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IL89035A - 1,4-Benzoxazine and 1,4-benzothiazine derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

1,4-Benzoxazine and 1,4-benzothiazine derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL89035A
IL89035A IL8903589A IL8903589A IL89035A IL 89035 A IL89035 A IL 89035A IL 8903589 A IL8903589 A IL 8903589A IL 8903589 A IL8903589 A IL 8903589A IL 89035 A IL89035 A IL 89035A
Authority
IL
Israel
Prior art keywords
phenyl
compound
formula
benzoxazine
dihydro
Prior art date
Application number
IL8903589A
Other languages
English (en)
Other versions
IL89035A0 (en
Inventor
Mario Varasi
Piero Melloni
Maria Antonietta Cervini
Alberto Bonsignori
Roberto Commisso
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IL89035A0 publication Critical patent/IL89035A0/xx
Publication of IL89035A publication Critical patent/IL89035A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL8903589A 1988-02-15 1989-01-23 1,4-Benzoxazine and 1,4-benzothiazine derivatives, their preparation and pharmaceutical compositions containing them IL89035A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888803419A GB8803419D0 (en) 1988-02-15 1988-02-15 1 4-benzoxazine & 1 4-benzothiazine derivatives & process for their preparation

Publications (2)

Publication Number Publication Date
IL89035A0 IL89035A0 (en) 1989-08-15
IL89035A true IL89035A (en) 1994-05-30

Family

ID=10631705

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8903589A IL89035A (en) 1988-02-15 1989-01-23 1,4-Benzoxazine and 1,4-benzothiazine derivatives, their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US5084454A (fr)
EP (1) EP0359790B1 (fr)
JP (1) JPH02503200A (fr)
KR (1) KR900700468A (fr)
CA (1) CA1327575C (fr)
DE (1) DE68910451T2 (fr)
DK (1) DK506289A (fr)
ES (1) ES2012648A6 (fr)
FI (1) FI894798A0 (fr)
GB (1) GB8803419D0 (fr)
GR (1) GR1000373B (fr)
HU (1) HU204517B (fr)
IE (1) IE890464L (fr)
IL (1) IL89035A (fr)
NZ (1) NZ227739A (fr)
PT (1) PT89715B (fr)
RU (1) RU1826968C (fr)
WO (1) WO1989007596A1 (fr)
ZA (1) ZA891107B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
FR2702477B1 (fr) * 1993-03-08 1995-04-28 Synthelabo Dérivés de benzoxazine, leur préparation et leur application en thérapeutique.
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
US5691323A (en) * 1995-05-12 1997-11-25 Merck & Co., Inc. Muscarine antagonists
US6162803A (en) * 1998-04-08 2000-12-19 American Home Products Corp. Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression
JP3201998B2 (ja) * 1998-12-16 2001-08-27 サムソン ジェネラル ケミカルズ カンパニー リミテッド （ｓ）−ベンゾオキサジン誘導体の製造方法及び（ｒ）−ベンゾオキサジン誘導体のラセミ化方法
US6221863B1 (en) 1999-01-07 2001-04-24 American Home Products Corp. 3,4-dihydro-2H-benzo[1,4]oxazine derivatives
WO2000040581A1 (fr) * 1999-01-07 2000-07-13 American Home Products Corporation Derives de la 3,4-dihydro-2h benzo[1,4]oxazine
TW546299B (en) * 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
US6313114B1 (en) 1999-01-07 2001-11-06 American Home Products Corp 3,4-Dihydro-2H-benzo[1,4]oxazinyl-methyl)-[3-(1H-indol-3yl)-alkyl]- amines
US6586433B2 (en) 1999-09-23 2003-07-01 Pharmacia Corporation Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US6544974B2 (en) 1999-09-23 2003-04-08 G.D. Searle & Co. (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity
CN100532369C (zh) * 2003-12-09 2009-08-26 弗·哈夫曼-拉罗切有限公司 苯并噁嗪衍生物及其用途
CN101836993B (zh) 2010-05-20 2011-06-22 山东大学 2，3-二氢-3-羟甲基-6-氨基-[1，4]-苯并噁嗪在制备诱导胚胎干细胞向血管内皮细胞分化药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058980A (en) * 1962-10-16 Substitution products of benzo-
GB2080791B (en) * 1980-06-19 1984-02-22 Erba Farmitalia 1,4-benzoxazines
GB8511526D0 (en) * 1985-05-07 1985-06-12 Hoechst Uk Ltd 1 4 benzodioxin & 1 4 benzoxazine derivatives
EP0233728A1 (fr) * 1986-02-11 1987-08-26 Takeda Chemical Industries, Ltd. Dérivés de 1,4-benzoxazine, leur préparation et leur application

Also Published As

Publication number Publication date
GB8803419D0 (en) 1988-03-16
CA1327575C (fr) 1994-03-08
IL89035A0 (en) 1989-08-15
FI894798A7 (fi) 1989-10-10
DE68910451T2 (de) 1994-03-03
FI894798A0 (fi) 1989-10-10
HU204517B (en) 1992-01-28
NZ227739A (en) 1990-08-28
WO1989007596A1 (fr) 1989-08-24
IE890464L (en) 1989-08-15
JPH02503200A (ja) 1990-10-04
PT89715B (pt) 1994-03-31
RU1826968C (ru) 1993-07-07
DE68910451D1 (de) 1993-12-09
HU891441D0 (en) 1990-01-28
ES2012648A6 (es) 1990-04-01
DK506289D0 (da) 1989-10-12
PT89715A (pt) 1989-10-04
HUT56354A (en) 1991-08-28
DK506289A (da) 1989-10-12
GR1000373B (el) 1992-06-30
KR900700468A (ko) 1990-08-13
EP0359790A1 (fr) 1990-03-28
ZA891107B (en) 1989-10-25
US5084454A (en) 1992-01-28
EP0359790B1 (fr) 1993-11-03

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