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IN2013CH02295A - - Google Patents

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Publication number
IN2013CH02295A
IN2013CH02295A IN2295CH2013A IN2013CH02295A IN 2013CH02295 A IN2013CH02295 A IN 2013CH02295A IN 2295CH2013 A IN2295CH2013 A IN 2295CH2013A IN 2013CH02295 A IN2013CH02295 A IN 2013CH02295A
Authority
IN
India
Prior art keywords
extruder
excipient
zone
fragments
fragmenting
Prior art date
Application number
Other languages
English (en)
Inventor
Babu Padmanabhan
Suneela Prodduturi
Himadrisen
Original Assignee
Steer Engineering Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2016505932A priority Critical patent/JP6077713B2/ja
Priority to EP14803934.0A priority patent/EP3003682B1/fr
Priority to CN201810660247.4A priority patent/CN109080099B/zh
Priority to US14/888,916 priority patent/US9956709B2/en
Priority to CN201480042104.7A priority patent/CN105899195B/zh
Priority to PCT/IN2014/000358 priority patent/WO2014192026A2/fr
Application filed by Steer Engineering Private Ltd filed Critical Steer Engineering Private Ltd
Priority to EP17203025.6A priority patent/EP3308938B1/fr
Priority to IN2295CH2013 priority patent/IN2013CH02295A/en
Priority to HUE14803934A priority patent/HUE048041T2/hu
Priority to ES14803934T priority patent/ES2778040T3/es
Publication of IN2013CH02295A publication Critical patent/IN2013CH02295A/en
Priority to US15/920,133 priority patent/US10213948B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/04—Particle-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00—Mixing; Kneading
    • B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
    • B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
    • B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
    • B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
    • B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
    • B29B7/482—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00—Mixing; Kneading
    • B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
    • B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
    • B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
    • B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
    • B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
    • B29B7/482—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs
    • B29B7/483—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs the other mixing parts being discs perpendicular to the screw axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00—Mixing; Kneading
    • B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
    • B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
    • B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
    • B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
    • B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
    • B29B7/488—Parts, e.g. casings, sealings; Accessories, e.g. flow controlling or throttling devices
    • B29B7/489—Screws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/405—Intermeshing co-rotating screws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
    • B29C48/80—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the plasticising zone, e.g. by heating cylinders
    • B29C48/82—Cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
    • B29C48/875—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling for achieving a non-uniform temperature distribution, e.g. using barrels having both cooling and heating zones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2091/00—Use of waxes as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN2295CH2013 2013-05-27 2014-05-27 IN2013CH02295A (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP14803934.0A EP3003682B1 (fr) 2013-05-27 2014-05-27 Extrudeuse et procédé pour fragmentation par fusion
CN201810660247.4A CN109080099B (zh) 2013-05-27 2014-05-27 热熔破碎挤出机和方法
US14/888,916 US9956709B2 (en) 2013-05-27 2014-05-27 Hot melt fragmentation extruder and process
CN201480042104.7A CN105899195B (zh) 2013-05-27 2014-05-27 热熔破碎挤出机和方法
PCT/IN2014/000358 WO2014192026A2 (fr) 2013-05-27 2014-05-27 Extrudeuse et procédé pour fragmentation par fusion
JP2016505932A JP6077713B2 (ja) 2013-05-27 2014-05-27 ホットメルト断片化押出機およびプロセス
EP17203025.6A EP3308938B1 (fr) 2013-05-27 2014-05-27 Extrudeuse de fragmentation thermofusible et procédé
IN2295CH2013 IN2013CH02295A (fr) 2013-05-27 2014-05-27
HUE14803934A HUE048041T2 (hu) 2013-05-27 2014-05-27 Forró olvadék-fragmentációs extruder és eljárás
ES14803934T ES2778040T3 (es) 2013-05-27 2014-05-27 Un extrusor y proceso de fragmentación por fusión en caliente
US15/920,133 US10213948B2 (en) 2013-05-27 2018-03-13 Hot melt fragmentation extruder and process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2295CH2013 IN2013CH02295A (fr) 2013-05-27 2014-05-27

Publications (1)

Publication Number Publication Date
IN2013CH02295A true IN2013CH02295A (fr) 2015-10-02

Family

ID=51989490

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2295CH2013 IN2013CH02295A (fr) 2013-05-27 2014-05-27

Country Status (8)

Country Link
US (2) US9956709B2 (fr)
EP (2) EP3308938B1 (fr)
JP (1) JP6077713B2 (fr)
CN (2) CN105899195B (fr)
ES (1) ES2778040T3 (fr)
HU (1) HUE048041T2 (fr)
IN (1) IN2013CH02295A (fr)
WO (1) WO2014192026A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3308938B1 (fr) 2013-05-27 2025-03-19 Steerlife India Private Limited Extrudeuse de fragmentation thermofusible et procédé
US20160244573A1 (en) * 2015-02-20 2016-08-25 Steer Engineering Private Limited Blend having a styrene resin and polyphenylene ether
JP6509153B2 (ja) * 2015-03-23 2019-05-08 スティア エンジニアリング プライベート リミテッド 共回転二軸スクリュー処理装置のための要素
CN105058743B (zh) * 2015-07-24 2018-06-26 广东轻工职业技术学院 头数渐变全程自洁的同向自洁双螺杆挤出机及其加工方法
WO2017021864A1 (fr) * 2015-07-31 2017-02-09 Steerlife India Private Limited Procédé et appareil pour la granulation continue de matériau en poudre
CN109310960B (zh) * 2016-04-22 2022-02-22 斯提尔生命印度私人有限公司 分数叶式加工机及造粒方法
EP3445558B1 (fr) * 2016-04-22 2021-10-27 Steerlife India Private Limited Dispositif de traitement de lobe fractionnaire, et procédé associé pour l'extrusion thermofusible
JP7342303B2 (ja) * 2020-07-14 2023-09-11 ステアライフ・インディア・プライベート・リミテッド 連続造粒システム及び調整顆粒を得るための方法
JP2024516600A (ja) * 2021-04-20 2024-04-16 イエン，ウイリアム，ウインチン 多孔質シート製品並びにその作製方法及び使用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804313D0 (en) 1988-02-24 1988-03-23 Apv Plc Improvements in/relating to mixers
FR2717476B1 (fr) * 1994-03-16 1996-04-19 Rhone Poulenc Chimie Sphérules de coumarine et/ou dérivés et leur procédé d'obtention.
DE19721467A1 (de) * 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
US6783270B1 (en) * 2000-07-31 2004-08-31 Steer Engineering (P) Limited Fractional and higher lobed co-rotating twin-screw elements
US7364755B2 (en) * 2003-07-07 2008-04-29 Synthon Ip Inc. Modified calcium phosphate excipient
MY148074A (en) * 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
EP1832281A1 (fr) 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Procédé pour la production d'une dispersion solide d'un ingredient actif
US20070259070A1 (en) * 2006-05-03 2007-11-08 Joo Song Infra-red curing processes for confectionery coatings
US8951570B2 (en) * 2007-04-26 2015-02-10 Sigmoid Pharma Limited Manufacture of multiple minicapsules
RU2491918C2 (ru) * 2008-07-03 2013-09-10 Новартис Аг Способ грануляции из расплава
US20110063940A1 (en) * 2009-09-14 2011-03-17 Steer Engineering Private Limited Method of extruder operation
WO2011033522A1 (fr) * 2009-09-18 2011-03-24 Steer Information Technologies Pvt. Ltd. Procédé et système de configuration et de visualisation d'une extrudeuse
PL2594138T3 (pl) * 2011-11-17 2016-07-29 Wrigley W M Jun Co Wytłaczany chrupki wyrób cukierniczy
EP2747980B1 (fr) * 2012-02-28 2016-07-20 Steer Engineering Private Limited Élément de mélange d'extrusion
EP3308938B1 (fr) 2013-05-27 2025-03-19 Steerlife India Private Limited Extrudeuse de fragmentation thermofusible et procédé

Also Published As

Publication number Publication date
CN109080099A (zh) 2018-12-25
CN109080099B (zh) 2021-11-09
US20160082640A1 (en) 2016-03-24
EP3308938B1 (fr) 2025-03-19
EP3003682A2 (fr) 2016-04-13
JP6077713B2 (ja) 2017-02-08
US9956709B2 (en) 2018-05-01
US20180200938A1 (en) 2018-07-19
EP3308938A1 (fr) 2018-04-18
HUE048041T2 (hu) 2020-05-28
CN105899195A (zh) 2016-08-24
EP3003682A4 (fr) 2017-04-26
ES2778040T3 (es) 2020-08-07
US10213948B2 (en) 2019-02-26
EP3003682B1 (fr) 2019-11-20
JP2016521155A (ja) 2016-07-21
WO2014192026A2 (fr) 2014-12-04
WO2014192026A3 (fr) 2016-05-12
CN105899195B (zh) 2018-10-19

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