundation | Production microbienne d'hydroxyacetone et de 1,2-propanediol |
| AU2003251381B2 (en) | 2002-05-30 | 2008-04-03 | Natureworks Llc | Fermentation process using specific oxygen uptake rates as a process control |
| US7300787B2 (en) | 2002-07-05 | 2007-11-27 | Archer-Daniels-Midland Company | Lactobacillus strains and use thereof in fermentation for L-lactic acid production |
| KR100864672B1 (ko) | 2003-04-02 | 2008-10-23 | 씨제이제일제당 (주) | 클렙시엘라 뉴모니아를 이용한 1,2-프로판디올의 생산방법 |
| ES2619176T3 (es) | 2003-09-30 | 2017-06-23 | Mitsui Chemicals, Inc. | Biocatalizador para producir ácido D-láctico |
| US20050112737A1 (en) | 2003-11-20 | 2005-05-26 | A. E. Staley Manufacturing Co. | Lactic acid producing yeast |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| WO2005095536A2 (fr) | 2004-03-25 | 2005-10-13 | Suppes Galen J | Procede de production d'alcools inferieurs a partir de glycerol |
| ES2573980T3 (es) | 2005-08-10 | 2016-06-13 | University Of Florida Research Foundation, Inc. | Materiales y métodos para la producción eficaz de ácido láctico |
| US8197645B2 (en) | 2005-12-29 | 2012-06-12 | Basf Aktiengesellschaft | Process for separating propylene glycol from aqueous compositions |
| BRPI0809039A2 (pt) | 2007-03-23 | 2014-09-16 | Metabolic Explorer Sa | Microorganismos metabolicamente projetados úteis para a produção de 1,2-propanodiol |
| US20110262980A1 (en) | 2007-03-23 | 2011-10-27 | Philippe Soucaille | Micro-organisms for the production of acetol obtained by a combination of evolution and rational design |
| EP2142637A1 (fr) | 2007-03-23 | 2010-01-13 | Metabolic Explorer | Micro-organisme obtenu par génie métabolique utile pour produire acétol |
| BRPI0808972B1 (pt) | 2007-03-23 | 2016-11-29 | Metabolic Explorer Sa | método para a preparação de uma cepa de escherichia coli para a produção de 1,2-propanodiol a partir de uma fonte de carbono |
-
2010
- 2010-07-30 EP EP10737072.8A patent/EP2459710B1/fr active Active
- 2010-07-30 CN CN201080043839.3A patent/CN102575235B/zh active Active
- 2010-07-30 BR BR112012002153A patent/BR112012002153A2/pt not_active Application Discontinuation
- 2010-07-30 IN IN302DEN2012 patent/IN2012DN00302A/en unknown
- 2010-07-30 JP JP2012522178A patent/JP5913099B2/ja not_active Expired - Fee Related
- 2010-07-30 KR KR1020127005195A patent/KR101771266B1/ko active Active
- 2010-07-30 CA CA2767962A patent/CA2767962C/fr active Active
- 2010-07-30 WO PCT/EP2010/061094 patent/WO2011012693A1/fr not_active Ceased
- 2010-07-30 US US13/387,095 patent/US8497102B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102575235A (zh) | 2012-07-11 |
| CN102575235B (zh) | 2015-05-20 |
| US20120122166A1 (en) | 2012-05-17 |
| JP5913099B2 (ja) | 2016-04-27 |
| CA2767962C (fr) | 2017-11-28 |
| EP2459710B1 (fr) | 2016-11-09 |
| JP2013500032A (ja) | 2013-01-07 |
| US8497102B2 (en) | 2013-07-30 |
| KR101771266B1 (ko) | 2017-08-24 |
| WO2011012693A1 (fr) | 2011-02-03 |
| BR112012002153A2 (pt) | 2015-09-15 |
| EP2459710A1 (fr) | 2012-06-06 |
| KR20120047276A (ko) | 2012-05-11 |
| CA2767962A1 (fr) | 2011-02-03 |
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